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1. 发明授权

US06200624B1 Enteral formula or nutritional supplement containing arachidonic and docosahexaenoic acids 失效
标题翻译：含有花生四烯酸和二十二碳六烯酸的肠内配方或营养补充剂
公开(公告)号：US06200624B1
公开(公告)日：2001-03-13
申请号：US08592832
申请日：1996-01-26
申请人： Terrence Bruce Mazer , Robert Alan Miller , Charles Allan McCombs , Scott Donald Barnicki , James Cecil Phillips , Charles Edwan Sumner, Jr.
发明人： Terrence Bruce Mazer , Robert Alan Miller , Charles Allan McCombs , Scott Donald Barnicki , James Cecil Phillips , Charles Edwan Sumner, Jr.
IPC分类号： A23L200
CPC分类号： A23L33/17 , A23L33/12 , A23L33/40 , Y10S426/80 , Y10S426/801
摘要： This invention is directed to the use of triglycerides containing fatty ester moieties that include arachidonic acid (AA) and docosahexaenoic acid (DHA) in enteral nutritionals or nutritional supplements. These triglycerides are derived from lipid mixtures which have high levels of sterols and phosphorous. A preferred embodiment of the invention comprises an infant or enteral nutritional, or nutritional supplement, that comprises a lipid source derived from egg yolk. The lipid source derived from egg yolk is prepared by transesterification or hydrolysis, subjecting the mixture to distillation, and esterification with glycerin to result in a triglyceride containing the desired fatty acids of AA and DHA and little or no sterols and phosphorus.
摘要翻译：本发明涉及含有花生四烯酸（AA）和二十二碳六烯酸（DHA）的脂肪酸酯部分的甘油三酯在肠内营养或营养补充剂中的用途。这些甘油三酯衍生自具有高水平的甾醇和磷的脂质混合物。本发明的优选实施方案包括婴儿或肠内营养或营养补充剂，其包含源自蛋黄的脂质源。来自蛋黄的脂质源通过酯交换或水解制备，使混合物蒸馏，并用甘油进行酯化，得到含有所需的AA和DHA脂肪酸的甘油三酯，很少或没有固醇和磷。

2. 发明授权

US6063946A Process for the isolation of polyunsaturated fatty acids and esters thereof from complex mixtures which contain sterols and phosphorus compounds 失效
标题翻译：用于从含有甾醇和磷化合物的复杂混合物中分离多不饱和脂肪酸及其酯的方法
公开(公告)号：US6063946A
公开(公告)日：2000-05-16
申请号：US592797
申请日：1996-01-26
申请人： Robert Alan Miller , Terrence Bruce Mazer , Scott Donald Barnicki , Charles Edwan Sumner, Jr.
发明人： Robert Alan Miller , Terrence Bruce Mazer , Scott Donald Barnicki , Charles Edwan Sumner, Jr.
IPC分类号： A23L5/20 , C11C1/02 , C11C1/10 , C11C3/00 , C11C3/02 , C11C1/00
CPC分类号： C11C3/02 , C11C1/025 , C11C1/10 , C11C3/003
摘要： This invention relates to a process for the isolation of fatty acids and fatty acid esters from complex naturally occurring mixtures which contain sterols, triglycerides and phospholipids. A preferred embodiment of the invention comprises extracting lipids from egg yolk solids with methanol; separating lipids including sterols from insoluble egg yolk components; submitting the methanolic solution of lipids to (a) alkaline hydrolysis and subsequent neutralization to convert lipids to free fatty acids together with sterols; (b) separating the said sterols and acids from an aqueous phase formed in the hydrolysis reaction; (c) heating said free fatty acids and sterols to convert the sterols to fatty acid sterol esters; (d) subjecting the mixture to distillation to separate the sterol esters from the free fatty acids; and (e) subjecting the said acids to esterification in the presence of glycerol to produce triglycerides of said fatty acids wherein the resulting triglycerides contain reduced quantities of sterols and phosphorus. An enteral nutritional formula containing the triglycerides produced in the above process is also disclosed.
摘要翻译：本发明涉及从含有甾醇，甘油三酯和磷脂的复杂天然存在的混合物中分离脂肪酸和脂肪酸酯的方法。本发明的优选实施方案包括用甲醇从蛋黄固体中提取脂质; 分离包括固醇的脂质不溶于蛋黄成分; 将脂质的甲醇溶液（a）碱性水解并随后中和，将脂质与甾醇一起转化为游离脂肪酸; （b）将所述甾醇和酸与水解反应中形成的水相分离; （c）加热所述游离脂肪酸和甾醇以将甾醇转化为脂肪酸甾醇酯; （d）使混合物进行蒸馏以将固醇酯与游离脂肪酸分离; 和（e）在甘油存在下使所述酸进行酯化以产生所述脂肪酸的甘油三酯，其中所得甘油三酸酯含有降低量的甾醇和磷。还公开了含有在上述方法中生产的甘油三酯的肠内营养配方。

3. 发明授权

US5883273A Polyunsaturated fatty acids and fatty acid esters free of sterols and phosphorus compounds 失效
标题翻译：多不饱和脂肪酸和不含甾醇和磷化合物的脂肪酸酯
公开(公告)号：US5883273A
公开(公告)日：1999-03-16
申请号：US592831
申请日：1996-01-26
申请人： Robert Alan Miller , Terrence Bruce Mazer , Charles Allan McCombs
发明人： Robert Alan Miller , Terrence Bruce Mazer , Charles Allan McCombs
IPC分类号： C11B3/12 , C11B7/00 , C11C3/04 , C11C3/10 , C11C1/00
CPC分类号： C11B3/12 , C11B7/0008 , C11C3/04 , C11C3/10
摘要： Fatty acid esters such as those containing arachidonic acid (AA) and docosahexaenoic acid (DHA) derived from lipid mixtures are prepared with reduced levels of sterols and phosphorus. A preferred embodiment of the invention comprises extracting lipids from egg with methanol; separating lipids including sterols from insoluble egg components; submitting the methanolic solution of lipids to transesterification and subsequent neutralization to convert the lipids to methyl esters of said free fatty acids together with sterols; separating the said sterols and esters from an aqueous phase including phosphorus compounds formed in the transesterification; subjecting the said fatty acid esters and sterols to distillation to separate sterols from the fatty acid esters; and subjecting the said esters to transesterification in the presence of glycerol to produce triglycerides of said esters thereof including that of AA and DHA wherein the resulting triglycerides contain reduced quantities of sterols and phosphorus.
摘要翻译：脂肪酸酯如含有花生四烯酸（AA）和来源于脂质混合物的二十二碳六烯酸（DHA）的脂肪酸酯被制备成具有降低水平的固醇和磷。本发明的优选实施方案包括用甲醇从鸡蛋中提取脂质; 分离包括固醇的脂质不溶于蛋组分; 将脂质的甲醇溶液酯交换并随后中和，将脂质与甾醇一起转化成所述游离脂肪酸的甲酯; 将所述甾醇和酯与包含在酯交换中形成的磷化合物的水相分离; 对所述脂肪酸酯和甾醇进行蒸馏以将甾醇与脂肪酸酯分离; 并在所述甘油存在下使所述酯进行酯交换反应以产生所述酯的甘油三酸酯，其包括AA和DHA的甘油三酯，其中所得甘油三酸酯含有减少量的甾醇和磷。

4. 发明授权

US5755689A Apparatus for adding marker dye to nutritional product during enteral tube feeding 失效
标题翻译：用于在肠管喂养期间向营养产品中添加标记染料的装置
公开(公告)号：US5755689A
公开(公告)日：1998-05-26
申请号：US671876
申请日：1996-06-28
申请人： Terrence Bruce Mazer , Joseph Edward Walton , Ronita Kay Geckle , Carl Joseph Piontek , Susan Beth Duel , Andre Daab-Krzykowski , Robert Louis Joseph , William Guy Pierson , Thomas Daniel Loughrin , Thomas Walter Osip
发明人： Terrence Bruce Mazer , Joseph Edward Walton , Ronita Kay Geckle , Carl Joseph Piontek , Susan Beth Duel , Andre Daab-Krzykowski , Robert Louis Joseph , William Guy Pierson , Thomas Daniel Loughrin , Thomas Walter Osip
IPC分类号： A61J15/00 , A61M5/00 , A61M5/14 , A61M5/168 , A61M31/00 , G01N27/327 , A61M37/00
CPC分类号： A61M31/002 , A61J15/0026 , A61J15/0069 , A61M5/007 , A61M5/1407 , A61J15/00 , G01N33/02
摘要： An apparatus is useful for dye marking a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient. A formulation chamber, such as a drip chamber, is connectable to the supply container. At least one sustained release reservoir containing a physiologically acceptable marker dye is positioned within the formulation chamber, or if not, is included as part of a kit. The sustained release reservoir may be in the form of a coated tablet, osmotically driven device, coated capsule, microencapsulated microspheres, agglomerated molecular sieving material, or chopped hollow fibers having permeable walls. A liquid communication means connects the formulation chamber to the feeding tube of a patient. The marker dye may be a colorant dye or a fluorescing dye or a mixture thereof. In using the apparatus for dye marking the nutritional product is flowed through the apparatus and a feeding tube to enter the gastrointestinal tract of a patient.
摘要翻译：一种装置可用于将液体肠内营养产品在从供应容器输送到将营养产品输送到患者的胃肠道的喂食管中时进行标记。诸如滴水室的配制室可连接到供应容器。包含生理上可接受的标记染料的至少一个持续释放储存器位于制剂室内，或者如果不包含，则作为试剂盒的一部分。持续释放储存器可以是包衣片剂，渗透驱动装置，包衣胶囊，微囊化微球，聚集分子筛材料或具有可渗透壁的切碎中空纤维的形式。液体连通装置将制剂室连接到患者的进料管。标记染料可以是着色剂染料或荧光染料或其混合物。在使用染色标记设备时，营养产品流过设备和进料管进入患者的胃肠道。

5. 发明授权

US5741243A Method of altering composition of nutritional product during enteral tube feeding 失效
公开(公告)号：US5741243A
公开(公告)日：1998-04-21
申请号：US673941
申请日：1996-07-01
申请人： Ronita Kay Geckle , Terrence Bruce Mazer , Joseph Edward Walton , Carl Joseph Piontek , Susan Beth Duel , Andre Daab-Krzykowski , Mark Anthony McCamish , Robert Louis Joseph , William Guy Pierson
发明人： Ronita Kay Geckle , Terrence Bruce Mazer , Joseph Edward Walton , Carl Joseph Piontek , Susan Beth Duel , Andre Daab-Krzykowski , Mark Anthony McCamish , Robert Louis Joseph , William Guy Pierson
IPC分类号： A61J15/00 , A61K9/22 , A61M5/00 , A61M5/14 , A61M31/00
CPC分类号： A61M31/002 , A61J15/0026 , A61J15/0069 , A61M5/007 , A61M5/1407 , A61J15/00
摘要： A method is disclosed for modifying a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient. During enteral tube feeding the nutritional product passes through a formulation chamber, e.g., a drip chamber, having located therein at least one controlled release dosage form unit containing at least one beneficial agent. The beneficial agent may be selected from nutrients, medicaments, probiotics, or diagnostic agents or mixtures thereof, and any such together with a physiologically acceptable marker dye in controlled release dosage form and/or the same or different additional beneficial agent not in controlled release dosage form. Controlled release dosage forms may be of a conventional sustained release type or an osmotically driven delivery device.

6. 发明授权

US5641531A Nutritional liquid supplement beverage and method of making same 失效
标题翻译：营养液补充饮料及其制作方法
公开(公告)号：US5641531A
公开(公告)日：1997-06-24
申请号：US534906
申请日：1995-09-28
申请人： Jeffery Wayne Liebrecht , Terrence Bruce Mazer , Michael Allen Chandler , Gerald Edward Schopinsky , Normanella Torres Dewille
发明人： Jeffery Wayne Liebrecht , Terrence Bruce Mazer , Michael Allen Chandler , Gerald Edward Schopinsky , Normanella Torres Dewille
IPC分类号： A23G9/32 , A23G9/40 , A23G9/44 , A23G9/52 , A23L1/29 , A23L1/302 , A23L1/304 , A23L1/305 , A23L2/00 , A23L2/38 , A23L2/52 , A23L2/60 , A23L2/66 , A23L2/68 , A23C21/10
CPC分类号： A23G9/40 , A23L2/66 , A23L33/19
摘要： A protein containing nutritional supplement that contains from 1 to 10% by weight of whey protein isolate, at least one source of carbohydrate, vitamins, trace minerals and ultra trace minerals and ultra trace minerals. The pH of the liquid nutritional supplement is from about 2.8 to about 3.3 and is essentially devoid of added macro-nutrients and fat. A supplement which is clear and low in viscosity, is produced by preparing (1) an acidified aqueous solution of whey protein isolate having a pH of about 2.8 to about 3.3 and (2) an aqueous solution of carbohydrate; and thereafter combining the two solutions.
摘要翻译：含蛋白质的营养补充剂含有1-10重量％的乳清蛋白分离物，至少一种碳水化合物，维生素，微量矿物质，超微量矿物质和超微量矿物质来源。液体营养补充剂的pH为约2.8至约3.3，基本上不含添加的大量营养物质和脂肪。透明和低粘度的补充剂通过制备（1）pH为约2.8至约3.3的乳清蛋白分离物的酸化水溶液和（2）碳水化合物水溶液而制备; 然后组合这两种方案。

7. 发明授权

US5921955A Oral administration of beneficial agents 失效
标题翻译：口服有益药物
公开(公告)号：US5921955A
公开(公告)日：1999-07-13
申请号：US3718
申请日：1998-01-05
申请人： Terrence Bruce Mazer , Joseph Edward Walton , Ronita Kay Geckle , Carl Joseph Piontek
发明人： Terrence Bruce Mazer , Joseph Edward Walton , Ronita Kay Geckle , Carl Joseph Piontek
IPC分类号： A47G21/18 , A61J7/00 , A61J9/00 , A61M37/00
CPC分类号： A61J9/006 , A47G21/183 , A61J7/00 , A61J7/0038 , A61J7/0046 , A61J9/00
摘要： Apparatus for adding a beneficial agent to a liquid for drinking during oral administration includes a support structure extending transversely across an imperforate walled zone such as the upper end or neck of a bottle or vessel, or of a funnel-like adapter attached to the top of the vessel, with a retention pocket with liquid penetrable walls held by the support structure and comprising at least one beneficial agent secured therein whereby the beneficial agent is taken up in the liquid for drinking during or just prior to oral administration. The beneficial agent may be in either or both of controlled release dosage form or non-controlled release dosage form and may be one or more of nutrients, medicaments, probiotics, electrolytes, rehydration solutions and diagnostic agents, to which a flavoring agent may be added. In the novel method a support structure with a retention pocket comprising at least one beneficial agent is provided in a bottle or vessel with the support structure extending transversely of the neck or top of the bottle or vessel or a drinking tube extending thereinto. The bottle or vessel is provided with a liquid for drinking selected from a liquid nutritional product, a beverage or water and the liquid is contacted with the beneficial agent during or just before oral administration thereof.
摘要翻译：用于在口服给药期间将有益剂添加到用于饮用的液体中的装置包括横向跨越无孔壁区域（例如瓶或容器的上端或颈部）延伸的支撑结构，或者连接到顶部的漏斗状适配器所述容器具有保持袋，其具有由所述支撑结构保持的液体可穿透壁，并且包含固定在其中的至少一种有益剂，由此所述有益剂在所述液体中被吸收以在口服给药期间或之前口服。有益药物可以是控制释放剂型或非控释剂型中的一种或两种，并且可以是可以加入调味剂的营养素，药物，益生菌，电解质，补液溶液和诊断剂中的一种或多种。在新颖方法中，在瓶或容器中提供具有包含至少一种有益剂的保留袋的支撑结构，其中支撑结构横向延伸到瓶或容器的颈部或顶部或延伸到其中的饮用管。在瓶子或容器中设置有用于饮用的液体，所述液体选自液体营养产品，饮料或水，并且在口服给药期间或之前将液体与有益剂接触。

8. 发明授权

US5707353A Oral administration of beneficial agents 失效
公开(公告)号：US5707353A
公开(公告)日：1998-01-13
申请号：US576728
申请日：1995-12-21
申请人： Terrence Bruce Mazer , Joseph Edward Walton , Ronita Kay Geckle , Carl Joseph Piontek
发明人： Terrence Bruce Mazer , Joseph Edward Walton , Ronita Kay Geckle , Carl Joseph Piontek
IPC分类号： A47G21/18 , A61J7/00 , A61J9/00 , A61M37/00
CPC分类号： A61J9/006 , A47G21/183 , A61J7/00 , A61J7/0038 , A61J7/0046 , A61J9/00
摘要： Apparatus for adding a beneficial agent to a liquid for drinking during oral administration includes a support structure extending transversely across an imperforate walled zone such as the upper end or neck of a bottle or vessel, or of a funnel-like adapter attached to the top of the vessel, with a retention pocket with liquid penetrable walls held by the support structure and comprising at least one beneficial agent secured therein whereby the beneficial agent is taken up in the liquid for drinking during or just prior to oral administration. The beneficial agent may be in either or both of controlled release dosage form or non-controlled release dosage form and may be one or more of nutrients, medicaments, probiotics, electrolytes, rehydration solutions and diagnostic agents, to which a flavoring agent may be added. In the novel method a support structure with a retention pocket comprising at least one beneficial agent is provided in a bottle or vessel with the support structure extending transversely of the neck or top of the bottle or vessel or a drinking tube extending thereinto. The bottle or vessel is provided with a liquid for drinking selected from a liquid nutritional product, a beverage or water and the liquid is contacted with the beneficial agent during or just before oral administration thereof.

9. 发明授权

US5658893A Method for inhibition of rotavirus infection with carrageenan 失效
标题翻译：用角叉菜胶抑制轮状病毒感染的方法
公开(公告)号：US5658893A
公开(公告)日：1997-08-19
申请号：US412808
申请日：1995-03-29
申请人： Steven Neal Anderson , Joseph Paul Schaller , Terrence Bruce Mazer , Stephen John Kirchner
发明人： Steven Neal Anderson , Joseph Paul Schaller , Terrence Bruce Mazer , Stephen John Kirchner
IPC分类号： A61K31/731 , A61K31/737 , A61K31/715
CPC分类号： A61K31/737 , A61K31/731
摘要： A method is provided for inhibiting rotavirus infection of human cells by treating the rotavirus with a carrageenan. The most effective agent in inhibiting cellular rotavirus infection is lambda-carrageenan, which may be formulated in a liquid and ingested enterally. A composition containing lambda-carrageenan is an aspect of the invention.
摘要翻译：提供了通过用卡拉胶处理轮状病毒来抑制人类细胞轮状病毒感染的方法。抑制细胞轮状病毒感染的最有效的药剂是λ-角叉菜胶，其可以配制成液体并肠内摄入。含有λ-角叉菜胶的组合物是本发明的一个方面。

10. 发明授权

US5746715A Method of adding marker dye to nutritional product during enternal tube feeding 失效
标题翻译：在内管喂养期间向营养产品添加标记染料的方法
公开(公告)号：US5746715A
公开(公告)日：1998-05-05
申请号：US673446
申请日：1996-06-28
申请人： Terrence Bruce Mazer , Joseph Edward Walton , Ronita Kay Geckle , Carl Joseph Piontek , Susan Beth Duel , Andre Daab-Krzykowski , Robert Louis Joseph , William Guy Pierson , Thomas Daniel Loughrin , Thomas Walter Osip
发明人： Terrence Bruce Mazer , Joseph Edward Walton , Ronita Kay Geckle , Carl Joseph Piontek , Susan Beth Duel , Andre Daab-Krzykowski , Robert Louis Joseph , William Guy Pierson , Thomas Daniel Loughrin , Thomas Walter Osip
IPC分类号： A61J15/00 , A61M5/00 , A61M5/14 , A61M31/00 , A61M37/00
CPC分类号： A61M31/002 , A61J15/0026 , A61J15/0069 , A61M5/007 , A61M5/1407 , A61J15/00
摘要： A method for dye marking a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient includes the steps of: (1) providing apparatus such as a formulation chamber, e.g., a drip chamber, connectable to the supply container, with at least one sustained release reservoir containing a physiologically acceptable and dispersible marker dye positioned within the formulation chamber, and, liquid communication means connecting the formulation chamber to the feeding tube of a patient; (2) providing a supply container containing the nutritional product; (3) connecting the formulation chamber to the supply container and the liquid commmunication means to the feeding tube; and (4) flowing the dye-marked nutritional product through the apparatus and into the feeding tube. The sustained release reservoir may be a conventional slow release coated tablet, microspheres, or capsule type or an osmotically driven device. The marker dye may be a colorant dye or a fluorescing dye or a mixture thereof. If quick coloration is desired, the sustained release reservoir may be coated with a soluble layer of the marker dye or marker dye not in a sustained release reservoir may be placed in the formulation chamber along with a sustained release reservoir containing dye.
摘要翻译：一种将液体肠内营养产品从供应容器输送至将营养产品输送到患者的胃肠道的喂食管中的染色标记方法包括以下步骤：（1）提供诸如配制室的装置，可连接到供应容器的滴水室与至少一个包含位于配制室内的生理上可接受和可分散的标记染料的缓释储存器，以及将配制室连接到患者的进料管的液体连通装置; （2）提供容纳营养产品的供应容器; （3）将制剂室与供给容器和液体通信装置连接到进料管; 和（4）使染料标记的营养产品通过设备流入饲管。持续释放储存器可以是常规的缓释包衣片剂，微球体或胶囊型或渗透驱动装置。标记染料可以是着色剂染料或荧光染料或其混合物。如果需要快速着色，则持续释放储存器可以涂覆有标记染料的可溶层或不在持续释放储存器中的标记染料，可以与含有染料的持续释放储存器一起放置在配制室中。

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