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    • 1. 再颁专利
    • Disinfection method and composition therefor
    • 消毒方法及其组成
    • USRE36064E
    • 1999-01-26
    • US052641
    • 1993-04-23
    • Eugene A. DavidsonRobert D. Kross
    • Eugene A. DavidsonRobert D. Kross
    • A01N59/00A61K33/14
    • A01N59/00
    • There is disclosed, in one aspect, chlorous acid generating compositions useful for disinfecting substrates. The compositions comprise aqueous solutions containing a suitable amount of a protic acid, such as citric or malic acid, and a suitable amount of a metal chlorite, such as sodium chlorite. The chlorite ion concentration which is in the form of chlorous acid in the composition is no more than about 15 percent by weight of the total amount of chlorite ion concentration. In a preferred embodiment, the composition also contains a vicinal dihydroxy or polyhydroxy compound. In another preferred embodiment, the composition contains at least a 10-fold molar excess of a water soluble chloride ion compared to the total concentration of chlorite ion. In another aspect, there is disclosed a process for disinfecting substrates. This process comprises applying the compositions described above to a substrate. In yet another aspect, there is disclosed a process for preparing the compositions described above. This process comprises contacting the protic acid with the metal chlorite to form the disinfecting composition.
    • 在一方面,公开了可用于消毒底物的产生氯酸的组合物。 组合物包含含有适量的质子酸如柠檬酸或苹果酸的水溶液和适量的金属亚氯酸盐,例如亚氯酸钠。 组合物中亚氯酸形式的亚氯酸根离子浓度不超过亚氯酸根离子浓度总量的约15重量%。 在优选的实施方案中,组合物还含有邻位二羟基或多羟基化合物。 在另一个优选的实施方案中,与亚氯酸盐离子的总浓度相比,组合物含有至少10倍摩尔过量的水溶性氯离子。 另一方面,公开了一种消毒底物的方法。 该方法包括将上述组合物施用于底物。 在另一方面,公开了一种制备上述组合物的方法。 该方法包括使质子酸与亚氯酸金属接触以形成消毒组合物。
    • 2. 发明授权
    • Disinfection method and composition therefor
    • 消毒方法及其组成
    • US5185161A
    • 1993-02-09
    • US618729
    • 1990-11-27
    • Eugene A. DavidsonRobert D. Kross
    • Eugene A. DavidsonRobert D. Kross
    • A01N59/00
    • A01N59/00
    • There is disclosed, in one aspect, chlorous acid generating compositions useful for disinfecting substrates. The compositions comprise aqueous solutions containing a suitable amount of a protic acid, such as citric or malic acid, and a suitable amount of a metal chlorite, such as sodium chlorite. The chlorite ion concentration which is in the form of chlorous acid in the composition is no more than about 15 percent by weight of the total amount of chlorite ion concentration. In a preferred embodiment, the composition also contains a vicinal dihydroxy or polyhydroxy compound. In another preferred embodiment, the composition contains at least a 10-fold molar excess of a water soluble chloride ion compared to the total concentration of chlorite ion. In another aspect, there is disclosed a process for disinfecting substrates. This process comprises applying the compositions described above to a substrate. In yet another aspect, there is disclosed a process for preparing the compositions described above. This process comprises contacting the protic acid with the metal chlorite to form the disinfecting composition.
    • 在一方面,公开了可用于消毒底物的产生氯酸的组合物。 组合物包含含有适量的质子酸如柠檬酸或苹果酸的水溶液和适量的金属亚氯酸盐,例如亚氯酸钠。 组合物中亚氯酸形式的亚氯酸根离子浓度不超过亚氯酸根离子浓度总量的约15重量%。 在优选的实施方案中,组合物还含有邻位二羟基或多羟基化合物。 在另一个优选的实施方案中,与亚氯酸盐离子的总浓度相比,组合物含有至少10倍摩尔过量的水溶性氯离子。 另一方面,公开了一种消毒底物的方法。 该方法包括将上述组合物施用于底物。 在另一方面,公开了一种制备上述组合物的方法。 该方法包括使质子酸与亚氯酸金属接触以形成消毒组合物。
    • 3. 发明授权
    • Disinfection method and composition therefor
    • 消毒方法及其组成
    • US4986990A
    • 1991-01-22
    • US420651
    • 1989-10-11
    • Eugene A. DavidsonRobert D. Kross
    • Eugene A. DavidsonRobert D. Kross
    • A01N59/00
    • A01N59/00
    • There is disclosed, in one aspect, chlorous acid generating compositions useful for disinfecting substrates. The compositions comprise aqueous solutions containing a suitable amount of a protic acid, such as citric or malic acid, and a suitable amount of a metal chlorite, such as sodium chlorite. The chlorite ion concentration which is in the form of chlorous acid in the composition is no more than about 15 percent by weight of the total amount of chlorite ion concentration. In a preferred embodiment, the composition also contains a vicinal dihydroxy or polyhydroxy compound. In another preferred embodiment, the composition contains at least a 10-fold molar excess of a water soluble chloride ion compared to the total concentration of chlorite ion. In another aspect, there is disclosed a process for disinfecting substrates. This process comprises applying the compositions described above to a substrate. In yet another aspect, there is disclosed a process for preparing the compositions described above. This process comprises contacting the protic acid with the metal chlorite to form the disinfecting composition.
    • 在一方面,公开了可用于消毒底物的产生氯酸的组合物。 组合物包含含有适量的质子酸如柠檬酸或苹果酸的水溶液和适量的金属亚氯酸盐,例如亚氯酸钠。 组合物中亚氯酸形式的亚氯酸根离子浓度不超过亚氯酸根离子浓度总量的约15重量%。 在优选的实施方案中,组合物还含有邻位二羟基或多羟基化合物。 在另一个优选的实施方案中,与亚氯酸盐离子的总浓度相比,组合物含有至少10倍摩尔过量的水溶性氯离子。 另一方面,公开了一种消毒底物的方法。 该方法包括将上述组合物施用于底物。 在另一方面,公开了一种制备上述组合物的方法。 该方法包括使质子酸与亚氯酸金属接触以形成消毒组合物。
    • 8. 发明授权
    • Misfolded protein sensor method
    • 误差蛋白传感器方法
    • US08062895B2
    • 2011-11-22
    • US12726941
    • 2010-03-18
    • Cindy OrserAnne GrossetEugene A. Davidson
    • Cindy OrserAnne GrossetEugene A. Davidson
    • G01N33/52G01N33/50G01N33/00G01N33/48
    • G01N33/542G01N33/6896G01N2800/2828
    • A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes the transformation of the probe to a predominately beta sheet conformation and allows the probe to bind the abnormal proteinaceous particle. This in turn, catalyzes the propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles. The peptide probes can be designed to bind to a desired peptide sequence or can even be based on dendrimer structure to control further aggregate propagation.
    • 用于检测异常蛋白质和蛋白质颗粒的催化构象传感器方法。 该方法基于肽片段或探针与异常蛋白质颗粒的相互作用。 相互作用催化探针转化为主要的β片段构象,并允许探针结合异常的蛋白质颗粒。 这反过来又催化与测试样品结合探针相关联的信号的传播。 因此,即使从含有非常低浓度的异常蛋白质颗粒的样品也可以传播信号。 肽探针可以设计成结合所需的肽序列,或者甚至可以基于树枝状大分子结构来控制进一步的聚集体传播。
    • 9. 发明授权
    • Misfolded protein sensor method
    • 误差蛋白传感器方法
    • US07691639B2
    • 2010-04-06
    • US10494906
    • 2002-05-30
    • Cindy OrserAnne GrossetEugene A. Davidson
    • Cindy OrserAnne GrossetEugene A. Davidson
    • G01N33/52G01N33/50G01N33/00G01N33/48
    • G01N33/542G01N33/6896G01N2800/2828
    • A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes transformation of the probe to a predominately beta sheet conformation and allows the probe to bind to the abnormal proteinaceous particle. This in turn, catalyzes propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles. The peptide probes can be designed to bind to a desired peptide sequence or can even be based on dendrimer structure to control further aggregate propagation.
    • 用于检测异常蛋白质和蛋白质颗粒的催化构象传感器方法。 该方法基于肽片段或探针与异常蛋白质颗粒的相互作用。 相互作用催化探针转化为主要的β片段构象,并允许探针结合异常的蛋白质颗粒。 这反过来,催化与测试样品结合探针相关联的信号的传播。 因此,即使从含有非常低浓度的异常蛋白质颗粒的样品也可以传播信号。 肽探针可以设计成结合所需的肽序列,或者甚至可以基于树枝状大分子结构来控制进一步的聚集体传播。