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1. 发明申请

US20060264468A1 Use of substituted-1, 5-dideoxy-1, 5-imino-D-glucitol compounds for treating hepatitis virus infections 审中-公开
标题翻译：使用取代-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物治疗肝炎病毒感染
公开(公告)号：US20060264468A1
公开(公告)日：2006-11-23
申请号：US11472542
申请日：2006-06-22
申请人： Richard Mueller , Martin Bryant , Richard Partis
发明人： Richard Mueller , Martin Bryant , Richard Partis
IPC分类号： A61K31/445 , A61K31/454
CPC分类号： A61K31/436 , A61K31/444 , A61K31/445 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K45/06 , Y10S514/885
摘要： N-Substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds of Formula I are effective in treatment of hepatitis infections, including hepatitis B and hepatitis C. In treating hepatitis infections, the compounds of Formula I may be used alone, or in combination with another antiviral agents selected from among nucleosides, nucleotides, immunomodulators, immunostimulants or various combinations of such other agents.
摘要翻译：式I的N-取代的-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物在治疗肝炎感染中是有效的，包括乙型肝炎和丙型肝炎。在治疗肝炎感染中，式I化合物可以是或者与选自核苷，核苷酸，免疫调节剂，免疫刺激剂或其它药剂的各种组合的另一种抗病毒剂组合使用。

2. 发明申请

US20050267153A1 Use of N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections 审中-公开
标题翻译：使用N-取代-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物治疗肝炎病毒感染
公开(公告)号：US20050267153A1
公开(公告)日：2005-12-01
申请号：US10910197
申请日：2004-08-03
申请人： Richard Mueller , Martin Bryant , Richard Partis , Gary Jacob , Timothy Block , Raymond Dwek
发明人： Richard Mueller , Martin Bryant , Richard Partis , Gary Jacob , Timothy Block , Raymond Dwek
IPC分类号： A61K31/445 , A61K31/7042 , A61K31/7052 , A61K31/7064 , A61K31/7068 , A61K45/06 , A61P1/16 , A61P31/20 , C07D211/46 , C07H19/10
CPC分类号： C07D211/46 , A61K31/445 , A61K45/06
摘要： Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immuno-stimulating agents.
摘要翻译：提供用于治疗哺乳动物，特别是人类的肝炎病毒感染的方法和组合物。方法包括（1）单独或与核苷抗病毒剂，核苷酸抗病毒剂，其混合物或免疫调节/免疫刺激剂单独或组合施用N-取代的-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物，或（2）单独或与核苷抗病毒剂，核苷酸抗病毒剂或其混合物以及免疫调节/免疫刺激剂组合施用N-取代-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物。

3. 发明申请

US20050119310A1 Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections 审中-公开
标题翻译：使用正己烷-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物治疗肝炎病毒感染
公开(公告)号：US20050119310A1
公开(公告)日：2005-06-02
申请号：US10203769
申请日：2001-02-13
申请人： Richard Mueller , Martin Bryant , Kimberly Bryant
发明人： Richard Mueller , Martin Bryant , Kimberly Bryant
IPC分类号： C07D211/46 , A61K31/445 , A61K45/06 , A61P1/16 , A61P31/14 , A61P31/20
CPC分类号： A61K31/445 , A61K45/06 , A61K2300/00
摘要： Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immuno-stimulating agents.
摘要翻译：提供用于治疗哺乳动物，特别是人类的肝炎病毒感染的方法和组合物。方法包括（1）单独或与核苷抗病毒剂，核苷酸抗病毒剂，其混合物或免疫调节/免疫刺激剂单独或组合施用N-取代的-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物，或（2）单独或与核苷抗病毒剂，核苷酸抗病毒剂或其混合物以及免疫调节/免疫刺激剂组合施用N-取代-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物。

4. 发明申请

US20120167425A1 Semiautomatic Firearm Having Lighter Cocking Action 有权
标题翻译：半自动火器具有较轻的动作
公开(公告)号：US20120167425A1
公开(公告)日：2012-07-05
申请号：US13032815
申请日：2011-02-23
申请人： James M. Buschow , Martin Bryant
发明人： James M. Buschow , Martin Bryant
IPC分类号： F41A3/12
CPC分类号： F41A25/12 , F41A3/86 , F41A25/14
摘要： An improved semiautomatic firearm is provided comprising as assembly which reduces the effort of cocking the firearm or loading a first cartridge. A spring tube contains an inner recoil spring which is employed only during cycling of the firearm when firing. For initial cocking purposes, the inner recoil spring is bypassed in favor of a lighter outer spring which is selectively engaged by the user. When the inner recoil spring is engaged, both inner and outer springs are employed without adversely affecting the recoil dynamics of the firearm.
摘要翻译：提供了一种改进的半自动枪械，其包括作为组装件，其减少了起动枪支或装载第一药筒的努力。弹簧管包含内部反弹弹簧，该弹簧仅在射击时枪械骑自行车时使用。为了初始起弧目的，内部反冲弹簧被旁路以有利于用户选择性地接合的较轻的外部弹簧。当内部反冲弹簧接合时，使用内弹簧和外弹簧，而不会不利地影响枪支的反冲动力学。

5. 发明申请

US20050164175A1 Recombinant RSV virus expression systems and vaccines 失效
公开(公告)号：US20050164175A1
公开(公告)日：2005-07-28
申请号：US11078900
申请日：2005-03-11
申请人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
发明人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
IPC分类号： A61K39/00 , C07K14/11 , C07K14/135 , C12N7/01 , C12N7/04 , C12N15/86 , C12Q1/70 , C07H21/02 , C12N7/00
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2760/16022 , C12N2760/16122 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： The present invention relates to genetically engineered recombinant RS viruses and viral vectors which contain heterologous genes which for the use as vaccines. In accordance with the present invention, the recombinant RS viral vectors and viruses are engineered to contain heterologous genes, including genes of other viruses, pathogens, cellular genes, tumor antigens, or to encode combinations of genes from different strains of RSV.

6. 发明申请

US20120308602A1 Recombinant RSV Virus Expression Systems And Vaccines 审中-公开
标题翻译：重组RSV病毒表达系统和疫苗
公开(公告)号：US20120308602A1
公开(公告)日：2012-12-06
申请号：US13488700
申请日：2012-06-05
申请人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant , David Kirkwood Clarke , Peter Palese
发明人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant , David Kirkwood Clarke , Peter Palese
IPC分类号： A61K39/155 , A61P31/14 , C12N7/04 , A61P37/04
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2760/16022 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to the attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
摘要翻译：本发明涉及遗传工程重组呼吸道合胞病毒和病毒载体，其含有单独或组合的各种病毒辅助基因的缺失。根据本发明，重组呼吸道合胞病毒载体和病毒被工程化以含有M2-2，NS1，NS2或SH病毒附属基因或其各种组合的完全缺失。此外，本发明涉及通过M2-1基因的诱变来减轻呼吸道合胞病毒。

7. 发明申请

US20100028377A1 Recombinant RSV Virus Expression Systems And Vaccines 审中-公开
标题翻译：重组RSV病毒表达系统和疫苗
公开(公告)号：US20100028377A1
公开(公告)日：2010-02-04
申请号：US12434781
申请日：2009-05-04
申请人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant , David Kirkwood Clarke , Peter Palese
发明人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant , David Kirkwood Clarke , Peter Palese
IPC分类号： A61K39/155 , C12N7/00 , C12N15/11 , A61K35/76
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2760/16022 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to the attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
摘要翻译：本发明涉及遗传工程重组呼吸道合胞病毒和病毒载体，其含有单独或组合的各种病毒辅助基因的缺失。根据本发明，重组呼吸道合胞病毒载体和病毒被工程化以含有M2-2，NS1，NS2或SH病毒附属基因或其各种组合的完全缺失。此外，本发明涉及通过M2-1基因的诱变来减轻呼吸道合胞病毒。

8. 发明申请

US20080064655A1 Beta-L-2'-Deoxy-Nucleosides for the Treatment of Hepatitis B 审中-公开
标题翻译：用于治疗乙型肝炎的β-L-2'-Deoxy-Nucleosides
公开(公告)号：US20080064655A1
公开(公告)日：2008-03-13
申请号：US11929807
申请日：2007-10-30
申请人： Gilles Gosselin , Jean-Louis Imbach , Martin Bryant
发明人： Gilles Gosselin , Jean-Louis Imbach , Martin Bryant
IPC分类号： A61K31/7072 , A61P31/12
CPC分类号： C07H19/06 , A61K31/70 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K45/06 , C07H19/16 , A61K2300/00
摘要： This invention is directed to a method for treating a host infected with hepatitis B comprising administering an effective amount of an anti-HBV biologically active 2′-deoxy-β-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug thereof, wherein the 2′deoxy-β-L-erythro-pentofuranonucleoside has the formula: wherein R is selected from the group consisting of H, straight chained, branched or cyclic alkyl, CO-alkyl, CO-axyl, CO-alkoxyalkyl, CO-aryloxyalkyl, CO-substituted aryl, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, amino acid residue, mono, di, or triphosphate, or a phosphate derivative; and BASE is a purine or pyrimidine base which may be optionally substituted. The 2′-deoxy-β-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug thereof may be administered either alone or in combination with another 2′-deoxy-β-L-erythro pentofuranonucleoside or in combination with another anti-hepatitis B agent.
摘要翻译：本发明涉及一种用于治疗感染乙型肝炎的宿主的方法，其包括施用有效量的抗HBV生物活性2'-脱氧-β-L-赤 - 戊呋喃核苷或其药学上可接受的盐或前药，其中 2脱氧-β-L-赤 - 戊呋喃核苷具有下式：其中R选自H，直链，支链或环状烷基，CO-烷基，CO-烷基，CO-烷氧基烷基，CO-芳氧基烷基， CO取代的芳基，烷基磺酰基，芳基磺酰基，芳烷基磺酰基，氨基酸残基，单，二或三磷酸，或磷酸酯衍生物; 并且BASE是嘌呤或嘧啶碱基，其可任选被取代。 2'-脱氧-β-L-赤 - 戊呋喃核苷或其药学上可接受的盐或前体药物可以单独给药或与另外2'-脱氧-β-L-赤藓糖呋喃核苷一起施用，或与另一种抗肝炎 B代理。

9. 发明申请

US20060240410A1 Retroviral protease inhibitor combinations 审中-公开
公开(公告)号：US20060240410A1
公开(公告)日：2006-10-26
申请号：US11396957
申请日：2006-04-04
申请人： Martin Bryant , Karen Potts , Mary Smidt , Simon Tucker
发明人： Martin Bryant , Karen Potts , Mary Smidt , Simon Tucker
IPC分类号： C12Q1/70
CPC分类号： A61K45/06 , A61K31/44 , A61K31/4709 , A61K31/496 , A61K31/5513 , A61K38/04 , C12Q1/18 , G01N2333/16 , A61K2300/00
摘要： The present invention is directed to a method for the treatment of mammalian retrovirus infections, such as HIV, using combinations of retroviral protease inhibitors which are effective in preventing the replication of the retroviruses in vitro or in vivo. This invention, in particular, relates to protease inhibitor compounds used in combination therapy with other protease inhibitor compounds. This invention also relates to combination therapy with a combination of protease inhibitors and antiviral agents other than protease inhibitors.

10. 发明申请

US20060084624A1 beta-L-2'-deoxy-nucleosides for the treatment of hepatitis B 有权
标题翻译： β-L-2'-脱氧核苷用于治疗乙型肝炎
公开(公告)号：US20060084624A1
公开(公告)日：2006-04-20
申请号：US11232818
申请日：2005-09-22
申请人： Gilles Gosselin , Jean-Louis Imbach , Martin Bryant
发明人： Gilles Gosselin , Jean-Louis Imbach , Martin Bryant
IPC分类号： A61K31/7076
CPC分类号： C07H19/06 , A61K31/70 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K45/06 , C07H19/16 , A61K2300/00
摘要： This invention is directed to a method for treating a host infected with hepatitis B comprising administering an effective amount of an anti-HBV biologically active 2′-deoxy-β-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug thereof, wherein the 2′-deoxy-β-L-erythro-pentofuranonucleoside has the formula: wherein R is selected from the group consisting of H, straight chained, branched or cyclic alkyl, CO-alkyl, CO-aryl, CO-alkoxyalkyl, CO-aryloxyalkyl, CO-substituted aryl, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, amino acid residue, mono, di, or triphosphate, or a phosphate derivative; and BASE is a purine or pyrimidine base which may be optionally substituted. The 2′-deoxy-β-L-eythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug thereof may be administered either alone or in combination with another 2′-deoxy-β-L-erythro pentofuranonucleoside or in combination with another anti-hepatitis B agent.
摘要翻译：本发明涉及一种用于治疗感染乙型肝炎的宿主的方法，其包括施用有效量的抗HBV生物活性2'-脱氧-β-L-赤 - 戊呋喃核苷或其药学上可接受的盐或前药，其中 2'-脱氧-β-L-赤 - 戊呋喃核苷具有下式：其中R选自H，直链，支链或环状烷基，CO-烷基，CO-芳基，CO-烷氧基烷基，CO-芳氧基烷基烷基磺酰基，芳基磺酰基，芳烷基磺酰基，氨基酸残基，单，二或三磷酸酯，或磷酸酯衍生物; 并且BASE是嘌呤或嘧啶碱基，其可任选被取代。 2'-脱氧-β-L-选择性 - 戊呋喃核苷或其药学上可接受的盐或前体药物可以单独给药或与其它2'-脱氧-β-L-赤藓寡糖核苷或其它抗肝炎联合施用 B代理。

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