专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060004223A1 Method of making halophthalic acids and halophthalic anhydrides 审中-公开
标题翻译：制备卤代邻苯二甲酸和卤代邻苯二甲酸酐的方法
公开(公告)号：US20060004223A1
公开(公告)日：2006-01-05
申请号：US10882762
申请日：2004-06-30
申请人： Robert Colborn , David Hall , Peter Koch , Bernd Demuth , Thomas Wessel , KarlErnst Mack
发明人： Robert Colborn , David Hall , Peter Koch , Bernd Demuth , Thomas Wessel , KarlErnst Mack
IPC分类号： C07C51/265
CPC分类号： C07C51/265 , C07C63/68
摘要： A method of preparing a halophthalic acid is disclosed which comprises the steps of contacting in a liquid phase reaction mixture at least one halogen-substituted ortho-xylene with oxygen and acetic acid at a temperature in a range between about 120° C. and about 220° C. in the presence of a catalyst system yielding a product mixture comprising less than 10 percent halogen-substituted ortho-xylene starting material, a halophthalic acid product, and less than about 10,000 ppm halobenzoic acid and less than about 1000 ppm halophthalide by-products based on a total amount of halophthalic acid present in the product mixture. In addition a method for the preparation of halophthalic anhydride is also disclosed.
摘要翻译：公开了一种制备卤代邻苯二甲酸的方法，其包括以下步骤：在液相反应混合物中使至少一种卤素取代的邻二甲苯与氧和乙酸在约120℃至约220℃的温度下接触在催化剂体系的存在下，产生包含小于10％的卤素取代的邻二甲苯原料，卤代邻苯二甲酸产物和小于约10,000ppm的卤代苯甲酸和小于约1000ppm的卤代苯甲酸副产物的产物混合物，基于产物混合物中存在的卤代邻苯二甲酸的总量的产物。另外还公开了制备卤代邻苯二甲酸酐的方法。

2. 发明申请

US20060004224A1 Method of making halophthalic acids and halophthalic anhydrides 有权
公开(公告)号：US20060004224A1
公开(公告)日：2006-01-05
申请号：US11170708
申请日：2005-06-29
申请人： Robert Colborn , David Hall , Peter Koch , Bernd Demuth , Thomas Wessel , KarlErnst Mack , Prashant Tatake , Utpal Vakil , Shyamal Gondkar , John Pace , Kwang Won
发明人： Robert Colborn , David Hall , Peter Koch , Bernd Demuth , Thomas Wessel , KarlErnst Mack , Prashant Tatake , Utpal Vakil , Shyamal Gondkar , John Pace , Kwang Won
IPC分类号： C07C51/265
CPC分类号： C07C51/265 , C07C63/68
摘要： A method of preparing a halophthalic acid is disclosed which comprises the steps of contacting in a liquid phase reaction mixture at least one halogen-substituted ortho-xylene with oxygen and acetic acid at a temperature in a range between about 120° C. and about 220° C. in the presence of a catalyst system yielding a product mixture comprising less than 10 percent halogen-substituted ortho-xylene starting material, a halophthalic acid product, and less than about 10,000 ppm halobenzoic acid and less than about 1000 ppm halophthalide by-products based on a total amount of halophthalic acid present in the product mixture. In addition methods for the preparation of halophthalic anhydride, and recovery of high purity acetic acid from an aqueous acetic acid stream comprising HCl, which is generated during the preparation of the halophthalic acid are also disclosed.

3. 发明授权

US07541489B2 Method of making halophthalic acids and halophthalic anhydrides 有权
标题翻译：制备卤代邻苯二甲酸和卤代邻苯二甲酸酐的方法
公开(公告)号：US07541489B2
公开(公告)日：2009-06-02
申请号：US11170708
申请日：2005-06-29
申请人： Robert Edgar Colborn , David Bruce Hall , Peter Alois Koch , Bernd Volker Demuth , Thomas Wessel , KarlErnst Mack , Prashant Anil Tatake , Utpal Mahendra Vakil , Shyamal Bhaskar Gondkar , John Edward Pace , Kwang Woong Won
发明人： Robert Edgar Colborn , David Bruce Hall , Peter Alois Koch , Bernd Volker Demuth , Thomas Wessel , KarlErnst Mack , Prashant Anil Tatake , Utpal Mahendra Vakil , Shyamal Bhaskar Gondkar , John Edward Pace , Kwang Woong Won
IPC分类号： C07C51/16
CPC分类号： C07C51/265 , C07C63/68
摘要： A method of preparing a halophthalic acid is disclosed which comprises the steps of contacting in a liquid phase reaction mixture at least one halogen-substituted ortho-xylene with oxygen and acetic acid at a temperature in a range between about 120° C. and about 220° C. in the presence of a catalyst system yielding a product mixture comprising less than 10 percent halogen-substituted ortho-xylene starting material, a halophthalic acid product, and less than about 10,000 ppm halobenzoic acid and less than about 1000 ppm halophthalide by-products based on a total amount of halophthalic acid present in the product mixture. In addition methods for the preparation of halophthalic anhydride, and recovery of high purity acetic acid from an aqueous acetic acid stream comprising HCl, which is generated during the preparation of the halophthalic acid are also disclosed.
摘要翻译：公开了一种制备卤代邻苯二甲酸的方法，其包括以下步骤：在液相反应混合物中使至少一种卤素取代的邻二甲苯与氧和乙酸在约120℃至约220℃的温度下接触在催化剂体系的存在下，产生包含小于10％的卤素取代的邻二甲苯原料，卤代邻苯二甲酸产物和小于约10,000ppm的卤代苯甲酸和小于约1000ppm的卤代苯甲酸副产物的产物混合物，基于产物混合物中存在的卤代邻苯二甲酸的总量的产物。另外还公开了制备卤代邻苯二甲酸酐的方法，以及在制备卤代邻苯二甲酸期间产生的包含HCl的乙酸水溶液中回收高纯度乙酸。

4. 发明授权

US5705674A Process for preparing ortho-nitrobenzonitriles 失效
标题翻译：邻硝基苯腈制备方法
公开(公告)号：US5705674A
公开(公告)日：1998-01-06
申请号：US698792
申请日：1996-08-16
申请人： Thomas Wessel , Peter Koch
发明人： Thomas Wessel , Peter Koch
IPC分类号： C07B61/00 , C07C253/14 , C07C255/50
CPC分类号： C07C253/14 , C07C255/50
摘要： The present invention relates to a process for preparing ortho-nitrobenzonitriles of the formula I, ##STR1## where R.sup.1 and R.sup.2 are as defined in claim 1, by reacting the corresponding ortho-fluoronitrobenzenes with alkali metal cyanides or cyanide-donating substances in the presence of phase transfer catalysts.
摘要翻译：本发明涉及通过在相转移催化剂存在下使相应的邻氟代硝基苯与碱金属氰化物或氰化物供体物质反应来制备式I，权利要求1的邻硝基苯腈的方法。

5. 发明授权

US5886218A Process for preparing 4, 5-dichloro-2-methylbenzoic acid 失效
标题翻译：制备4,5-二氯-2-甲基苯甲酸的方法
公开(公告)号：US5886218A
公开(公告)日：1999-03-23
申请号：US846313
申请日：1997-04-30
申请人： Thomas Wessel , Peter Koch
发明人： Thomas Wessel , Peter Koch
IPC分类号： B01J27/125 , C07B61/00 , C07C49/80 , C07C51/29 , C07C51/373 , C07C63/70 , C07C51/16
CPC分类号： C07C49/80 , C07C51/29 , C07C63/70
摘要： The present invention relates to a process for preparing 4,5-dichloro-2-methylbenzoic acid and also its salts in high yields and in high purities by reacting 3,4-dichlorotoluene with acetyl chloride or chloroacetyl chloride in the presence of a Friedel-Crafts catalyst and subsequently oxidizing the acetylated intermediate to give the carboxylic acid.
摘要翻译：本发明涉及一种通过使3,4-二氯甲苯与乙酰氯或氯乙酰氯在Friedel-1的存在下反应而以高产率和高纯度制备4,5-二氯-2-甲基苯甲酸及其盐的方法， Crafts催化剂，随后氧化乙酰化的中间体得到羧酸。

6. 发明授权

US08097625B2 Combination of sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression 有权
标题翻译：镇静剂和神经递质调节剂的组合，以及改善睡眠质量和治疗抑郁症的方法
公开(公告)号：US08097625B2
公开(公告)日：2012-01-17
申请号：US11761235
申请日：2007-06-11
申请人： Karim Lalji , Timothy J. Barberich , Judy Caron , Thomas Wessel
发明人： Karim Lalji , Timothy J. Barberich , Judy Caron , Thomas Wessel
IPC分类号： A01N43/58 , A01N43/40 , A61K31/50 , A61K31/497 , A61K31/435
CPC分类号： A61K31/4985 , A61K31/137 , A61K31/138 , A61K31/495 , A61K31/724 , A61K45/06 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., insomnia and/or depression. The first component of the pharmaceutical composition is a GABA receptor modulating compound. The second component of the pharmaceutical composition is a serotonin reuptake inhibitor, a norepinephrine reuptake inhibitor, a 5-HT2A modulator, or dopamine reuptake inhibitor. In certain embodiments, the pharmaceutical composition comprises eszopiclone. In a preferred embodiment, the pharmaceutical composition comprises eszopiclone and fluoxetine. The present invention also relates to a method of treating a sleep abnormality, treating insomnia, treating depression, augmenting antidepressant therapy, eliciting a dose-sparing effect, reducing depression relapse, improving the efficacy of antidepressant therapy or improving the tolerability of antidepressant therapy, comprising co-administering to a patient in need thereof a GABA-receptor-modulating compound; and a SRI, NRI, 5-HT2A modulator or DRI.
摘要翻译：本发明的一个方面涉及含有两种或更多种活性剂的药物组合物，当它们一起被用于治疗，例如失眠和/或抑郁症时。药物组合物的第一组分是调节GABA受体的化合物。药物组合物的第二组分是5-羟色胺再摄取抑制剂，去甲肾上腺素再摄取抑制剂，5-HT2A调节剂或多巴胺再摄取抑制剂。在某些实施方案中，药物组合物包含依佐匹克。在优选的实施方案中，药物组合物包含依佐匹克和氟西汀。本发明还涉及一种治疗睡眠异常，治疗失眠，治疗抑郁症，增强抗抑郁药治疗，引发剂量保留作用，减少抑郁症复发，改善抗抑郁治疗疗效或提高抗抑郁治疗耐受性的方法，包括向有需要的患者共同施用GABA受体调节化合物; 和SRI，NRI，5-HT2A调节剂或DRI。

7. 发明授权

US08071599B2 Methods of treatment of chronic pain using eszopiclone 有权
标题翻译：使用左前列酮治疗慢性疼痛的方法
公开(公告)号：US08071599B2
公开(公告)日：2011-12-06
申请号：US12838554
申请日：2010-07-19
申请人： Thomas Wessel , Judy Caron
发明人： Thomas Wessel , Judy Caron
IPC分类号： A61K31/498
CPC分类号： A61K31/4985 , Y02A50/401
摘要： The invention relates to the use of eszopiclone for the treatment of low-level, chronic pain and fatigue associated with pain.
摘要翻译：本发明涉及使用依佐唑隆治疗与疼痛相关的低水平，慢性疼痛和疲劳。

8. 发明申请

US20090111817A1 Combinations of Eszopiclone and an Antidepressant 审中-公开
标题翻译：依曲普洛酮和抗抑郁药的组合
公开(公告)号：US20090111817A1
公开(公告)日：2009-04-30
申请号：US11994647
申请日：2006-07-05
申请人： Judy Caron , Thomas Wessel , Karim Lalji , Mark A. Varney
发明人： Judy Caron , Thomas Wessel , Karim Lalji , Mark A. Varney
IPC分类号： A61K31/4985
CPC分类号： A61K31/4985 , A61K31/343 , A61K31/381 , A61K31/4745 , A61K45/06 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is an antidepressant. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.
摘要翻译：本发明的一个方面涉及含有两种或更多种活性剂的药物组合物，所述活性剂当一起用于治疗例如更年期，情绪障碍，焦虑障碍或认知障碍时。药物组合物的第一组分是镇静剂佐佐匹克。药物组合物的第二组分是抗抑郁药。本发明还涉及治疗绝经，围绝经期，情绪障碍，焦虑障碍和认知障碍的方法。

9. 发明申请

US20080275211A1 METHOD OF MAKING HALOPHTHALIC ACIDS AND HALOPHTHALIC ANHYDRIDES 有权
标题翻译：制备半胱氨酸和半胱氨酸的方法
公开(公告)号：US20080275211A1
公开(公告)日：2008-11-06
申请号：US12175502
申请日：2008-07-18
申请人： Robert Edgar Colborn , David Bruce Hall , Peter Alois Koch , Bernd Volker Demuth , Thomas Wessel , Karl Ernst Mack , Prashant Anil Tatake , Utpal Mahendra Vakil , Shyamal Bhaskar Gondkar , John Edward Pace , Kwang Woong Won
发明人： Robert Edgar Colborn , David Bruce Hall , Peter Alois Koch , Bernd Volker Demuth , Thomas Wessel , Karl Ernst Mack , Prashant Anil Tatake , Utpal Mahendra Vakil , Shyamal Bhaskar Gondkar , John Edward Pace , Kwang Woong Won
IPC分类号： C08G73/10 , C07D307/77
CPC分类号： C07C51/265 , C07C63/68
摘要： A method of preparing a halophthalic acid is disclosed which comprises the steps of contacting in a liquid phase reaction mixture at least one halogen-substituted ortho-xylene with oxygen and acetic acid at a temperature in a range between about 120° C. and about 220° C. in the presence of a catalyst system yielding a product mixture comprising less than 10 percent halogen-substituted ortho-xylene starting material, a halophthalic acid product, and less than about 10,000 ppm halobenzoic acid and less than about 1000 ppm halophthalide by-products based on a total amount of halophthalic acid present in the product mixture. In addition methods for the preparation of halophthalic anhydride, and recovery of high purity acetic acid from an aqueous acetic acid stream comprising HCl, which is generated during the preparation of the halophthalic acid are also disclosed.
摘要翻译：公开了一种制备卤代邻苯二甲酸的方法，其包括以下步骤：在液相反应混合物中使至少一种卤素取代的邻二甲苯与氧和乙酸在约120℃至约220℃的温度下接触在催化剂体系的存在下，产生包含小于10％的卤素取代的邻二甲苯原料，卤代邻苯二甲酸产物和小于约10,000ppm的卤代苯甲酸和小于约1000ppm的卤代苯甲酸副产物的产物混合物，基于产物混合物中存在的卤代邻苯二甲酸的总量的产物。另外还公开了制备卤代邻苯二甲酸酐的方法，以及在制备卤代邻苯二甲酸期间产生的包含HCl的乙酸水溶液中回收高纯度乙酸。

10. 发明申请

US20070299055A1 COMBINATION OF SEDATIVE AND A NEUROTRANSMITTER MODULATOR, AND METHODS FOR IMPROVING SLEEP QUALITY AND TREATING DEPRESSION 有权
标题翻译：消融和神经递质调节剂的组合以及改善睡眠质量和治疗呕吐的方法
公开(公告)号：US20070299055A1
公开(公告)日：2007-12-27
申请号：US11761235
申请日：2007-06-11
申请人： Karim Lalji , Timothy Barberich , Judy Caron , Thomas Wessel
发明人： Karim Lalji , Timothy Barberich , Judy Caron , Thomas Wessel
IPC分类号： A61K31/495 , A61K31/13 , A61K31/135 , A61K31/165 , A61K31/535 , A61P43/00 , A61K31/55 , A61K31/34 , A61K31/38 , A61K31/445
CPC分类号： A61K31/4985 , A61K31/137 , A61K31/138 , A61K31/495 , A61K31/724 , A61K45/06 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., insomnia and/or depression. The first component of the pharmaceutical composition is a GABA receptor modulating compound. The second component of the pharmaceutical composition is a serotonin reuptake inhibitor, a norepinephrine reuptake inhibitor, a 5-HT2A modulator, or dopamine reuptake inhibitor. In certain embodiments, the pharmaceutical composition comprises eszopiclone. In a preferred embodiment, the pharmaceutical composition comprises eszopiclone and fluoxetine. The present invention also relates to a method of treating a sleep abnormality, treating insomnia, treating depression, augmenting antidepressant therapy, eliciting a dose-sparing effect, reducing depression relapse, improving the efficacy of antidepressant therapy or improving the tolerability of antidepressant therapy, comprising co-administering to a patient in need thereof a GABA-receptor-modulating compound; and a SRI, NRI, 5-HT2A modulator or DRI.
摘要翻译：本发明的一个方面涉及含有两种或更多种活性剂的药物组合物，当它们一起被用于治疗，例如失眠和/或抑郁症时。药物组合物的第一组分是调节GABA受体的化合物。药物组合物的第二组分是5-羟色胺再摄取抑制剂，去甲肾上腺素再摄取抑制剂，5-HT 2AA调节剂或多巴胺再摄取抑制剂。在某些实施方案中，药物组合物包含依佐匹克。在优选的实施方案中，药物组合物包含依佐匹克和氟西汀。本发明还涉及一种治疗睡眠异常，治疗失眠，治疗抑郁症，增强抗抑郁药治疗，引发剂量保留作用，减少抑郁症复发，改善抗抑郁治疗疗效或提高抗抑郁治疗耐受性的方法，包括向有需要的患者共同施用GABA受体调节化合物; 和SRI，NRI，5-HT 2A调节剂或DRI。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式