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1. 发明授权

US09687502B2 Methods and compositions for treating mammalian nerve tissue injuries 有权
公开(公告)号：US09687502B2
公开(公告)日：2017-06-27
申请号：US10901481
申请日：2004-07-28
申请人： Riyi Shi , Richard B. Borgens , Raphael C. Lee
发明人： Riyi Shi , Richard B. Borgens , Raphael C. Lee
IPC分类号： A61K31/765 , A61K31/00 , A61K9/19 , C08L71/02 , A61K31/74 , A61K31/77
CPC分类号： A61K31/765 , A61K31/00 , A61K31/74 , A61K31/77 , A61K2300/00
摘要： To achieve, an in vivo repair of injured mammalian nerve tissue, an effective amount of a biomembrane fusion agent is administered to the injured nerve tissue. The application of the biomembrane fusion agent may be performed by directly contacting the agent with the nerve tissue at the site of the injury. Alternatively, the biomembrane fusion agent is delivered to the site of the injury through the blood supply after administration of the biomembrane fusion agent to the patient. The administration is preferably by parenteral administration including including intravascular, intramuscular, subcutaneous, or intraperitoneal injection of an effective quantity of the biomembrane fusion agent so that an effective amount is delivered to the site of the nerve tissue injury.

2. 发明授权

US08460646B2 Methods and compositions for treating mammalian nerve tissue injuries 有权
公开(公告)号：US08460646B2
公开(公告)日：2013-06-11
申请号：US12508184
申请日：2009-07-23
申请人： Riyi Shi , Richard B. Borgens
发明人： Riyi Shi , Richard B. Borgens
IPC分类号： A61K31/74 , A61F13/00 , A61F2/00
CPC分类号： A61K31/765 , A61K31/00 , A61K31/74 , A61K31/77 , A61K2300/00
摘要： To achieve, an in vivo repair of injured mammalian nerve tissue, an effective amount of a biomembrane fusion agent is administered to the injured nerve tissue. The application of the biomembrane fusion agent may be performed by directly contacting the agent with the nerve tissue at the site of the injury. Alternatively, the biomembrane fusion agent is delivered to the site of the injury through the blood supply after administration of the biomembrane fusion agent to the patient. The administration is preferably by parenteral administration including intravascular, intramuscular, subcutaneous, or intraperitoneal injection of an effective quantity of the biomembrane fusion agent so that an effective amount is delivered to the site of the nerve tissue injury.

3. 发明授权

US08097638B2 Pyridines for treating injured mammalian nerve tissue 有权
标题翻译：吡啶类用于治疗受伤的哺乳动物神经组织
公开(公告)号：US08097638B2
公开(公告)日：2012-01-17
申请号：US11778524
申请日：2007-07-16
申请人： Richard B. Borgens , Riyi Shi , Stephen R. Byrn , Daniel T. Smith
发明人： Richard B. Borgens , Riyi Shi , Stephen R. Byrn , Daniel T. Smith
IPC分类号： A61K31/44
CPC分类号： C07D213/40 , C07D213/74 , C07D213/75 , C07D471/04
摘要： The invention provides novel pyridines, pharmaceutical compositions comprising such pyridines, and the use of such compositions in treating injured mammalian nerve tissue, including but not limited to an injured spinal cord, in one embodiment, the compounds, compositions, and methods of the instant invention treat a mammalian nerve tissue injury by restoring action potential or nerve impulse conduction through a nerve tissue lesion. Significantly, in vivo application of compounds of the instant invention established, on the basis of SSEP testing, that the compounds provide longer lasting effects at lower concentrations than comparable treatment with the known agent 4-aminopyridine (4 AP).
摘要翻译：本发明提供新颖的吡啶，包含这种吡啶的药物组合物，以及这些组合物在治疗受损的哺乳神经组织中的用途，包括但不限于受损的脊髓，在一个实施方案中，本发明的化合物，组合物和方法通过神经组织损伤恢复动作电位或神经冲动传导来治疗哺乳动物神经组织损伤。重要的是，本发明的化合物的体内应用基于SSEP测试确定，化合物在比已知药物4-氨基吡啶（4 AP）的可比治疗低的浓度下提供更持久的效果。

4. 发明授权

US07837987B2 Methods and compositions for treating mammalian nerve tissue injuries 有权
标题翻译：治疗哺乳动物神经组织损伤的方法和组合物
公开(公告)号：US07837987B2
公开(公告)日：2010-11-23
申请号：US10132542
申请日：2002-04-24
申请人： Riyi Shi , Richard B. Borgens
发明人： Riyi Shi , Richard B. Borgens
IPC分类号： A61K31/765 , A61K31/74
CPC分类号： A61K31/765 , A61K31/00 , A61K31/74 , A61K31/77 , A61K2300/00
摘要： To achieve, an in vivo repair of injured mammalian nerve tissue, an effective amount of a biomembrane fusion agent is administered to the injured nerve tissue. The application of the biomembrane fusion agent may be preformed by directly contacting the agent with the nerve tissue at the site of the injury. Alternatively, the biomembrane fusion agent is delivered to the site of the injury through the blood supply after administration of the biomembrane fusion agent to the patient. The administration is preferably by parenteral administration including intravascular, intramuscular, subcutaneous, or intraperitoneal injection of an effective quantity of the biomembrane fusion agent so that an effective amount is delivered to the site of the nerve tissue injury.
摘要翻译：为了实现受损的哺乳动物神经组织的体内修复，向受损的神经组织施用有效量的生物膜融合剂。生物膜融合剂的应用可以通过在损伤部位直接接触该药剂与神经组织来进行。或者，通过将生物膜融合剂施用于患者后，通过供血将生物膜融合剂递送至损伤部位。给药优选通过肠胃外给药，包括血管内，肌内，皮下或腹膜内注射有效量的生物膜融合剂，使得有效量被递送到神经组织损伤部位。

5. 发明授权

US08729107B2 Pyridines for treating injured mammalian nerve tissue 有权
标题翻译：吡啶类用于治疗受伤的哺乳动物神经组织
公开(公告)号：US08729107B2
公开(公告)日：2014-05-20
申请号：US12878495
申请日：2010-09-09
申请人： Richard B. Borgens , Riyi Shi , Stephen R. Byrn , Daniel T. Smith
发明人： Richard B. Borgens , Riyi Shi , Stephen R. Byrn , Daniel T. Smith
IPC分类号： A61K31/44
CPC分类号： C07D213/74 , C07D213/73 , C07D213/75 , C07D471/04
摘要： Embodiments of the present disclosure provide a novel pyridine, pharmaceutical compositions comprising such pyridine, and the use of such compositions in treating injured mammalian nerve tissue, including but not limited to an injured spinal cord. In at least one embodiment of the method, the method comprises the step of administering to the mammal in need thereof with a pharmaceutical composition, or pharmaceutically acceptable salt, comprising 4-aminopyridine-3-methanol.
摘要翻译：本公开的实施方案提供了一种新颖的吡啶，包含这种吡啶的药物组合物，以及这些组合物在治疗受损的哺乳动物神经组织中的用途，包括但不限于受损的脊髓。在该方法的至少一个实施方案中，该方法包括以下步骤：向需要的哺乳动物施用包含4-氨基吡啶-3-甲醇的药物组合物或药学上可接受的盐。

6. 发明申请

US20110130429A1 PYRIDINES FOR TREATING INJURED MAMMALIAN NERVE TISSUE 有权
标题翻译：用于治疗受伤的哺乳动物神经组织的吡啶
公开(公告)号：US20110130429A1
公开(公告)日：2011-06-02
申请号：US12878495
申请日：2010-09-09
申请人： Richard B. Borgens , Riyi Shi , Stephen R. Byrn , Daniel T. Smith
发明人： Richard B. Borgens , Riyi Shi , Stephen R. Byrn , Daniel T. Smith
IPC分类号： A61K31/44 , A61P25/00
CPC分类号： C07D213/74 , C07D213/73 , C07D213/75 , C07D471/04
摘要： Embodiments of the present disclosure provide a novel pyridine, pharmaceutical compositions comprising such pyridine, and the use of such compositions in treating injured mammalian nerve tissue, including but not limited to an injured spinal cord. In at least one embodiment of the method, the method comprises the step of administering to the mammal in need thereof with a pharmaceutical composition, or pharmaceutically acceptable salt, comprising 4-aminopyridine-3-methanol.
摘要翻译：本公开的实施方案提供了一种新颖的吡啶，包含这种吡啶的药物组合物，以及这些组合物在治疗受损的哺乳动物神经组织中的用途，包括但不限于受损的脊髓。在该方法的至少一个实施方案中，该方法包括以下步骤：向需要的哺乳动物施用包含4-氨基吡啶-3-甲醇的药物组合物或药学上可接受的盐。

7. 发明授权

US07582680B1 Methods and compositions for treating mammalian spinal cord injuries 有权
标题翻译：治疗哺乳动物脊髓损伤的方法和组合物
公开(公告)号：US07582680B1
公开(公告)日：2009-09-01
申请号：US09438206
申请日：1999-11-12
申请人： Riyi Shi , Richard B. Borgens
发明人： Riyi Shi , Richard B. Borgens
IPC分类号： A61K31/08 , A61K31/44
CPC分类号： A61K31/44 , A61K31/08 , A61K45/06 , A61L27/18 , A61L2430/38 , A61K2300/00 , C08L71/02
摘要： Methods of treating an injured vertebrate spinal cord are described. In one aspect of the invention, a method of treating an injured vertebrate spinal cord includes contacting the spinal cord with a biomembrane fusion agent such as a polyalkylene glycol, especially polyethylene glycol. In alternative embodiments of the invention, methods of treating an injured vertebrate spinal cord include contacting the cord with a biomembrane fusion agent and a potassium channel blocker. Other aspects of the invention include compositions for treating a vertebrate nervous system. A preferred composition includes a biomembrane fusion agent, such as a polyalkylene glycol, and a potassium channel blocker, such as an amino-substituted pyridine.
摘要翻译：描述了治疗受损的脊椎动物脊髓的方法。在本发明的一个方面，治疗受损的脊椎动物脊髓的方法包括使脊髓与生物膜融合剂如聚亚烷基二醇，特别是聚乙二醇接触。在本发明的替代实施例中，治疗受损的脊椎动物脊髓的方法包括将绳索与生物膜融合剂和钾通道阻断剂接触。本发明的其它方面包括用于治疗脊椎动物神经系统的组合物。优选的组合物包括生物膜融合剂，例如聚亚烷基二醇和钾通道阻断剂，例如氨基取代的吡啶。

8. 发明授权

US07244748B2 Pyridines for treating injured mammalian nerve tissue 有权
标题翻译：吡啶类用于治疗受伤的哺乳动物神经组织
公开(公告)号：US07244748B2
公开(公告)日：2007-07-17
申请号：US10730495
申请日：2003-12-05
申请人： Richard B. Borgens , Riyi Shi , Stephen R. Byrn , Daniel T. Smith
发明人： Richard B. Borgens , Riyi Shi , Stephen R. Byrn , Daniel T. Smith
IPC分类号： A61K31/44
CPC分类号： C07D213/40 , C07D213/74 , C07D213/75 , C07D471/04
摘要： The invention provides novel pyridines, pharmaceutical compositions comprising such pyridines, and the use of such compositions in treating injured mammalian nerve tissue, including but not limited to an injured spinal cord. In one embodiment, the compounds, compositions, and methods of the instant invention treat a mammalian nerve tissue injury by restoring action potential or nerve impulse conduction through a nerve tissue lesion. Significantly, in vivo application of compounds of the instant invention established, on the basis of SSEP testing, that the compounds provide longer lasting effects at lower concentrations than comparable treatment with the known agent 4-aminopyridine (4 AP).
摘要翻译：本发明提供新颖的吡啶，包含这种吡啶的药物组合物，以及这些组合物在治疗受损的哺乳动物神经组织中的应用，包括但不限于受损的脊髓。在一个实施方案中，本发明的化合物，组合物和方法通过恢复通过神经组织损伤的动作电位或神经脉冲传导来治疗哺乳动物神经组织损伤。重要的是，本发明的化合物的体内应用基于SSEP测试确定，化合物在比已知药物4-氨基吡啶（4 AP）的可比治疗低的浓度下提供更持久的效果。

9. 发明授权

US07792576B2 Method of treatment for central nervous system injury 失效
标题翻译：中枢神经系统损伤的治疗方法
公开(公告)号：US07792576B2
公开(公告)日：2010-09-07
申请号：US11708427
申请日：2007-02-20
申请人： Richard B. Borgens , Scott A. Shapiro
发明人： Richard B. Borgens , Scott A. Shapiro
IPC分类号： A61K31/7076 , A61K31/708 , A61N1/36 , A61N1/05 , C07H19/16 , C07H19/167 , C07H19/173
CPC分类号： A61K31/708 , A61N1/36103
摘要： Injuries to the central nervous system, particularly spinal cord injuries, are treated by administering a purine nucleoside or analog to the patient and, optionally, electrically stimulating the site of injury.
摘要翻译：通过向患者施用嘌呤核苷或类似物并任选地电刺激损伤部位来治疗中枢神经系统的损伤，特别是脊髓损伤。

10. 发明申请

US20080306571A1 Devices For Treatment of Central Nervous System Injuries 审中-公开
标题翻译：用于治疗中枢神经系统损伤的装置
公开(公告)号：US20080306571A1
公开(公告)日：2008-12-11
申请号：US11919784
申请日：2006-03-16
申请人： Richard B. Borgens , Pedro Irazoqui , John M. Cirillo
发明人： Richard B. Borgens , Pedro Irazoqui , John M. Cirillo
IPC分类号： A61N1/00
CPC分类号： A61N1/205 , A61N1/326
摘要： A device for stimulating axon growth of the nerve cells in the spinal cord of mammals includes a device having a DC stimulus generator (356, 358, 360, 362, 364, 366, 388, 390, 368, 370, 372, 374, 376, 378, 392, 394, 606, 608) having first and second oppositely polarized output terminals (341, 343, 345, 385, 648; 347, 349, 351, 387 646), first and second electrodes (340, 342, 344, 384, 612; 346, 348, 350, 386, 610) electrically coupled to the first and second terminals respectively, and a polarity reversing circuit (382, 380; 602, 604) electrically connected to the constant current DC stimulus generator and configured to reverse the polarity of the DC stimulus each time a predetermined period of time elapses. A method for stimulating axon growth of the nerve cells in the spinal cord of mammals includes providing such a device and implanting the provides device in a mammal.
摘要翻译：用于刺激哺乳动物脊髓中的神经细胞的轴突生长的装置包括具有DC刺激发生器（356,358,360,362,364,366,388,368,368,370,372,374,376）的装置具有第一和第二相对极化的输出端子（341,343,345,385,648; 347,349,351,387 646）的第一和第二电极（340,342,648）电连接到第一和第二端子的电极，384,612; 346,348,350,386,610，以及电连接到恒流DC刺激发生器的极性反转电路（382,380; 602,604）每次经过预定时间段来反转DC刺激的极性。用于刺激哺乳动物脊髓中的神经细胞的轴突生长的方法包括提供这样的装置并将提供的装置植入哺乳动物中。

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