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1. 发明授权

US09687502B2 Methods and compositions for treating mammalian nerve tissue injuries 有权
公开(公告)号：US09687502B2
公开(公告)日：2017-06-27
申请号：US10901481
申请日：2004-07-28
申请人： Riyi Shi , Richard B. Borgens , Raphael C. Lee
发明人： Riyi Shi , Richard B. Borgens , Raphael C. Lee
IPC分类号： A61K31/765 , A61K31/00 , A61K9/19 , C08L71/02 , A61K31/74 , A61K31/77
CPC分类号： A61K31/765 , A61K31/00 , A61K31/74 , A61K31/77 , A61K2300/00
摘要： To achieve, an in vivo repair of injured mammalian nerve tissue, an effective amount of a biomembrane fusion agent is administered to the injured nerve tissue. The application of the biomembrane fusion agent may be performed by directly contacting the agent with the nerve tissue at the site of the injury. Alternatively, the biomembrane fusion agent is delivered to the site of the injury through the blood supply after administration of the biomembrane fusion agent to the patient. The administration is preferably by parenteral administration including including intravascular, intramuscular, subcutaneous, or intraperitoneal injection of an effective quantity of the biomembrane fusion agent so that an effective amount is delivered to the site of the nerve tissue injury.

2. 发明授权

US5605687A Methods and compositions of a polymer (poloxamer) for repair of electrical injury 失效
标题翻译：用于修复电气伤害的聚合物（泊洛沙姆）的方法和组成
公开(公告)号：US5605687A
公开(公告)日：1997-02-25
申请号：US461255
申请日：1995-06-05
申请人： Raphael C. Lee
发明人： Raphael C. Lee
IPC分类号： A61K31/765 , A61K31/77 , A61K31/785 , A61K33/14 , C12N5/08 , A61K9/06 , A61K9/12
CPC分类号： A61K31/785 , A61K31/765 , A61K31/77 , A61K33/14 , Y10S424/13
摘要： Novel methods for the treatment of tissue damage resulting from cell membrane permeabilization due to electrical injury are disclosed. Such methods include treatment with a surface active copolymer which is herein shown to promote membrane repair. The administration of Poloxamer 188 is shown to reduce tissue inflammation and damage following electrical injury in vivo. Also disclosed are methods for the treatment of cell and tissue damage after electrical injury using a surface active copolymer in combination with a high energy phosphate compound capable of recharging cellular energy stores and potentiating cell repair and survival. Compositions comprising surface active copolymers for intravenous, intramuscular, and topical use are also disclosed, along with novel compositions comprising a combination of a surface active copolymer and a high energy phosphate compound.
摘要翻译：公开了用于治疗由于电损伤导致的细胞膜透化引起的组织损伤的新方法。这些方法包括用本文显示促进膜修复的表面活性共聚物进行处理。泊洛沙姆188的给药显示出在体内电损伤后减少组织炎症和损伤。还公开了使用表面活性共聚物与能够再次充电细胞能量存储并增强细胞修复和存活的高能量磷酸盐化合物组合的电损伤后治疗细胞和组织损伤的方法。还公开了包含静脉内，肌肉内和局部使用的表面活性共聚物的组合物，以及包含表面活性共聚物和高能磷酸盐化合物的组合的新型组合物。

3. 发明授权

US5569678A Control of wound scar production 失效
标题翻译：控制伤口瘢痕生成
公开(公告)号：US5569678A
公开(公告)日：1996-10-29
申请号：US190239
申请日：1994-02-01
申请人： Raphael C. Lee
发明人： Raphael C. Lee
IPC分类号： A61K31/00 , A61K31/135 , A61K31/275 , A61K31/44 , A61K31/54 , A61K31/55 , A61K31/57 , A61K33/24 , A61K31/56 , A61K31/58
CPC分类号： A61K31/57 , A61K31/00 , A61K31/135 , A61K31/275 , A61K31/44 , A61K31/54 , A61K31/55 , A61K33/24
摘要： This invention pertains to a method for controlling wound scar production by administering a calcium antagonist, alone or in a combination with or followed by a steroid, to the wound site. The method can be used to minimize wound scars, such as hypertrophic wound healing disorders, keloids and burn scar contractures in humans or other mammals, particularly those individually prone to excesssive scarring.
摘要翻译：本发明涉及一种通过向伤口部位施用单独或与类固醇组合或与之结合的钙拮抗剂来控制伤口瘢痕产生的方法。该方法可用于最小化人或其他哺乳动物，特别是单独容易发生过度瘢痕形成的伤口瘢痕，例如肥大性伤口愈合障碍，瘢痕疙瘩和烧伤瘢痕挛缩。

4. 发明授权

US5552162A Method for improvement of scar size and appearance 失效
标题翻译：改善疤痕大小和外观的方法
公开(公告)号：US5552162A
公开(公告)日：1996-09-03
申请号：US15216
申请日：1993-02-09
申请人： Raphael C. Lee
发明人： Raphael C. Lee
IPC分类号： A61L26/00 , A61K31/275
CPC分类号： A61L26/008 , A61L26/0066 , A61L2300/432
摘要： A method for improving the size and appearance of a scar associated with a fibromatosis, a keloid, or a hypertrophic wound healing disorder comprises stimulating collagenase activity in the scar. Preferably, stimulating collagenase activity is accomplished by covering said scar with a thermal insulating material that elevates the surface temperature of the scar. Further disclosed is a method for improving the size and appearance of a scar comprises covering said scar with a thermal insulating material that elevates the surface temperature of the scar and that contains a therapeutically effective amount of a medicament.
摘要翻译：用于改善与纤维瘤病，瘢痕疙瘩或肥厚性伤口愈合障碍相关的瘢痕的大小和外观的方法包括刺激瘢痕中的胶原酶活性。优选地，通过用提高瘢痕的表面温度的绝热材料覆盖所述疤痕来实现刺激胶原酶活性。还公开了一种用于改善瘢痕的尺寸和外观的方法，包括用提高瘢痕的表面温度并且含有治疗有效量的药物的绝热材料覆盖所述疤痕。

5. 发明授权

US5700688A Method for producing oriented connective tissue cells 失效
标题翻译：生产定向结缔组织细胞的方法
公开(公告)号：US5700688A
公开(公告)日：1997-12-23
申请号：US488134
申请日：1995-06-07
申请人： Raphael C. Lee , David Huang
发明人： Raphael C. Lee , David Huang
IPC分类号： A61F2/08 , A61L27/38 , C12M3/00 , C12N5/077 , G01N3/00 , A61B17/56
CPC分类号： A61L27/3804 , A61L27/386 , C12M21/08 , C12M35/04 , C12N5/066 , A61F2/08 , C12N2501/15 , C12N2533/54
摘要： The present invention pertains to a mechanical testing apparatus for determining the mechanical properties of an oriented tissue-equivalent, while simultaneously providing a suitable cell culture environment. The mechanical testing apparatus comprises an incubator equipped with means for controlling the atmosphere and means for controlling the temperature inside said incubator. Located within the incubator chamber are means for securing, in a desired location, the oriented tissue-equivalent to be mechanically tested. Further, the apparatus is equipped with means for controlling the length of the oriented tissue-equivalent, means for determining the force generated by the oriented tissue-equivalent, means for determining the length of the oriented tissue-equivalent and means for conditioning and recording force and length measurements.
摘要翻译：本发明涉及用于确定定向组织等效物的机械性质的机械测试装置，同时提供合适的细胞培养环境。机械测试装置包括配备有用于控制气氛的装置的培养箱和用于控制所述培养箱内的温度的装置。位于培养箱内的装置是用于在所需位置固定待机械测试的取向组织等价物的装置。此外，该装置配备有用于控制定向组织等效物的长度的装置，用于确定由定向组织等效物产生的力的装置，用于确定定向组织等效物的长度的装置和用于调节和记录力的装置和长度测量。

6. 发明授权

US5470568A Methods and compositions of a polymer (poloxamer) for cell repair 失效
标题翻译：用于细胞修复的聚合物（泊洛沙姆）的方法和组合物
公开(公告)号：US5470568A
公开(公告)日：1995-11-28
申请号：US835271
申请日：1992-02-13
申请人： Raphael C. Lee
发明人： Raphael C. Lee
IPC分类号： A61K31/77 , A61K31/785 , A61P39/00 , A61K9/06 , A61K9/12
CPC分类号： A61K31/785 , A61K31/77 , Y10S424/13 , Y10S514/917 , Y10S514/975
摘要： Novel methods for prophylaxis and treatment of tissue damage resulting from cell membrane permeabilization are disclosed. Compositions comprising a surface active copolymer are employed to prevent permeabilization or to promote membrane repair. Methods for enhancement of cell survival following membrane permeabilization in vitro are also disclosed, along with methods for increasing the efficacy of transfection of cells with foreign exogenous macromolecules, in particular DNA, also involving treatment of permeabilized cells with a surface active copolymer. Also disclosed are novel methods for prophylaxis and treatment of tissue damage, and for enhancement of cell survival and transfection efficacy, using a surface active copolymer in combination with high energy phosphate compounds which are capable of recharging cellular energy stores and thereby potentiating cell repair and survival. Compositions comprising surface active copolymers for intravenous, intramuscular, and topical use are also disclosed, along with novel compositions comprising a combination of a surface active copolymer and a high energy phosphate compound.
摘要翻译：公开了用于预防和治疗由细胞膜透化产生的组织损伤的新方法。包含表面活性共聚物的组合物用于防止透化或促进膜修复。还公开了在体外膜透化后增强细胞存活的方法，以及用于增加用外源外源大分子特别是DNA转染细胞的功效的方法，还涉及用表面活性共聚物处理透化细胞。还公开了用于预防和治疗组织损伤以及用于增强细胞存活和转染功效的新方法，使用表面活性共聚物与能够再次充电细胞能量储存并由此增强细胞修复和存活的高能磷酸酯化合物。还公开了包含静脉内，肌肉内和局部使用的表面活性共聚物的组合物，以及包含表面活性共聚物和高能磷酸盐化合物的组合的新型组合物。

7. 发明授权

US08815557B2 Compositions and methods for refolding of denatured proteins 有权
标题翻译：变性蛋白重折叠的组合物和方法
公开(公告)号：US08815557B2
公开(公告)日：2014-08-26
申请号：US11483898
申请日：2006-07-10
申请人： Raphael C. Lee , Annie Kuo , Hanne Gissel Hyldkrog , Florin Despa , Devkumar Mustafi
发明人： Raphael C. Lee , Annie Kuo , Hanne Gissel Hyldkrog , Florin Despa , Devkumar Mustafi
IPC分类号： C12N9/00
CPC分类号： A01N1/0226 , C07K1/1136
摘要： Compounds and methods for refolding of proteins in an aqueous solution. In particular, biocompatible multiblock copolymer surfactants such as poloxamers, meroxapols, poloxamines, or polyols are used to catalyze proper refolding without changing the protein composition, and restore the protein to its native conformation and native biological function. The methods can be practiced both in vivo and in vitro. The biocompatible multiblock copolymer surfactants can be used for renaturation of recombinantly expressed proteins, and for renaturation of proteins that are unfolded due to heat, irradiation, mechanical shearing, electrical shock, frostbite, chemical stress, and other abiotic or biotic stresses.
摘要翻译：用于在水溶液中重折叠蛋白质的化合物和方法。特别地，生物相容性多嵌段共聚物表面活性剂如泊洛沙姆，meroxapols，泊洛沙胺或多元醇用于催化正确的重折叠而不改变蛋白质组成，并将蛋白质恢复到其天然构象和天然生物学功能。该方法可以在体内和体外实施。生物相容性多嵌段共聚物表面活性剂可用于重组表达蛋白的复性，以及由于热，照射，机械剪切，电击，冻伤，化学应力和其他非生物或生物胁迫而展开的蛋白质的复性。

8. 发明授权

US07255627B2 Garment device convertible to one or more facemasks 有权
标题翻译：服装设备可转换为一个或多个面罩
公开(公告)号：US07255627B2
公开(公告)日：2007-08-14
申请号：US11049525
申请日：2005-02-01
申请人： Elena N. Bodnar , Raphael C. Lee , Sandra Marijan
发明人： Elena N. Bodnar , Raphael C. Lee , Sandra Marijan
IPC分类号： A41D13/00 , A41C3/12 , A41C3/00
CPC分类号： A41C3/10 , A41C3/005 , A41D13/1138 , A41D15/00
摘要： A garment device convertible to one or more facemasks wherein the garment device has a plurality of detachable cup sections. Each of the cup sections has a filter device, an inner portion positionable adjacent to the inner area of the user's chest, and an outer portion positionable adjacent to the outer area of the user's chest. The garment device has at least one securing device detachably coupling the inner portions of the cup sections to one another, and the garment device has at least one other securing device attached to the outer portion of at least one of the cup sections. This other securing device is operable to: (a) detachably couple the outer portions of the cup regions to one another; and (b) for each one of the cup sections, attach the outer portion of said cup region to the inner portion of said cup region after said cup region is detached from the other cup region, thereby converting the garment device to a plurality of facemasks.
摘要翻译：一种衣服装置，其可转换成一个或多个面罩，其中所述衣服装置具有多个可拆卸杯部分。每个杯部分具有过滤装置，可邻近使用者胸部的内部区域定位的内部部分和可邻近使用者胸部的外部区域定位的外部部分。衣服装置具有至少一个固定装置，其将杯部分的内部彼此可拆卸地联接，并且衣服装置具有附连到至少一个杯部分的外部部分的至少一个其它固定装置。该另一固定装置可操作以：（a）将杯状区域的外部部分彼此可拆卸地联接; 和（b）对于杯形部分中的每一个，在所述杯区域从另一杯区域分离之后，将所述杯区域的外部部分附接到所述杯区域的内部，从而将衣服装置转换成多个面罩。

9. 发明授权

US5902609A Composition for the control of wound scar production 失效
标题翻译：用于控制伤口瘢痕生成的组成
公开(公告)号：US5902609A
公开(公告)日：1999-05-11
申请号：US740242
申请日：1996-10-25
申请人： Raphael C. Lee
发明人： Raphael C. Lee
IPC分类号： A61K31/00 , A61K31/135 , A61K31/275 , A61K31/44 , A61K31/54 , A61K31/55 , A61K31/57 , A61K33/24 , A61K33/26 , A61K31/58
CPC分类号： A61K31/57 , A61K31/00 , A61K31/135 , A61K31/275 , A61K31/44 , A61K31/54 , A61K31/55 , A61K33/24
摘要： This invention pertains to a composition for controlling wound scar production containing a calcium antagonist and a protein synthesis inhibitor. The method can be used to minimize wound scars, such as hypertrophic wound healing disorders keloids and burn scar contractures in humans or other mammals, particularly those individually prone to excesssive scarring Calcium antagonist treatment can also be used to control diseases associated with excessive scarring. such as cirrhosis of the liver, constructive pericarditis Dupuytren's disease of the hand, plantar fibrosis of the foot, and various other fibromatoses.
摘要翻译：本发明涉及用于控制含有钙拮抗剂和蛋白质合成抑制剂的伤口瘢痕产生的组合物。该方法可用于最小化伤口瘢痕，例如增生性伤口愈合障碍瘢痕疙瘩和人类或其他哺乳动物中的瘢痕挛缩，特别是那些容易发生过度瘢痕的患者。钙拮抗剂治疗也可用于控制与过度瘢痕形成相关的疾病。如肝硬化，建设性心包炎手法杜邦氏病，足底足底纤维化，以及各种其他纤维瘤病。

10. 发明授权

US5521087A Method for producing oriented connective tissue cells in a ligament configuration 失效
标题翻译：用于在韧带构型中产生定向结缔组织细胞的方法
公开(公告)号：US5521087A
公开(公告)日：1996-05-28
申请号：US370555
申请日：1995-01-09
申请人： Raphael C. Lee , David Huang
发明人： Raphael C. Lee , David Huang
IPC分类号： A61F2/08 , A61L27/38 , C12M3/00 , C12N5/077 , A61F2/06 , A61F2/10 , C12N5/02
CPC分类号： A61L27/3804 , A61L27/386 , C12M21/08 , C12M35/04 , C12N5/066 , A61F2/08 , C12N2501/15 , C12N2533/54
摘要： The present invention pertains to an oriented tissue-equivalent formed by contracting a collagen solution with connective tissue cells. In the method of the present invention, the contraction of collagen fibrils by the connective tissue cells is restrained along an axis of cell alignment defined by at least two structural members within the gel, whereby the connective tissue cells align along the axis thereby producing an oriented tissue-equivalent. In a preferred embodiment fibroblast cells are used to contract a collagen gel to form connective tissue into a ligament configuration.
摘要翻译：本发明涉及通过用结缔组织细胞收缩胶原溶液形成的定向组织当量。在本发明的方法中，通过结缔组织细胞的胶原原纤维的收缩沿着由凝胶内的至少两个结构构件限定的细胞对准轴限制，由此结缔组织细胞沿着轴对准，从而产生定向组织等价物在优选的实施方案中，使用成纤维细胞收缩胶原凝胶以形成结缔组织进入韧带构型。

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