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1. 发明授权

US06462770B1 Imaging system with automatic gain control for reflectance and fluorescence endoscopy 失效
公开(公告)号：US06462770B1
公开(公告)日：2002-10-08
申请号：US09064667
申请日：1998-04-20
申请人： Richard W. Cline , John J. P. Fengler , Curtis B. Figley , Remy Dawson , Bruno W. Jaggi
发明人： Richard W. Cline , John J. P. Fengler , Curtis B. Figley , Remy Dawson , Bruno W. Jaggi
IPC分类号： A62B104
CPC分类号： A61B1/043 , A61B1/00009 , A61B1/045 , A61B5/0071 , A61B5/0084
摘要： An imaging system for white light and fluorescence endoscopy that includes an automatic gain control circuit 30 that adjusts the brightness of an image produced based on distribution of pixel intensities in one or more video frames. The magnitude of the image signals produced by a pair of high sensitivity imaging devices such as intensified CCD transducers are compared to a number of reference thresholds. A time-over-threshold counter (112) determines the number of pixels in the image signals having magnitudes greater than or less than the reference thresholds. The distribution of pixel intensities is supplied to a decision tree algorithm (116) that determines whether the gain of the-intensified CCD transducers (44a, 44b) used to produced the autofluorescence images or the intensity of the excitation light produced by a light source (36) should be increased or decreased. In addition, a mode switch mechanism is provided to change rapidly from the fluorescence imaging mode to the white light imaging mode or vice versa. This mechanism includes provisions to prevent the accidental application of reflected white illumination light to the image-intensified CCD transducers. Proximity switches (192, 194) monitor the position of a light directing mechanism such as a mirror (186) to allow light to pass to fluorescence camera head (42) or to a color video camera head (46). The light source is not switched to produce white light until it is known that the mirror is in position to direct the reflected light to the color video camera head. Finally, the present invention produces a quantitative display of the relative intensities of the autofluorescence light produced in a pair of spectral bands.

2. 发明授权

US07722534B2 Compact fluorescence endoscopy video system 有权
标题翻译：紧凑型荧光内窥镜视频系统
公开(公告)号：US07722534B2
公开(公告)日：2010-05-25
申请号：US11969974
申请日：2008-01-07
申请人： Richard W Cline , John J. P. Fengler , Joachim W. Boehm
发明人： Richard W Cline , John J. P. Fengler , Joachim W. Boehm
IPC分类号： A61B1/04
CPC分类号： A61B5/0071 , A61B1/00009 , A61B1/00057 , A61B1/00186 , A61B1/041 , A61B1/043 , A61B1/045 , A61B1/051 , A61B1/06 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B1/2676 , A61B5/0084 , G01N21/6458 , G06F19/00
摘要： A fluorescence endoscopy video system includes a multimode light source that produces light for color and fluorescence imaging modes. Light from the light source is transmitted through an endoscope to the tissue under observation. The system also includes a compact camera for color and fluorescence imaging. Images obtained through the endoscope are optically divided and projected onto one or more image sensors by a fixed beam splitter in the camera. The fixed beam splitter eliminates the need for inserting a movable mirror into the light path between the endoscope and the image sensors. Image signals from the camera are processed in the system processor/controller where a contrast enhancement function can be applied. The contrast enhancement function increases the color contrast between normal tissue and tissue suspicious for early cancer. Finally, the system also includes a calibration feature whereby the system performance can be maintained when used with different endoscopes.
摘要翻译：荧光内窥镜视频系统包括产生用于彩色和荧光成像模式的光的多模光源。来自光源的光通过内窥镜透射到观察的组织。该系统还包括一个用于彩色和荧光成像的小型相机。通过内窥镜获得的图像通过照相机中的固定分束器被光学分割并投影到一个或多个图像传感器上。固定分束器不需要将可移动反射镜插入到内窥镜和图像传感器之间的光路中。来自相机的图像信号在可应用对比度增强功能的系统处理器/控制器中进行处理。对比度增强功能增加了早期癌症可疑的正常组织和组织之间的颜色对比。最后，该系统还包括校准特征，从而当与不同的内窥镜一起使用时可以维持系统性能。

3. 发明授权

US08961403B2 Compact fluorescence endoscopy video system 有权
标题翻译：紧凑型荧光内窥镜视频系统
公开(公告)号：US08961403B2
公开(公告)日：2015-02-24
申请号：US12761462
申请日：2010-04-16
申请人： Richard W. Cline , John J. P. Fengler , Joachim W. Boehm
发明人： Richard W. Cline , John J. P. Fengler , Joachim W. Boehm
IPC分类号： A61B1/04 , A61B1/06 , A61B5/00 , A61B1/045 , A61B1/05 , A61B1/267 , A61B1/00
CPC分类号： A61B5/0071 , A61B1/00009 , A61B1/00057 , A61B1/00186 , A61B1/041 , A61B1/043 , A61B1/045 , A61B1/051 , A61B1/06 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B1/2676 , A61B5/0084 , G01N21/6458 , G06F19/00
摘要： A fluorescence endoscopy video system includes a multimode light source that produces light for color and fluorescence imaging modes. Light from the light source is transmitted through an endoscope to the tissue under observation. The system also includes a compact camera for color and fluorescence imaging. Images obtained through the endoscope are optically divided and projected onto one or more image sensors by a fixed beam splitter in the camera. The fixed beam splitter eliminates the need for inserting a movable mirror into the light path between the endoscope and the image sensors. Image signals from the camera are processed in the system processor/controller where a contrast enhancement function can be applied. The contrast enhancement function increases the color contrast between normal tissue and tissue suspicious for early cancer. Finally, the system also includes a calibration feature whereby the system performance can be maintained when used with different endoscopes.
摘要翻译：荧光内窥镜视频系统包括产生用于彩色和荧光成像模式的光的多模光源。来自光源的光通过内窥镜透射到观察的组织。该系统还包括一个用于彩色和荧光成像的小型相机。通过内窥镜获得的图像通过照相机中的固定分束器被光学分割并投影到一个或多个图像传感器上。固定分束器不需要将可移动反射镜插入到内窥镜和图像传感器之间的光路中。来自相机的图像信号在可应用对比度增强功能的系统处理器/控制器中进行处理。对比度增强功能增加了早期癌症可疑的正常组织和组织之间的颜色对比。最后，该系统还包括校准特征，从而当与不同的内窥镜一起使用时可以维持系统性能。

4. 发明授权

US07341557B2 Compact fluorescence endoscopy video system 有权
标题翻译：紧凑型荧光内窥镜视频系统
公开(公告)号：US07341557B2
公开(公告)日：2008-03-11
申请号：US10899648
申请日：2004-07-26
申请人： Richard W. Cline , John J. P. Fengler , Joachim W. Boehm
发明人： Richard W. Cline , John J. P. Fengler , Joachim W. Boehm
IPC分类号： A61B1/04
CPC分类号： A61B5/0071 , A61B1/00009 , A61B1/00057 , A61B1/00186 , A61B1/041 , A61B1/043 , A61B1/045 , A61B1/051 , A61B1/06 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B1/2676 , A61B5/0084 , G01N21/6458 , G06F19/00
摘要： A fluorescence endoscopy video system includes a multimode light source that produces light for color and fluorescence imaging modes. Light from the light source is transmitted through an endoscope to the tissue under observation. The system also includes a compact camera for color and fluorescence imaging. Images obtained through the endoscope are optically divided and projected onto one or more image sensors by a fixed beam splitter in the camera. The fixed beam splitter eliminates the need for inserting a movable mirror into the light path between the endoscope and the image sensors. Image signals from the camera are processed in the system processor/controller where a contrast enhancement function can be applied. The contrast enhancement function increases the color contrast between normal tissue and tissue suspicious for early cancer. Finally, the system also includes a calibration feature whereby the system performance can be maintained when used with different endoscopes.
摘要翻译：荧光内窥镜视频系统包括产生用于彩色和荧光成像模式的光的多模光源。来自光源的光通过内窥镜透射到观察的组织。该系统还包括一个用于彩色和荧光成像的小型相机。通过内窥镜获得的图像通过照相机中的固定分束器被光学分割并投影到一个或多个图像传感器上。固定分束器不需要将可移动反射镜插入到内窥镜和图像传感器之间的光路中。来自相机的图像信号在可应用对比度增强功能的系统处理器/控制器中进行处理。对比度增强功能增加了早期癌症可疑的正常组织和组织之间的颜色对比。最后，该系统还包括校准特征，从而当与不同的内窥镜一起使用时可以维持系统性能。

5. 发明授权

US06899675B2 Fluorescence endoscopy video systems with no moving parts in the camera 有权
标题翻译：荧光内窥镜视频系统，相机中没有移动部件
公开(公告)号：US06899675B2
公开(公告)日：2005-05-31
申请号：US10050601
申请日：2002-01-15
申请人： Richard W. Cline , John J. P. Fengler
发明人： Richard W. Cline , John J. P. Fengler
IPC分类号： A61B1/00 , A61B1/04 , A61B1/06 , A61B5/00 , A61B6/00 , A61B1/05
CPC分类号： A61B1/0646 , A61B1/00009 , A61B1/00186 , A61B1/043 , A61B1/0638 , A61B5/0071 , A61B5/0084
摘要： A fluorescence endoscopy video system includes a multi-mode light source that produces light for white light and fluorescence imaging modes. Light from the light source is transmitted through an endoscope to the tissue under observation. The system also includes a compact camera for white light and fluorescence imaging, which may be located in the insertion portion of the endoscope, or attached to the portion of the endoscope outside the body. The camera can be utilized for both white light imaging and fluorescence imaging, and in its most compact form, contains no moving parts.
摘要翻译：荧光内窥镜视频系统包括产生用于白光和荧光成像模式的光的多模光源。来自光源的光通过内窥镜透射到观察的组织。该系统还包括用于白光和荧光成像的小型相机，其可以位于内窥镜的插入部分中，或者附接到身体外部的内窥镜的部分。该相机可用于白光成像和荧光成像，其最紧凑的形式不包含移动部件。

6. 发明授权

US06821245B2 Compact fluorescence endoscopy video system 有权
标题翻译：紧凑型荧光内窥镜视频系统
公开(公告)号：US06821245B2
公开(公告)日：2004-11-23
申请号：US09905642
申请日：2001-07-13
申请人： Richard W. Cline , John J. P. Fengler , Joachim W. Boehm
发明人： Richard W. Cline , John J. P. Fengler , Joachim W. Boehm
IPC分类号： A61B104
CPC分类号： A61B5/0071 , A61B1/00009 , A61B1/00057 , A61B1/00186 , A61B1/041 , A61B1/043 , A61B1/045 , A61B1/051 , A61B1/06 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B1/2676 , A61B5/0084 , G01N21/6458 , G06F19/00
摘要： A fluorescence endoscopy video system includes a multimode light source that produces light for color and fluorescence imaging modes. Light from the light source is transmitted through an endoscope to the tissue under observation. The system also includes a compact camera for color and fluorescence imaging. Images obtained through the endoscope are optically divided and projected onto one or more image sensors by a fixed beam splitter in the camera. The fixed beam splitter eliminates the need for inserting a movable mirror into the light path between the endoscope and the image sensors. Image signals from the camera are processed in the system processor/controller where a contrast enhancement function can be applied. The contrast enhancement function increases the color contrast between normal tissue and tissue suspicious for early cancer. Finally, the system also includes a calibration feature whereby the system performance can be maintained when used with different endoscopes.
摘要翻译：荧光内窥镜视频系统包括产生用于彩色和荧光成像模式的光的多模光源。来自光源的光通过内窥镜透射到观察的组织。该系统还包括一个用于彩色和荧光成像的小型相机。通过内窥镜获得的图像通过照相机中的固定分束器被光学分割并投影到一个或多个图像传感器上。固定分束器不需要将可移动反射镜插入到内窥镜和图像传感器之间的光路中。来自相机的图像信号在可应用对比度增强功能的系统处理器/控制器中进行处理。对比度增强功能增加了早期癌症可疑的正常组织和组织之间的颜色对比。最后，该系统还包括校准特征，从而当与不同的内窥镜一起使用时可以维持系统性能。

7. 发明授权

US07420151B2 Device for short wavelength visible reflectance endoscopy using broadband illumination 有权
标题翻译：使用宽带照明的短波长可见反射内窥镜检查装置
公开(公告)号：US07420151B2
公开(公告)日：2008-09-02
申请号：US11546013
申请日：2006-10-10
申请人： John J. P. Fengler , Paul R. Westwick , Joachim W. Boehm
发明人： John J. P. Fengler , Paul R. Westwick , Joachim W. Boehm
IPC分类号： A61B1/04
CPC分类号： A61B1/00009 , A61B1/00186 , A61B5/0084
摘要： A system for performing short wavelength imaging with a broadband illumination source includes an image processor that receives signals from a color image sensor. The image processor reduces the contribution of red illumination light to an image by computing blue, green, and blue-green (cyan) color components of display pixels from the signals received from the image sensor. The blue, green, and cyan color component values are coupled to inputs of a color monitor for display to produce a false color image of the tissue.
摘要翻译：用宽带照明源执行短波长成像的系统包括从彩色图像传感器接收信号的图像处理器。图像处理器通过从从图像传感器接收的信号计算显示像素的蓝色，绿色和蓝色（青色）颜色分量来减少红色照明光对图像的贡献。蓝色，绿色和青色颜色分量值耦合到用于显示的彩色监视器的输入以产生组织的假彩色图像。

8. 发明授权

US08630698B2 Filter for use with imaging endoscopes 有权
标题翻译：用于成像内窥镜的过滤器
公开(公告)号：US08630698B2
公开(公告)日：2014-01-14
申请号：US11412715
申请日：2006-04-26
申请人： John J. P. Fengler , Francis Regamey
发明人： John J. P. Fengler , Francis Regamey
IPC分类号： A61B6/00
CPC分类号： A61B1/043 , A61B1/00006 , A61B1/00009 , A61B1/00045 , A61B1/00101 , A61B1/00186 , A61B1/05 , A61B1/0638 , A61B1/0646 , A61B1/0661 , G02B23/2423 , H04N5/2254 , H04N5/2256 , H04N2005/2255
摘要： A fluorescence endoscopy video system includes a multi-mode light source that produces light for white light and fluorescence imaging modes. A filter is positioned at the distal end of an imaging endoscope so that the endoscope can produce fluorescence and white light images of a tissue sample.
摘要翻译：荧光内窥镜视频系统包括产生用于白光和荧光成像模式的光的多模光源。过滤器位于成像内窥镜的远端，使得内窥镜能够产生组织样本的荧光和白光图像。

9. 发明授权

US08773756B2 Compensating optical coupler for visible and NIR imaging 有权
标题翻译：用于可见光和NIR成像的补偿光耦合器
公开(公告)号：US08773756B2
公开(公告)日：2014-07-08
申请号：US13122770
申请日：2009-10-06
申请人： John C. Tesar , Paul Cottle , John J. P. Fengler
发明人： John C. Tesar , Paul Cottle , John J. P. Fengler
IPC分类号： G02B23/04 , G02B13/14
CPC分类号： G02B13/146 , A61B1/00126 , A61B1/042 , A61B5/0075 , A61B5/0086 , G01J3/32 , G01J3/36 , G02B23/2453 , G02B23/2484 , G02B27/0025 , G02B27/141
摘要： An optical system, in particular for endoscopic applications, is disclosed which uses wavelength-compensating optical components, in particular prisms, made of materials with different inter-element coatings and refractive indices to image significantly different wavelength-ranges (VIS and NIR) onto the same image plane of an image acquisition device, such as a CCD sensor.
摘要翻译：公开了一种特别用于内窥镜应用的光学系统，其使用由具有不同元件间涂层和折射率的材料制成的波长补偿光学部件，特别是棱镜，以将显着不同的波长范围（VIS和NIR）成像到图像采集装置的相同图像平面，例如CCD传感器。

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