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1. 发明申请

US20090056825A1 Device for the Monitored Filling of Containers with Tablets 审中-公开
标题翻译：用片剂监测填充容器的装置
公开(公告)号：US20090056825A1
公开(公告)日：2009-03-05
申请号：US12200042
申请日：2008-08-28
申请人： Richard Mertens , Heino Prinz
发明人： Richard Mertens , Heino Prinz
IPC分类号： B65B3/26
CPC分类号： B65B5/103 , B65B57/10 , B65B57/20
摘要： A device for the monitored filling of containers with tablets which includes a feed device for feeding tablets to a free-fall section and a capacitive sensor for checking each falling tablet in the free-fell section. In addition, the device includes a separating device for separating the bad tablets from the good tablets, the separating device being located below or underneath the sensor in the free-fall section. A control unit is included which is connected to the separating device and which actuates the separating device on the basis of the values supplied by the capacitive sensor.
摘要翻译：用于监测填充片剂的容器的装置，包括用于将片剂送入自由落体部分的进料装置和用于检查自由落体部分中的每个落片的电容传感器。此外，该装置还包括一个分离装置，用于将好的片剂与好的片剂分开，该分离装置位于自由落体部分的传感器的下方或下方。包括控制单元，其连接到分离装置，并且基于由电容传感器提供的值来致动分离装置。

2. 发明申请

US20080285013A1 Method of Checking the Filling Volume of Blisters 审中-公开
标题翻译：检查泡罩灌装体积的方法
公开(公告)号：US20080285013A1
公开(公告)日：2008-11-20
申请号：US12118844
申请日：2008-05-12
申请人： Richard Mertens , Heino Prinz
发明人： Richard Mertens , Heino Prinz
IPC分类号： G01J3/00
CPC分类号： G01N21/359 , B65B1/48 , G01N21/3563 , G01N21/9508 , G01N2021/4769
摘要： A method for checking the volume of material in the form of a thin layer of a powdery substance in pockets of a blister pack including: bringing at least one blister pack to the measuring area of a measuring system, the pack including a plurality of pockets which are designed to be reflective and are filled with a thin layer of the substance; exposing the substance in at least one of the pockets to near-infrared radiation; recording at least partial ranges of an actual reflectance spectrum for each pocket by detecting the radiation reflected from the pocket; calculating actual values associated with the intensities displayed in the actual reflectance spectrum for at least partial ranges of the actual reflectance spectrum; comparing, in at least partial ranges of the actual reflectance spectrum, the calculated actual values with corresponding reference values associated with the intensities displayed in at least one model spectrum; and checking the ratio of the layer thickness to the density of the powdery substance as a function of the result of the comparison.
摘要翻译：一种用于在泡罩包装袋的口袋中检查粉末状物质薄层形式的材料的体积的方法，包括：将至少一个泡罩包装带到测量系统的测量区域，所述包装袋包括多个袋被设计为反射性的并且填充有薄层的物质; 将至少一个口袋中的物质暴露于近红外辐射; 通过检测从口袋反射的辐射来记录每个口袋的实际反射光谱的至少部分范围; 在实际反射光谱的至少部分范围内计算与实际反射光谱中显示的强度相关联的实际值; 在实际反射光谱的至少部分范围内，将所计算的实际值与与至少一个模型光谱中显示的强度相关联的相应参考值进行比较; 并且根据比较结果检查层厚度与粉末状物质的密度之比。

3. 发明申请

US20070023664A1 METHOD AND DEVICE FOR THE QUANTITATIVE ANALYSIS OF SOLUTIONS AND DISPERSIONS BY MEANS OF NEAR INFRARED SPECTROSCOPY 审中-公开
标题翻译：通过近红外光谱法定量分析溶液和分散体的方法和装置
公开(公告)号：US20070023664A1
公开(公告)日：2007-02-01
申请号：US11470370
申请日：2006-09-06
申请人： Christian-Peter Christiansen , Hans-Joachim Ploss , Richard Mertens , Heino Prinz
发明人： Christian-Peter Christiansen , Hans-Joachim Ploss , Richard Mertens , Heino Prinz
IPC分类号： G01J5/02
CPC分类号： G01N21/9027 , G01J3/28 , G01J3/42 , G01J3/433 , G01N21/274 , G01N21/3563 , G01N21/359 , G01N21/90 , G01N2201/08
摘要： The present invention relates to a method for quantifying the composition of a product, with the following steps: irradiating the product with a radiation source in the near infrared range; receiving radiation which is reflected by or transmitted through the product, and providing an output signal corresponding to the intensity of the radiation received at a number of different wavelengths; determining whether or not the product lies within predetermined integrity criteria on the basis of the output signal using a mathematical method, wherein the product contains a solution or homogeneous dispersion, and the content of at least one substance contained in the dispersion or solution is quantitatively determined on the basis of the output signal., The present invention also relates to an apparatus for carrying out this method.
摘要翻译：本发明涉及一种用于量化产品组成的方法，其具有以下步骤：用近红外范围的辐射源照射产品; 接收由产品反射或透过产品的辐射，并提供对应于以多个不同波长接收的辐射的强度的输出信号; 使用数学方法确定产品是否处于基于输出信号的预定完整性标准内，其中产品包含溶液或均匀分散体，并且定量确定分散体或溶液中所含的至少一种物质的含量基于输出信号，本发明还涉及一种用于执行该方法的装置。

4. 发明申请

US20050092941A1 Method and device for the quantitative analysis of solutions and dispersions by means of near infrared spectroscopy 审中-公开
标题翻译：通过近红外光谱定量分析溶液和分散体的方法和装置
公开(公告)号：US20050092941A1
公开(公告)日：2005-05-05
申请号：US10861675
申请日：2004-06-04
申请人： Christian-Peter Christiansen , Hans-Joachim Ploss , Richard Mertens , Heino Prinz
发明人： Christian-Peter Christiansen , Hans-Joachim Ploss , Richard Mertens , Heino Prinz
IPC分类号： A61B5/00 , G01J1/00
CPC分类号： G01N21/9027
摘要： The present invention relates to a method for quantifying the composition of a product, with the following steps: irradiating the product with a radiation source in the near infrared range; receiving radiation which is reflected by or transmitted through the product, and providing an output signal corresponding to the intensity of the radiation received at a number of different wavelengths; determining whether or not the product lies within predetermined integrity criteria on the basis of the output signal using a mathematical method, wherein the product contains a solution or homogeneous dispersion, and the content of at least one substance contained in the dispersion or solution is quantitatively determined on the basis of the output signal. The present invention also relates to an apparatus for carrying out this method.
摘要翻译：本发明涉及一种用于量化产品组成的方法，其具有以下步骤：用近红外范围的辐射源照射产品; 接收由产品反射或透过产品的辐射，并提供对应于以多个不同波长接收的辐射的强度的输出信号; 使用数学方法确定产品是否处于基于输出信号的预定完整性标准内，其中产品包含溶液或均匀分散体，并且定量确定分散体或溶液中所含的至少一种物质的含量在输出信号的基础上。本发明还涉及一种用于执行该方法的装置。

5. 发明授权

US06757637B2 Method for checking the content of pockets in a blister package 失效
标题翻译：用于检查泡罩包装袋中的内容物的方法
公开(公告)号：US06757637B2
公开(公告)日：2004-06-29
申请号：US09965416
申请日：2001-09-27
申请人： Richard Mertens , Heino Prinz
发明人： Richard Mertens , Heino Prinz
IPC分类号： G01B1128
CPC分类号： B65B57/18 , B65B1/48 , B65B57/16 , G01N21/9508
摘要： The present invention relates to a method for checking the filling or content of pockets in a blister package in particular for pharmaceuticals which is filled with a powdery, solid, liquid or pasteous substance whereby the volume filled of the substance is detected by a sensor and the detected volume value is supplied to an evaluation unit in which a comparison of the detected volume value with a volume target value is carried out. The sensor can preferably be formed both as a line sensor as well as a matrix sensor.
摘要翻译：本发明涉及一种用于检查泡罩包装中的袋的填充或含量的方法，特别是用于填充粉末状，固体，液体或糊状物质的药物，由此通过传感器检测物质的体积，检测体积值被提供给其中执行检测到的体积值与体积目标值的比较的评估单元。传感器可以优选地形成为线传感器以及矩阵传感器。

6. 发明申请

US20090056826A1 Device and Method for the Quantity-Controlled Filling of Containers with Powdered Substances 审中-公开
标题翻译：用粉末物质进行数量控制填充的装置和方法
公开(公告)号：US20090056826A1
公开(公告)日：2009-03-05
申请号：US12200230
申请日：2008-08-28
申请人： Richard Mertens , Heino Prinz , Karlheinz Seyfang
发明人： Richard Mertens , Heino Prinz , Karlheinz Seyfang
IPC分类号： B65B1/04
CPC分类号： B65B1/08 , B65B1/30 , B65B1/36 , B65B1/48 , G01F1/64 , G01F13/001 , G01F15/003
摘要： A device for the controlled filling of containers with powdered substance includes a supply vessel with a narrow exit opening for temporarily holding the powdered substance and for discharging a predetermined quantity of the powdered substance into a container located underneath the supply vessel, a vibrator means is connected to the supply vessel for effecting the discharge of the powdered substance. A sensor for determining the quantity of powdered substance discharged from the supply vessel into the container, and a control unit, which converts the data acquired by the sensor into control commands for the vibrator means is included. The sensor includes a capacitive sensor for the quantitative determination of the quantity of powdered substance falling there through during the filling process and is located between the supply vessel and the container.
摘要翻译：用粉末状物质容器控制填充的装置包括供给容器，其具有用于暂时保持粉末物质的狭窄出口，并将预定量的粉末物质排放到位于供应容器下方的容器中，连接一个振动装置到供给容器进行粉状物质的排出。包括用于确定从供给容器排入容器的粉末物质的量的传感器，以及控制单元，其将由传感器获取的数据转换成用于振动器装置的控制命令。传感器包括电容式传感器，用于定量确定填充过程中通过的粉状物质的数量，并位于供应容器和容器之间。

7. 发明申请

US20080271417A1 Method of Manufacturing Packaging Comprising Pharmaceutical Products 审中-公开
标题翻译：制药包装制造方法
公开(公告)号：US20080271417A1
公开(公告)日：2008-11-06
申请号：US12110917
申请日：2008-04-28
申请人： Siegfried Drost , Gunter Felk , Georg Pfau , Hans-Werner Bongers-Ambrosius , Heino Prinz , Richard Mertens
发明人： Siegfried Drost , Gunter Felk , Georg Pfau , Hans-Werner Bongers-Ambrosius , Heino Prinz , Richard Mertens
IPC分类号： B65B17/00 , B65B35/36 , B65B35/38 , B65B43/00
CPC分类号： B65B11/50 , A61J1/035 , A61J7/0084 , A61M2207/00 , B65B5/103 , B65B5/105
摘要： The method for producing a multi-day package containing various drugs has the following steps: a bottom layer is formed with a plurality of wells arranged in a pattern; a predetermined number of different drugs is arranged in predetermined positions at various dispensing stations of a filling device; the desired number of drugs are picked in a controlled manner from their predetermined positions at each dispensing station by at least one movable suction or gripper device, and the drugs are deposited in the predetermined wells; and a sealing film is applied to the bottom layer to seal off the wells. In the course of this method, in at least one dispensing station several suction or gripper devices, which are arranged in correspondence with the pattern of the wells in the multi-day package and which travel parallel to each other, are actuated individually.
摘要翻译：制备含有各种药物的多日包装的方法具有以下步骤：底层形成有以图案排列的多个孔; 预定数量的不同药物被布置在填充装置的各种分配站处的预定位置; 通过至少一个可移动的抽吸或夹持装置，在每个分配站的预定位置以受控的方式挑选所需数量的药物，并将药物沉积在预定的孔中; 并且将密封膜施加到底层以密封孔。在该方法的过程中，在至少一个分配站中，与多天包装中的孔的图案相对应并且彼此平行地行进的多个抽吸或夹持装置被单独致动。

8. 发明申请

US20080230700A1 METHOD AND DEVICE FOR THE QUANTITATIVE ANALYSIS OF SOLUTIONS AND DISPERSIONS BY MEANS OF NEAR INFRARED SPECTROSCOPY 有权
标题翻译：通过近红外光谱法定量分析溶液和分散体的方法和装置
公开(公告)号：US20080230700A1
公开(公告)日：2008-09-25
申请号：US11762968
申请日：2007-06-14
申请人： Christian-Peter Christiansen , Hans-Joachim Ploss , Richard Mertens , Heino Prinz
发明人： Christian-Peter Christiansen , Hans-Joachim Ploss , Richard Mertens , Heino Prinz
IPC分类号： G01N21/35 , G01J3/02 , G01N21/85
CPC分类号： G01N21/9027 , G01J3/28 , G01J3/42 , G01J3/433 , G01N21/274 , G01N21/3563 , G01N21/359 , G01N21/90 , G01N2201/08
摘要： The present invention relates to a method for quantifying the composition of a product, including: irradiating the product with a radiation source in the near infrared range; receiving radiation which is reflected by or transmitted through the product; providing an output signal corresponding to the intensity of the radiation received at a number of different wavelengths; and determining whether or not the product lies within predetermined integrity criteria on the basis of the output signal using a mathematical method. The moving product contains a solution or homogeneous dispersion and the content of at least one substance contained in the dispersion or solution is quantitatively determined on the basis of the output signal. The invention also relates to a device for carrying out this method.
摘要翻译：本发明涉及一种定量产品组成的方法，包括：用近红外范围的辐射源照射产品; 接收由产品反射或透过产品的辐射; 提供与在多个不同波长处接收的辐射的强度对应的输出信号; 以及基于使用数学方法的输出信号来确定产品是否处于预定的完整性标准内。移动产品含有溶液或均匀分散体，并且基于输出信号定量确定分散液或溶液中所含的至少一种物质的含量。本发明还涉及一种用于执行该方法的装置。

9. 发明授权

US07294837B2 Tablets press with integral NIR measuring device 有权
标题翻译：平板电脑采用整体式NIR测量装置
公开(公告)号：US07294837B2
公开(公告)日：2007-11-13
申请号：US11133830
申请日：2005-05-20
申请人： Richard Mertens , Heino Prinz
发明人： Richard Mertens , Heino Prinz
IPC分类号： G01N21/35 , B30B11/00
CPC分类号： B30B11/08 , B30B11/005 , G01N21/15 , G01N21/3563 , G01N21/9508 , G01N2021/151 , G01N2201/08 , G01N2201/084
摘要： The tablets press according to the invention comprises an integral measuring device for the determination of the quantitative content of at least one substance in a tablet, comprising: at least one radiation source, which emits radiation in the near infrared range, for the irradiation of the tablet, a radiation receiving device contained in a measuring head, which receives the radiation reflected by the tablet, a spectrometer for receiving the radiation from the radiation receiving device and for supplying an output signal according to the intensity of the received radiation at a number of different wavelengths and a device for the quantitative determination of the content of at least one substance contained in the tablet and/or for the determination of the ratios of all or some of the contained components based on the output signal, wherein the measuring device is suitable for measuring each individual pressed tablet, and the trigger times of the measurements are correlated with the conveying speed of the tablets press.
摘要翻译：根据本发明的压片机包括用于确定片剂中至少一种物质的定量含量的整体测量装置，包括：至少一个辐射源，其在近红外范围内发射辐射，用于照射片剂，包含在测量头中的辐射接收装置，其接收由平板电脑反射的辐射，用于接收来自辐射接收装置的辐射的光谱仪，并且用于根据所接收的辐射的强度以多个不同的波长和用于定量确定片剂中所含的至少一种物质的含量的装置和/或用于基于输出信号确定所含或部分所含成分的比例，其中测量装置是合适的用于测量每个单独的压制片，并且测量的触发时间与c相关片剂的输送速度。

10. 发明授权

US07755051B2 Method and device for the quantitative analysis of solutions and dispersions by means of near infrared spectroscopy 有权
标题翻译：通过近红外光谱定量分析溶液和分散体的方法和装置
公开(公告)号：US07755051B2
公开(公告)日：2010-07-13
申请号：US11762968
申请日：2007-06-14
申请人： Christian-Peter Christiansen , Hans-Joachim Ploss , Richard Mertens , Heino Prinz
发明人： Christian-Peter Christiansen , Hans-Joachim Ploss , Richard Mertens , Heino Prinz
IPC分类号： G01N21/35
CPC分类号： G01N21/9027 , G01J3/28 , G01J3/42 , G01J3/433 , G01N21/274 , G01N21/3563 , G01N21/359 , G01N21/90 , G01N2201/08
摘要： The present invention relates to a method for quantifying the composition of a product, including: irradiating the product with a radiation source in the near infrared range; receiving radiation which is reflected by or transmitted through the product; providing an output signal corresponding to the intensity of the radiation received at a number of different wavelengths; and determining whether or not the product lies within predetermined integrity criteria on the basis of the output signal using a mathematical method. The moving product contains a solution or homogeneous dispersion and the content of at least one substance contained in the dispersion or solution is quantitatively determined on the basis of the output signal. The invention also relates to a device for carrying out this method.
摘要翻译：本发明涉及一种定量产品组成的方法，包括：用近红外范围的辐射源照射产品; 接收由产品反射或透过产品的辐射; 提供与在多个不同波长处接收的辐射的强度对应的输出信号; 以及基于使用数学方法的输出信号来确定产品是否处于预定的完整性标准内。移动产品含有溶液或均匀分散体，并且基于输出信号定量确定分散液或溶液中所含的至少一种物质的含量。本发明还涉及一种用于执行该方法的装置。

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