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1. 发明申请

US20100152526A1 Blood pump device and method of producing 审中-公开
标题翻译：血泵装置及其制造方法
公开(公告)号：US20100152526A1
公开(公告)日：2010-06-17
申请号：US12655492
申请日：2009-12-31
申请人： John J. Pacella , Andrew H. Goldstein , Dennis R. Trumble , Richard E. Clark , Fred W. Moeller , George J. Magovern
发明人： John J. Pacella , Andrew H. Goldstein , Dennis R. Trumble , Richard E. Clark , Fred W. Moeller , George J. Magovern
IPC分类号： A61M1/10
CPC分类号： A61M1/102 , A61M1/1008 , A61M1/101 , A61M1/1031 , A61M1/1086 , A61M1/122 , A61M2205/3334
摘要： A pumping system for blood for a patient includes a sensorless pump having no sensors disposed in the pump itself for moving the blood, a motor and a blood transport port through which blood is received from the patient and is pumped into the patient. The system also includes a controller connected to the pump for controlling the pump so a desired flow rate of blood can be maintained by the pump.
摘要翻译：用于患者的血液的泵送系统包括无传感器泵，其没有设置在泵本身中的用于移动血液的传感器，马达和血液输送端口，通过该血液输送端口从患者接收血液并被泵送到患者体内。该系统还包括连接到泵的控制器，用于控制泵，从而可以通过泵保持期望的血液流量。

2. 发明授权

US06808482B1 Blood pump device and method of producing 有权
标题翻译：血泵装置及其制造方法
公开(公告)号：US06808482B1
公开(公告)日：2004-10-26
申请号：US09668090
申请日：2000-09-22
申请人： John J. Pacella , Andrew H. Goldstein , Dennis R. Trumble , Richard E. Clark , Fred W. Moeller , George J. Magovern
发明人： John J. Pacella , Andrew H. Goldstein , Dennis R. Trumble , Richard E. Clark , Fred W. Moeller , George J. Magovern
IPC分类号： A61M110
CPC分类号： A61M1/102 , A61M1/1008 , A61M1/101 , A61M1/1031 , A61M1/1086 , A61M1/122 , A61M2205/3334
摘要： A blood pump device comprises a blood pump having blood transport ports, cannulae connected to the ports, and a coating material covering the junction between the inner surfaces of the ports and cannulae. This forms a smooth transition so blood can flow unimpeded therefrom and collection cavities for the blood are eliminated. Also included is a method for producing a smooth coating. The blood pump device comprises a second portion including a stator mechanism, a rotor mechanism, an impeller, a journal, and a seat member. The second portion is constructed to pump blood through the cannulae when power is provided. The blood pump device is also equipped with a safety occluder device, a sensor for detecting back emf in the stator mechanism, and a controller having the capability of indicating stator current and rotor speed.
摘要翻译：血液泵装置包括具有血液输送端口的血液泵，连接到端口的套管，以及覆盖端口和套管的内表面之间的连接处的涂覆材料。这形成平滑的过渡，因此血液可以不受阻碍地流动，消除了血液的收集腔。还包括生产光滑涂层的方法。血泵装置包括第二部分，其包括定子机构，转子机构，叶轮，轴颈和座椅构件。第二部分被构造成当提供动力时通过套管泵血。血泵装置还配备有安全封堵装置，用于检测定子机构中的反电动势的传感器，以及具有指示定子电流和转子速度的能力的控制器。

3. 发明授权

US6162167A Blood pump device having a journal 失效
标题翻译：具有日志的血泵装置
公开(公告)号：US6162167A
公开(公告)日：2000-12-19
申请号：US898584
申请日：1997-07-21
申请人： Andrew H. Goldstein , John J. Pacella , Dennis R. Trumble , Richard E. Clark , Fred W. Moeller , George J. Magovern
发明人： Andrew H. Goldstein , John J. Pacella , Dennis R. Trumble , Richard E. Clark , Fred W. Moeller , George J. Magovern
IPC分类号： A61L31/00 , A61M1/10 , A61M1/12 , F04D13/06 , F04D29/10
CPC分类号： A61M1/102 , A61M1/1008 , A61M1/101 , A61M1/1086 , A61M1/122 , A61M2205/3334
摘要： A blood pump device which includes a blood pump having blood transport ports and cannulae connected to the ports. The blood pump device also includes a coating material covering the junction between the inner surfaces of the ports and cannulae. A method of producing a smooth coating. A blood pump device including a second portion having a stator mechanism and a rotor mechanism disposed adjacent to and driven by the stator mechanism. The second portion has a journal disposed about the rotor mechanism to provide support therewith. The second portion has an impeller disposed in the chamber and a seal member for sealing about a shaft of the impeller. The seal member is fixedly attached to the journal so that the seal member is supported by the journal. A mechanism for providing power to the blood pump so that blood can be pumped through a cannula.
摘要翻译：一种血液泵装置，其包括具有血液输送口的血泵和连接到所述端口的套管。血液泵装置还包括覆盖端口的内表面和套管之间的连接处的涂覆材料。一种制备光滑涂层的方法。一种血泵装置，包括具有定子机构的第二部分和邻近定子机构驱动的转子机构。第二部分具有围绕转子机构设置的轴颈，以便为其提供支撑。第二部分具有设置在腔室中的叶轮和用于围绕叶轮的轴线密封的密封构件。密封构件固定地连接到轴颈上，使得密封构件由轴颈支撑。为血泵提供动力以使血液能够通过套管泵送的机构。

4. 发明授权

US5711753A Blood pump device and method of pumping blood 失效
标题翻译：血泵装置及血液泵送方法
公开(公告)号：US5711753A
公开(公告)日：1998-01-27
申请号：US618084
申请日：1996-03-18
申请人： John J. Pacella , Andrew H. Goldstein , Dennis R. Trumble , Richard E. Clark , Fred W. Moeller
发明人： John J. Pacella , Andrew H. Goldstein , Dennis R. Trumble , Richard E. Clark , Fred W. Moeller
IPC分类号： A61L31/00 , A61M1/10 , A61M1/12 , F04D13/06 , F04D29/10
CPC分类号： A61M1/101 , A61M1/102 , A61M1/122
摘要： The present invention pertains to a blood pump device which comprises a blood pump having blood transport ports and cannulae connected to the ports. The blood pump device also comprises a coating material covering the junction between the inner surfaces of the ports and cannulae. This forms a smooth transition so blood can flow unimpeded therefrom and collection cavities for the blood are eliminated. The invention is also related to a method of producing a smooth coating. The present invention is a blood pump device comprising a second portion having a stator mechanism and a rotor mechanism disposed adjacent to and driven by the stator mechanism. The second portion has a journal disposed about the rotor mechanism to provide support therewith. The second portion has an impeller disposed in the chamber and a one-piece seal member for sealing about a shaft of the impeller. The seal member is fixedly attached to the journal so that the seal member is supported by the journal. The present invention is also related to means for providing power to the blood pump so that blood can be pumped through a cannulae. The providing means includes a controller having means for sensing pump failure and an output terminal for actuating a safety occluder in an event of pump failure. Preferably, there is a safety occluder device disposed about the cannulae and in communication with the output terminal. Preferably, the blood pump comprises a motor having stator mechanism and a rotor mechanism driven by the stator mechanism. The sensing means comprises means for determining back electromagnetic force within the stator mechanism. Preferably, the controlling means has means for providing signals indicate of stator current and rotor speed, respectively. The providing means is in communication with the means for determining back electromagnetic force in the stator mechanism.
摘要翻译：本发明涉及一种血液泵装置，其包括具有血液输送口的血液泵和与端口连接的插管。血液泵装置还包括覆盖端口的内表面和套管之间的接合处的涂层材料。这形成平滑的过渡，因此血液可以不受阻碍地流动，消除了血液的收集腔。本发明还涉及一种制备光滑涂层的方法。本发明是一种血泵装置，包括具有定子机构的第二部分和与定子机构相邻并由定子机构驱动的转子机构。第二部分具有围绕转子机构设置的轴颈，以便为其提供支撑。第二部分具有设置在室中的叶轮和用于围绕叶轮的轴密封的一体式密封构件。密封构件固定地连接到轴颈上，使得密封构件由轴颈支撑。本发明还涉及用于向血液泵提供动力以使血液能够通过套管泵送的装置。提供装置包括具有用于感测泵故障的装置的控制器和用于在泵故障的情况下致动安全闭塞器的输出端子。优选地，存在围绕插管设置并与输出端子连通的安全闭塞器装置。优选地，血泵包括具有定子机构的马达和由定子机构驱动的转子机构。感测装置包括用于确定定子机构内的反向电磁力的装置。优选地，控制装置具有分别提供定子电流和转子速度的信号的装置。提供装置与用于确定定子机构中的反向电磁力的装置通信。

5. 发明授权

US06186149B1 Occluder device and method of making 失效
标题翻译：封堵装置及其制作方法
公开(公告)号：US06186149B1
公开(公告)日：2001-02-13
申请号：US09524647
申请日：2000-03-13
申请人： John J. Pacella , Richard E. Clark
发明人： John J. Pacella , Richard E. Clark
IPC分类号： A61M112
CPC分类号： A61M1/122 , A61M1/1008 , A61M1/101 , A61M1/1018 , A61M1/107 , A61M1/1086 , A61M1/1087 , A61M1/12 , A61M1/127 , A61M39/228 , A61M2205/33 , A61M2205/3303
摘要： The present invention pertains to a circulatory system, such as a circulatory assist system for a patient. The system comprises a blood pump having tubing fluidically communicating with a person's blood vessel. The blood pump can be, for instance, a centrifugal blood pump but is not limited thereto. The system also comprises an occluder device for controlling flow of the blood pump. The occluder device is in contact with the tubing of the blood pump. The occluder device can be incorporated into an anti-kink sheath over the outlet graft tubing of the blood pump. Preferably, the system comprises control means for actuating the occluder device when the blood pump malfunctions. In this manner, potentially fatal retrograde blood due to pump failure is automatically prevented. In a preferred embodiment, the occluder device comprises a cylindrical tube and a bladder mechanism connected to the inside surface of the tube. Type bladder mechanism preferably comprises a bladder and means for inflating the bladder. The inflating means preferably comprises a bladder pump having a tube in fluidic communication with the bladder. The bladder can be of a variety of constructions in the tube. The bladder can cover all or a portion of the inner surface of the tube. Also, two bladders can oppose each other, in a non-overlapping manner, within the tube. Alternatively, the bladder can cover the entire 360° of the inner surface. In this manner, as the bladder is inflated, the orifice closes with decreasing diameter, much like a natural biological valve. The occluder device could be rapidly inflated and deflated for applications as a valve either internally or externally. This would transform the normal steady flow output of a blood pump to a pulsatile output.
摘要翻译：本发明涉及循环系统，例如患者的循环辅助系统。该系统包括具有与人的血管流体连通的管的血泵。血液泵可以是例如离心式血液泵，但不限于此。该系统还包括用于控制血液泵流动的封堵装置。封堵装置与血液泵的管路接触。封堵器装置可以并入到血泵的出口移植管上的抗扭结护套中。优选地，该系统包括用于当血液泵发生故障时致动封堵器装置的控制装置。以这种方式，由于泵故障引起的潜在致命的逆行血液被自动防止。在优选实施例中，封堵器装置包括连接到管的内表面的圆柱形管和囊状机构。膀胱机构优选地包括膀胱和用于使膀胱充气的装置。膨胀装置优选地包括具有与气囊流体连通的管的囊泵。膀胱可以是管中的各种结构。囊可以覆盖管的内表面的全部或一部分。此外，两个囊可以以不重叠的方式在管内相互对抗。或者，膀胱可以覆盖内表面的整个360°。以这种方式，当气囊膨胀时，孔口以直径减小的方式闭合，非常类似于天然生物瓣膜。封闭器装置可以在内部或外部作为阀门快速充气和放气用于应用。这将将血泵的正常稳定流量输出转换为脉动输出。

6. 发明授权

US6045496A Occluder device and method of making 失效
标题翻译：封堵装置及其制作方法
公开(公告)号：US6045496A
公开(公告)日：2000-04-04
申请号：US228150
申请日：1994-04-15
申请人： John J. Pacella , Richard E. Clark
发明人： John J. Pacella , Richard E. Clark
IPC分类号： A61M1/10 , A61M1/12 , A61M39/22 , A61F2/00
CPC分类号： A61M1/101 , A61M1/1018 , A61M1/122 , A61M1/107 , A61M39/228
摘要： The present invention pertains to a circulatory system, such as a circulatory assist system for a patient. The system comprises a blood pump having tubing fluidically communicating with a person's blood vessel. The blood pump can be, for instance, a centrifugal blood pump but is not limited thereto. The system also comprises an occluder device for controlling flow of the blood pump. The occluder device is in contact with the tubing of the blood pump. The occluder device can be incorporated into an anti-kink sheath over the outlet graft tubing of the blood pump. Preferably, the system comprises control means for actuating the occluder device when the blood pump malfunctions. In this manner, potentially fatal retrograde blood due to pump failure is automatically prevented. In a preferred embodiment, the occluder device comprises a cylindrical tube and a bladder mechanism connected to the inside surface of the tube. The bladder mechanism preferably comprises a bladder and means for inflating the bladder. The inflating means preferably comprises a bladder pump having a tube in fluidic communication with the bladder. The bladder can be of a variety of constructions in the tube. The bladder can cover all or a portion of the inner surface of the tube. Also, two bladders can oppose each other, in a non-overlapping manner, within the tube. Alternatively, the bladder can cover the entire 360.degree. of the inner surface. In this manner, as the bladder is inflated, the orifice closes with decreasing diameter, much like a natural biological valve. The occluder device could be rapidly inflated and deflated for applications as a valve either internally or externally. This would transform the normal steady flow output of a blood pump to a pulsatile output.
摘要翻译：本发明涉及循环系统，例如患者的循环辅助系统。该系统包括具有与人的血管流体连通的管的血泵。血液泵可以是例如离心式血液泵，但不限于此。该系统还包括用于控制血液泵流动的封堵装置。封堵装置与血液泵的管路接触。封堵器装置可以并入到血泵的出口移植管上的抗扭结护套中。优选地，该系统包括用于当血液泵发生故障时致动封堵器装置的控制装置。以这种方式，由于泵故障引起的潜在致命的逆行血液被自动防止。在优选实施例中，封堵器装置包括连接到管的内表面的圆柱形管和囊状机构。膀胱机构优选地包括膀胱和用于使膀胱充气的装置。膨胀装置优选地包括具有与气囊流体连通的管的囊泵。膀胱可以是管中的各种结构。囊可以覆盖管的内表面的全部或一部分。此外，两个囊可以以不重叠的方式在管内相互对抗。或者，膀胱可以覆盖内表面的整个360度。以这种方式，当气囊膨胀时，孔口以直径减小的方式闭合，非常类似于天然生物瓣膜。封闭器装置可以在内部或外部作为阀门快速充气和放气用于应用。这将将血泵的正常稳定流量输出转换为脉动输出。

7. 发明授权

US4535902A Intermediate article of manufacture for a plastic container 失效
标题翻译：塑料容器的中间制品
公开(公告)号：US4535902A
公开(公告)日：1985-08-20
申请号：US423358
申请日：1982-09-24
申请人： Richard E. Clark
发明人： Richard E. Clark
IPC分类号： B29C49/04 , B29C49/06 , B29C69/00 , B65D1/02 , B65D1/22 , B29C17/08 , B29D23/03
CPC分类号： B29C49/4278 , B29C65/58 , B29C66/542 , B29C66/545 , B29C66/742 , B65D1/0223 , B65D15/18 , B29C65/568 , B29L2031/712 , B29L2031/717 , B65D2501/0081 , Y10S428/91 , Y10T428/1397
摘要： This relates to the blow molding of containers wherein the containers are formed of biaxially oriented plastic material. A multi-sided hollow member is blown within a convention blow mold using a conventional type of preform. Each side, when severed from the top and bottom of the hollow member and from each other forms a tray or box like container having a bottom, side walls and a peripheral sealing flange. The efficiency of the container from a weight to capacity standpoint is at a maximum due to the biaxial orientation of the plastic material.
摘要翻译：这涉及容器的吹塑，其中容器由双轴取向的塑料材料形成。使用常规类型的预成型件在常规吹塑模具内吹塑多面中空构件。当从中空构件的顶部和底部切断并且彼此形成具有底部，侧壁和周边密封凸缘的托盘或盒状容器时，每一侧。由于塑料材料的双轴取向，容器从重量到容量的立场的效率最大。

8. 发明授权

US4665682A Method for producing a hot fillable, collapse resistant polyester container without the need to utilize set process techniques and/or non-conventional container geometries 失效
标题翻译：用于生产可热填充的抗塌缩的聚酯容器的方法，而不需要利用固定的工艺技术和/或非常规的容器几何形状
公开(公告)号：US4665682A
公开(公告)日：1987-05-19
申请号：US730113
申请日：1985-05-03
申请人： Gerard J. Kerins , Wayne N. Collette , Martin H. Beck , Richard E. Clark , Ieuan L. Harry , Suppayan Krishnakumar , Bryan H. Miller , Richard C. Nichols , David Piccioli , Louis D. Tacito , Eileene M. Worsowicz
发明人： Gerard J. Kerins , Wayne N. Collette , Martin H. Beck , Richard E. Clark , Ieuan L. Harry , Suppayan Krishnakumar , Bryan H. Miller , Richard C. Nichols , David Piccioli , Louis D. Tacito , Eileene M. Worsowicz
IPC分类号： B29C49/08 , B29C49/00 , B29C49/06 , B29C49/64 , B29C49/78 , B29C69/00 , B29K67/00 , B29L22/00 , B65D1/00 , B65D1/40 , B65D8/14 , B65D8/16 , B65B3/04 , B29C49/22 , B65B7/00
CPC分类号： B65D1/40 , B29C49/0005 , B29C49/085 , B29C49/4278 , B29C49/64 , B29C49/6418 , B29B2911/1402 , B29B2911/14026 , B29B2911/14033 , B29B2911/1404 , B29B2911/14053 , B29B2911/14066 , B29B2911/1408 , B29B2911/14093 , B29B2911/14106 , B29B2911/14126 , B29B2911/14133 , B29B2911/14153 , B29B2911/1416 , B29B2911/1418 , B29C2049/0089 , B29C2793/009 , B29C49/06 , B29K2067/00 , B29K2105/0094 , B29K2105/258 , B29K2105/26 , B29K2667/00 , B29K2995/0017 , B29K2995/004 , B29K2995/0041 , B29K2995/0053 , B29K2995/0063 , B29K2995/0069 , B29L2031/716 , Y10S264/907 , Y10S264/909
摘要： This relates to a method of forming a thermal/collapse-resistant highly oriented polyester container for use in hot fill applications. In accordance with the method of a polyester preform is reheated and then placed in a blow mold cavity whereat the preform is distended to match the blow mold cavity to form an intermediate article including a container having an oriented end unit receiving finish of a diameter materially greater than the diameter of the preform. The method is characterized in that in providing the preform the composition of the polyester, the draw ratio during distending of the preform and reheat conditions are all controlled to provide a container with a sidewall and finish density in the range of 1.350 to substantially but less than 1.370 grams/cubic centimeter.

9. 发明授权

US4582664A Method of forming a plastic container 失效
标题翻译：塑料容器的成型方法
公开(公告)号：US4582664A
公开(公告)日：1986-04-15
申请号：US620776
申请日：1984-07-16
申请人： Richard E. Clark
发明人： Richard E. Clark
IPC分类号： B29C49/04 , B65D1/02 , B29C49/08
CPC分类号： B65D1/0223 , B65D15/18
摘要： This relates to the blow molding of containers wherein the containers are formed of biaxially oriented plastic material. A multi-sided hollow member is blown within a convention blow mold using a conventional type of preform. Each side, when severed from the top and bottom of the hollow member and from each other forms a tray or box like container having a bottom, side walls and a peripheral sealing flange. The efficiency of the container from a weight to capacity standpoint is at a maximum due to the biaxial orientation of the plastic material.
摘要翻译：这涉及容器的吹塑，其中容器由双轴取向的塑料材料形成。使用常规类型的预成型件在常规吹塑模具内吹塑多面中空构件。当从中空构件的顶部和底部切断并且彼此形成具有底部，侧壁和周边密封凸缘的托盘或盒状容器时，每一侧。由于塑料材料的双轴取向，容器从重量到容量的立场的效率最大。

10. 发明授权

US4340091A Elastomeric sheet materials for heart valve and other prosthetic implants 失效
标题翻译：用于心脏瓣膜和其他假体植入物的弹性片材
公开(公告)号：US4340091A
公开(公告)日：1982-07-20
申请号：US125120
申请日：1980-02-27
申请人： John Skelton , Richard E. Clark , Robert B. Davis
发明人： John Skelton , Richard E. Clark , Robert B. Davis
IPC分类号： A61L27/00 , A61F2/06 , A61F2/24 , A61L27/14 , A61L27/18 , D03D3/02 , D03D7/00 , D03D15/00 , A61F1/22 , D04C1/00
CPC分类号： A61F2/2418 , A61F2/06 , A61F2/2412 , A61L27/14 , A61L27/18 , B21F45/008 , D03D15/00 , D03D15/0061 , D03D15/08 , D03D3/02 , D03D7/00 , A61F2220/005 , D10B2331/06 , D10B2509/00
摘要： Sheet materials for cardiovascular and other prosthetic implants are fabricated of synthetic elastomers. These materials are characterized by molecular configurations that produce a nonlinear tensile modulus characteristic similar in shape to that of natural tissue. Selected elastomers, when formed as sheet material of appropriate geometrical configuration, promote the formation of natural tissue thereon which is appropriate for the mechanical characteristics desired.
摘要翻译：用于心血管和其他假体植入物的片材由合成弹性体制成。这些材料的特征在于产生与天然组织相似形状的非线性拉伸模量特征的分子构型。所选择的弹性体当形成为具有适当几何构型的片状材料时，促进其上适合于所需机械特性的天然组织的形成。

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