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1. 发明授权

US11439606B2 Reduction of hyperglycemia by administration of dimethylformamide for treating hyperglycemic conditions, including diabetes mellitus 有权
公开(公告)号：US11439606B2
公开(公告)日：2022-09-13
申请号：US16699674
申请日：2019-12-01
申请人： Robert D. Kross , Guadalupe Cleva Villanueva Lopez
发明人： Robert D. Kross , Guadalupe Cleva Villanueva Lopez
IPC分类号： A61K31/16 , A61K9/00 , A61P3/10
摘要： A treatment for a hyperglycemic condition, including diabetes mellitus, includes the step of administering to a human being dimethylformamide (“DMF”), which has the chemical structural formula: DMF can be administered to the human patient in a wide variety of ways, however it is preferable that the administration of DMF be performed orally and the dose of DMF could be combined with numerous inert substances known to the prior art, such as a sugarless fruit juice concentrate. The preferred daily dosage of DMF administered to a person would be about 0.041 mg/kg body weight to about 1.23 mg/kg of body weight of the person.

2. 发明申请

US20160206632A1 MULTIFUNCTIONAL TOPICAL FORMULATION FOR THE TREATMENT OF ACNE VULGARIS AND OTHER SKIN CONDITIONS 审中-公开
公开(公告)号：US20160206632A1
公开(公告)日：2016-07-21
申请号：US15082098
申请日：2016-03-28
申请人： Robert D. Kross
发明人： Robert D. Kross
IPC分类号： A61K31/60 , A61K31/192 , A61K9/08 , A61K33/00 , A61K9/00
CPC分类号： A61K31/60 , A61K9/0014 , A61K9/08 , A61K31/19 , A61K31/192 , A61K31/194 , A61K33/00 , A61K47/38 , A61K2300/00
摘要： A two-part aqueous composition for treating skin ailments, such as acne vulgaris, includes an acidic part having salicylic acid and an α-hydroxy acid, and an alkaline part having an alkaline nitrite salt. The α-hydroxy acid is preferably glycolic acid, lactic acid, malic acid, mandelic acid or a combination thereof. The alkaline nitrite salt is preferably sodium nitrite. The acidic part and the alkaline part are an acidic aqueous solution and an alkaline aqueous solution, respectively, which may either be mixed with one another then applied to an affected portion of a patient's skin or, alternatively, may be sequentially applied to the affected portion of the patient's skin, preferably within 15 minutes of one another.

3. 发明授权

US08834904B1 Oil-free viscoelastic elastomer gels for application to human skin 有权
标题翻译：无油粘弹性凝胶，适用于人体皮肤
公开(公告)号：US08834904B1
公开(公告)日：2014-09-16
申请号：US10964982
申请日：2004-10-14
申请人： Robert D. Kross
发明人： Robert D. Kross
IPC分类号： A61K8/00 , A61K8/02 , A61Q1/12 , A61Q90/00
CPC分类号： C08K5/0016 , C08K5/10 , C08L53/02 , C08L53/025
摘要： A composition article, which may be applied to human, includes a non-oil thermoplastic gelatinous elastomer composition, which is formed into a composite by heating with a substrate material. The gelatinous elastomer includes a hydrogenated styrene/isoprene/butadiene block copolymer, at least one polymer or copolymer of the group poly(styrene-butadiene-styrene), poly(styrene-isoprene), poly(styrene-isoprene-styrene), poly(styrene-isoprene), poly(styrene-ethylene-propylene), poly(styrene-ethylene-propylene-styrene), poly(styrene-ethylene-butylene-styrene) or poly(styrene-ethylene-butylene), and a non-oil plasticizer.
摘要翻译：可以应用于人的组合物制品包括通过用基材加热而形成复合材料的非油热塑性胶状弹性体组合物。凝胶状弹性体包括氢化苯乙烯/异戊二烯/丁二烯嵌段共聚物，至少一种聚（苯乙烯 - 丁二烯 - 苯乙烯），聚（苯乙烯 - 异戊二烯），聚（苯乙烯 - 异戊二烯 - 苯乙烯），聚（苯乙烯 - 异戊二烯），聚（苯乙烯 - 乙烯 - 丙烯），聚（苯乙烯 - 乙烯 - 丙烯 - 苯乙烯），聚（苯乙烯 - 乙烯 - 丁烯 - 苯乙烯）或聚（苯乙烯 - 乙烯 - 丁烯）增塑剂

4. 发明授权

US08507011B2 Method for suppressing or preventing fibrous adhesion formation using a multicomponent aqueous oxychlorine composition prepared on-site 有权
标题翻译：使用现场制备的多组分含水氯氧化合物组合物抑制或预防纤维粘附形成的方法
公开(公告)号：US08507011B2
公开(公告)日：2013-08-13
申请号：US12727725
申请日：2010-03-19
申请人： Robert D. Kross , Cleva Villanueva
发明人： Robert D. Kross , Cleva Villanueva
IPC分类号： A61K33/14 , A61K33/20 , A61L2/00 , A61L2/18
CPC分类号： A61K33/20 , A61K9/0019 , A61K33/00 , A61K33/14 , A61K33/40 , A61K45/06 , A61K47/12 , A61K2300/00
摘要： A composition and method are described for suppressing or preventing fibrous adhesion formation using a multicomponent aqueous oxychlorine composition. Fibrous adhesions typically form during healing of tissue, for example following a surgical procedure. A multicomponent oxychlorine composition is provided for irrigating the tissue which minimizes post-surgical adhesion formation, the composition containing both chlorine dioxide and chlorite ion, and a complexion thereof. The chlorine dioxide level generally is in an effective range of ClO2 concentration from about 10 ppm to a maximum of about 110 ppm. In a preferred embodiment, a physiological composition is provided in a thickened form to increase retention in the area being treated. The composition is preferably based on a standard saline solution converted to the oxychlorine composition just prior to use by sequential addition of aqueous concentrates of a chlorite salt, a hypochlorite salt combined with a physiological buffer-producing salt of a multibasic acid, and an acidifying agent, optionally including a thickening agent.
摘要翻译：描述了使用多组分含水氯氧化合物组合物抑制或防止纤维粘附形成的组合物和方法。通常在组织愈合期间形成纤维粘连，例如在外科手术之后。提供多组分氧氯组合物用于冲洗组织，使术后粘连形成最小化，该组合物含有二氧化氯和亚氯酸根离子，以及其肤色。二氧化氯水平通常在约10ppm至最大约110ppm的ClO 2浓度的有效范围内。在优选的实施方案中，以增稠形式提供生理组合物以增加被治疗区域的保留。该组合物优选基于在使用之前通过顺序加入亚氯酸盐，次氯酸盐与多元酸的生理缓冲液生成盐组合的次氯酸盐浓缩物和酸化剂的浓缩物，将其转化为氯氧化合物组合物，任选地包括增稠剂。

5. 发明授权

US07470726B1 Method for controlling a hydrogel composition during processing 有权
标题翻译：在处理过程中控制水凝胶组合物的方法
公开(公告)号：US07470726B1
公开(公告)日：2008-12-30
申请号：US11289166
申请日：2005-11-29
申请人： Robert D. Kross
发明人： Robert D. Kross
IPC分类号： C08J3/07 , B01J13/00
CPC分类号： B01J13/0069 , Y10S516/924 , Y10S516/926
摘要： A method for transiently and controllably enhancing the adhesion of a hydrogel composition to select substrates for facilitating the handling of the hydrogel composition during processing, includes the steps of placing the hydrogel composition in a liquid state onto a plastic film facestock, which has biaxially-oriented polypropylene, microporous cellulose acetate or a combination thereof, for temporarily adhering the hydrogel composition to the sheets of the roll stock during processing of the hydrogel composition, and then removing the hydrogel composition from the sheets of the roll stock, after processing of the hydrogel composition is complete, without any adverse affect on the textural qualities of the hydrogel composition.
摘要翻译：一种用于瞬时和可控地增强水凝胶组合物以选择用于促进处理过程中水凝胶组合物的处理的底物的粘合性的方法包括以下步骤：将水凝胶组合物置于液态下，使其具有双轴取向聚丙烯，微孔醋酸纤维素或其组合，用于在水凝胶组合物的加工过程中将水凝胶组合物临时粘合到卷材的片材上，然后在水凝胶组合物加工之后从辊料的片材中除去水凝胶组合物是完整的，对水凝胶组合物的质地质量没有任何不利影响。

6. 发明授权

US06599432B2 Methods for disinfecting small diameter water lines 失效
标题翻译：消毒小口径水线的方法
公开(公告)号：US06599432B2
公开(公告)日：2003-07-29
申请号：US09847493
申请日：2001-05-02
申请人： Robert D. Kross , William Wade
发明人： Robert D. Kross , William Wade
IPC分类号： C02F176
CPC分类号： A61C1/0076 , C02F1/76 , C02F2103/006
摘要： The present invention is directed to disinfecting compositions for dental unit water lines, particularly effective against microbial flora in biofilms which form on the luminal walls of the piping and reservoir components of dental equipment, as well as methods related to the use of such compositions to reduce microbial numbers in water-bearing dental and other equipment and maintain reduced levels on a continuous basis.
摘要翻译：本发明涉及用于牙科单元水线的消毒组合物，特别是有效抵抗在牙科设备的管道和储存器部件的腔壁上形成的生物膜中的微生物菌群，以及与使用这种组合物相关的方法减少含水牙齿和其他设备中的微生物数量，并持续降低水平。

7. 发明授权

US5651977A Adherent disinfecting compositions and methods relating thereto 失效
标题翻译：附着消毒组合物及其相关方法
公开(公告)号：US5651977A
公开(公告)日：1997-07-29
申请号：US356068
申请日：1994-12-14
申请人： Robert D. Kross
发明人： Robert D. Kross
IPC分类号： A01N25/24 , A01N59/00 , A61K9/00 , A01N25/26 , A01N25/28 , A61K47/30
CPC分类号： A61K9/0041 , A01N25/24 , A01N59/00
摘要： Disinfecting compositions directed to the prevention of microbial infections are disclosed. The disinfecting compositions comprise a protic acid, a metal chlorite and a gelling agent which, when combined, provide an effective adherent matrix that acts as a disinfectant barrier for preventing transmission and propagation of microbial infections. The gelling agent includes at least 15% polyacrylamide. The compositions of this invention may be used as teat disinfectants, specifically for use in the dairy industry.
摘要翻译：公开了针对预防微生物感染的消毒组合物。消毒组合物包含质子酸，金属亚氯酸盐和胶凝剂，当它们组合时，提供有效的粘附基质，其作为用于防止微生物感染传播和增殖的消毒屏障。胶凝剂包括至少15％的聚丙烯酰胺。本发明的组合物可用作乳清消毒剂，特别用于乳制品工业。

8. 发明授权

US5185161A Disinfection method and composition therefor 失效
标题翻译：消毒方法及其组成
公开(公告)号：US5185161A
公开(公告)日：1993-02-09
申请号：US618729
申请日：1990-11-27
申请人： Eugene A. Davidson , Robert D. Kross
发明人： Eugene A. Davidson , Robert D. Kross
IPC分类号： A01N59/00
CPC分类号： A01N59/00
摘要： There is disclosed, in one aspect, chlorous acid generating compositions useful for disinfecting substrates. The compositions comprise aqueous solutions containing a suitable amount of a protic acid, such as citric or malic acid, and a suitable amount of a metal chlorite, such as sodium chlorite. The chlorite ion concentration which is in the form of chlorous acid in the composition is no more than about 15 percent by weight of the total amount of chlorite ion concentration. In a preferred embodiment, the composition also contains a vicinal dihydroxy or polyhydroxy compound. In another preferred embodiment, the composition contains at least a 10-fold molar excess of a water soluble chloride ion compared to the total concentration of chlorite ion. In another aspect, there is disclosed a process for disinfecting substrates. This process comprises applying the compositions described above to a substrate. In yet another aspect, there is disclosed a process for preparing the compositions described above. This process comprises contacting the protic acid with the metal chlorite to form the disinfecting composition.
摘要翻译：在一方面，公开了可用于消毒底物的产生氯酸的组合物。组合物包含含有适量的质子酸如柠檬酸或苹果酸的水溶液和适量的金属亚氯酸盐，例如亚氯酸钠。组合物中亚氯酸形式的亚氯酸根离子浓度不超过亚氯酸根离子浓度总量的约15重量％。在优选的实施方案中，组合物还含有邻位二羟基或多羟基化合物。在另一个优选的实施方案中，与亚氯酸盐离子的总浓度相比，组合物含有至少10倍摩尔过量的水溶性氯离子。另一方面，公开了一种消毒底物的方法。该方法包括将上述组合物施用于底物。在另一方面，公开了一种制备上述组合物的方法。该方法包括使质子酸与亚氯酸金属接触以形成消毒组合物。

9. 发明授权

US3980084A Ostomy gasket 失效
标题翻译：造口垫片
公开(公告)号：US3980084A
公开(公告)日：1976-09-14
申请号：US554709
申请日：1975-03-03
申请人： Robert D. Kross
发明人： Robert D. Kross
IPC分类号： A61F5/445 , A61L28/00 , A61F5/44
CPC分类号： A61L28/0026 , A61F5/445 , A61L28/0011 , Y10S128/24
摘要： An improved ostomy sealing gasket for application to the opening between the intestinal or urethral stoma of the patient and a post-surgical external pouch. The sealing gasket is made from a hydroxyalkyl acrylate or methacrylate with an alkylene glycol or polyalkylene glycol in the presence of a reducing agent and water. Embodiments designed for higher absorptive capacity also include an absorptive material such as natural or synthetic gums or a cellulosic material.
摘要翻译：改进的造口术密封垫片，用于应用于患者的肠道或尿道造口与外科手术后的小袋之间的开口。密封垫片由丙烯酸羟烷基酯或甲基丙烯酸烷基酯与亚烷基二醇或聚亚烷基二醇在还原剂和水的存在下制成。设计用于更高吸收能力的实施方案还包括吸收材料，例如天然或合成树胶或纤维素材料。

10. 发明授权

US09393184B2 Oxychlorine oral rinse composition having enhanced oral-tissue compatibility for the destruction of malodorants, their putrefactive microbial sources and gum-disease pathogens and a method for the preparation thereof 有权
标题翻译：具有增强的口服 - 组织相容性以消除恶臭，其腐败性微生物来源和牙龈疾病病原体的氧氯化口服冲洗组合物及其制备方法
公开(公告)号：US09393184B2
公开(公告)日：2016-07-19
申请号：US14182754
申请日：2014-02-18
申请人： Robert D. Kross , Nicholas D. Mulder
发明人： Robert D. Kross , Nicholas D. Mulder
IPC分类号： A61K8/20 , A61Q11/00 , A61Q17/00
CPC分类号： A61K8/20 , A61Q11/00 , A61Q17/005
摘要： An antimicrobial oxychlorine oral rinse composition for preventing and treating oral malodor and diseases, tooth decay with improved palatability and tissue compatibility, includes an aqueous chlorine dioxide and chlorite ion solution with the chlorite ion predominating in the multiple oxychlorine rinse composition. A method for preparing such antimicrobial oxychlorine oral rinse composition comprising 3 ppm to about 200 ppm of chlorine dioxide, by first preparing an aqueous solution with about 7 to 400 ppm of chlorite ion; then an aqueous acidifying agent concentrate which, upon introduction to the chlorite solution, reduces its pH to about 4.5 to 6.0; then a second aqueous buffer-producing oxidant combination concentrate. The first acidifying agent concentrate is added to the chlorite ion solution and the second aqueous buffer-producing oxidant combination concentrate is added to the acidified chlorite ion solution, producing an antimicrobial oxychlorine oral rinse composition at about 5.0 to 6.8 pH.
摘要翻译：用于预防和治疗口腔恶臭和疾病，具有改善的适口性和组织相容性的蛀牙的抗微生物氯氯口服冲洗组合物包括在多氯氧化物漂洗组合物中以亚氯酸根离子为主的二氧化氯水溶液和亚氯酸盐离子溶液。通过首先制备具有约7至400ppm亚氯酸根离子的水溶液，制备包含3ppm至约200ppm二氧化氯的抗微生物氯氧化物口服冲洗组合物的方法; 然后是一种含水酸化剂浓缩物，其在引入亚氯酸盐溶液时将其pH降低至约4.5至6.0; 然后是第二产生水溶性缓冲液的氧化剂组合浓缩物。将第一酸化剂浓缩物加入到亚氯酸盐离子溶液中，将第二含水缓冲液生成氧化剂组合浓缩物加入到酸化的亚氯酸盐离子溶液中，在约5.0至6.8的pH下产生抗微生物氯氧化物口服冲洗组合物。

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