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1. 发明授权

US5874219A Methods for concurrently processing multiple biological chip assays 失效
标题翻译：同时处理多种生物芯片测定方法
公开(公告)号：US5874219A
公开(公告)日：1999-02-23
申请号：US630051
申请日：1996-04-09
申请人： Richard P. Rava , Stephen P.A. Fodor , Mark Trulson
发明人： Richard P. Rava , Stephen P.A. Fodor , Mark Trulson
IPC分类号： B01J19/00 , B01L3/00 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N21/64 , G01N35/02 , C12P19/34
CPC分类号： G01N35/028 , B01J19/0046 , B01L3/5085 , C12Q1/6837 , B01J2219/00315 , B01J2219/00317 , B01J2219/00432 , B01J2219/00529 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00662 , B01J2219/00702 , B01J2219/00707 , B01J2219/00722 , B01L2300/0636 , B01L2300/0829 , C40B40/06 , C40B60/14 , G01N21/64
摘要： Methods for concurrently processing multiple biological chip assays by providing a biological chip plate comprising a plurality of test wells, each test well having a biological chip having a molecular probe array; introducing samples into the test wells; subjecting the biological chip plate to manipulation by a fluid handling device that automatically performs steps to carry out reactions between target molecules in the samples and probes; and subjecting the biological chip plate to a biological chip plate reader that interrogates the probe arrays to detect any reactions between target molecules and probes.
摘要翻译：通过提供包括多个测试孔的生物芯片板同时处理多个生物芯片测定的方法，每个测试孔具有具有分子探针阵列的生物芯片; 将样品引入测试井; 使生物芯片板通过流体处理装置进行操作，所述流体处理装置自动执行步骤以进行样品和探针中的靶分子之间的反应; 并将生物芯片板经受询问探针阵列的生物芯片读板器，以检测靶分子和探针之间的任何反应。

2. 发明申请

US20120329677A9 ARRAYS OF NUCLEIC ACID PROBES FOR DETECTING CYSTIC FIBROSIS 审中-公开
标题翻译：用于检测CYSTIC FIBROSIS的核酸探针阵列
公开(公告)号：US20120329677A9
公开(公告)日：2012-12-27
申请号：US11506176
申请日：2006-08-18
申请人： Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P.A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
发明人： Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P.A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
IPC分类号： C40B40/06 , C40B50/14
CPC分类号： C12Q1/6874 , C12Q1/6886
摘要： The invention provides arrays of immobilized probes, and methods employing the arrays, for detecting mutations in the CFTR gene.
摘要翻译：本发明提供了固定化探针的阵列，以及采用阵列的方法，用于检测CFTR基因中的突变。

3. 发明申请

US20080261832A1 Arrays of nucleic acid probes for detecting cystic fibrosis 审中-公开
标题翻译：用于检测囊性纤维化的核酸探针阵列
公开(公告)号：US20080261832A1
公开(公告)日：2008-10-23
申请号：US11506176
申请日：2006-08-18
申请人： Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P.A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
发明人： Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P.A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
IPC分类号： C40B40/06 , C40B50/14
CPC分类号： C12Q1/6874 , C12Q1/6886
摘要： The invention provides arrays of immobilized probes, and methods employing the arrays, for detecting mutations in the CFTR gene.
摘要翻译：本发明提供了固定化探针的阵列，以及采用阵列的方法，用于检测CFTR基因中的突变。

4. 发明授权

US5800992A Method of detecting nucleic acids 失效
标题翻译：检测核酸的方法
公开(公告)号：US5800992A
公开(公告)日：1998-09-01
申请号：US670118
申请日：1996-06-25
申请人： Stephen P.A. Fodor , Dennis W. Solas , William J. Dower
发明人： Stephen P.A. Fodor , Dennis W. Solas , William J. Dower
IPC分类号： B01J19/00 , C07B61/00 , C07C229/14 , C07C229/16 , C07D263/44 , C07D317/62 , C07H19/04 , C07H19/10 , C07H21/00 , C07K1/04 , C07K7/06 , C07K17/06 , C07K17/14 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/14 , G01N21/25 , G01N21/64 , G03F7/00 , G03F7/26 , G03F7/38 , G11C13/02 , C07H21/02 , C07H21/04
CPC分类号： G11C13/0019 , B01J19/0046 , B82Y10/00 , B82Y30/00 , C07C229/14 , C07C229/16 , C07D263/44 , C07D317/62 , C07H19/04 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K1/047 , C07K17/06 , C07K17/14 , C07K7/06 , C12Q1/6809 , C12Q1/6816 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6874 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G03F7/00 , G03F7/265 , G03F7/38 , G11C13/0014 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475
摘要： The present invention provides method and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
摘要翻译：本发明提供了用于对生物大分子（通常为生物聚合物）进行测序，指纹图谱和绘图的方法和装置。该方法利用多种序列特异性识别试剂，其也可用于生物样品的分类和表征其来源。

5. 发明授权

US5744305A Arrays of materials attached to a substrate 失效
标题翻译：连接到基底的材料阵列
公开(公告)号：US5744305A
公开(公告)日：1998-04-28
申请号：US466632
申请日：1995-06-06
申请人： Stephen P.A. Fodor , Lubert Stryer , J. Leighton Read , Michael C. Pirrung
发明人： Stephen P.A. Fodor , Lubert Stryer , J. Leighton Read , Michael C. Pirrung
IPC分类号： B01J19/00 , C07B61/00 , C07C229/14 , C07C229/16 , C07D263/44 , C07D317/62 , C07H19/04 , C07H19/10 , C07H21/00 , C07K1/04 , C07K1/06 , C07K7/06 , C07K17/06 , C07K17/14 , C08F2/46 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/14 , G01N21/25 , G01N21/64 , G03F7/00 , G03F7/004 , G03F7/26 , G03F7/38 , G11C13/02 , C07H21/02 , C07H21/04
CPC分类号： G01N21/6452 , B01J19/0046 , B82Y10/00 , B82Y30/00 , C07C229/14 , C07C229/16 , C07D263/44 , C07D317/62 , C07H19/04 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K1/047 , C07K1/062 , C07K17/06 , C07K17/14 , C07K7/06 , C12Q1/6809 , C12Q1/6816 , C12Q1/6837 , C12Q1/6874 , C40B80/00 , G01N21/253 , G01N21/6428 , G03F7/00 , G03F7/0045 , G03F7/265 , G03F7/38 , G11C13/0014 , G11C13/0019 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475 , G01N21/6458 , Y02P20/55 , Y10S435/969 , Y10S435/973 , Y10S436/807 , Y10S436/809
摘要： A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
摘要翻译：创造大规模化学多样性的综合战略。使用固相化学，光不稳定保护基团和光刻法来实现光定向空间可寻址并行化学合成。在一个实施例中使用二进制掩蔽技术。还公开了反应器系统，可光除保护组和改进的数据收集和处理技术。还提供了筛选接头分子的技术。

6. 发明申请

US20120157325A1 Combinatorial Affinity Selection 有权
标题翻译：组合亲和度选择
公开(公告)号：US20120157325A1
公开(公告)日：2012-06-21
申请号：US13399543
申请日：2012-02-17
申请人： Stephen P.A. Fodor
发明人： Stephen P.A. Fodor
IPC分类号： C40B20/00
CPC分类号： C12Q1/6809 , C12Q2565/515 , C12Q2563/149
摘要： In one aspect of the invention, methods for analyzing nucleic acid sample are provided. In a preferred embodiment, nucleic acids are selected using affinity matrices prior hybridization with a microarray.
摘要翻译：在本发明的一个方面，提供了分析核酸样品的方法。在优选的实施方案中，使用亲和基质在与微阵列进行杂交之前选择核酸。

7. 发明申请

US20110009294A1 Methods for Genotyping Selected Polymorphism 有权
标题翻译：基因分型选择多态性的方法
公开(公告)号：US20110009294A1
公开(公告)日：2011-01-13
申请号：US12326596
申请日：2008-12-02
申请人： Keith W. Jones , Michael H. Shapero , Stephen P.A. Fodor
发明人： Keith W. Jones , Michael H. Shapero , Stephen P.A. Fodor
IPC分类号： C40B40/06
CPC分类号： C12Q1/6827 , C12Q1/6809 , C12Q1/6837 , C12Q1/6855 , C12Q2600/156
摘要： Methods for genotyping polymorphisms using a locus specific primer that is complementary to a region near a selected polymorphism are described. Methods for synthesizing pools of locus specific primers that incorporate some degenerate positions are also disclosed. A plurality of different sequence capture probes are synthesized simultaneously using degenerate oligonucleotide synthesis. The sequence of the locus specific regions of the capture probes are related in that they have some bases that are identical in each sequence in the plurality of sequences and positions that vary from one locus specific region to another. The sequences are selected based on proximity to a polymorphism of interest and because they conform to a similar sequence pattern.
摘要翻译：描述使用与选定多态性附近的区域互补的位点特异性引物进行基因分型多态性的方法。还公开了合并含有一些退化位置的基因座特异性引物库的方法。使用简并寡核苷酸合成同时合成多个不同的序列捕获探针。捕获探针的基因座特异性区域的序列是相关的，因为它们具有在从一个基因座特异性区域到另一个基因座特异性区域变化的多个序列和位置中的每个序列中具有相同的一些碱基。基于与感兴趣的多态性的接近度并且因为它们符合类似的序列模式来选择序列。

8. 发明授权

US06420169B1 Apparatus for forming polynucleotides or polypeptides 失效
标题翻译：用于形成多核苷酸或多肽的装置
公开(公告)号：US06420169B1
公开(公告)日：2002-07-16
申请号：US08348471
申请日：1994-11-30
申请人： J. Leighton Read , Stephen P.A. Fodor , Lubert Stryer , Michael C. Pirrung , Paul D. Hoeprich, Jr.
发明人： J. Leighton Read , Stephen P.A. Fodor , Lubert Stryer , Michael C. Pirrung , Paul D. Hoeprich, Jr.
IPC分类号： C12M136
CPC分类号： G11C13/0019 , B01J19/0046 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01L7/52 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07C229/14 , C07C229/16 , C07D263/44 , C07D317/62 , C07H19/04 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K1/047 , C07K7/06 , C07K17/06 , C07K17/14 , C12Q1/6809 , C12Q1/6816 , C12Q1/6837 , C12Q1/6874 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475 , G01N21/6428 , G01N21/6452 , G03F7/00 , G03F7/26 , G03F7/265 , G03F7/38 , G11C13/0014 , Y02P20/55 , Y10S436/809
摘要： A method for synthesizing oligonucleotides on a solid substrate. The method provides for the irradiation of a first predefined region of the substrate without irradiation of a second predefined region of the substrate. The irradiation step removes a protecting group therefrom. The substrate is contacted with a first nucleotide to couple the nucleotide to the substrate in the first predefined region. By repeating these steps, an array of diverse oligonucleotides is formed on the substrate.
摘要翻译：一种在固体底物上合成寡核苷酸的方法。该方法提供了在不照射基板的第二预定区域的情况下照射基板的第一预定区域。照射步骤从其中除去保护基团。底物与第一核苷酸接触，以将核苷酸与第一预定区域中的底物偶联。通过重复这些步骤，在衬底上形成多种不同寡核苷酸的阵列。

9. 发明申请

US20130150248A1 Arrays of Nucleic Acid Probes for Analyzing Biotransformation Genes 审中-公开
标题翻译：用于分析生物转化基因的核酸探针阵列
公开(公告)号：US20130150248A1
公开(公告)日：2013-06-13
申请号：US12959359
申请日：2010-12-02
申请人： Maureen T. Cronin , Charles G. Miyada , Earl A. Hubbell , Mark Chee , Stephen P.A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
发明人： Maureen T. Cronin , Charles G. Miyada , Earl A. Hubbell , Mark Chee , Stephen P.A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00432 , B01J2219/00529 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00644 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C07B2200/11 , C07H21/00 , C12Q1/6874 , C12Q1/6876 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , C40B40/06 , C40B60/14
摘要： The invention provides arrays of immobilized probes, and methods employing the arrays, for detecting mutations in the biotransformation genes, such as cytochromes P450. For example, one such array comprises four probe sets. A first probe set comprises a plurality of probes, each probe comprising a segment of at least three nucleotides exactly complementary to a subsequence of a reference sequence from a biotransformation gene, the segment including at least one interrogation position complementary to a corresponding nucleotide in the reference sequence. Second, third and fourth probe sets each comprise a corresponding probe for each probe in the first probe set. The probes in the second, third and fourth probe sets are identical to a sequence comprising the corresponding probe from the first probe set or a subsequence of at least three nucleotides thereof that includes the at least one interrogation position, except that the at least one interrogation position is occupied by a different nucleotide in each of the four corresponding probes from the four probe sets.
摘要翻译：本发明提供了固定化探针的阵列，以及采用该阵列的方法，用于检测生物转化基因如细胞色素P450中的突变。例如，一个这样的阵列包括四个探针组。第一探针组包含多个探针，每个探针包含与来自生物转化基因的参考序列的亚序列完全互补的至少三个核苷酸的片段，该片段包含与参考文献中的相应核苷酸互补的至少一个询问位置序列。第二，第三和第四探针组各自包括在第一探针组中的每个探针的相应探针。第二，第三和第四探针组中的探针与包含来自第一探针组的相应探针或包含至少一个询问位置的至少三个核苷酸的亚序列的序列相同，除了至少一个询问位置由来自四个探针组的四个相应探针中的每一个中的不同核苷酸占据。

10. 发明申请

US20130116130A1 Digital Counting of Individual Molecules by Stochastic Attachment of Diverse Label-Tags 有权
标题翻译：通过随机附加不同标签标签对个体分子的数字计数
公开(公告)号：US20130116130A1
公开(公告)日：2013-05-09
申请号：US13327526
申请日：2011-12-15
申请人： Glenn K. Fu , Stephen P.A. Fodor
发明人： Glenn K. Fu , Stephen P.A. Fodor
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6809 , C12Q1/6869 , C12Q1/6874 , C12Q2525/191 , C12Q2537/157 , C12Q2537/16 , C12Q2565/102
摘要： Compositions, methods and kits are disclosed for high-sensitivity counting of individual molecules by stochastic labeling of a identical molecules in mixtures of molecules by attachment of a unique label-tags from a diverse pool of label tags to confer uniqueness to otherwise identical or indistinguishable events. Individual occurrences of target molecules randomly choose from a non-depleting reservoir of diverse label-tags. Labeled molecules may be detected by hybridization or sequencing based methods. Molecules that would otherwise be identical in information content are labeled to create a separately detectable product that can be distinctly detected. The disclosed stochastic transformation methods reduce the problem of counting molecules from one of locating and identifying identical molecules to a series of binary digital questions detecting whether preprogrammed label-tags are present. The methods may be used, for example, to count a given species of molecule within a sample.
摘要翻译：公开了组合物，方法和试剂盒，用于通过从不同标签标签池中附加独特的标签标签随机标记分子混合物中的相同分子来对各个分子进行高灵敏度计数，以赋予其他相同或不可区分的事件的唯一性。从各种标签标签的非消耗性储层中随机选择目标分子的个体出现。标记的分子可以通过杂交或基于测序的方法来检测。否则在信息内容中相同的分子被标记以产生可以被清楚地检测到的可单独检测的产物。所公开的随机转换方法减少了将分子从定位和识别相同分子之一计数到检测是否存在预编程标签标签的一系列二进制数字问题的问题。该方法可以用于例如计数样品中的给定种类的分子。

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