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1. 发明授权

US5810807A Sphincterotome with deflectable cutting plane and method of using the same 失效
标题翻译：具有可偏转切割平面的括约肌切开术及其使用方法
公开(公告)号：US5810807A
公开(公告)日：1998-09-22
申请号：US732092
申请日：1996-10-15
申请人： Robert A. Ganz , Jonathan Kagan , Ricci D. Smelser , Brian D. Zelickson , Robert D. Mackie
发明人： Robert A. Ganz , Jonathan Kagan , Ricci D. Smelser , Brian D. Zelickson , Robert D. Mackie
IPC分类号： A61B18/14 , A61B17/36
CPC分类号： A61B18/1492 , A61B2018/00553 , A61B2018/00916
摘要： A sphincterotome adapted to be used in the lumen of an endoscope for cutting a sphincter in a patient's body using a cutting wire energized by an electrosurgical unit. The sphincterotome has a distal end segment and cutting plane orienting mechanism extending through the length of a sphincterotome tubular body between a handle assembly at the proximal end of the sphincterotome body and a distal end segment thereof for shifting the cutting plane laterally with respect to the longitudinal axis of the sphincterotome tubular body exiting the endoscope lumen. The lateral shift is in at least one lateral direction from an un-shifted position of the cutting plane with respect to the longitudinal axis whereby in use during a sphincterotomy, the cutting wire may be oriented into alignment with a particular feature of the sphincter, e.g. the twelve o'clock position of the sphincter of Oddi and papilla of Vater, without having to reposition the endoscope and/or withdraw and reposition the sphincterotome in the endoscope lumen.
摘要翻译：一种适于在内窥镜的内腔中使用的切口切割器，其使用由电外科单元激励的切割线来切割患者体内的括约肌。括约肌切开机具有远端段和切割平面定向机构，其延伸穿过括约肌切开管体的长度，在括约肌切开体本体的近端处的手柄组件和其远端段之间，用于相对于纵向方向横向移动切割平面离开内窥镜腔的括约肌切断管管体的轴线。横向移位在切割平面相对于纵向轴线的未偏移位置的至少一个横向方向上，从而在括约肌切开术期间的使用中，切割线可以定向成与括约肌的特定特征对准，例如， Oddi括约肌和Vater乳头的十二点钟位置，而不必重新定位内窥镜和/或撤回和重新定位内窥镜腔内的括约肌切开术。

2. 发明授权

US5624379A Endoscopic probe with discrete rotatable tip 失效
标题翻译：具有分立旋转尖端的内窥镜探头
公开(公告)号：US5624379A
公开(公告)日：1997-04-29
申请号：US543180
申请日：1995-10-13
申请人： Robert A. Ganz , Jonathan Kagan , Brian D. Zelickson , Ricci D. Smelser
发明人： Robert A. Ganz , Jonathan Kagan , Brian D. Zelickson , Ricci D. Smelser
IPC分类号： A61B10/00 , A61B10/06 , A61B17/00 , A61B17/28 , A61B1/00
CPC分类号： A61B10/06 , A61B2017/003 , A61B2017/2905 , A61B2017/2927 , A61B2017/2929
摘要： An endoscopic probe has an elongate flexible member and a radially extending tip rotatably mounted on a remote end thereof. A wire extends through the elongate flexible member and into the tip. The wire rotates relative to the elongate flexible member to rotate the radially extending tip to any desired orientation about the axis of the elongate flexible member.
摘要翻译：内窥镜探针具有细长的柔性构件和可旋转地安装在其远端上的径向延伸的尖端。线延伸穿过细长的柔性构件并进入尖端。线相对于细长的柔性构件旋转，以将径向延伸的尖端旋转到围绕细长柔性构件的轴线的任何期望的取向。

3. 发明授权

US07933659B2 Device and method for treatment of gastroesophageal reflux disease 有权
标题翻译：用于治疗胃食管反流病的装置和方法
公开(公告)号：US07933659B2
公开(公告)日：2011-04-26
申请号：US12839112
申请日：2010-07-19
申请人： Brian D. Zelickson , Robert A. Ganz
发明人： Brian D. Zelickson , Robert A. Ganz
IPC分类号： A61B12/00 , A61B18/18
CPC分类号： A61B18/1815 , A61B1/00082 , A61B1/018 , A61B18/08 , A61B18/1492 , A61B18/20 , A61B2018/00011 , A61B2018/00214 , A61B2018/00553
摘要： A lower esophageal sphincter tightening device for treating gastroesophageal reflux disease which includes an insertion device, an energy source, and an energy transmitting device. The insertion device, by insertion through a body opening, positions the energy transmitting device in the proximity of the lower esophageal sphincter. The energy source generates and transmits energy via the insertion device to the energy transmitting device which directs the transmitted energy onto the lower esophageal sphincter which is comprised largely of collagen. The energy source transmits energy at a level sufficient to cause heating of the sphincter's collagen resulting in a shrinkage of the collagen and a tightening of the sphincter.
摘要翻译：一种用于治疗胃食管反流病的下食道括约肌紧固装置，其包括插入装置，能量源和能量传递装置。插入装置通过插入体开口将能量传递装置定位在食管下括约肌附近。能量源通过插入装置产生能量并将能量传递到能量传递装置，该能量传递装置将传播的能量引导到主要由胶原蛋白组成的下部食管括约肌上。能量源以足以引起括约肌胶原加热的水平传输能量，从而导致胶原蛋白的收缩和括约肌紧缩。

4. 发明授权

US06551310B1 System and method of treating abnormal tissue in the human esophagus 有权
标题翻译：治疗人类食管异常组织的系统和方法
公开(公告)号：US06551310B1
公开(公告)日：2003-04-22
申请号：US09714344
申请日：2000-11-16
申请人： Robert A. Ganz , Brian D. Zelickson , Roger A. Stern
发明人： Robert A. Ganz , Brian D. Zelickson , Roger A. Stern
IPC分类号： A61B1818
CPC分类号： A61B18/18 , A61B18/1485 , A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00482 , A61B2018/00553 , A61B2018/00577 , A61B2018/00738 , A61B2018/00797 , A61B2018/126 , A61B2018/1467
摘要： An ablation catheter system and method of use is provided to endoscopically access portions of the human esophagus experiencing undesired growth of columnar epithelium. The ablation catheter system and method includes controlled depth of ablation features and use of either radio frequency spectrum, non-ionizing ultraviolet radiation, warm fluid or microwave radiation, which may also be accompanied by improved sensitizer agents.
摘要翻译：提供了一种消融导管系统和使用方法，用于内窥镜检查经历柱状上皮不期望生长的人食管部分。消融导管系统和方法包括受控的消融深度特征以及无线电频谱，非电离紫外线辐射，暖流体或微波辐射的使用，还可伴随改进的敏化剂。

5. 发明申请

US20120330298A1 SYSTEM AND METHOD OF TREATING ABNORMAL TISSUE IN THE HUMAN ESOPHAGUS 审中-公开
标题翻译：在人类ESOPHAGUS中治疗异常组织的系统和方法
公开(公告)号：US20120330298A1
公开(公告)日：2012-12-27
申请号：US13530464
申请日：2012-06-22
申请人： Robert A. Ganz , Brian D. Zelickson , Roger A. Stern
发明人： Robert A. Ganz , Brian D. Zelickson , Roger A. Stern
IPC分类号： A61B18/18
CPC分类号： A61B18/18 , A61B18/1485 , A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00482 , A61B2018/00553 , A61B2018/00577 , A61B2018/00738 , A61B2018/00797 , A61B2018/126 , A61B2018/1467
摘要： An ablation catheter system and method of use is provided to endoscopically access portions of the human esophagus experiencing undesired growth of columnar epithelium. The ablation catheter system and method includes controlled depth of ablation features and use of either radio frequency spectrum, non-ionizing ultraviolet radiation, warm fluid or microwave radiation, which may also be accompanied by improved sensitizer agents.
摘要翻译：提供了一种消融导管系统和使用方法，用于内窥镜检查经历柱状上皮不期望生长的人食管部分。消融导管系统和方法包括受控的消融深度特征以及无线电频谱，非电离紫外线辐射，暖流体或微波辐射的使用，还可伴随改进的敏化剂。

6. 发明授权

US07761169B2 Device and method for treatment of gastroesophageal reflux disease 失效
标题翻译：用于治疗胃食管反流病的装置和方法
公开(公告)号：US07761169B2
公开(公告)日：2010-07-20
申请号：US12136730
申请日：2008-06-10
申请人： Brian D. Zelickson , Robert A. Ganz
发明人： Brian D. Zelickson , Robert A. Ganz
IPC分类号： A61B18/18
CPC分类号： A61B18/1815 , A61B1/00082 , A61B1/018 , A61B18/08 , A61B18/1492 , A61B18/20 , A61B2018/00011 , A61B2018/00214 , A61B2018/00553
摘要： A lower esophageal sphincter tightening device for treating gastroesophageal reflux disease which includes an insertion device, an energy source, and an energy transmitting device. The insertion device, by insertion through a body opening, positions the energy transmitting device in the proximity of the lower esophageal sphincter. The energy source generates and transmits energy via the insertion device to the energy transmitting device which directs the transmitted energy onto the lower esophageal sphincter which is comprised largely of collagen. The energy source transmits energy at a level sufficient to cause heating of the sphincter's collagen resulting in a shrinkage of the collagen and a tightening of the sphincter.
摘要翻译：一种用于治疗胃食管反流病的下食道括约肌紧固装置，其包括插入装置，能量源和能量传递装置。插入装置通过插入体开口将能量传递装置定位在食管下括约肌附近。能量源通过插入装置产生能量并将能量传递到能量传递装置，该能量传递装置将传播的能量引导到主要由胶原蛋白组成的下部食管括约肌上。能量源以足以引起括约肌胶原加热的水平传输能量，从而导致胶原蛋白的收缩和括约肌紧缩。

7. 发明授权

US07043307B1 Device and method for treatment of gastroesophageal reflux disease 失效
公开(公告)号：US07043307B1
公开(公告)日：2006-05-09
申请号：US10633820
申请日：2003-08-04
申请人： Brian D. Zelickson , Robert A. Ganz
发明人： Brian D. Zelickson , Robert A. Ganz
IPC分类号： A61B18/18
CPC分类号： A61B18/1815 , A61B1/00082 , A61B1/018 , A61B18/08 , A61B18/1492 , A61B18/20 , A61B2018/00011 , A61B2018/00214 , A61B2018/00553
摘要： A lower esophageal sphincter tightening device for treating gastroesophageal reflux disease which includes an insertion device, an energy source, and an energy transmitting device. The insertion device, by insertion through a body opening, positions the energy transmitting device in the proximity of the lower esophageal sphincter. The energy source generates and transmits energy via the insertion device to the energy transmitting device which directs the transmitted energy onto the lower esophageal sphincter which is comprised largely of collagen. The energy source transmits energy at a level sufficient to cause heating of the sphincter's collagen resulting in a shrinkage of the collagen and a tightening of the sphincter.

8. 发明授权

US06321121B1 Device and method for treatment of gastroesophageal reflux disease 有权
标题翻译：用于治疗胃食管反流病的装置和方法
公开(公告)号：US06321121B1
公开(公告)日：2001-11-20
申请号：US09475580
申请日：1999-12-30
申请人： Brian D. Zelickson , Robert A. Ganz
发明人： Brian D. Zelickson , Robert A. Ganz
IPC分类号： A61F200
CPC分类号： A61B18/1815 , A61B1/00082 , A61B1/018 , A61B18/08 , A61B18/1492 , A61B18/20 , A61B2018/00011 , A61B2018/00214 , A61B2018/00553
摘要： A lower esophageal sphincter tightening device for treating gastroesophageal reflux disease which includes an insertion device, an energy source, and an energy transmitting device. The insertion device, by insertion through a body opening, positions the energy transmitting device in the proximity of the lower esophageal sphincter. The energy source generates and transmits energy via the insertion device to the energy transmitting device which directs the transmitted energy onto the lower esophageal sphincter which is comprised largely of collagen. The energy source transmits energy at a level sufficient to cause heating of the sphincter's collagen resulting in a shrinkage of the collagen and a tightening of the sphincter.
摘要翻译：一种用于治疗胃食管反流病的下食道括约肌紧固装置，其包括插入装置，能量源和能量传递装置。插入装置通过插入体开口将能量传递装置定位在食管下括约肌附近。能量源通过插入装置产生能量并将能量传递到能量传递装置，该能量传递装置将传播的能量引导到主要由胶原蛋白组成的下部食管括约肌上。能量源以足以引起括约肌胶原加热的水平传输能量，从而导致胶原蛋白的收缩和括约肌紧缩。

9. 发明授权

US08398631B2 System and method of treating abnormal tissue in the human esophagus 有权
公开(公告)号：US08398631B2
公开(公告)日：2013-03-19
申请号：US12259136
申请日：2008-10-27
申请人： Robert A. Ganz , Brian D. Zelickson , Roger A. Stern
发明人： Robert A. Ganz , Brian D. Zelickson , Roger A. Stern
IPC分类号： A61B18/18 , A61N1/00
CPC分类号： A61B18/18 , A61B18/1485 , A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00482 , A61B2018/00553 , A61B2018/00577 , A61B2018/00738 , A61B2018/00797 , A61B2018/126 , A61B2018/1467
摘要： An ablation catheter system and method of use is provided to endoscopically access portions of the human esophagus experiencing undesired growth of columnar epithelium. The ablation catheter system and method includes controlled depth of ablation features and use of either radio frequency spectrum, non-ionizing ultraviolet radiation, warm fluid or microwave radiation, which may also be accompanied by improved sensitizer agents.

10. 发明授权

US07400929B2 Device and method for treatment of gastroesophageal reflux disease 有权
标题翻译：用于治疗胃食管反流病的装置和方法
公开(公告)号：US07400929B2
公开(公告)日：2008-07-15
申请号：US11279025
申请日：2006-04-07
申请人： Brian D. Zelickson , Robert A. Ganz
发明人： Brian D. Zelickson , Robert A. Ganz
IPC分类号： A61B18/18
CPC分类号： A61B18/1815 , A61B1/00082 , A61B1/018 , A61B18/08 , A61B18/1492 , A61B18/20 , A61B2018/00011 , A61B2018/00214 , A61B2018/00553
摘要： A lower esophageal sphincter tightening device for treating gastroesophageal reflux disease which includes an insertion device, an energy source, and an energy transmitting device. The insertion device, by insertion through a body opening, positions the energy transmitting device in the proximity of the lower esophageal sphincter. The energy source generates and transmits energy via the insertion device to the energy transmitting device which directs the transmitted energy onto the lower esophageal sphincter which is comprised largely of collagen. The energy source transmits energy at a level sufficient to cause heating of the sphincter's collagen resulting in a shrinkage of the collagen and a tightening of the sphincter.
摘要翻译：一种用于治疗胃食管反流病的下食道括约肌紧固装置，其包括插入装置，能量源和能量传递装置。插入装置通过插入体开口将能量传递装置定位在食管下括约肌附近。能量源通过插入装置产生能量并将能量传递到能量传递装置，该能量传递装置将传播的能量引导到主要由胶原蛋白组成的下部食管括约肌上。能量源以足以引起括约肌胶原加热的水平传输能量，从而导致胶原蛋白的收缩和括约肌紧缩。

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