专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06251143B1 Cartilage repair unit 失效
公开(公告)号：US06251143B1
公开(公告)日：2001-06-26
申请号：US09325957
申请日：1999-06-04
申请人： Robert E. Schwartz , Daniel A. Grande
发明人： Robert E. Schwartz , Daniel A. Grande
IPC分类号： A61F202
CPC分类号： A61B17/064 , A61B17/0642 , A61B17/0643 , A61B17/58 , A61B2017/00004 , A61B2017/0646 , A61B2017/0647 , A61F2/30749 , A61F2/30756 , A61F2/3094 , A61F2/30965 , A61F2/38 , A61F2002/2817 , A61F2002/30013 , A61F2002/30062 , A61F2002/30064 , A61F2002/30113 , A61F2002/30123 , A61F2002/30125 , A61F2002/3013 , A61F2002/30143 , A61F2002/30146 , A61F2002/30153 , A61F2002/30156 , A61F2002/30159 , A61F2002/30171 , A61F2002/30291 , A61F2002/30299 , A61F2002/30306 , A61F2002/30354 , A61F2002/30382 , A61F2002/30405 , A61F2002/30451 , A61F2002/30456 , A61F2002/30457 , A61F2002/30477 , A61F2002/30484 , A61F2002/30492 , A61F2002/30495 , A61F2002/305 , A61F2002/30502 , A61F2002/30565 , A61F2002/30579 , A61F2002/30593 , A61F2002/30594 , A61F2002/30598 , A61F2002/30604 , A61F2002/30611 , A61F2002/30751 , A61F2002/30761 , A61F2002/30777 , A61F2002/30785 , A61F2002/30841 , A61F2002/30878 , A61F2002/30879 , A61F2002/30881 , A61F2002/30891 , A61F2002/30892 , A61F2002/30904 , A61F2002/30952 , A61F2002/30971 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2220/0058 , A61F2230/0006 , A61F2230/0008 , A61F2230/001 , A61F2230/0017 , A61F2230/0019 , A61F2230/0023 , A61F2230/0028 , A61F2230/005 , A61F2230/0091 , A61F2230/0093 , A61F2230/0097 , A61F2240/001 , A61F2250/0024 , A61F2250/0063 , A61F2310/00365
摘要： A bio-absorbable cartilage repair system is provided for regenerating damaged or destroyed articular cartilage on a joint surface of a bone by establishing a chondrogenic growth-supporting matrix between an area of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and subchondral cancellous bone. The system is an assembly of a delivery unit and a porous insert. The delivery unit is formed of bio-absorbable material and configured and dimensioned to be mounted in both an area of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and cancellous bone. The delivery unit has a central body and a plurality of radially extending, flexible support arms projecting outwardly from the central body and configured and dimensioned to support the insert at least partially thereover. The insert is supported by the delivery unit, formed of bio-absorbable material, and establishes communication between the removed area and the adjacent healthy area for a chondrogenic growth-supporting matrix.

2. 发明授权

US06468314B2 Cartilage repair unit 有权
标题翻译：软骨修复单位
公开(公告)号：US06468314B2
公开(公告)日：2002-10-22
申请号：US09801450
申请日：2001-03-08
申请人： Robert E. Schwartz , Daniel A. Grande
发明人： Robert E. Schwartz , Daniel A. Grande
IPC分类号： A61F202
CPC分类号： A61B17/064 , A61B17/0642 , A61B17/0643 , A61B17/58 , A61B2017/00004 , A61B2017/0646 , A61B2017/0647 , A61F2/30749 , A61F2/30756 , A61F2/3094 , A61F2/30965 , A61F2/38 , A61F2002/2817 , A61F2002/30013 , A61F2002/30062 , A61F2002/30064 , A61F2002/30113 , A61F2002/30123 , A61F2002/30125 , A61F2002/3013 , A61F2002/30143 , A61F2002/30146 , A61F2002/30153 , A61F2002/30156 , A61F2002/30159 , A61F2002/30171 , A61F2002/30291 , A61F2002/30299 , A61F2002/30306 , A61F2002/30354 , A61F2002/30382 , A61F2002/30405 , A61F2002/30451 , A61F2002/30456 , A61F2002/30457 , A61F2002/30477 , A61F2002/30484 , A61F2002/30492 , A61F2002/30495 , A61F2002/305 , A61F2002/30502 , A61F2002/30565 , A61F2002/30579 , A61F2002/30593 , A61F2002/30594 , A61F2002/30598 , A61F2002/30604 , A61F2002/30611 , A61F2002/30751 , A61F2002/30761 , A61F2002/30777 , A61F2002/30785 , A61F2002/30841 , A61F2002/30878 , A61F2002/30879 , A61F2002/30881 , A61F2002/30891 , A61F2002/30892 , A61F2002/30904 , A61F2002/30952 , A61F2002/30971 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2220/0058 , A61F2230/0006 , A61F2230/0008 , A61F2230/001 , A61F2230/0017 , A61F2230/0019 , A61F2230/0023 , A61F2230/0028 , A61F2230/005 , A61F2230/0091 , A61F2230/0093 , A61F2230/0097 , A61F2240/001 , A61F2250/0024 , A61F2250/0063 , A61F2310/00365
摘要： A bio-absorbable cartilage repair system is provided for regenerating damaged or destroyed articular cartilage on a joint surface of a bone by establishing a chondrogenic growth-supporting matrix between an area of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and subchondral cancellous bone. The system is an assembly of a delivery unit and a porous insert. The delivery unit is formed of bio-absorbable material and configured and dimensioned to be mounted in both an area of damaged or destroyed articular cartilage that has been removed and an adjacent healthy area of articular cartilage and cancellous bone. The delivery unit has a central body and a plurality of radially extending, flexible support arms projecting outwardly from the central body and configured and dimensioned to support the insert at least partially thereover. The insert is supported by the delivery unit, formed of bio-absorbable material, and establishes communication between the removed area and the adjacent healthy area for a chondrogenic growth-supporting matrix.
摘要翻译：提供生物可吸收的软骨修复系统，用于通过在被去除的损伤或破坏的关节软骨的区域和相邻的健康区域之间建立软骨形成生长支持基质来再生骨骼的关节表面上的损伤或破坏的关节软骨关节软骨和软骨下松质骨。该系统是输送单元和多孔插入件的组件。递送单元由生物吸收材料形成，并且构造和尺寸被安装在被去除的损伤或破坏的关节软骨的区域中，以及相关的关节软骨和松质骨的健康区域。输送单元具有中心体和从中心体向外突出的多个径向延伸的柔性支撑臂，并且构造和尺寸设计成至少部分地支撑插入件。插入物由可生物吸收材料形成的递送单元支撑，并且在去除区域和相邻健康区域之间建立连接，用于软骨形成生长支持基质。

3. 发明授权

US5906934A Mesenchymal stem cells for cartilage repair 失效
标题翻译：间充质干细胞用于软骨修复
公开(公告)号：US5906934A
公开(公告)日：1999-05-25
申请号：US403640
申请日：1995-03-14
申请人： Daniel A. Grande , Paul A. Lucas
发明人： Daniel A. Grande , Paul A. Lucas
IPC分类号： A61F2/30 , A61K35/12 , A61K35/34 , A61K35/36 , A61L27/38 , C12N5/0775 , C12N5/00 , A61F2/00 , C12N5/02
CPC分类号： A61L27/3834 , A61F2/30756 , A61K35/34 , A61K35/36 , A61L27/3847 , A61L27/3852 , C12N5/0668 , A61K35/12 , A61L2430/02 , A61L2430/06 , C12N2533/40
摘要： It has been discovered that mesenchymal stem cells (MSCs) in a polymeric carrier implanted into a cartilage and/or bone defect will differentiate to form cartilage and/or bone, as appropriate. Suitable polymeric carriers include porous meshes or sponges formed of synthetic or natural polymers, as well as polymer solutions. A presently preferred material is a polyglycolic acid mesh.
摘要翻译：已经发现，植入到软骨和/或骨缺损中的聚合物载体中的间充质干细胞（MSC）将根据需要分化形成软骨和/或骨。合适的聚合物载体包括由合成或天然聚合物形成的多孔网孔或海绵，以及聚合物溶液。目前优选的材料是聚乙醇酸网。

4. 发明授权

US06214369B1 Mesenchymal stem cells for cartilage repair 有权
标题翻译：间充质干细胞用于软骨修复
公开(公告)号：US06214369B1
公开(公告)日：2001-04-10
申请号：US09306487
申请日：1999-05-06
申请人： Daniel A. Grande , Paul A. Lucas
发明人： Daniel A. Grande , Paul A. Lucas
IPC分类号： A61F200
CPC分类号： A61L27/3834 , A61F2/30756 , A61K35/12 , A61K35/34 , A61K35/36 , A61L27/3847 , A61L27/3852 , A61L2430/02 , A61L2430/06 , C12N5/0668 , C12N2533/40
摘要： It has been discovered that mesenchymal stem cells (MSCs) in a polymeric carrier implanted into a cartilage and/or bone defect will differentiate to form cartilage and/or bone, as appropriate. Suitable polymeric carriers include porous meshes or sponges formed of synthetic or natural polymers, as well as polymer solutions. A presently preferred material is a polyglycolic acid mesh.
摘要翻译：已经发现，植入到软骨和/或骨缺损中的聚合物载体中的间充质干细胞（MSC）将根据需要分化形成软骨和/或骨。合适的聚合物载体包括由合成或天然聚合物形成的多孔网孔或海绵，以及聚合物溶液。目前优选的材料是聚乙醇酸网。

5. 发明授权

US06398816B1 Genetic engineering of cells to enhance healing and tissue regeneration 失效
标题翻译：细胞的遗传工程，以增强愈合和组织再生
公开(公告)号：US06398816B1
公开(公告)日：2002-06-04
申请号：US09489756
申请日：2000-01-21
申请人： Arnold S. Breitbart , Daniel A. Grande , James M. Mason
发明人： Arnold S. Breitbart , Daniel A. Grande , James M. Mason
IPC分类号： A61F236
CPC分类号： A61K38/1875 , A61K48/00
摘要： A method for enhancing and/or increasing the efficiency of repair of tissues, primarily bone or cartilage, using genetically engineered cells has been developed. In the preferred embodiment, mesenchymal stem cells are isolated from periosteum tissue, and transfected with the gene encoding a growth factor for the particular cell type to be repaired. For example, for repair of bone, a gene (or genes) encoding bone morphogenic protein is transfected into periosteal cells. The transfected periosteal cells then express the bone morphogenic protein in culture to promote bone repair as a function of the expressed bone morphogenic protein. Cells can be transfected using any appropriate means, including viral vectors, as shown by the example, chemical transfectants, or physico-mechanical methods such as electroporation and direct diffusion of DNA. Genes can encode any useful protein, for example, a specific growth factor, morphogenesis factor, a structural protein, or a cytokine which enhances the temporal sequence of wound repair, alters the rate of proliferation, increases the metabolic synthesis of extracellular matrix proteins, or directs phenotypic expression in endogenous cell populations. Representative genes encoding proteins include bone growth factor genes, cartilage growth factor genes, nerve growth factor genes, and general growth factors important in wound healing, such as platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF-1), epidermal growth factor (EGF), basic fibroblast growth factor (FGF), endothelial derived growth supplement.
摘要翻译：已经开发了使用基因工程细胞增强和/或增加组织，主要是骨或软骨的修复效率的方法。在优选的实施方案中，从骨膜组织中分离间充质干细胞，并用编码待修复的特定细胞类型的生长因子的基因转染。例如，为了修复骨，将编码骨形态发生蛋白的基因（或基因）转染到骨膜细胞中。转染的骨膜细胞然后在培养物中表达骨形态发生蛋白，以促进骨修复作为表达的骨形态发生蛋白的函数。可以使用任何适当的方式，包括病毒载体，如实施例所示，化学转染子，或物理 - 机械方法如DNA的电穿孔和直接扩散来转染细胞。基因可以编码任何有用的蛋白质，例如特异性生长因子，形态发生因子，结构蛋白质或细胞因子，其增强伤口修复的时间序列，改变增殖速率，增加细胞外基质蛋白质的代谢合成，或指导内源性细胞群体中的表型表达。编码蛋白质的代表性基因包括骨生长因子基因，软骨生长因子基因，神经生长因子基因和伤口愈合中重要的一般生长因子，例如血小板衍生生长因子（PDGF），血管内皮生长因子（VEGF）类似生长因子（IGF-1），表皮生长因子（EGF），碱性成纤维细胞生长因子（FGF），内皮衍生生长补体。

6. 发明申请

US20110206648A1 Gene-enhanced tissue engineering 审中-公开
标题翻译：基因增强组织工程
公开(公告)号：US20110206648A1
公开(公告)日：2011-08-25
申请号：US12928805
申请日：2010-12-20
申请人： James M. Mason , Paul C. Edwards , Daniel A. Grande
发明人： James M. Mason , Paul C. Edwards , Daniel A. Grande
IPC分类号： A61K35/12 , A61P17/02 , A61P19/02 , A61P19/08 , A61P25/00
CPC分类号： A61K31/522 , A61K35/12 , A61K48/005 , C12N5/0654 , C12N2501/41 , C12N2533/54 , C12N2533/74
摘要： Provided are mammalian cells comprising a recombinant sonic hedgehog (SHH) gene such that a recombinant SHH protein can be expressed by the cell. Also provided are matrices suitable for applying to a tissue defect. Additionally provided are tissue regeneration compositions. Methods of regenerating tissue at the site of a tissue defect in a mammal are also provided.
摘要翻译：提供包含重组声刺猬（SHH）基因的哺乳动物细胞，使得重组SHH蛋白可以被细胞表达。还提供了适用于组织缺损的基质。另外提供组织再生组合物。还提供了在哺乳动物组织缺损部位再生组织的方法。

7. 发明授权

US5700289A Tissue-engineered bone repair using cultured periosteal cells 失效
标题翻译：使用培养的骨膜细胞的组织工程骨修复
公开(公告)号：US5700289A
公开(公告)日：1997-12-23
申请号：US545988
申请日：1995-10-20
申请人： Arnold S. Breitbart , Daniel A. Grande
发明人： Arnold S. Breitbart , Daniel A. Grande
IPC分类号： A61K35/12 , A61L27/38 , C12N5/00 , C12N5/077 , A61F2/28 , A61F2/54
CPC分类号： A61L27/3804 , A61L27/3847 , C12N5/0068 , C12N5/0654 , A61K35/12 , C12N2533/40
摘要： Periosteal cells have been grown in cell culture and have been shown to have an osteoblastic phenotype, with production of osteocalcin and glycosaminoglycan. When seeded into polymeric implants, repair of critical size cranial defects was demonstrated and was confirmed by histology, biochemical assays, and radiodensitometry.
摘要翻译：已经在细胞培养物中生长了骨膜细胞，并且已经显示具有成骨细胞表型，产生骨钙素和糖胺聚糖。当接种到聚合物植入物中时，证实了临界尺寸颅骨缺损的修复，并通过组织学，生物化学测定和放射性光度法来证实。

8. 发明授权

US09089117B2 Bioactive scaffolds 有权
标题翻译：生物活性支架
公开(公告)号：US09089117B2
公开(公告)日：2015-07-28
申请号：US12322262
申请日：2009-01-30
申请人： Daniel A. Grande , James M. Mason
发明人： Daniel A. Grande , James M. Mason
IPC分类号： A01K67/027 , A61K47/48 , A61L27/38 , A61L27/56 , A61K38/18 , A61K38/30
CPC分类号： A01K67/0271 , A61K38/1841 , A61K38/1858 , A61K38/1875 , A61K38/30 , A61K47/6901 , A61L27/38 , A61L27/56
摘要： Provided are tissue scaffolds colonized by vertebrate cells expressing a transgenic bioactive molecule, where the vertebrate cells are unable to undergo mitosis. Also provided are methods of growing tissue in a mammal and methods of delivering a transgenic bioactive molecule to a tissue of a mammal, using the tissue scaffolds. Additionally, methods of making the tissue scaffolds are provided.
摘要翻译：提供的是由表达转基因生物活性分子的脊椎动物细胞定植的组织支架，其中脊椎动物细胞不能发生有丝分裂。还提供了在哺乳动物中培养组织的方法和使用组织支架将转基因生物活性分子递送至哺乳动物的组织的方法。另外，提供了制作组织支架的方法。

9. 发明申请

US20100008967A1 Bioactive scaffolds 有权
标题翻译：生物活性支架
公开(公告)号：US20100008967A1
公开(公告)日：2010-01-14
申请号：US12322262
申请日：2009-01-30
申请人： Daniel A. Grande , James M. Mason
发明人： Daniel A. Grande , James M. Mason
IPC分类号： A61K9/00 , C12N5/06 , C12N5/08 , A61K45/00 , A61K39/395 , A61P19/02
CPC分类号： A01K67/0271 , A61K38/1841 , A61K38/1858 , A61K38/1875 , A61K38/30 , A61K47/6901 , A61L27/38 , A61L27/56
摘要： Provided are tissue scaffolds colonized by vertebrate cells expressing a transgenic bioactive molecule, where the vertebrate cells are unable to undergo mitosis. Also provided are methods of growing tissue in a mammal and methods of delivering a transgenic bioactive molecule to a tissue of a mammal, using the tissue scaffolds. Additionally, methods of making the tissue scaffolds are provided.
摘要翻译：提供的是由表达转基因生物活性分子的脊椎动物细胞定植的组织支架，其中脊椎动物细胞不能发生有丝分裂。还提供了在哺乳动物中培养组织的方法和使用组织支架将转基因生物活性分子递送至哺乳动物的组织的方法。另外，提供了制作组织支架的方法。

10. 发明授权

US4846835A Technique for healing lesions in cartilage 失效
标题翻译：软骨病变愈合技术
公开(公告)号：US4846835A
公开(公告)日：1989-07-11
申请号：US61952
申请日：1987-06-15
申请人： Daniel A. Grande
发明人： Daniel A. Grande
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61K35/12 , A61K35/32 , A61L27/38 , C12N5/077
CPC分类号： C12N5/0655 , A61F2/02 , A61F2/30756 , A61L27/38 , A61F2/2846 , A61F2310/00365 , A61K35/12 , C12N2500/32 , C12N2533/54
摘要： A grafting technique entailing the transplantation of chondrocytes for promoting the healing of lesions in articular cartilage, use being made for this purpose of in vitro autologous cultured chondrocytes prior to transplantation. The chondrocytes are preferably seeded in a three-dimensional collagen matrix which serves as the graft material. In order to internally fix the graft during the healing process, use is made of a periosteal flap which is sutured to the cartilage after the graft material is implanted therein.
摘要翻译：用于移植软骨细胞以促进关节软骨损伤愈合的移植技术，在移植前用于体外自体培养的软骨细胞的目的。软骨细胞优选接种在用作移植材料的三维胶原基质中。为了在愈合过程中内部固定移植物，使用在将植入材料植入其中之后缝合软骨的骨膜瓣。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式