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1. 发明申请

US20080300252A1 EMBEDDING ANTIBIOTIC COMPOUNDS IN SOLID POLYMERS 有权
标题翻译：嵌入固体聚合物中的抗生素化合物
公开(公告)号：US20080300252A1
公开(公告)日：2008-12-04
申请号：US12129805
申请日：2008-05-30
申请人： Robert Engel , JaimeLee Iolani Rizzo , Karin Melkonian Fincher , Gary Innocenti
发明人： Robert Engel , JaimeLee Iolani Rizzo , Karin Melkonian Fincher , Gary Innocenti
IPC分类号： A01N43/60 , A01P1/00
CPC分类号： A01N43/90 , A01N25/10 , C08K5/0058 , C08K5/19 , C08K9/08 , A01N33/12 , A01N43/40 , A01N43/60
摘要： The present invention is directed to providing antimicrobial compositions consisting of a polymeric material and, embedded therein, an antimicrobial compound. The antimicrobial compound contains at least one quaternary ammonium group, at least one hydrocarbon chain comprising a minimum of 10 carbon atoms and a maximum of 24 carbon atoms, and one or more anions to balance the charge of the quaternary ammonium groups. The invention is also directed to a method of making antimicrobial compositions containing an antimicrobial compound embedded in a polymeric material.
摘要翻译：本发明涉及提供由聚合物材料组成的抗微生物组合物，并在其中嵌入抗微生物化合物。抗微生物化合物含有至少一个季铵基团，至少一个包含至少10个碳原子和最多24个碳原子的烃链，以及一个或多个平衡季铵基团电荷的阴离子。本发明还涉及制备含有嵌入聚合物材料中的抗微生物化合物的抗微生物组合物的方法。

2. 发明授权

US08470351B2 Embedding antibiotic compounds in solid polymers 有权
标题翻译：将固体聚合物中的抗生素化合物嵌入
公开(公告)号：US08470351B2
公开(公告)日：2013-06-25
申请号：US12129805
申请日：2008-05-30
申请人： Robert Engel , JaimeLee Iolani Rizzo , Karin Melkonian Fincher , Gary Innocenti
发明人： Robert Engel , JaimeLee Iolani Rizzo , Karin Melkonian Fincher , Gary Innocenti
IPC分类号： A01N25/34
CPC分类号： A01N43/90 , A01N25/10 , C08K5/0058 , C08K5/19 , C08K9/08 , A01N33/12 , A01N43/40 , A01N43/60
摘要： The present invention is directed to providing antimicrobial compositions consisting of a polymeric material and, embedded therein, an antimicrobial compound. The antimicrobial compound contains at least one quaternary ammonium group, at least one hydrocarbon chain comprising a minimum of 10 carbon atoms and a maximum of 24 carbon atoms, and one or more anions to balance the charge of the quaternary ammonium groups. The invention is also directed to a method of making antimicrobial compositions containing an antimicrobial compound embedded in a polymeric material.
摘要翻译：本发明涉及提供由聚合物材料组成的抗微生物组合物，并在其中嵌入抗微生物化合物。抗微生物化合物含有至少一个季铵基团，至少一个包含至少10个碳原子和最多24个碳原子的烃链，以及一个或多个平衡季铵基团电荷的阴离子。本发明还涉及制备含有嵌入聚合物材料中的抗微生物化合物的抗微生物组合物的方法。

3. 发明申请

US20080299070A1 Antiviral Compounds 有权
标题翻译：抗病毒化合物
公开(公告)号：US20080299070A1
公开(公告)日：2008-12-04
申请号：US12130303
申请日：2008-05-30
申请人： Robert Engel , JaimeLee Iolani Rizzo , Karin Melkonian Fincher
发明人： Robert Engel , JaimeLee Iolani Rizzo , Karin Melkonian Fincher
IPC分类号： A61K31/785 , A61P31/12
CPC分类号： A61K31/785 , A01N43/90 , D06M13/477 , D06M16/00 , A01N25/34 , A01N2300/00
摘要： The present invention relates to novel antiviral compounds which are covalently attached to solid, macro surfaces. In another embodiment, the invention relates to novel antiviral compositions including a polymeric material and, embedded therein, an antiviral compound. In other embodiments, the invention relates to making a surface antiviral and making a polymeric material antiviral.
摘要翻译：本发明涉及共价连接到固体宏观表面上的新的抗病毒化合物。在另一个实施方案中，本发明涉及新型抗病毒组合物，包括聚合物材料，并且其中嵌入有抗病毒化合物。在其它实施方案中，本发明涉及制备表面抗病毒剂并制备抗病毒的聚合物材料。

4. 发明授权

US08999316B2 Antiviral compounds 有权
标题翻译：抗病毒化合物
公开(公告)号：US08999316B2
公开(公告)日：2015-04-07
申请号：US12130303
申请日：2008-05-30
申请人： Robert Engel , JaimeLee Iolani Rizzo , Karin Melkonian Fincher
发明人： Robert Engel , JaimeLee Iolani Rizzo , Karin Melkonian Fincher
IPC分类号： A61K31/785 , A61P31/12 , A01N43/90 , D06M13/477 , D06M16/00
CPC分类号： A61K31/785 , A01N43/90 , D06M13/477 , D06M16/00 , A01N25/34 , A01N2300/00
摘要： The present invention relates to novel antiviral compounds which are covalently attached to solid, macro surfaces. In another embodiment, the invention relates to novel antiviral compositions including a polymeric material and, embedded therein, an antiviral compound. In other embodiments, the invention relates to making a surface antiviral and making a polymeric material antiviral.
摘要翻译：本发明涉及共价连接到固体宏观表面上的新的抗病毒化合物。在另一个实施方案中，本发明涉及新型抗病毒组合物，包括聚合物材料，并且其中嵌入有抗病毒化合物。在其它实施方案中，本发明涉及制备表面抗病毒剂并制备抗病毒的聚合物材料。

5. 发明申请

US20100179156A1 Antimicrobial compositions 审中-公开
标题翻译：抗微生物组合物
公开(公告)号：US20100179156A1
公开(公告)日：2010-07-15
申请号：US12310636
申请日：2007-08-28
申请人： Robert Engel , JaimeLee Iolani Rizzo , Karin Melkonian Fincher
发明人： Robert Engel , JaimeLee Iolani Rizzo , Karin Melkonian Fincher
IPC分类号： A01N43/60 , C07D487/08 , A01P1/00
CPC分类号： A61K31/4995 , A61K31/787
摘要： The present invention is directed to providing antimicrobial surfaces containing 1,4-diazoniabicyclo[2.2.2]octane and hydrocarbon groups and/or chains. More specifically, the present invention is directed to antimicrobial compositions wherein the hydroxyl groups on polyols are replaced by 1,4-diazoniabicyclo[2.2.2]octane. The invention is also directed to methods of making antimicrobial compositions containing polyols.
摘要翻译：本发明涉及提供含有1,4-二氮鎓双环[2.2.2]辛烷和烃基和/或链的抗微生物表面。更具体地，本发明涉及抗微生物组合物，其中多元醇上的羟基被1,4-二氮鎓双环[2.2.2]辛烷替代。本发明还涉及制备含多元醇的抗微生物组合物的方法。

6. 发明授权

US07285286B2 Antimicrobial surfaces 有权
标题翻译：抗菌面
公开(公告)号：US07285286B2
公开(公告)日：2007-10-23
申请号：US11420666
申请日：2006-05-26
申请人： Robert Engel , JaimeLee Iolani Cohen , Karin Melkonian Fincher
发明人： Robert Engel , JaimeLee Iolani Cohen , Karin Melkonian Fincher
IPC分类号： A01N24/34
CPC分类号： D06M13/338 , A01N25/34 , A01N33/12 , A01N43/32 , A01N57/34 , D06M13/285 , D06M13/46 , D21H21/36 , A01N25/10 , A01N2300/00
摘要： The invention relates to an antimicrobial surface having the formula SS−(V+2−W)X wherein: SS represents a solid surface, said solid surface comprising hydroxyl groups attached to a carbon atom in the unmodified state thereof; V+2 represents a doubly positively charged moiety having the formula —+NR2-T-NR2+—, or 1,4-diazoniabicyclo[2.2.2]octane; T represents a saturated or unsaturated straight-chain hydrocarbon having 1-24 carbon atoms; R represents a saturated or unsaturated hydrocarbon group having 1-24 carbon atoms; phenyl; or benzyl; W represents a saturated or unsaturated straight-chain hydrocarbon having 10-24 carbon atoms; and X represents an anion that balances the charge of V wherein a nitrogen atom of V replaces at least some of the hydroxyl groups.
摘要翻译：本发明涉及一种抗微生物表面，其具有式<βin-line-formula description =“In-line Formulas”end =“lead”→> SS-（V SUP +2W）其中：SS表示固体表面，所述固体表面包含在未改性状态下连接到碳原子上的羟基; V 2 + 2表示具有下式的双正电荷的部分： - NR 2 -T-NR 2 - 或1,4-二氮鎓双环[2.2.2]辛烷; T表示具有1-24个碳原子的饱和或不饱和直链烃; R表示具有1-24个碳原子的饱和或不饱和烃基; 苯基; 或苄基; W表示具有10-24个碳原子的饱和或不饱和直链烃; 并且X表示平衡V的电荷的阴离子，其中V的氮原子取代至少一些羟基。

7. 发明授权

US07241453B2 Antimicrobial surfaces 有权
标题翻译：抗菌面
公开(公告)号：US07241453B2
公开(公告)日：2007-07-10
申请号：US10117311
申请日：2002-04-05
申请人： Robert Engel , JaimeLee Iolani Cohen , Karin Melkonian Fincher
发明人： Robert Engel , JaimeLee Iolani Cohen , Karin Melkonian Fincher
IPC分类号： A01N24/34
CPC分类号： D06M13/338 , A01N25/34 , A01N33/12 , A01N43/32 , A01N57/34 , D06M13/285 , D06M13/46 , D21H21/36 , A01N25/10 , A01N2300/00
摘要： These and other objectives will be apparent to those having ordinary skill in the art have been achieved by providing an antimicrobial surface having formula 1: SS—(Ua—V+b1—W)b2dX−eformula 1 wherein: SS represents a modified solid surface that comprises a hydroxyl group in the unmodified state thereof; a represents 0 or 1; U represents —Y1T-; Y1 represents —O—, —S—, or —NQ-; Q represents H; a saturated or unsaturated hydrocarbon group having 1-24 atoms; phenyl; or benzyl; T represents a saturated or unsaturated hydrocarbon chain having 1-24 atoms; V represents a positively charged moiety; b1 represents 1 or 2; b2 represents 1-3; W represents LZ; L represents a saturated or unsaturated hydrocarbon chain having 10-24 atoms; Z represents —H, —OH, —SH, —F, —Cl, —Br, —I, —OR, —HN(O)CQ, or —O(O)CQ; R represents a saturated or unsaturated hydrocarbon group having 1-24 carbon atoms; phenyl; or benzyl; X represents an anion; d represents 1 or 2; and e represents 1-3; wherein b1×b2=d×e.
摘要翻译：通过提供具有式1的抗微生物表面已经实现了本领域普通技术人员的这些和其它目的：<？in-line-formula description =“In-line formula”end =“lead”？> SS 式（1）式（1）其中，式（1）其中， -formulae description =“In-line Formulas”end =“tail”？>其中：SS表示包含未改性状态的羟基的改性固体表面; a表示0或1; U表示-Y 1→T; Y 1表示-O - ， - S-或-NQ-; Q表示H; 具有1-24个原子的饱和或不饱和烃基; 苯基; 或苄基; T表示具有1-24个原子的饱和或不饱和烃链; V表示带正电的部分; b1表示1或2; b2表示1-3; W表示LZ; L表示具有10-24个原子的饱和或不饱和烃链; Z表示-H，-OH，-SH，-F，-Cl，-Br，-I，-OR，-HN（O）CQ或-O（O） R表示具有1-24个碳原子的饱和或不饱和烃基; 苯基; 或苄基; X表示阴离子; d表示1或2; e表示1-3; 其中b1xb2 = dxe。

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