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1. 发明申请

US20050197299A1 Peptidomimetic protease inhibitors 有权
标题翻译：拟肽蛋白酶抑制剂
公开(公告)号：US20050197299A1
公开(公告)日：2005-09-08
申请号：US10344112
申请日：2001-08-31
申请人： Robert Babine , Shu-Hul Chen , Jason Lamar , Nancy Snyder , Xicheng Sun , Mark Tebbe , Frantz Victor , Q. Wang , Yvonne Yip , Ivan Collado , Cristina Garcia-Paredes , Raymond Parker , Ling Jing , Deqi Guo , John Glass
发明人： Robert Babine , Shu-Hul Chen , Jason Lamar , Nancy Snyder , Xicheng Sun , Mark Tebbe , Frantz Victor , Q. Wang , Yvonne Yip , Ivan Collado , Cristina Garcia-Paredes , Raymond Parker , Ling Jing , Deqi Guo , John Glass
IPC分类号： C12N9/99 , A61K20060101 , A61K31/13 , A61K31/437 , A61K31/7052 , A61K31/713 , A61K38/00 , A61K38/04 , A61K38/05 , A61K38/21 , A61K38/55 , A61K45/00 , A61P20060101 , A61P1/16 , A61P31/14 , A61P43/00 , C07D209/02 , C07D209/52 , C07K20060101 , C07K5/02 , C07K5/023 , C07K5/027 , C07K5/03 , C07K5/04 , C07K5/06 , C07K7/02 , C07K7/06 , C07K14/18 , C12N7/06
CPC分类号： C07K7/02 , A61K38/07 , A61K38/08 , A61K38/21 , A61K38/212 , A61K38/215 , A61K45/06 , C07D209/02 , C07D209/52 , C07K5/0202 , C07K5/0205 , C07K5/06052 , C07K5/0808 , C07K5/101 , C07K5/1016 , C07K7/06 , C07K14/005 , C12N2770/24222 , Y02P20/55 , A61K2300/00
摘要： The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.
摘要翻译：本发明涉及可用作蛋白酶抑制剂的肽模拟化合物，特别是作为丝氨酸蛋白酶抑制剂，更具体地，涉及丙型肝炎NS3蛋白酶抑制剂; 中间体; 它们的制备方法包括对中间体的新型置换步骤。本发明还涉及药物组合物和使用该化合物抑制HCV蛋白酶或治疗患有HCV感染或与感染有关的生理病症的患者的方法。还提供了药物组合，除一种或多种HCV丝氨酸蛋白酶抑制剂外还包含一种或多种表现出抗HCV活性的干扰素和/或一种或多种具有抗HCV活性的化合物和药学上可接受的载体，以及用于治疗或预防的方法使用该组合物的患者中的HCV感染。本发明还涉及用于治疗或预防患者HCV感染的试剂盒或药物包装。

2. 发明申请

US20150037890A1 Methods and Apparatus for Transplantation of Nucleic Acid Molecules 有权
标题翻译：用于移植核酸分子的方法和装置
公开(公告)号：US20150037890A1
公开(公告)日：2015-02-05
申请号：US14449106
申请日：2014-07-31
申请人： Andreas Mershin , James Pelletier , Neil Gershenfeld , John Glass , Elizabeth Strychalski
发明人： Andreas Mershin , James Pelletier , Neil Gershenfeld , John Glass , Elizabeth Strychalski
IPC分类号： C12N15/04 , C12M1/42 , C12N15/87
CPC分类号： C12M35/08 , C12N15/87
摘要： In exemplary implementations, transplantation of nucleic acids into cells occurs in microfluidic chambers. The nucleic acids may be large nucleic acid molecules with more than 100 kbp. In some cases, the microfluidic chambers have only one orifice that opens to a flow channel. In some cases, flow through a microfluidic chamber temporarily ceases due to closing one or more valves. Transplantation occurs during a period in which the contents of the chambers are shielded from shear forces. Diffusion, centrifugation, suction from a vacuum channel, or dead-end loading may be used to move cells or buffers into the chambers.
摘要翻译：在示例性实施方案中，将核酸移植到细胞中发生在微流体室中。核酸可以是大于100kbp的大核酸分子。在一些情况下，微流体室仅具有一个通向流动通道的孔口。在一些情况下，由于关闭一个或多个阀门，流过微流体室的流动暂时停止。移植发生在室内容物被剪切力屏蔽的期间。可以使用扩散，离心，真空通道抽吸或死端装载将细胞或缓冲液移动到腔室中。

3. 发明申请

US20080125367A1 Agents for treatment of HCV and methods of use 有权
公开(公告)号：US20080125367A1
公开(公告)日：2008-05-29
申请号：US11899393
申请日：2007-09-04
申请人： Jeffrey Glenn , Tina Myers , John Glass
发明人： Jeffrey Glenn , Tina Myers , John Glass
IPC分类号： A61K38/00 , C07K14/00 , A61P43/00 , C07K7/00
CPC分类号： C07K14/005 , A61K38/162 , A61K39/00 , C07K2319/00 , C12N2740/16322 , C12N2770/24222 , G01N33/5767 , G01N2500/02 , G01N2500/10
摘要： An amphipathic helix at the approximate N-terminus of Hepatitis C virus (HCV) nonstructural proteins mediates the association of these proteins with cytoplasmic membranes in infected cells. This association is essential for replication. Thus, assessing the ability of compounds or protocols to disrupt the association of such helices with cytoplasmic membranes permits identification of compounds and protocols which are useful in the treatment of HCV infection. Also useful in the invention are mimics, or function-disrupting ligands, of an amphipathic helix of the nonstructural proteins described herein and antibodies and fragments thereof immunoreactive with said helix.

4. 发明授权

US07890310B2 Method for analysis of control systems 有权
标题翻译：控制系统分析方法
公开(公告)号：US07890310B2
公开(公告)日：2011-02-15
申请号：US10991899
申请日：2004-11-17
申请人： John Glass , Pascal Gahinet
发明人： John Glass , Pascal Gahinet
IPC分类号： G06G7/48
CPC分类号： G05B19/0426 , G05B2219/23258
摘要： The present invention provides a framework to let users systematically analyze, and design controllers for, complex non-linear dynamic systems modeled in a block diagram environment. By extracting linearized models from non-linear plant models (block diagrams), users can use one or more control design and tuning methodologies available for linear systems. Complex side effects, such as cross-coupling and exogenous disturbances, are viewable and can be dealt with in real-time during a design. The results of a design are automatically implemented in a block diagram.
摘要翻译：本发明提供了一种框架，以允许用户系统地分析并设计用于在框图环境中建模的复杂非线性动态系统的控制器。通过从非线性工厂模型（框图）提取线性化模型，用户可以使用一个或多个可用于线性系统的控制设计和调优方法。复杂的副作用，如交叉耦合和外部干扰，是可见的，可以在设计过程中实时处理。设计结果以框图自动实现。

5. 发明申请

US20070150252A1 Digital effects analysis in modeling environments 有权
标题翻译：建模环境中的数字效果分析
公开(公告)号：US20070150252A1
公开(公告)日：2007-06-28
申请号：US11320214
申请日：2005-12-27
申请人： John Glass , Thomas Erkkinen
发明人： John Glass , Thomas Erkkinen
IPC分类号： G06F9/45
CPC分类号： G06F17/5009 , G06F11/3447 , G06F2201/865 , G06F2217/04
摘要： An analysis tool analyzes a model to determine the digital effect of the model in a modeling or programming environment. With the analysis tool, a user can determine minimum hardware functionality needed to execute the software generated from the model. The hardware functionality may include the word size of the microprocessor that executes the software appropriately. The hardware functionality may also include the execution speed of the microprocessor executing the software. The hardware functionality may further include the functionality of other hardware elements, such as the word length of an Analog to Digital converter. The analysis tool enables a user to produce a system at a low cost while achieving necessary performance criteria.
摘要翻译：分析工具分析模型以确定模型在建模或编程环境中的数字效应。使用分析工具，用户可以确定执行从模型生成的软件所需的最低硬件功能。硬件功能可以包括适当地执行软件的微处理器的字大小。硬件功能还可以包括执行软件的微处理器的执行速度。硬件功能还可以包括其他硬件元件的功能，例如模数转换器的字长。分析工具使用户能够以低成本生产系统，同时实现必要的性能标准。

6. 发明授权

US08046207B2 Digital effects analysis in modeling environments 有权
标题翻译：建模环境中的数字效果分析
公开(公告)号：US08046207B2
公开(公告)日：2011-10-25
申请号：US11320214
申请日：2005-12-27
申请人： John Glass , Thomas J. Erkkinen
发明人： John Glass , Thomas J. Erkkinen
IPC分类号： G06F17/50
CPC分类号： G06F17/5009 , G06F11/3447 , G06F2201/865 , G06F2217/04
摘要： An analysis tool analyzes a model to determine the digital effect of the model in a modeling or programming environment. With the analysis tool, a user can determine minimum hardware functionality needed to execute the software generated from the model. The hardware functionality may include the word size of the microprocessor that executes the software appropriately. The hardware functionality may also include the execution speed of the microprocessor executing the software. The hardware functionality may further include the functionality of other hardware elements, such as the word length of an Analog to Digital converter. The analysis tool enables a user to produce a system at a low cost while achieving necessary performance criteria.
摘要翻译：分析工具分析模型以确定模型在建模或编程环境中的数字效应。使用分析工具，用户可以确定执行从模型生成的软件所需的最低硬件功能。硬件功能可以包括适当地执行软件的微处理器的字大小。硬件功能还可以包括执行软件的微处理器的执行速度。硬件功能还可以包括其他硬件元件的功能，例如模数转换器的字长。分析工具使用户能够以低成本生产系统，同时实现必要的性能标准。

7. 发明授权

US07865254B2 Modeling of control systems with open-loop representations and factorization of components 有权
标题翻译：具有开环表示和组件分解的控制系统的建模
公开(公告)号：US07865254B2
公开(公告)日：2011-01-04
申请号：US11977299
申请日：2007-10-24
申请人： Pascal Gahinet , John Glass , Alec Stothert , Craig Buhr
发明人： Pascal Gahinet , John Glass , Alec Stothert , Craig Buhr
IPC分类号： G05B13/02 , G06G7/48
CPC分类号： G05B19/0426 , G05B17/02 , G05B2219/23258 , G05B2219/23261
摘要： A method of manipulating a block diagram model with a plurality of graphical modeling components by defining an open loop anywhere on the block diagram model is provided. Graphical modeling components in series with the open loop may be automatically recognized and a plurality of parameters of the graphical modeling components in series with the open loop may be displayed on a display device. A user may simultaneously tune the parameters of the graphical modeling components in series with the open loop. Factorization points breaking the block diagram model in two disconnected parts may be identified in the block diagram model. A virtual graphical model may be generated by replacing a pattern of the graphical modeling components between two factorization points with a single graphical modeling component representing the pattern.
摘要翻译：提供了通过在框图模型上的任何地方定义开环来操纵具有多个图形建模组件的框图模型的方法。可以自动识别与开环串联的图形建模组件，并且可以在显示设备上显示与开环串联的图形建模组件的多个参数。用户可以同时调整与开环串联的图形建模组件的参数。可以在框图模型中识别在两个断开的部分中打破框图模型的因式分解点。可以通过用表示图案的单个图形建模部件替换两个分解点之间的图形建模部件的图案来生成虚拟图形模型。

8. 发明授权

US07643973B2 Analyzing linearization of models in modeling environments 有权
标题翻译：分析建模环境中模型的线性化
公开(公告)号：US07643973B2
公开(公告)日：2010-01-05
申请号：US10940104
申请日：2004-09-13
申请人： John Glass
发明人： John Glass
IPC分类号： G06G7/48
CPC分类号： G06F17/5009 , G06F17/13
摘要： Method and systems for analyzing the linearization of a model in a modeling environment are disclosed. The modeling environment may provide tools for linearizing the model to generate a linear model. The modeling environment may also provide tools for analyzing the linearization of the model. The tools for analyzing the linearization of the model may inspect the linear model to determine whether the model is properly linearized. The results of the linearization may be provided to users so that the users are able modify the linearization result and have the model linearized again using the modified information.
摘要翻译：公开了在建模环境中分析模型的线性化的方法和系统。建模环境可以提供用于线性化模型以生成线性模型的工具。建模环境还可以提供用于分析模型线性化的工具。用于分析模型线性化的工具可以检查线性模型以确定模型是否被适当地线性化。可以向用户提供线性化的结果，使得用户能够修改线性化结果，并且使用修改的信息再次使模型线性化。

9. 发明申请

US20080172212A1 Modeling of control systems with open-loop representations and factorization of components 有权
标题翻译：具有开环表示和组件分解的控制系统的建模
公开(公告)号：US20080172212A1
公开(公告)日：2008-07-17
申请号：US11977299
申请日：2007-10-24
申请人： Pascal Gahinet , John Glass , Alec Stothert , Craig Buhr
发明人： Pascal Gahinet , John Glass , Alec Stothert , Craig Buhr
IPC分类号： G06G7/48 , G06F17/00
CPC分类号： G05B19/0426 , G05B17/02 , G05B2219/23258 , G05B2219/23261
摘要： A method of manipulating a block diagram model with a plurality of graphical modeling components by defining an open loop anywhere on the block diagram model is provided. Graphical modeling components in series with the open loop may be automatically recognized and a plurality of parameters of the graphical modeling components in series with the open loop may be displayed on a display device. A user may simultaneously tune the parameters of the graphical modeling components in series with the open loop. Factorization points breaking the block diagram model in two disconnected parts may be identified in the block diagram model. A virtual graphical model may be generated by replacing a pattern of the graphical modeling components between two factorization points with a single graphical modeling component representing the pattern.
摘要翻译：提供了通过在框图模型上的任何地方定义开环来操纵具有多个图形建模组件的框图模型的方法。可以自动识别与开环串联的图形建模组件，并且可以在显示设备上显示与开环串联的图形建模组件的多个参数。用户可以同时调整与开环串联的图形建模组件的参数。可以在框图模型中识别在两个断开的部分中打破框图模型的因式分解点。可以通过用表示图案的单个图形建模部件替换两个分解点之间的图形建模部件的图案来生成虚拟图形模型。

10. 发明授权

US09834747B2 Methods and apparatus for transplantation of nucleic acid molecules 有权
公开(公告)号：US09834747B2
公开(公告)日：2017-12-05
申请号：US14449106
申请日：2014-07-31
申请人： Andreas Mershin , James Pelletier , Neil Gershenfeld , John Glass , Elizabeth Strychalski
发明人： Andreas Mershin , James Pelletier , Neil Gershenfeld , John Glass , Elizabeth Strychalski
IPC分类号： C12N15/04 , C12M1/42 , C12N15/87
CPC分类号： C12M35/08 , C12N15/87
摘要： In exemplary implementations, transplantation of nucleic acids into cells occurs in microfluidic chambers. The nucleic acids may be large nucleic acid molecules with more than 100 kbp. In some cases, the microfluidic chambers have only one orifice that opens to a flow channel. In some cases, flow through a microfluidic chamber temporarily ceases due to closing one or more valves. Transplantation occurs during a period in which the contents of the chambers are shielded from shear forces. Diffusion, centrifugation, suction from a vacuum channel, or dead-end loading may be used to move cells or buffers into the chambers.

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