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1. 发明授权

US4192020A Heart valve prosthesis 失效
标题翻译：心脏瓣膜假体
公开(公告)号：US4192020A
公开(公告)日：1980-03-11
申请号：US790442
申请日：1977-04-25
申请人： Robert B. Davis , John Skelton , Richard E. Clark , Wilbur M. Swanson
发明人： Robert B. Davis , John Skelton , Richard E. Clark , Wilbur M. Swanson
IPC分类号： A61F2/06 , A61F2/24 , D03D3/02 , D03D7/00 , D03D15/00 , A61F1/22
CPC分类号： D03D15/00 , A61F2/06 , A61F2/2412 , B21F45/008 , D03D3/02 , D03D7/00 , D10B2321/022 , D10B2331/04 , D10B2401/061 , D10B2509/00 , Y10S623/90
摘要： A prosthesis for an inadequate or diseased heart valve, the prosthesis being formed of a porous fabric comprising multifilament synthetic yarns supported on a plural-lobed frame. The frame has generally parallel legs each comprising a pair of rod portions. The fabric is inserted between the rod portions of the legs to form flexible leaflets. Each leaflet consists essentially of a textile of filaments having a substantial number of open interstitial spaces in the range of 20 to 40 microns evenly distributed throughout the fabric. The resulting composite structures are free of thrombogenic complications.
摘要翻译：用于不充分或患病的心脏瓣膜的假体，所述假体由多孔织物形成，所述多孔织物包括支撑在多叶状框架上的复丝合成纱线。框架具有大致平行的腿，每个腿包括一对杆部分。将织物插入腿的杆部之间以形成柔性传单。每个小叶基本上由长丝的织物组成，其具有在整个织物中均匀分布的在20至40微米范围内的相当数量的开放间隙。所得到的复合结构没有血栓形成并发症。

2. 发明授权

US4297749A Heart valve prosthesis 失效
标题翻译：心脏瓣膜假体
公开(公告)号：US4297749A
公开(公告)日：1981-11-03
申请号：US125121
申请日：1980-02-27
申请人： Robert B. Davis , John Skelton , Richard E. Clark , Wilbur M. Swanson
发明人： Robert B. Davis , John Skelton , Richard E. Clark , Wilbur M. Swanson
IPC分类号： A61F2/24 , A61F1/22
CPC分类号： B21F45/008 , A61F2/2412 , Y10S623/90
摘要： A frame system for heart valve prosthesis. A first frame has at least three generally parallel legs each comprising a pair of rod portions connected at one end and diverging at the other end as lobes respectively connecting with rod portions of others of said legs. The lobes form an aperture therebetween and the legs are adapted to receive the margin of a valve leaflet between the rod portions thereof. Thus, the leaflet may be secured to two adjacent legs and the interconnecting lobe so as to have a free edge extending between said adjacent legs. A second frame is adapted to nest with the first frame and comprises a rod formed to be substantially congruent with the interconnecting lobes, whereby the leaflets may be secured to and between the frames.
摘要翻译：心脏瓣膜假体的框架系统。第一框架具有至少三个大致平行的腿，每个腿包括一对杆部分，该杆部分在一端连接并且在另一端处以分别与所述腿部中的其他杆的杆部分连接的凸起分开。叶片在它们之间形成孔，并且腿部适于在其杆部之间容纳瓣膜小叶的边缘。因此，小叶可以固定到两个相邻的腿和互连瓣，以便具有在所述相邻腿之间延伸的自由边缘。第二框架适于与第一框架嵌套并且包括形成为与互连凸角基本一致的杆，由此传单可以固定到框架之间并且在框架之间。

3. 发明授权

US4340091A Elastomeric sheet materials for heart valve and other prosthetic implants 失效
标题翻译：用于心脏瓣膜和其他假体植入物的弹性片材
公开(公告)号：US4340091A
公开(公告)日：1982-07-20
申请号：US125120
申请日：1980-02-27
申请人： John Skelton , Richard E. Clark , Robert B. Davis
发明人： John Skelton , Richard E. Clark , Robert B. Davis
IPC分类号： A61L27/00 , A61F2/06 , A61F2/24 , A61L27/14 , A61L27/18 , D03D3/02 , D03D7/00 , D03D15/00 , A61F1/22 , D04C1/00
CPC分类号： A61F2/2418 , A61F2/06 , A61F2/2412 , A61L27/14 , A61L27/18 , B21F45/008 , D03D15/00 , D03D15/0061 , D03D15/08 , D03D3/02 , D03D7/00 , A61F2220/005 , D10B2331/06 , D10B2509/00
摘要： Sheet materials for cardiovascular and other prosthetic implants are fabricated of synthetic elastomers. These materials are characterized by molecular configurations that produce a nonlinear tensile modulus characteristic similar in shape to that of natural tissue. Selected elastomers, when formed as sheet material of appropriate geometrical configuration, promote the formation of natural tissue thereon which is appropriate for the mechanical characteristics desired.
摘要翻译：用于心血管和其他假体植入物的片材由合成弹性体制成。这些材料的特征在于产生与天然组织相似形状的非线性拉伸模量特征的分子构型。所选择的弹性体当形成为具有适当几何构型的片状材料时，促进其上适合于所需机械特性的天然组织的形成。

4. 发明授权

US4191218A Fabrics for heart valve and vascular prostheses and methods of fabricating same 失效
标题翻译：用于心脏瓣膜和血管假体的织物及其制造方法
公开(公告)号：US4191218A
公开(公告)日：1980-03-04
申请号：US901085
申请日：1978-04-28
申请人： Richard E. Clark , John Skelton , Robert B. Davis
发明人： Richard E. Clark , John Skelton , Robert B. Davis
IPC分类号： A61F2/06 , A61F2/24 , D03D3/02 , D03D7/00 , D03D15/00 , A61F1/22 , D04C1/00
CPC分类号： D03D15/0088 , A61F2/06 , A61F2/2412 , D03D15/00 , D03D3/02 , D03D7/00 , D10B2331/04 , D10B2401/061 , D10B2509/00
摘要： Prostheses for inadequate or diseased heart valves and blood vessels, formed of fabrics comprising multifilament synthetic yarns. For a heart valve the fabric is supported on a three-lobed frame. During manufacture, the fabric is subjected to a plural step compressive shrinking and crimping process to impart nonisotropic elastic compliance approximating the natural mechanical properties. The resulting composite structures are free of thrombogenic complications.
摘要翻译：用于由包括复丝合成纱线的织物形成的不充分或患病的心脏瓣膜和血管的假体。对于心脏瓣膜，织物支撑在三叶框架上。在制造过程中，织物经受多步压缩收缩和卷曲处理，以赋予接近自然机械性能的非均质弹性柔量。所得到的复合结构没有血栓形成并发症。

5. 发明授权

US06186149B1 Occluder device and method of making 失效
标题翻译：封堵装置及其制作方法
公开(公告)号：US06186149B1
公开(公告)日：2001-02-13
申请号：US09524647
申请日：2000-03-13
申请人： John J. Pacella , Richard E. Clark
发明人： John J. Pacella , Richard E. Clark
IPC分类号： A61M112
CPC分类号： A61M1/122 , A61M1/1008 , A61M1/101 , A61M1/1018 , A61M1/107 , A61M1/1086 , A61M1/1087 , A61M1/12 , A61M1/127 , A61M39/228 , A61M2205/33 , A61M2205/3303
摘要： The present invention pertains to a circulatory system, such as a circulatory assist system for a patient. The system comprises a blood pump having tubing fluidically communicating with a person's blood vessel. The blood pump can be, for instance, a centrifugal blood pump but is not limited thereto. The system also comprises an occluder device for controlling flow of the blood pump. The occluder device is in contact with the tubing of the blood pump. The occluder device can be incorporated into an anti-kink sheath over the outlet graft tubing of the blood pump. Preferably, the system comprises control means for actuating the occluder device when the blood pump malfunctions. In this manner, potentially fatal retrograde blood due to pump failure is automatically prevented. In a preferred embodiment, the occluder device comprises a cylindrical tube and a bladder mechanism connected to the inside surface of the tube. Type bladder mechanism preferably comprises a bladder and means for inflating the bladder. The inflating means preferably comprises a bladder pump having a tube in fluidic communication with the bladder. The bladder can be of a variety of constructions in the tube. The bladder can cover all or a portion of the inner surface of the tube. Also, two bladders can oppose each other, in a non-overlapping manner, within the tube. Alternatively, the bladder can cover the entire 360° of the inner surface. In this manner, as the bladder is inflated, the orifice closes with decreasing diameter, much like a natural biological valve. The occluder device could be rapidly inflated and deflated for applications as a valve either internally or externally. This would transform the normal steady flow output of a blood pump to a pulsatile output.
摘要翻译：本发明涉及循环系统，例如患者的循环辅助系统。该系统包括具有与人的血管流体连通的管的血泵。血液泵可以是例如离心式血液泵，但不限于此。该系统还包括用于控制血液泵流动的封堵装置。封堵装置与血液泵的管路接触。封堵器装置可以并入到血泵的出口移植管上的抗扭结护套中。优选地，该系统包括用于当血液泵发生故障时致动封堵器装置的控制装置。以这种方式，由于泵故障引起的潜在致命的逆行血液被自动防止。在优选实施例中，封堵器装置包括连接到管的内表面的圆柱形管和囊状机构。膀胱机构优选地包括膀胱和用于使膀胱充气的装置。膨胀装置优选地包括具有与气囊流体连通的管的囊泵。膀胱可以是管中的各种结构。囊可以覆盖管的内表面的全部或一部分。此外，两个囊可以以不重叠的方式在管内相互对抗。或者，膀胱可以覆盖内表面的整个360°。以这种方式，当气囊膨胀时，孔口以直径减小的方式闭合，非常类似于天然生物瓣膜。封闭器装置可以在内部或外部作为阀门快速充气和放气用于应用。这将将血泵的正常稳定流量输出转换为脉动输出。

6. 发明授权

US5711753A Blood pump device and method of pumping blood 失效
标题翻译：血泵装置及血液泵送方法
公开(公告)号：US5711753A
公开(公告)日：1998-01-27
申请号：US618084
申请日：1996-03-18
申请人： John J. Pacella , Andrew H. Goldstein , Dennis R. Trumble , Richard E. Clark , Fred W. Moeller
发明人： John J. Pacella , Andrew H. Goldstein , Dennis R. Trumble , Richard E. Clark , Fred W. Moeller
IPC分类号： A61L31/00 , A61M1/10 , A61M1/12 , F04D13/06 , F04D29/10
CPC分类号： A61M1/101 , A61M1/102 , A61M1/122
摘要： The present invention pertains to a blood pump device which comprises a blood pump having blood transport ports and cannulae connected to the ports. The blood pump device also comprises a coating material covering the junction between the inner surfaces of the ports and cannulae. This forms a smooth transition so blood can flow unimpeded therefrom and collection cavities for the blood are eliminated. The invention is also related to a method of producing a smooth coating. The present invention is a blood pump device comprising a second portion having a stator mechanism and a rotor mechanism disposed adjacent to and driven by the stator mechanism. The second portion has a journal disposed about the rotor mechanism to provide support therewith. The second portion has an impeller disposed in the chamber and a one-piece seal member for sealing about a shaft of the impeller. The seal member is fixedly attached to the journal so that the seal member is supported by the journal. The present invention is also related to means for providing power to the blood pump so that blood can be pumped through a cannulae. The providing means includes a controller having means for sensing pump failure and an output terminal for actuating a safety occluder in an event of pump failure. Preferably, there is a safety occluder device disposed about the cannulae and in communication with the output terminal. Preferably, the blood pump comprises a motor having stator mechanism and a rotor mechanism driven by the stator mechanism. The sensing means comprises means for determining back electromagnetic force within the stator mechanism. Preferably, the controlling means has means for providing signals indicate of stator current and rotor speed, respectively. The providing means is in communication with the means for determining back electromagnetic force in the stator mechanism.
摘要翻译：本发明涉及一种血液泵装置，其包括具有血液输送口的血液泵和与端口连接的插管。血液泵装置还包括覆盖端口的内表面和套管之间的接合处的涂层材料。这形成平滑的过渡，因此血液可以不受阻碍地流动，消除了血液的收集腔。本发明还涉及一种制备光滑涂层的方法。本发明是一种血泵装置，包括具有定子机构的第二部分和与定子机构相邻并由定子机构驱动的转子机构。第二部分具有围绕转子机构设置的轴颈，以便为其提供支撑。第二部分具有设置在室中的叶轮和用于围绕叶轮的轴密封的一体式密封构件。密封构件固定地连接到轴颈上，使得密封构件由轴颈支撑。本发明还涉及用于向血液泵提供动力以使血液能够通过套管泵送的装置。提供装置包括具有用于感测泵故障的装置的控制器和用于在泵故障的情况下致动安全闭塞器的输出端子。优选地，存在围绕插管设置并与输出端子连通的安全闭塞器装置。优选地，血泵包括具有定子机构的马达和由定子机构驱动的转子机构。感测装置包括用于确定定子机构内的反向电磁力的装置。优选地，控制装置具有分别提供定子电流和转子速度的信号的装置。提供装置与用于确定定子机构中的反向电磁力的装置通信。

7. 发明授权

US4535902A Intermediate article of manufacture for a plastic container 失效
标题翻译：塑料容器的中间制品
公开(公告)号：US4535902A
公开(公告)日：1985-08-20
申请号：US423358
申请日：1982-09-24
申请人： Richard E. Clark
发明人： Richard E. Clark
IPC分类号： B29C49/04 , B29C49/06 , B29C69/00 , B65D1/02 , B65D1/22 , B29C17/08 , B29D23/03
CPC分类号： B29C49/4278 , B29C65/58 , B29C66/542 , B29C66/545 , B29C66/742 , B65D1/0223 , B65D15/18 , B29C65/568 , B29L2031/712 , B29L2031/717 , B65D2501/0081 , Y10S428/91 , Y10T428/1397
摘要： This relates to the blow molding of containers wherein the containers are formed of biaxially oriented plastic material. A multi-sided hollow member is blown within a convention blow mold using a conventional type of preform. Each side, when severed from the top and bottom of the hollow member and from each other forms a tray or box like container having a bottom, side walls and a peripheral sealing flange. The efficiency of the container from a weight to capacity standpoint is at a maximum due to the biaxial orientation of the plastic material.
摘要翻译：这涉及容器的吹塑，其中容器由双轴取向的塑料材料形成。使用常规类型的预成型件在常规吹塑模具内吹塑多面中空构件。当从中空构件的顶部和底部切断并且彼此形成具有底部，侧壁和周边密封凸缘的托盘或盒状容器时，每一侧。由于塑料材料的双轴取向，容器从重量到容量的立场的效率最大。

8. 发明授权

US6162167A Blood pump device having a journal 失效
标题翻译：具有日志的血泵装置
公开(公告)号：US6162167A
公开(公告)日：2000-12-19
申请号：US898584
申请日：1997-07-21
申请人： Andrew H. Goldstein , John J. Pacella , Dennis R. Trumble , Richard E. Clark , Fred W. Moeller , George J. Magovern
发明人： Andrew H. Goldstein , John J. Pacella , Dennis R. Trumble , Richard E. Clark , Fred W. Moeller , George J. Magovern
IPC分类号： A61L31/00 , A61M1/10 , A61M1/12 , F04D13/06 , F04D29/10
CPC分类号： A61M1/102 , A61M1/1008 , A61M1/101 , A61M1/1086 , A61M1/122 , A61M2205/3334
摘要： A blood pump device which includes a blood pump having blood transport ports and cannulae connected to the ports. The blood pump device also includes a coating material covering the junction between the inner surfaces of the ports and cannulae. A method of producing a smooth coating. A blood pump device including a second portion having a stator mechanism and a rotor mechanism disposed adjacent to and driven by the stator mechanism. The second portion has a journal disposed about the rotor mechanism to provide support therewith. The second portion has an impeller disposed in the chamber and a seal member for sealing about a shaft of the impeller. The seal member is fixedly attached to the journal so that the seal member is supported by the journal. A mechanism for providing power to the blood pump so that blood can be pumped through a cannula.
摘要翻译：一种血液泵装置，其包括具有血液输送口的血泵和连接到所述端口的套管。血液泵装置还包括覆盖端口的内表面和套管之间的连接处的涂覆材料。一种制备光滑涂层的方法。一种血泵装置，包括具有定子机构的第二部分和邻近定子机构驱动的转子机构。第二部分具有围绕转子机构设置的轴颈，以便为其提供支撑。第二部分具有设置在腔室中的叶轮和用于围绕叶轮的轴线密封的密封构件。密封构件固定地连接到轴颈上，使得密封构件由轴颈支撑。为血泵提供动力以使血液能够通过套管泵送的机构。

9. 发明授权

US4665682A Method for producing a hot fillable, collapse resistant polyester container without the need to utilize set process techniques and/or non-conventional container geometries 失效
标题翻译：用于生产可热填充的抗塌缩的聚酯容器的方法，而不需要利用固定的工艺技术和/或非常规的容器几何形状
公开(公告)号：US4665682A
公开(公告)日：1987-05-19
申请号：US730113
申请日：1985-05-03
申请人： Gerard J. Kerins , Wayne N. Collette , Martin H. Beck , Richard E. Clark , Ieuan L. Harry , Suppayan Krishnakumar , Bryan H. Miller , Richard C. Nichols , David Piccioli , Louis D. Tacito , Eileene M. Worsowicz
发明人： Gerard J. Kerins , Wayne N. Collette , Martin H. Beck , Richard E. Clark , Ieuan L. Harry , Suppayan Krishnakumar , Bryan H. Miller , Richard C. Nichols , David Piccioli , Louis D. Tacito , Eileene M. Worsowicz
IPC分类号： B29C49/08 , B29C49/00 , B29C49/06 , B29C49/64 , B29C49/78 , B29C69/00 , B29K67/00 , B29L22/00 , B65D1/00 , B65D1/40 , B65D8/14 , B65D8/16 , B65B3/04 , B29C49/22 , B65B7/00
CPC分类号： B65D1/40 , B29C49/0005 , B29C49/085 , B29C49/4278 , B29C49/64 , B29C49/6418 , B29B2911/1402 , B29B2911/14026 , B29B2911/14033 , B29B2911/1404 , B29B2911/14053 , B29B2911/14066 , B29B2911/1408 , B29B2911/14093 , B29B2911/14106 , B29B2911/14126 , B29B2911/14133 , B29B2911/14153 , B29B2911/1416 , B29B2911/1418 , B29C2049/0089 , B29C2793/009 , B29C49/06 , B29K2067/00 , B29K2105/0094 , B29K2105/258 , B29K2105/26 , B29K2667/00 , B29K2995/0017 , B29K2995/004 , B29K2995/0041 , B29K2995/0053 , B29K2995/0063 , B29K2995/0069 , B29L2031/716 , Y10S264/907 , Y10S264/909
摘要： This relates to a method of forming a thermal/collapse-resistant highly oriented polyester container for use in hot fill applications. In accordance with the method of a polyester preform is reheated and then placed in a blow mold cavity whereat the preform is distended to match the blow mold cavity to form an intermediate article including a container having an oriented end unit receiving finish of a diameter materially greater than the diameter of the preform. The method is characterized in that in providing the preform the composition of the polyester, the draw ratio during distending of the preform and reheat conditions are all controlled to provide a container with a sidewall and finish density in the range of 1.350 to substantially but less than 1.370 grams/cubic centimeter.

10. 发明授权

US4582664A Method of forming a plastic container 失效
标题翻译：塑料容器的成型方法
公开(公告)号：US4582664A
公开(公告)日：1986-04-15
申请号：US620776
申请日：1984-07-16
申请人： Richard E. Clark
发明人： Richard E. Clark
IPC分类号： B29C49/04 , B65D1/02 , B29C49/08
CPC分类号： B65D1/0223 , B65D15/18
摘要： This relates to the blow molding of containers wherein the containers are formed of biaxially oriented plastic material. A multi-sided hollow member is blown within a convention blow mold using a conventional type of preform. Each side, when severed from the top and bottom of the hollow member and from each other forms a tray or box like container having a bottom, side walls and a peripheral sealing flange. The efficiency of the container from a weight to capacity standpoint is at a maximum due to the biaxial orientation of the plastic material.
摘要翻译：这涉及容器的吹塑，其中容器由双轴取向的塑料材料形成。使用常规类型的预成型件在常规吹塑模具内吹塑多面中空构件。当从中空构件的顶部和底部切断并且彼此形成具有底部，侧壁和周边密封凸缘的托盘或盒状容器时，每一侧。由于塑料材料的双轴取向，容器从重量到容量的立场的效率最大。

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