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1. 发明授权

US07285286B2 Antimicrobial surfaces 有权
标题翻译：抗菌面
公开(公告)号：US07285286B2
公开(公告)日：2007-10-23
申请号：US11420666
申请日：2006-05-26
申请人： Robert Engel , JaimeLee Iolani Cohen , Karin Melkonian Fincher
发明人： Robert Engel , JaimeLee Iolani Cohen , Karin Melkonian Fincher
IPC分类号： A01N24/34
CPC分类号： D06M13/338 , A01N25/34 , A01N33/12 , A01N43/32 , A01N57/34 , D06M13/285 , D06M13/46 , D21H21/36 , A01N25/10 , A01N2300/00
摘要： The invention relates to an antimicrobial surface having the formula SS−(V+2−W)X wherein: SS represents a solid surface, said solid surface comprising hydroxyl groups attached to a carbon atom in the unmodified state thereof; V+2 represents a doubly positively charged moiety having the formula —+NR2-T-NR2+—, or 1,4-diazoniabicyclo[2.2.2]octane; T represents a saturated or unsaturated straight-chain hydrocarbon having 1-24 carbon atoms; R represents a saturated or unsaturated hydrocarbon group having 1-24 carbon atoms; phenyl; or benzyl; W represents a saturated or unsaturated straight-chain hydrocarbon having 10-24 carbon atoms; and X represents an anion that balances the charge of V wherein a nitrogen atom of V replaces at least some of the hydroxyl groups.
摘要翻译：本发明涉及一种抗微生物表面，其具有式<βin-line-formula description =“In-line Formulas”end =“lead”→> SS-（V SUP +2W）其中：SS表示固体表面，所述固体表面包含在未改性状态下连接到碳原子上的羟基; V 2 + 2表示具有下式的双正电荷的部分： - NR 2 -T-NR 2 - 或1,4-二氮鎓双环[2.2.2]辛烷; T表示具有1-24个碳原子的饱和或不饱和直链烃; R表示具有1-24个碳原子的饱和或不饱和烃基; 苯基; 或苄基; W表示具有10-24个碳原子的饱和或不饱和直链烃; 并且X表示平衡V的电荷的阴离子，其中V的氮原子取代至少一些羟基。

2. 发明授权

US07241453B2 Antimicrobial surfaces 有权
标题翻译：抗菌面
公开(公告)号：US07241453B2
公开(公告)日：2007-07-10
申请号：US10117311
申请日：2002-04-05
申请人： Robert Engel , JaimeLee Iolani Cohen , Karin Melkonian Fincher
发明人： Robert Engel , JaimeLee Iolani Cohen , Karin Melkonian Fincher
IPC分类号： A01N24/34
CPC分类号： D06M13/338 , A01N25/34 , A01N33/12 , A01N43/32 , A01N57/34 , D06M13/285 , D06M13/46 , D21H21/36 , A01N25/10 , A01N2300/00
摘要： These and other objectives will be apparent to those having ordinary skill in the art have been achieved by providing an antimicrobial surface having formula 1: SS—(Ua—V+b1—W)b2dX−eformula 1 wherein: SS represents a modified solid surface that comprises a hydroxyl group in the unmodified state thereof; a represents 0 or 1; U represents —Y1T-; Y1 represents —O—, —S—, or —NQ-; Q represents H; a saturated or unsaturated hydrocarbon group having 1-24 atoms; phenyl; or benzyl; T represents a saturated or unsaturated hydrocarbon chain having 1-24 atoms; V represents a positively charged moiety; b1 represents 1 or 2; b2 represents 1-3; W represents LZ; L represents a saturated or unsaturated hydrocarbon chain having 10-24 atoms; Z represents —H, —OH, —SH, —F, —Cl, —Br, —I, —OR, —HN(O)CQ, or —O(O)CQ; R represents a saturated or unsaturated hydrocarbon group having 1-24 carbon atoms; phenyl; or benzyl; X represents an anion; d represents 1 or 2; and e represents 1-3; wherein b1×b2=d×e.
摘要翻译：通过提供具有式1的抗微生物表面已经实现了本领域普通技术人员的这些和其它目的：<？in-line-formula description =“In-line formula”end =“lead”？> SS 式（1）式（1）其中，式（1）其中， -formulae description =“In-line Formulas”end =“tail”？>其中：SS表示包含未改性状态的羟基的改性固体表面; a表示0或1; U表示-Y 1→T; Y 1表示-O - ， - S-或-NQ-; Q表示H; 具有1-24个原子的饱和或不饱和烃基; 苯基; 或苄基; T表示具有1-24个原子的饱和或不饱和烃链; V表示带正电的部分; b1表示1或2; b2表示1-3; W表示LZ; L表示具有10-24个原子的饱和或不饱和烃链; Z表示-H，-OH，-SH，-F，-Cl，-Br，-I，-OR，-HN（O）CQ或-O（O） R表示具有1-24个碳原子的饱和或不饱和烃基; 苯基; 或苄基; X表示阴离子; d表示1或2; e表示1-3; 其中b1xb2 = dxe。

3. 发明申请

US20080300252A1 EMBEDDING ANTIBIOTIC COMPOUNDS IN SOLID POLYMERS 有权
标题翻译：嵌入固体聚合物中的抗生素化合物
公开(公告)号：US20080300252A1
公开(公告)日：2008-12-04
申请号：US12129805
申请日：2008-05-30
申请人： Robert Engel , JaimeLee Iolani Rizzo , Karin Melkonian Fincher , Gary Innocenti
发明人： Robert Engel , JaimeLee Iolani Rizzo , Karin Melkonian Fincher , Gary Innocenti
IPC分类号： A01N43/60 , A01P1/00
CPC分类号： A01N43/90 , A01N25/10 , C08K5/0058 , C08K5/19 , C08K9/08 , A01N33/12 , A01N43/40 , A01N43/60
摘要： The present invention is directed to providing antimicrobial compositions consisting of a polymeric material and, embedded therein, an antimicrobial compound. The antimicrobial compound contains at least one quaternary ammonium group, at least one hydrocarbon chain comprising a minimum of 10 carbon atoms and a maximum of 24 carbon atoms, and one or more anions to balance the charge of the quaternary ammonium groups. The invention is also directed to a method of making antimicrobial compositions containing an antimicrobial compound embedded in a polymeric material.
摘要翻译：本发明涉及提供由聚合物材料组成的抗微生物组合物，并在其中嵌入抗微生物化合物。抗微生物化合物含有至少一个季铵基团，至少一个包含至少10个碳原子和最多24个碳原子的烃链，以及一个或多个平衡季铵基团电荷的阴离子。本发明还涉及制备含有嵌入聚合物材料中的抗微生物化合物的抗微生物组合物的方法。

4. 发明申请

US20080299070A1 Antiviral Compounds 有权
标题翻译：抗病毒化合物
公开(公告)号：US20080299070A1
公开(公告)日：2008-12-04
申请号：US12130303
申请日：2008-05-30
申请人： Robert Engel , JaimeLee Iolani Rizzo , Karin Melkonian Fincher
发明人： Robert Engel , JaimeLee Iolani Rizzo , Karin Melkonian Fincher
IPC分类号： A61K31/785 , A61P31/12
CPC分类号： A61K31/785 , A01N43/90 , D06M13/477 , D06M16/00 , A01N25/34 , A01N2300/00
摘要： The present invention relates to novel antiviral compounds which are covalently attached to solid, macro surfaces. In another embodiment, the invention relates to novel antiviral compositions including a polymeric material and, embedded therein, an antiviral compound. In other embodiments, the invention relates to making a surface antiviral and making a polymeric material antiviral.
摘要翻译：本发明涉及共价连接到固体宏观表面上的新的抗病毒化合物。在另一个实施方案中，本发明涉及新型抗病毒组合物，包括聚合物材料，并且其中嵌入有抗病毒化合物。在其它实施方案中，本发明涉及制备表面抗病毒剂并制备抗病毒的聚合物材料。

5. 发明授权

US08999316B2 Antiviral compounds 有权
标题翻译：抗病毒化合物
公开(公告)号：US08999316B2
公开(公告)日：2015-04-07
申请号：US12130303
申请日：2008-05-30
申请人： Robert Engel , JaimeLee Iolani Rizzo , Karin Melkonian Fincher
发明人： Robert Engel , JaimeLee Iolani Rizzo , Karin Melkonian Fincher
IPC分类号： A61K31/785 , A61P31/12 , A01N43/90 , D06M13/477 , D06M16/00
CPC分类号： A61K31/785 , A01N43/90 , D06M13/477 , D06M16/00 , A01N25/34 , A01N2300/00
摘要： The present invention relates to novel antiviral compounds which are covalently attached to solid, macro surfaces. In another embodiment, the invention relates to novel antiviral compositions including a polymeric material and, embedded therein, an antiviral compound. In other embodiments, the invention relates to making a surface antiviral and making a polymeric material antiviral.
摘要翻译：本发明涉及共价连接到固体宏观表面上的新的抗病毒化合物。在另一个实施方案中，本发明涉及新型抗病毒组合物，包括聚合物材料，并且其中嵌入有抗病毒化合物。在其它实施方案中，本发明涉及制备表面抗病毒剂并制备抗病毒的聚合物材料。

6. 发明授权

US08470351B2 Embedding antibiotic compounds in solid polymers 有权
标题翻译：将固体聚合物中的抗生素化合物嵌入
公开(公告)号：US08470351B2
公开(公告)日：2013-06-25
申请号：US12129805
申请日：2008-05-30
申请人： Robert Engel , JaimeLee Iolani Rizzo , Karin Melkonian Fincher , Gary Innocenti
发明人： Robert Engel , JaimeLee Iolani Rizzo , Karin Melkonian Fincher , Gary Innocenti
IPC分类号： A01N25/34
CPC分类号： A01N43/90 , A01N25/10 , C08K5/0058 , C08K5/19 , C08K9/08 , A01N33/12 , A01N43/40 , A01N43/60
摘要： The present invention is directed to providing antimicrobial compositions consisting of a polymeric material and, embedded therein, an antimicrobial compound. The antimicrobial compound contains at least one quaternary ammonium group, at least one hydrocarbon chain comprising a minimum of 10 carbon atoms and a maximum of 24 carbon atoms, and one or more anions to balance the charge of the quaternary ammonium groups. The invention is also directed to a method of making antimicrobial compositions containing an antimicrobial compound embedded in a polymeric material.
摘要翻译：本发明涉及提供由聚合物材料组成的抗微生物组合物，并在其中嵌入抗微生物化合物。抗微生物化合物含有至少一个季铵基团，至少一个包含至少10个碳原子和最多24个碳原子的烃链，以及一个或多个平衡季铵基团电荷的阴离子。本发明还涉及制备含有嵌入聚合物材料中的抗微生物化合物的抗微生物组合物的方法。

7. 发明申请

US20100179156A1 Antimicrobial compositions 审中-公开
标题翻译：抗微生物组合物
公开(公告)号：US20100179156A1
公开(公告)日：2010-07-15
申请号：US12310636
申请日：2007-08-28
申请人： Robert Engel , JaimeLee Iolani Rizzo , Karin Melkonian Fincher
发明人： Robert Engel , JaimeLee Iolani Rizzo , Karin Melkonian Fincher
IPC分类号： A01N43/60 , C07D487/08 , A01P1/00
CPC分类号： A61K31/4995 , A61K31/787
摘要： The present invention is directed to providing antimicrobial surfaces containing 1,4-diazoniabicyclo[2.2.2]octane and hydrocarbon groups and/or chains. More specifically, the present invention is directed to antimicrobial compositions wherein the hydroxyl groups on polyols are replaced by 1,4-diazoniabicyclo[2.2.2]octane. The invention is also directed to methods of making antimicrobial compositions containing polyols.
摘要翻译：本发明涉及提供含有1,4-二氮鎓双环[2.2.2]辛烷和烃基和/或链的抗微生物表面。更具体地，本发明涉及抗微生物组合物，其中多元醇上的羟基被1,4-二氮鎓双环[2.2.2]辛烷替代。本发明还涉及制备含多元醇的抗微生物组合物的方法。

8. 发明申请

US20100106349A1 METHOD FOR NAVIGATING AN UNDERSEA VEHICLE 有权
标题翻译：用于航行下车的方法
公开(公告)号：US20100106349A1
公开(公告)日：2010-04-29
申请号：US12531834
申请日：2008-02-07
申请人： Dirk Rathjen , Armin Schmiegel , Robert Engel
发明人： Dirk Rathjen , Armin Schmiegel , Robert Engel
IPC分类号： G05D1/04 , G01C21/00 , G01S5/18
CPC分类号： G01S15/025 , G01C21/00 , G01S5/186
摘要： In a method for navigating an undersea vehicle (12), navigation data about position, orientation, and absolute vehicle speed of the undersea vehicle (12) are determined from measurement data delivered by navigation sensors (17) via a navigation filter (18) which incorporates the measurement values of a Doppler log (14). To achieve a highly accurate tracking of the course taken by the undersea vehicle (12), particularly during submerging and surfacing phases, the stretch of water (10) traversed by the undersea vehicle (12) is divided into regions (13) which at least in the vertically oriented z-axis have a finite dimension within a Cartesian coordinate system (11). During the voyage of the undersea vehicle (12), the flow rates in the stretch of water (10) in relation to the individual spatial layers (13) are determined and stored from the relative vehicle speeds measured by the Doppler log (14) in successive measurement processes, and from the absolute vehicle speeds issued continuously by the navigation filter (18). The stored flow rates are input into the navigation filter (18) (FIG. 1) in accordance with the respective spatial layer (13) reached by the undersea vehicle (12).
摘要翻译：在用于导航水下车辆（12）的方法中，从由导航传感器（17）经由导航过滤器（18）传送的测量数据确定关于水下车辆（12）的位置，方向和绝对车辆速度的导航数据，导航过滤器（18）并入多普勒日志的测量值（14）。为了实现对海底车辆（12）所采取的过程的高度精确跟踪，特别是在浸没和铺面阶段期间，由水下车辆（12）穿过的水（10）的伸展被分成至少至少在垂直取向的z轴中，在笛卡尔坐标系（11）内具有有限的尺寸。在海底车辆（12）的航行期间，根据多普勒日志（14）测量的相对车辆速度来确定和存储相对于各个空间层（13）的水（10）的流速连续的测量过程，以及由导航过滤器（18）连续发出的绝对车辆速度。存储的流量根据由水下车辆（12）到达的相应的空间层（13）被输入到导航过滤器（18）（图1）中。

9. 发明授权

US06519636B2 Efficient classification, manipulation, and control of network transmissions by associating network flows with rule based functions 失效
标题翻译：通过将网络流量与基于规则的功能相关联，有效地分类，操纵和控制网络传输
公开(公告)号：US06519636B2
公开(公告)日：2003-02-11
申请号：US09181376
申请日：1998-10-28
申请人： Robert Engel , Tsipora P. Barzilai , Dilip Dinkar Kandlur , Ashish Mehra
发明人： Robert Engel , Tsipora P. Barzilai , Dilip Dinkar Kandlur , Ashish Mehra
IPC分类号： G06F15173
CPC分类号： H04L47/10 , H04L47/20 , H04L47/21 , H04L47/22 , H04L47/2416 , H04L47/2441 , H04L63/02 , H04L63/0227 , H04L63/0263 , H04L69/22
摘要： A computer connected to one or more networks through appropriate network interfaces is used to classify, manipulate, and/or control communications, e.g., packets sent and/or received over the network by one or more applications executing in the computer. Each application is connected to the network through one or more sockets to enable this communication. The computer also comprises one or more rule sets of one or more rules. A socket set of one or more of the sockets is associated with only one of the rule sets. The rules in the rule set are used to control one or more of the packets communicated by the applications communicating over the socket(s) associated with the respective rule set. Rules can be added to the rule set, deleted from the rule set, or modified in order to classify, manipulate, and/or control the communication of the packets, e.g. to control the rate at which the packets are sent or to provide certain security functions.
摘要翻译：通过适当的网络接口连接到一个或多个网络的计算机被用于通过在计算机中执行的一个或多个应用来分类，操纵和/或控制通信，例如通过网络发送和/或接收的分组。每个应用程序通过一个或多个套接字连接到网络，以实现此通信。计算机还包括一个或多个规则集合的一个或多个规则。一个或多个套接字的套接字集仅与规则集中的一个相关联。规则集中的规则用于控制通过与相应规则集相关联的套接字通信的应用传送的一个或多个分组。可以将规则添加到规则集中，从规则集中删除或修改，以便分类，操纵和/或控制分组的通信，例如。以控制分组发送的速率或提供某些安全功能。

10. 发明授权

US09296685B2 Method of producing nanoparticle suspensions 有权
标题翻译：制备纳米颗粒悬浮液的方法
公开(公告)号：US09296685B2
公开(公告)日：2016-03-29
申请号：US13583536
申请日：2011-03-07
申请人： Robert Engel , Wolfgang Gerlinger , Stefan Braese , Thierry Muller , Christina Belenki , Heike P. Schuchmann , Marion Gedrat
发明人： Robert Engel , Wolfgang Gerlinger , Stefan Braese , Thierry Muller , Christina Belenki , Heike P. Schuchmann , Marion Gedrat
IPC分类号： C07C69/36 , C07C271/08 , B01F17/00 , C07C69/38 , C07C233/56
CPC分类号： C07C271/08 , B01F17/0007 , B01F17/0021 , C07C69/36 , C07C69/38 , C07C233/56
摘要： Method of producing a nanoparticle suspension with the steps (i) preparation of an emulsion of a disperse polar phase, where the aqueous phase comprises one or more precursor substances forming the nanoparticles, in a continuous organic phase in the presence of an emulsifier stabilizing the emulsion, (ii) conversion of the one or more precursor substances to nanoparticles in the disperse aqueous phase, (iii) breaking of the emulsion and phase separation, where the nanoparticle suspension is obtained as one phase, (iv) separation off of the nanoparticle suspension, (v) optionally isolation of the nanoparticles from the nanoparticle suspension, wherein the emulsifier is selected from compounds of the general formula (I) in which X is O, NH, Y is C(O), NH, R is a saturated or a mono- or polyunsaturated, linear or branched hydrocarbon radical having 6 to 30 carbon atoms and R1 is hydrogen or C1-C4-alkyl, and R2 is a saturated or a mono- or polyunsaturated, linear or branched hydrocarbon radical having 1 to 30 carbon atoms, preferably 6 to 30 carbon atoms, R3 is C1-C4-alkyl, n is 0 or 1, and the breaking of the emulsion is effected by splitting the emulsifier.
摘要翻译：制备纳米颗粒悬浮液的方法，步骤（i）制备分散极性相的乳液，其中水相包含一种或多种形成纳米颗粒的前体物质，在连续的有机相中，在稳定乳液的乳化剂存在下，（ii）将一种或多种前体物质转化为分散水相中的纳米颗粒，（iii）破乳和相分离，其中纳米颗粒悬浮液作为一相获得，（iv）将纳米颗粒悬浮液分离，（v）任选地从纳米颗粒悬浮液中分离纳米颗粒，其中所述乳化剂选自X为O，NH，Y为C（O），NH，R为饱和的或通式具有6至30个碳原子的单或多不饱和的直链或支链烃基，R 1是氢或C 1 -C 4 - 烷基，R 2是饱和或单不饱和或多不饱和的直链或支链烃具有1至30个碳原子，优选6至30个碳原子的二烷基，R 3是C 1 -C 4 - 烷基，n是0或1，并且通过分裂乳化剂来实现乳液的断裂。

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