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1. 发明申请

US20060094010A1 Methods and compositions for analyzing comprised sample using single nucleotide polymorphism panels 审中-公开
标题翻译：使用单核苷酸多态性面板分析包含样品的方法和组合物
公开(公告)号：US20060094010A1
公开(公告)日：2006-05-04
申请号：US10519224
申请日：2003-06-26
申请人： Robert Giles , Jeanine Baisch , Brian McKeown
发明人： Robert Giles , Jeanine Baisch , Brian McKeown
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6876 , C12Q1/6881 , C12Q2600/156 , C12Q2600/16
摘要： The present invention provides methods and compositions for analyzing compromised nucleic acid samples. The present invention also includes methods of selecting panels and panels of single nucleotide polymorphisms that are selected so as to be outside of tandem repeat regions, and are not genetically linked.
摘要翻译：本发明提供了用于分析受损核酸样品的方法和组合物。本发明还包括选择单核苷酸多态性的面板和面板的方法，所述单核苷酸多态性选择为不在串联重复区域之外，并且不是基因连接的。

2. 发明申请

US20070066585A1 ARYL PHENYLHETEROCYCLYL SULFIDE DERIVATIVES AND THEIR USE AS CELL ADHESION-INHIBITING ANTI-INFLAMMATORY AND IMMUNE-SUPPRESSIVE AGENTS 审中-公开
标题翻译： ARYL苯乙烯基硫化物衍生物及其作为细胞粘附抑制抗炎和免疫抑制剂的用途
公开(公告)号：US20070066585A1
公开(公告)日：2007-03-22
申请号：US11535772
申请日：2006-09-27
申请人： Gary Wang , Sheldon Wang , Robert Giles
发明人： Gary Wang , Sheldon Wang , Robert Giles
IPC分类号： A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/454 , A61K31/40 , A61K31/397 , A61K31/4439
CPC分类号： C07D239/42 , C07D263/48 , C07D277/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12
摘要： The present invention relates to novel heterocyclyl-containing diaryl sulfide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
摘要翻译：本发明涉及可用于治疗炎性和免疫疾病的新型含杂环基的二芳基硫化物，包含这些化合物的药物组合物，以及抑制哺乳动物炎症或抑制免疫应答的方法。

3. 发明授权

US06379064B1 Printer chassis construction 失效
标题翻译：打印机底盘结构
公开(公告)号：US06379064B1
公开(公告)日：2002-04-30
申请号：US09504049
申请日：2000-02-14
申请人： Robert Giles , Jordi Gimenez , Rajan Ramaswamy , Emilio Angulo , Fernando Juan , Ventura Caamano , Richard H Lewis , Antoni Monclus
发明人： Robert Giles , Jordi Gimenez , Rajan Ramaswamy , Emilio Angulo , Fernando Juan , Ventura Caamano , Richard H Lewis , Antoni Monclus
IPC分类号： B41J2325
CPC分类号： B41J29/02
摘要： To assemble a printer chassis comprising three structural aluminium beams extending between two structural sideplates, the printer carriage beam is first attached to the sideplates by means of attachment points arranged along a straight line and then the printing beam and lower beam are attached to provide a vibration- and deformation-resistant chassis relative to which all the other printer components are referenced. Slider rods are mounted on the printer carriage beam by means of screws which hold the rods against the beam to keep them straight. The screws also pass through apertures in rod supports, the apertures being sized to permit longitudinal thermal movements of the rods relative to the beam.
摘要翻译：为了组装包括在两个结构侧板之间延伸的三个结构铝梁的打印机底盘，打印机托架梁首先通过沿着直线布置的附接点附接到侧板，然后连接印刷梁和下梁以提供振动 - 和抗变形的底盘相对于所有其他打印机组件参考。滑动杆通过螺钉安装在打印机托架梁上，螺钉将杆抵靠梁保持直线。螺钉还穿过杆支撑件中的孔，孔的尺寸设定成允许杆相对于梁的纵向热运动。

4. 发明申请

US20070167494A1 Process for preparing a polymorph or rosiglitazone maleate 审中-公开
标题翻译：制备多晶型物或马来酸罗格列酮的方法
公开(公告)号：US20070167494A1
公开(公告)日：2007-07-19
申请号：US10551021
申请日：2004-03-25
申请人： Andrew Craig , Robert Giles , Jonathan Smithers , Tim Ho , Michael Sasse
发明人： Andrew Craig , Robert Giles , Jonathan Smithers , Tim Ho , Michael Sasse
IPC分类号： A61K31/4439 , C07D417/02
CPC分类号： C07D417/12
摘要： A crystallization process for preparing a polymorph of rosiglitazone maleate (Compound 1), and a process for preparing Compound 1 with a polymorphic purity that is suitable for use as a seed material in a crystallization process for preparing Compound 1.
摘要翻译：用于制备马来酸罗格列酮（化合物1）的多晶型物的结晶方法以及制备化合物1的结晶方法中适合用作种子材料的多晶型纯度的化合物1的方法。

5. 发明申请

US20050080114A1 Polymorph of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt 审中-公开
标题翻译： 5- [4- [2-（N-甲基-N-（2-吡啶基）氨基）乙氧基]苄基]噻唑烷-2,4-二酮，马来酸盐的多晶型物
公开(公告)号：US20050080114A1
公开(公告)日：2005-04-14
申请号：US10935939
申请日：2004-09-08
申请人： Paul Blackler , Christine Browne , Timothy Coakley , Robert Giles , Gillian Morrissey
发明人： Paul Blackler , Christine Browne , Timothy Coakley , Robert Giles , Gillian Morrissey
IPC分类号： A61K20060101 , A61K31/00 , A61K31/4439 , A61P20060101 , A61P3/10 , C07D20060101 , C07D417/12 , C07D417/02
CPC分类号： C07D417/12
摘要： A polymorphic form of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, maleic acid salt (the “Polymorph”) characterized in that it provides: (i) an infra red spectrum containing peaks at 1763, 912, 856 and 709 cm−1; and/or (ii) a Raman spectrum containing peaks at 1762, 1284, 912 and 888 cm−1; and/or (iii) a solid-state 13C nuclear magnetic resonance spectrum containing peaks at 111.0, 113.6, 119.8, 129.1, 130.9, 131.8, 134.7, 138.7, 146.5, 152.7, 157.5, 169.5, 171.0, 178.7 ppm; and/or (iv) an X-ray powder diffraction (XRPD) pattern which gives calculated lattice spacings at 5.87, 5.30, 4.69, 4.09, 3.88, 3.61, 3.53, and 3.46 Angstroms; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound in medicine.
摘要翻译： 5- [4- [2-（N-甲基-N-（2-吡啶基）氨基）乙氧基]苄基]噻唑烷-2,4-二酮，马来酸盐（“多晶型”）的多晶形式，其特征在于它提供：（i）在1763,912,856和709cm -1处含有峰的红外光谱; 和/或（ii）在1762,1284,912和888cm -1处含有峰的拉曼光谱; 和/或（iii）在111.0,113.6,119.8,129.1,130.9,131.8,134.7,138.7,146.5,152.7,157.5,169.5,171.0,178.7ppm处含有峰的固态13 C核磁共振光谱; 和/或（iv）在5.87,5.30,4.69,4.09,3.88,3.61,3.53和3.46埃处给出计算的晶格间距的X射线粉末衍射（XRPD）图案; 制备这种化合物的方法，含有这种化合物的药物组合物和这种化合物在医药中的用途。

6. 发明授权

US6139135A Inkjet printing with replaceable set of ink-related components (printhead/service module/ink supply) for each color of ink 失效
标题翻译：喷墨打印可更换的油墨相关组件（打印头/服务模块/墨水供应），用于每种颜色的墨水
公开(公告)号：US6139135A
公开(公告)日：2000-10-31
申请号：US810485
申请日：1997-03-03
申请人： Rick Becker , Brian Canfield , Jesus Garcia , Doug Watson , Don Boutin , Eric Joseph Johnson , Robert Giles , Mark E. Young , Elizabeth Zapata , Felix Ruiz
发明人： Rick Becker , Brian Canfield , Jesus Garcia , Doug Watson , Don Boutin , Eric Joseph Johnson , Robert Giles , Mark E. Young , Elizabeth Zapata , Felix Ruiz
IPC分类号： B41J2/21 , B41J2/175
CPC分类号： B41J2/17523 , B41J2/17509
摘要： An inkjet printing system having a replaceable set of ink-related components which are installed together and replaced together as a single ink delivery system for each different color of ink. The set includes an ink printhead cartridge with an inlet port, an ink supply module, and a printhead service module, each of which is manually mountable by a user onto an inkjet printer. The ink supply module contains enough ink to completely replenish an entire printhead reservoir several times before the expected useful life of the printhead cartridge has expired, at which time a user can replace the entire set of ink-related components for a particular color. Similarly, the printhead service module is designed for reliable performance for the expected useful life of the printhead cartridge. This system enables the entire ink delivery system to be replaced for different printing needs, such as replacing indoor dye-based inks with outdoor pigment based inks.
摘要翻译：一种喷墨打印系统，其具有可替换的与油墨有关的组件的组合，它们一起安装在一起，作为用于每种不同颜色的油墨的单个油墨输送系统。该组件包括具有入口端口的墨水打印头墨盒，墨水供应模块和打印头服务模块，每个打印头服务模块可由用户手动安装到喷墨打印机上。墨水供应模块包含足够的墨水以在打印头墨盒的预期使用寿命期满之前多次完全补充整个打印头存储器，此时用户可以替换特定颜色的整个墨水组件。类似地，打印头服务模块被设计为在打印头墨盒的预期使用寿命期间的可靠性能。该系统使整个墨水输送系统可以替换为不同的打印需求，例如用室外颜料基油墨代替室内染料基油墨。

7. 发明申请

US20060106221A1 Process for the preparation of thiazolidinedione derivatives 审中-公开
标题翻译：噻唑烷二酮衍生物的制备方法
公开(公告)号：US20060106221A1
公开(公告)日：2006-05-18
申请号：US11326003
申请日：2006-01-05
申请人： Robert Giles , Norman Lewis , John Quick
发明人： Robert Giles , Norman Lewis , John Quick
IPC分类号： A61K31/4439 , C07D417/02
CPC分类号： C07D417/12
摘要： A process for preparing a compound of formula (I): or a tautomeric form thereof or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein: A1 represents a substituted or unsubstituted aromatic heterocyclyl group; R1 represents a hydrogen atom, an alkyl group, an acyl group, an aralkyl group, wherein the aryl moiety may be substituted or unsubstituted, or a substituted or unsubstituted aryl group; A2 represents a benzene ring having in total up to five substituents; and n represents an integer in the range of from 2 to 6, which process comprises catalytically reducing a compound of formula (II): wherein A1, R1, A2 and n are as defined in relation to formula (I), characterised in that the reduction reaction is carried out using a hydrogen pressure above 20 psi; and thereafter if required forming a pharmaceutically acceptable salt and/or a pharmaceutically acceptable solvate of the compound of formula (I).
摘要翻译：制备式（I）化合物或其互变异构体或其药学上可接受的盐或其药学上可接受的溶剂合物的方法，其中：A 1表示取代或未取代的芳族杂环基 ; R 1表示氢原子，烷基，酰基，芳烷基，其中芳基部分可以是取代或未取代的，或取代或未取代的芳基; 代表一个总共有五个取代基的苯环; 并且n表示2至6的整数，该方法包括催化还原式（II）的化合物：其中A 1，R 2， SUP> 2和n如关于式（I）所定义，其特征在于还原反应使用高于20psi的氢气压力进行; 然后如果需要，形成式（I）化合物的药学上可接受的盐和/或药学上可接受的溶剂化物。

8. 发明授权

US06315474B1 Automatic paper cutter for large format printer 失效
公开(公告)号：US06315474B1
公开(公告)日：2001-11-13
申请号：US09183872
申请日：1998-10-30
申请人： Robert Giles , David Hermida , Tony Lang
发明人： Robert Giles , David Hermida , Tony Lang
IPC分类号： B41J1502
CPC分类号： B26D5/02 , B26D1/0006 , B26D1/205 , B26D2001/0066 , B41J11/001 , B41J11/706 , Y10T83/7763 , Y10T83/8822
摘要： A paper cutter assembly for a printer/plotter is mounted on the printhead carriage for movement therewith to avoid separate mounting and guide structure. A cutter wheel is mounted in a housing for cam induced movement between a raised inactive position and a lower active position by engagement of a cam element carrier mounted for movement in the cutter housing with structure on the printer chassis. The printer platen has a stationary cutter bar which extends in a channel in the platen transversely of the path of paper movement and has a cutter wheel receiving well at one end of the channel into which the cutter wheel drops without contacting the platen or cutter bar at commencement of a cutting operation. Camming surfaces on the platen engage the side of a cutter drive wheel to move the cutter wheel into engagement with the cutter bar and then to raise the cutter wheel to the proper amount of operational overlap of the cutting edges as the cutter assembly moves across the paper path. The cutter wheel is moved between its inactive and active positions at one side of the media and damage to the cut edge of rollfeed media is prevented by retracting the rollfeed media edge away from the cutter bar as the cutter wheel returns to said one side of the media after a cut.

9. 发明授权

US06241347B1 Inkjet printing with replaceable set of ink-related components (printhead/service module/ink supply) for each color of ink 有权
标题翻译：喷墨打印可更换的油墨相关组件（打印头/服务模块/墨水供应），用于每种颜色的墨水
公开(公告)号：US06241347B1
公开(公告)日：2001-06-05
申请号：US09567839
申请日：2000-05-09
申请人： Rick Becker , Brian Canfield , Jesus Garcia , Doug Watson , Don Boutin , Eric Joseph Johnson , Robert Giles , Mark E. Young , Elizabeth Zapata , Felix Ruiz
发明人： Rick Becker , Brian Canfield , Jesus Garcia , Doug Watson , Don Boutin , Eric Joseph Johnson , Robert Giles , Mark E. Young , Elizabeth Zapata , Felix Ruiz
IPC分类号： B41J2175
CPC分类号： B41J2/17523 , B41J2/17509
摘要： An inkjet printing system having a replaceable set of ink-related components which are installed together and replaced together with a single ink delivery system for each different color of ink. The set includes an ink printhead with an inlet port, an ink supply module, and a printhead service module, each of which is manually mountable by a user onto an inkjet printer. The ink supply module contains enough ink to completely replenish an entire printhead reservoir several times before the expected useful life of the printhead has expired, at which time a user can replace the entire set of ink-related components for a particular color. Similarly, the printhead service module is designed for reliable performance for the expected useful life of the printhead. This system enables the entire ink delivery system to be replaced for different printing needs, such as replacing indoor dye-based inks with outdoor pigment based inks.
摘要翻译：一种喷墨打印系统，其具有可替换的与油墨相关的组件的组合，其与用于每种不同颜色的油墨的单个油墨输送系统一起安装在一起并被替换。该组件包括具有入口端口的墨水打印头，墨水供应模块和打印头服务模块，每个打印头服务模块可由用户手动安装到喷墨打印机上。在打印头的预期使用寿命期满之前，墨水供应模块包含足够的墨水以完全补充整个打印头容器数次，此时用户可以替换特定颜色的整个墨水相关部件。类似地，打印头服务模块被设计为在打印头的预期使用寿命期间的可靠性能。该系统使整个墨水输送系统可以替换为不同的打印需求，例如用室外颜料基油墨代替室内染料基油墨。

10. 发明授权

US06239822B1 Replaceable ink supply module (bag/box/tube/valve) for replenishment of on-carriage inkjet printhead 有权
标题翻译：用于补充托架喷墨打印头的可更换墨水供应模块（袋/盒/管/阀）
公开(公告)号：US06239822B1
公开(公告)日：2001-05-29
申请号：US09539559
申请日：2000-03-31
申请人： Elizabeth Zapata , Mark E. Young , Robert Giles , Felix Ruiz , Rosa Calatayud , Ronald D. Stephens, Jr. , Erich Coiner , Max S. Gunther
发明人： Elizabeth Zapata , Mark E. Young , Robert Giles , Felix Ruiz , Rosa Calatayud , Ronald D. Stephens, Jr. , Erich Coiner , Max S. Gunther
IPC分类号： B41J2175
CPC分类号： B41J2/17546 , B41J2/17506 , B41J2/17509 , B41J2/17513 , B41J2/1752 , B41J2/17523 , B41J2/17566
摘要： A replaceable ink supply module which provides replenishment of an inkjet printhead includes a collapsible bag, an enclosure box, a connective tube, and an on/off valve. These four components are incorporated into a composite sealed system which remains intact during shipment, storage, installation and operation. The collapsible bag is placed inside of the protective enclosure box and has an end-connect outlet permanently attached to one end of the connective tube. The other end of the connective tube carries a permanently attached on/off valve designed for periodic engagement with an inlet valve of an inkjet printhead.
摘要翻译：提供喷墨打印头补充的可更换墨水供应模块包括可折叠袋，外壳盒，连接管和开/关阀。这四个组件被并入复合密封系统，在运输，储存，安装和操作期间保持完整。可折叠袋放置在保护外壳的内部，并且具有永久连接到连接管的一端的端部连接出口。连接管的另一端承载设计成与喷墨打印头的入口阀周期性接合的永久附接的开关阀。

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