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1. 发明授权

US06841557B2 Compounds for the treatment of addictive disorders 失效
标题翻译：用于治疗成瘾性疾病的化合物
公开(公告)号：US06841557B2
公开(公告)日：2005-01-11
申请号：US09929666
申请日：2001-08-14
申请人： Richard W. Anderson , Sylvia S. McBrinn , David W. Robertson , Robert C. Marshall
发明人： Richard W. Anderson , Sylvia S. McBrinn , David W. Robertson , Robert C. Marshall
IPC分类号： A61K31/4745 , A61K31/35 , A61K31/38 , A61K31/451 , A61K31/48 , A61K31/497 , A61K31/498 , A61P25/30 , A61P25/32 , A61P25/34 , A61K31/44
CPC分类号： A61K31/48 , A61K31/35 , A61K31/38 , A61K31/451 , A61K31/4745 , A61K31/498
摘要： The treatment of addictive disorders, psychoactive substance use disorders, intoxication disorders, inhalation disorders, alcohol addiction, tobacco addiction, and nicotine addiction using a heterocyclic amine, a phenylazacycloalkane, a cabergoline, or an aromatic bicyclic amine active agent, or a pharmaceutically acceptable derivative or salt of any said active agent is described herein.
摘要翻译：使用杂环胺，苯基氮杂环烷烃，卡麦角林或芳香族双环胺活性剂的治疗上瘾性疾病，精神活性物质使用障碍，中毒障碍，吸入障碍，酒精成瘾，烟草成瘾和尼古丁成瘾，或药学上可接受的衍生物或任何所述活性剂的盐。

2. 发明授权

US5586905A Insulation displacement electrical connector with improved strain relief 失效
标题翻译：绝缘位移电连接器，具有改善的应力消除
公开(公告)号：US5586905A
公开(公告)日：1996-12-24
申请号：US146384
申请日：1993-11-01
申请人： Robert C. Marshall , Frank Pansari, Jr.
发明人： Robert C. Marshall , Frank Pansari, Jr.
IPC分类号： H01R4/24 , H01R13/58
CPC分类号： H01R4/2454 , H01R4/2433
摘要： An electrical connector assembly is provided for terminating an insulated electrical wire. The assembly includes a housing having a wire-receiving opening adapted to receive the insulated electrical wire. The housing is defined by two housing halves which are relatively movable between an open condition for insertion of an insulated wire into the opening and a closed condition. A terminal is mounted on the housing and has an insulation displacement slot positioned in the opening adapted to displace the insulation of the wire and electrically engage an inner conductor of the wire. Opposing flexible portions of the housing halves provide strain relief to the insulated electrical wire by gripping the wire substantially entirely thereabout when the housing halves are in their closed condition.
摘要翻译：提供电连接器组件用于终止绝缘电线。组件包括具有适于容纳绝缘电线的线接收开口的壳体。壳体由两个壳体半部限定，两个半壳体在用于将绝缘电线插入开口的打开状态和闭合状态之间可相对移动。端子安装在壳体上，并且具有定位在开口中的绝缘移动槽，其适于移动线的绝缘并电连接导线的内导体。外壳半部的相对的柔性部分通过在外壳半部处于其闭合状态时基本上完全夹紧导线来为绝缘电线提供应变消除。

3. 发明授权

US06987107B2 Method of treating incontinence 失效
标题翻译：治疗失禁的方法
公开(公告)号：US06987107B2
公开(公告)日：2006-01-17
申请号：US10055663
申请日：2002-01-23
申请人： Erik H. F. Wong , Saeeduddin Ahmed , Robert C. Marshall , Robert McArthur , Duncan P. Taylor , Lars Birgerson
发明人： Erik H. F. Wong , Saeeduddin Ahmed , Robert C. Marshall , Robert McArthur , Duncan P. Taylor , Lars Birgerson
IPC分类号： A61K31/44
CPC分类号： A61K31/5375 , A61K31/00 , A61K31/537
摘要： Methods and compositions for treating humans suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or a condition where inhibiting reuptake of norepinephrine is a benefit are disclosed. The compositions comprise a compound having a pharmacological selectivity of serotonin (Ki)/norepinephrine (Ki) of at least about 5000. Examples of such compounds include reboxetine, and more preferably optically pure (S,S) enantiomer of reboxetine. The methods generally include administration of a therapeutic amount of such compositions. Also disclosed are preparations of a medicament from the composition, and uses of the composition in a manufacture of the medicament to treat a human suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or condition.
摘要翻译：公开了用于治疗患有或预防人遭受生理或精神疾病，病症或抑制去甲肾上腺素再摄取的病症的人的方法和组合物。组合物包含具有至少约5000的5-羟色胺（N 1 O）/去甲肾上腺素（KI）的药理学选择性的化合物。这些化合物的实例包括瑞波西汀等优选光学纯的（S，S）对映异构体。方法通常包括施用治疗量的这种组合物。还公开了来自组合物的药物的制剂，以及该组合物在制备药物中治疗患有或预防人类遭受生理或精神疾病，病症或病症的人的用途。

4. 发明授权

US4602979A Technique for the growth of compositionally ungraded single crystals of solid solutions 失效
标题翻译：用于固体溶液组成不分级单晶生长的技术
公开(公告)号：US4602979A
公开(公告)日：1986-07-29
申请号：US731744
申请日：1985-05-07
申请人： Robert C. Marshall , John K. Kennedy , Charles S. Sahagian
发明人： Robert C. Marshall , John K. Kennedy , Charles S. Sahagian
IPC分类号： C30B15/02 , C30B15/10
CPC分类号： C30B15/10 , C30B15/02
摘要： This invention describes a modified method of growing high purity, compositionally ungraded, single crystals of multicomponent solid solutions by the Czochralski, Kyropoulos, Bridgman or other related melt growth technique. In the method of this invention, the container or crucible used to contain the multicomponent crystal growing melt is fabricated from the higher melting point component of the multicomponent melt while lower melting point components are positioned within the crucible. The temperature of the crucible is then raised beyond the melting point of the lower melting point component to a temperature which is the exact melting point of the solid solution, or crystal alloy desired. This will dissolve an amount of the crucible material (higher melting point component) equal to the exact amount required to produce a solid solution having the desired composition. A seed is then introduced into the melt and normal crystal pulling is initiated resulting in the growth of a compositionally ungraded crystal having a uniform compositional content throughout its structure.
摘要翻译：本发明描述了通过Czochralski，Kyropoulos，Bridgman或其它相关的熔融生长技术生长高分子多组分固溶体的高纯度，组成未分级的单晶的改进方法。在本发明的方法中，用于容纳多组分晶体生长熔体的容器或坩埚由多组分熔体的较高熔点组分制成，而较低熔点组分位于坩埚内。然后将坩埚的温度升高到低熔点组分的熔点以上至所需固溶体或晶体合金的精确熔点的温度。这将溶解一定量的坩埚材料（较高熔点成分）等于产生具有所需组成的固溶体所需的精确量。然后将晶种引入熔体中，引发正常的晶体拉伸，导致其整个结构具有均匀组成含量的组成未分级晶体的生长。

5. 发明授权

US07723334B2 Highly selective norepinephrine reuptake inhibitors and methods of using the same 失效
标题翻译：高选择性去甲肾上腺素再摄取抑制剂及其使用方法
公开(公告)号：US07723334B2
公开(公告)日：2010-05-25
申请号：US11928917
申请日：2007-10-30
申请人： Erik H. F. Wong , Saeeduddin Ahmed , Robert C. Marshall , Robert McArthur , Duncan P. Taylor , Lars Birgerson , Pasquale Cetera
发明人： Erik H. F. Wong , Saeeduddin Ahmed , Robert C. Marshall , Robert McArthur , Duncan P. Taylor , Lars Birgerson , Pasquale Cetera
IPC分类号： A61K31/5375 , A61P25/22 , A61P25/24 , A61P25/32 , A61P3/04
CPC分类号： A61K31/5375 , A61K31/00 , A61K31/537
摘要： Methods and compositions for treating humans suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or a condition where inhibiting reuptake of norepinephrine is a benefit are disclosed. The compositions comprise a compound having a pharmacological selectivity of serotonin (Ki)/norepinephrine (Ki) of at least about 5000. Examples of such compounds include reboxetine, and more preferably optically pure (S,S) enantiomer of reboxetine. The methods generally include administration of a therapeutic amount of such compositions. Also disclosed are preparations of a medicament from the composition, and uses of the composition in a manufacture of the medicament to treat a human suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or condition.
摘要翻译：公开了用于治疗患有或预防人遭受生理或精神疾病，病症或抑制去甲肾上腺素再摄取的病症的人的方法和组合物。组合物包含具有至少约5000的5-羟色胺（Ki）/去甲肾上腺素（Ki）的药理学选择性的化合物。这些化合物的实例包括瑞波西汀，更优选为瑞波西汀的光学纯的（S，S）对映异构体。方法通常包括施用治疗量的这种组合物。还公开了来自组合物的药物的制剂，以及该组合物在制备药物中治疗患有或预防人类遭受生理或精神疾病，病症或病症的人的用途。

6. 发明授权

US07241762B2 Method of treating peripheral neuropathy 失效
标题翻译：治疗周围神经病变的方法
公开(公告)号：US07241762B2
公开(公告)日：2007-07-10
申请号：US11349022
申请日：2006-02-07
申请人： Erik H. F. Wong , Saeeduddin Ahmed , Robert C. Marshall , Robert McArthur , Duncan P. Taylor
发明人： Erik H. F. Wong , Saeeduddin Ahmed , Robert C. Marshall , Robert McArthur , Duncan P. Taylor
IPC分类号： A61K35/535
CPC分类号： A61K31/5375 , A61K31/00 , A61K31/537
摘要： Disclosed herein are methods of treating an individual suffering from peripheral neuropathy. The methods generally include administration of a therapeutic amount of racemic reboxetine, or a pharmaceutically acceptable salt thereof, to the individual.
摘要翻译：本文公开了治疗患有周围神经病变的个体的方法。方法通常包括向个体施用治疗量的外消旋的瑞波西汀或其药学上可接受的盐。

7. 发明授权

US06465458B1 Method of treating or preventing chronic pain with a highly selective norepinephrine reuptake inhibitor 有权
标题翻译：用高选择性去甲肾上腺素再摄取抑制剂治疗或预防慢性疼痛的方法
公开(公告)号：US06465458B1
公开(公告)日：2002-10-15
申请号：US09599213
申请日：2000-06-22
申请人： Erik H. F. Wong , Saeeduddin Ahmed , Robert C. Marshall , Robert McArthur , Duncan P. Taylor , Lars Birgerson , Pasquale Cetera
发明人： Erik H. F. Wong , Saeeduddin Ahmed , Robert C. Marshall , Robert McArthur , Duncan P. Taylor , Lars Birgerson , Pasquale Cetera
IPC分类号： A61K31535
CPC分类号： A61K31/5375 , A61K31/00 , A61K31/537
摘要： Methods and compositions for treating humans suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or a condition where inhibiting reuptake of norepinephrine is a benefit are disclosed. The methods comprise administering the optically pure (S,S) enantiomer of reboxetine. The methods generally include administration of a therapeutic amount of such compositions. Also disclosed are preparations of a medicament from the composition, and uses of the composition in a manufacture of the medicament to treat a human suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or condition.
摘要翻译：公开了用于治疗患有或预防人遭受生理或精神疾病，病症或抑制去甲肾上腺素再摄取的病症的人的方法和组合物。所述方法包括施用瑞波西汀的光学纯的（S，S）对映异构体。方法通常包括施用治疗量的这种组合物。还公开了来自组合物的药物的制剂，以及该组合物在制备药物中治疗患有或预防人类遭受生理或精神疾病，病症或病症的人的用途。

8. 发明申请

US20090247528A1 METHOD OF TREATING ATTENTION DEFICIT DISORDER 审中-公开
标题翻译：治疗缺陷性疾病的方法
公开(公告)号：US20090247528A1
公开(公告)日：2009-10-01
申请号：US12430244
申请日：2009-04-27
申请人： Erik H.F. Wong , Saeeduddin Ahmed , Robert C. Marshall , Robert McArthur , Duncan P. Taylor , Lars Birgerson , Pasquale Cetera
发明人： Erik H.F. Wong , Saeeduddin Ahmed , Robert C. Marshall , Robert McArthur , Duncan P. Taylor , Lars Birgerson , Pasquale Cetera
IPC分类号： A61K31/5375 , A61P25/00
CPC分类号： A61K31/5375 , A61K31/00 , A61K31/537
摘要： Methods and compositions for treating humans suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or a condition where inhibiting reuptake of norepinephrine is a benefit are disclosed. The compositions comprise a compound having a pharmacological selectivity of serotonin (Ki)/norepinephrine (Ki) of at least about 5000. Examples of such compounds include reboxetine, and more preferably optically pure (S,S) enantiomer of reboxetine. The methods generally include administration of a therapeutic amount of such compositions. Also disclosed are preparations of a medicament from the composition, and uses of the composition in a manufacture of the medicament to treat a human suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or condition.
摘要翻译：公开了用于治疗患有或预防人遭受生理或精神疾病，病症或抑制去甲肾上腺素再摄取的病症的人的方法和组合物。组合物包含具有至少约5000的5-羟色胺（Ki）/去甲肾上腺素（Ki）的药理学选择性的化合物。该化合物的实例包括瑞波西汀，更优选为瑞波西汀的光学纯的（S，S）对映异构体。方法通常包括施用治疗量的这种组合物。还公开了来自组合物的药物的制剂，以及该组合物在制备药物中治疗患有或预防人类遭受生理或精神疾病，病症或病症的人的用途。

9. 发明授权

US07338953B2 Method of treating chronic fatigue syndrome 失效
标题翻译：治疗慢性疲劳综合症的方法
公开(公告)号：US07338953B2
公开(公告)日：2008-03-04
申请号：US11349331
申请日：2006-02-07
申请人： Erik H. F. Wong , Saeeduddin Ahmed , Robert C. Marshall , Robert McArthur , Duncan P. Taylor , Lars Birgerson
发明人： Erik H. F. Wong , Saeeduddin Ahmed , Robert C. Marshall , Robert McArthur , Duncan P. Taylor , Lars Birgerson
IPC分类号： A61K35/535
CPC分类号： A61K31/5375 , A61K31/00 , A61K31/537
摘要： Disclosed herein are methods of treating an individual suffering from, chronic fatigue syndrome. The methods generally include administration of a therapeutic amount of racemic reboxetine, or a pharmaceutically acceptable salt thereof, to the individual.
摘要翻译：本文公开了治疗患有慢性疲劳综合征的个体的方法。方法通常包括向个体施用治疗量的外消旋的瑞波西汀或其药学上可接受的盐。

10. 发明授权

US06703389B2 Method of treating chronic pain 失效
标题翻译：治疗慢性疼痛的方法
公开(公告)号：US06703389B2
公开(公告)日：2004-03-09
申请号：US10020261
申请日：2001-12-14
申请人： Erik H. F. Wong , Saeeduddin Ahmed , Robert C. Marshall , Robert McArthur , Duncan P. Taylor , Lars Birgerson , Pasquale Cetera
发明人： Erik H. F. Wong , Saeeduddin Ahmed , Robert C. Marshall , Robert McArthur , Duncan P. Taylor , Lars Birgerson , Pasquale Cetera
IPC分类号： A61K31535
CPC分类号： A61K31/5375 , A61K31/00 , A61K31/537
摘要： Methods and compositions for treating humans suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or a condition where inhibiting reuptake of norepinephrine is a benefit are disclosed. The compositions comprise a compound having a pharmacological selectivity of serotonin (Ki)/norepinephrine (Ki) of at least about 5000. Examples of such compounds include reboxetine, and more preferably optically pure (S,S) enantiomer of reboxetine. The methods generally include administration of a therapeutic amount of such compositions. Also disclosed are preparations of a medicament from the composition, and uses of the composition in a manufacture of the medicament to treat a human suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or condition.
摘要翻译：公开了用于治疗患有或预防人遭受生理或精神疾病，病症或抑制去甲肾上腺素再摄取的病症的人的方法和组合物。组合物包含具有至少约5000的5-羟色胺（Ki）/去甲肾上腺素（Ki）的药理学选择性的化合物。这些化合物的实例包括瑞波西汀，更优选为瑞波西汀的光学纯的（S，S）对映异构体。方法通常包括施用治疗量的这种组合物。还公开了来自组合物的药物的制剂，以及该组合物在制备药物中治疗患有或预防人类遭受生理或精神疾病，病症或病症的人的用途。

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