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1. 发明申请

US20080076750A1 Azetidinone Derivatives and Methods of Use Thereof 审中-公开
标题翻译：氮杂环丁酮衍生物及其使用方法
公开(公告)号：US20080076750A1
公开(公告)日：2008-03-27
申请号：US11854738
申请日：2007-09-13
申请人： Robert Aslanian , Tin-Yau Chan , Joel Harris , Brian McKittrick , Bernard Neustadt , Anandan Palani , Tony Priestley , Elizabeth Smith , Andrew Stamford , Henry Vaccaro , Dong Xiao
发明人： Robert Aslanian , Tin-Yau Chan , Joel Harris , Brian McKittrick , Bernard Neustadt , Anandan Palani , Tony Priestley , Elizabeth Smith , Andrew Stamford , Henry Vaccaro , Dong Xiao
IPC分类号： A61K31/397 , A61P25/04 , A61P3/00
CPC分类号： A61K31/4427 , C07D471/10 , C07D519/00
摘要： The present invention relates to methods for treating or preventing a disorder of lipid metabolism, pain, diabetes, a vascular condition, demyelination or nonalcoholic fatty liver disease, comprising administering a compound having the formula or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof, wherein: R1 and R2 are defined in Tables 1-6 herein, and R3 is -phenyl, -4-chlorophenyl, -2-pyridyl, or -3-pyridyl.
摘要翻译：本发明涉及治疗或预防脂质代谢紊乱，疼痛，糖尿病，血管病症，脱髓鞘或非酒精性脂肪性肝病的方法，包括给予具有下式的化合物或其药学上可接受的盐，溶剂合物，酯，前药或其中：R 1和R 2在本文的表1-6中定义，R 3是 - 苯基，氯苯基，-2-吡啶基或-3-吡啶基。

2. 发明申请

US20080076751A1 Azetidinone Derivatives and Methods of Use Thereof 失效
标题翻译：氮杂环丁酮衍生物及其使用方法
公开(公告)号：US20080076751A1
公开(公告)日：2008-03-27
申请号：US11854754
申请日：2007-09-13
申请人： Robert Aslanian , Chad Bennett , Duane Burnett , Tin-Yau Chan , Eugenia Kiselgof , Chad Knutson , Joel Harris , Brian McKittrick , Anandan Palani , Elizabeth Smith , Henry Vaccaro , Dong Xiao , Hyunjin Kim
发明人： Robert Aslanian , Chad Bennett , Duane Burnett , Tin-Yau Chan , Eugenia Kiselgof , Chad Knutson , Joel Harris , Brian McKittrick , Anandan Palani , Elizabeth Smith , Henry Vaccaro , Dong Xiao , Hyunjin Kim
IPC分类号： A61K31/397 , A61P25/04 , A61P3/00 , C07D471/10
CPC分类号： C07D471/10
摘要： The present invention relates to Azetidinone Derivatives, compositions comprising an Azetidinone Derivative and methods for treating or preventing a disorder of lipid metabolism, pain, diabetes, a vascular condition, demyelination or nonalcoholic fatty liver disease, comprising administering to a patient an effective amount of an Azetidinone Derivative.
摘要翻译：本发明涉及氮杂环丁酮衍生物，包含氮杂环丁酮衍生物的组合物和用于治疗或预防脂质代谢紊乱，疼痛，糖尿病，血管病症，脱髓鞘或非酒精性脂肪性肝病的方法，包括向患者施用有效量的氮杂环丁酮衍生物。

3. 发明申请

US20080070892A1 TREATING PAIN, DIABETES, AND DISORDERS OF LIPID METABOLISM 审中-公开
标题翻译：治疗脂肪代谢的疼痛，糖尿病和疾病
公开(公告)号：US20080070892A1
公开(公告)日：2008-03-20
申请号：US11854623
申请日：2007-09-13
申请人： Joel Harris , Bernard Neustadt , Stephen Sorota , Andrew Stamford , Deen Tulshian , Brian McKittrick
发明人： Joel Harris , Bernard Neustadt , Stephen Sorota , Andrew Stamford , Deen Tulshian , Brian McKittrick
IPC分类号： A61K31/439 , A61P3/06
CPC分类号： A61K31/438 , A61K31/444 , A61K31/495 , A61K31/497 , A61K31/513 , A61K45/06
摘要： Disclosed is a method of treating a disease or condition (e.g., pain, diabetes or disorders of lipid metabolism) comprising administering an azetidine derivative of the formula I selected from the group consisting of the compounds defined by Tables 1, 2, 3a, 3b, 3c, 3d and 4a.
摘要翻译：公开了治疗疾病或病症（例如，疼痛，糖尿病或脂质代谢紊乱）的方法，包括给予式I的氮杂环丁烷衍生物，其选自表1,2,3,2a，3b， 3c，3d和4a。

4. 发明申请

US20070066620A1 2-Heteroaryl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists 有权
标题翻译： 2-杂芳基 - 吡唑并[4,3-e] -1,2,4-三唑并 - [1,5-c] - 嘧啶腺苷A2a受体拮抗剂
公开(公告)号：US20070066620A1
公开(公告)日：2007-03-22
申请号：US11522221
申请日：2006-09-15
申请人： Bernard Neustadt , Craig Boyle , Samuel Chackalamannil , Joel Harris , Claire Lankin , Hong Liu , Unmesh Shah , Andrew Stamford
发明人： Bernard Neustadt , Craig Boyle , Samuel Chackalamannil , Joel Harris , Claire Lankin , Hong Liu , Unmesh Shah , Andrew Stamford
IPC分类号： A61K31/519 , C07D487/14
CPC分类号： C07D487/14
摘要： Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein R is R1-isoxazolyl, R1-oxadiazolyl, R1-dihydrofuranyl, R1-pyrazolyl, R1-imidazolyl, R1-pyrazinyl or R1-pyrimidinyl; R1 is 1, 2 or 3 substituents selected from H, alkyl, alkoxy and halo; Z is optionally substituted-aryl, or optionally substituted-heteroaryl; are disclosed, as well as their use in the treatment of central nervous system diseases, in particular Parkinson's disease and Extra Pyramidal Syndrome, pharmaceutical compositions comprising them, and combinations with other agents.
摘要翻译：具有结构式I的化合物或其药学上可接受的盐，其中R为R 1 - 异恶唑基，R 1 - 恶二唑基，R 1 - 二氢呋喃基，R 1 - 吡唑基，R 1 - 咪唑基，R 1 - 吡嗪基或R 1 - 嘧啶基; R 1是1,2或3个选自H，烷基，烷氧基和卤素的取代基; Z是任选取代的 - 芳基或任选取代的杂芳基; 以及它们在治疗中枢神经系统疾病，特别是帕金森病和额外锥体综合征，包含它们的药物组合物以及与其它药剂的组合中的用途。

5. 发明申请

US20050239795A1 Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists 有权
标题翻译：吡唑并[4,3-e] -1,2,4-三唑并 - [1,5-c] - 嘧啶腺苷A2a受体拮抗剂
公开(公告)号：US20050239795A1
公开(公告)日：2005-10-27
申请号：US11108916
申请日：2005-04-19
申请人： Bernard Neustadt , Jinsong Hao , Hong Liu , Craig Boyle , Samuel Chackalamannil , Unmesh Shah , Andrew Stamford , Joel Harris
发明人： Bernard Neustadt , Jinsong Hao , Hong Liu , Craig Boyle , Samuel Chackalamannil , Unmesh Shah , Andrew Stamford , Joel Harris
IPC分类号： A61K31/519 , C07D487/14
CPC分类号： C07D487/14
摘要： Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, furanyl, thienyl, pyridyl, pyridyl N-oxide, oxazolyl or pyrrolyl, or cycloalkenyl R1, R2, R3, R4 and R5 are H, alkyl or alkoxyalkyl; and Z is optionally substituted aryl or heteroaryl are disclosed. Also disclosed is the use of compounds of formula I in the treatment of central nervous system diseases, in particular Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, and pharmaceutical compositions comprising them.
摘要翻译：具有结构式I的化合物或其药学上可接受的盐，其中R是任选取代的苯基，呋喃基，噻吩基，吡啶基，吡啶基N-氧化物，恶唑基或吡咯基，或环烯基R 1， R 3，R 3，R 4和R 5是H，烷基或烷氧基烷基; 和Z是任选取代的芳基或杂芳基。还公开了式I化合物在治疗中枢神经系统疾病，特别是帕金森病中单独使用或与用于治疗帕金森病的其它药物组合的用途，以及包含它们的药物组合物的用途。

6. 发明申请

US20080089858A1 AZETIDINE DERIVATIVES USEFUL IN TREATING PAIN, DIABETES AND DISORDERS OF LIPID METABOLISM 失效
标题翻译：适用于治疗脂肪代谢的疼痛，糖尿病和疾病的AZETIDINE衍生物
公开(公告)号：US20080089858A1
公开(公告)日：2008-04-17
申请号：US11854600
申请日：2007-09-13
申请人： Brian McKittrick , Elizabeth Smith , Chad Bennett , Joel Harris , Eugenia Kiselgof , Chad Knutson , Peter Korakas , Deen Tulshian , Hyunjin Kim
发明人： Brian McKittrick , Elizabeth Smith , Chad Bennett , Joel Harris , Eugenia Kiselgof , Chad Knutson , Peter Korakas , Deen Tulshian , Hyunjin Kim
IPC分类号： A61K31/438 , A61K31/565 , A61K31/57 , A61K31/573 , A61K31/675 , A61K38/20 , A61P3/10 , C07D471/10
CPC分类号： C07D471/08
摘要： Disclosed are compounds of the formula: and compounds of the formula: wherein R1, R2, R3, R4, R5, u and v are as defined herein. Also disclosed are methods of treating pain (e.g., inflammatory pain, chronic pain, and neuropathic pain), methods of treating diabetes, and methods of inhibiting the absorption of cholesterol using compounds of formula I or IIA.
摘要翻译：公开了下式的化合物和下式的化合物：其中R 1，R 2，R 3，R 4， u，v和u如本文所定义。还公开了治疗疼痛（例如炎性疼痛，慢性疼痛和神经性疼痛）的方法，治疗糖尿病的方法，以及使用式I或IIA化合物抑制胆固醇吸收的方法。

7. 发明申请

US20160009696A1 COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY 有权
公开(公告)号：US20160009696A1
公开(公告)日：2016-01-14
申请号：US14772290
申请日：2014-02-27
申请人： Michael MILLER , Kallol BASU , Duane DEMONG , Jack SCOTT , Wei LI , Joel HARRIS , Andrew STAMFORD , Marc POIRIER , Paul TEMPEST , MERCK SHARP & DOHME CORP.
发明人： Michael Miller , Kallol Basu , Duane DeMong , Jack Scott , Wei Li , Joel Harris , Andrew Stamford , Marc Poirier , Paul Tempest
IPC分类号： C07D403/14 , C07D401/14 , C07D491/107 , C07D417/14 , C07D471/10 , C07D413/14 , C07D498/08
CPC分类号： C07D403/14 , A61K31/505 , A61K31/506 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/10 , C07D491/107 , C07D498/08
摘要： The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

8. 发明授权

US10046085B2 Biodegradable medical implants, polymer compositions and methods of use 有权
公开(公告)号：US10046085B2
公开(公告)日：2018-08-14
申请号：US13261054
申请日：2010-06-01
申请人： Mir Imran , Sanjay Patel , Joel Harris
发明人： Mir Imran , Sanjay Patel , Joel Harris
IPC分类号： A61L27/14 , A61F2/82 , A61L27/26 , A61L27/58 , A61L31/04 , A61L31/14 , A61F2/04 , A61F2/06 , A61F2/07
摘要： Embodiments of the invention provide compositions include bio degradable polymers, medical implants fabricated from these compositions and methods of using such implants. Many embodiments provide medical implants including a first polymer backbone having a first rate of biodegradation and a second polymer backbone having a second rate of biodegradation faster than the first rate. In some embodiments, the second backbone is configured to be replaced by a natural tissue layer. The first backbone provides a scaffold for the implant while the second backbone degrades. This scaffold can enhance mechanical properties of the implant including various aspects of mechanical strength such as tensile, bending, hoop and yield strength; and elasticity. The scaffold also serves to maintain a minimum level of structural support of the implant during the period of degradation of the second backbone or for the entire life of the implant so that the implant does not mechanically fail.

9. 发明申请

US20100268295A1 APPARATUS AND METHOD FOR THE DETECTION AND TREATMENT OF ATRIAL FIBRILLATION 有权
标题翻译：用于检测和治疗椎间盘突出症的装置和方法
公开(公告)号：US20100268295A1
公开(公告)日：2010-10-21
申请号：US12427733
申请日：2009-04-21
申请人： Mir Imran , Joel Harris
发明人： Mir Imran , Joel Harris
IPC分类号： A61N1/365
CPC分类号： A61N1/36514 , A61B5/046 , A61N1/056 , A61N1/0573 , A61N1/3621 , A61N1/3622 , A61N1/3624 , A61N1/36578 , A61N1/3684 , A61N1/3702 , A61N1/395
摘要： An embodiment of the invention provides an apparatus for the detection and treatment of atrial arrhythmia comprising an electrical lead having proximal and distal portions. The distal portion is positionable in an atrial chamber and the end of the proximal portion is configured to be coupled to a pacemaker. The lead comprises a plurality of conductive wires clad with an insulative coating and has sufficient flexibility to be positioned in the atria from a percutaneous introductory site. The conductive wires are coupled to a plurality of pairs of bipolar electrodes positioned on a membrane attachable to an endocardial wall. The electrode pairs are distributed in a pattern defining an area for detecting a location of a foci of aberrant electrical activity located within or adjacent the area and sending a pacing signal to that location to prevent or stop an occurrence of atrial fibrillation caused by that foci.
摘要翻译：本发明的一个实施方案提供了用于检测和治疗心房心律失常的装置，其包括具有近端部分和远端部分的电引线。远侧部分可定位在心房中，并且近端部分的端部被配置为联接到起搏器。引线包括用绝缘涂层包覆的多个导线，并且具有足够的灵活性，以便从经皮引导位置定位在心房中。导电线耦合到多个双极电极对，其位于可附接到心内膜壁的膜上。电极对以限定用于检测位于该区域内或邻近该区域的异常电活动焦点的位置的区域的图案分布，并向该位置发送起搏信号以防止或停止由该焦点引起的心房颤动的发生。

10. 发明申请

US20100114225A1 HOUSING STRUCTURE FOR A MEDICAL IMPLANT INCLUDING A MONOLITHIC SUBSTRATE 有权
标题翻译：包括单晶基底的医疗植入物的住房结构
公开(公告)号：US20100114225A1
公开(公告)日：2010-05-06
申请号：US12265690
申请日：2008-11-05
申请人： Mir Imran , Dean Andersen , Joel Harris
发明人： Mir Imran , Dean Andersen , Joel Harris
IPC分类号： H05K5/06 , A61N1/00
CPC分类号： A61N5/0622 , A61N1/0529 , A61N1/0536 , A61N1/36 , A61N1/36064 , A61N1/37 , A61N1/375 , A61N1/3754 , A61N5/0601 , A61N2005/063 , H01R13/5224 , H01R2201/12
摘要： Embodiments described herein provide lid structures for medical implant (MI) housing. In one embodiment, the invention provides a lid structure for a MI housing comprising a substrate comprising a dielectric material, a conductive portion fabricated on a substrate surface or interior, a frame at least partially surrounding the substrate perimeter, a plurality of vias projecting at least partially through the substrate, a plurality of conductive pins with at least one pin projecting through a via. The frame is hermetically joined to the substrate and can be hermetically joined to the housing. The conductive portion allows electrical components, including capacitors, inductors, resistor and antennas to be fabricated on or coupled to the substrate surface or interior. The antenna comprises a conductive trace positioned on a substrate top surface and is configured to send and receive signals between an implant within a patient's body and a communication device external to the body.
摘要翻译：本文描述的实施例提供用于医疗植入物（MI）壳体的盖结构。在一个实施例中，本发明提供了一种用于MI壳体的盖结构，其包括基底，其包括电介质材料，制造在基底表面或内部的导电部分，至少部分围绕基底周边的框架，至少突出的多个通孔部分地穿过衬底，具有至少一个销突出通过通孔的多个导电销。框架气密地接合到基板上并且可以气密地接合到壳体。导电部分允许包括电容器，电感器，电阻器和天线的电气部件制造在衬底表面或内部上或耦合到衬底表面或内部。天线包括位于衬底顶表面上的导电迹线，并被配置为在患者体内的植入物和身体外部的通信装置之间发送和接收信号。

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