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1. 发明授权

US5391192A Automatic ventricular pacing pulse threshold determination utilizing an external programmer and a surface electrocardiogram 失效
标题翻译：使用外部编程器和表面心电图进行自动心室起搏脉冲阈值测定
公开(公告)号：US5391192A
公开(公告)日：1995-02-21
申请号：US205721
申请日：1994-03-04
申请人： Richard M. T. Lu , Bruce M. Steinhaus , Peter A. Crosby , Janice Nolan
发明人： Richard M. T. Lu , Bruce M. Steinhaus , Peter A. Crosby , Janice Nolan
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/365 , A61N1/37
摘要： A clinical programming system is disclosed for use with an implanted cardiac pacemaker to automatically determine the minimum pacing energy which is necessary to evoke a ventricular depolarization. The system utilizes a series of pacing pulses of progressively decreasing energies to stimulate the ventricle, and detects evoked responses through measurements of the integrals of the R-waves provided by a surface electrocardiogram. Upon loss of capture, the minimum pacing energy is a function of the energy of the last pacing pulse which evoked a ventricular depolarization.
摘要翻译：公开临床编程系统用于植入的心脏起搏器以自动确定引起心室去极化所必需的最小起搏能量。该系统利用逐步降低能量的一系列起搏脉冲来刺激心室，并通过测量由表面心电图提供的R波的积分来检测诱发的反应。在捕获丧失时，最小起搏能量是引起心室去极化的最后起搏脉冲的能量的函数。

2. 发明授权

US5458623A Automatic atrial pacing threshold determination utilizing an external programmer and a surface electrogram 失效
标题翻译：使用外部编程器和表面电描记图进行自动心房起搏阈值确定
公开(公告)号：US5458623A
公开(公告)日：1995-10-17
申请号：US208140
申请日：1994-03-04
申请人： Richard M. T. Lu , Bruce M. Steinhaus , Peter A. Crosby
发明人： Richard M. T. Lu , Bruce M. Steinhaus , Peter A. Crosby
IPC分类号： A61N1/37 , A61N1/36
CPC分类号： A61N1/371 , A61N1/3714
摘要： A clinical programming system for use with an implanted cardiac pacemaker to automatically determine the minimum pacing energy which is necessary to evoke an atrial depolarization. The system utilizes a series of pacing pulses of progressively decreasing energies to stimulate the atrium, and detects an evoked response during the AV delay interval that follows each pulse. Initial P-wave intervals are subjected to morphological analysis to generate a P-wave template. Subsequent intervals are similarly analyzed and the results compared with the template. The absence of similarity with the template indicates the loss of atrial capture and that the minimum pacing energy has been reached.
摘要翻译：一种用于植入心脏起搏器的临床编程系统，用于自动确定唤起心房去极化所需的最小起搏能量。该系统利用逐渐降低能量的一系列起搏脉冲来刺激心房，并且检测在每个脉冲之后的AV延迟间隔期间的诱发响应。对初始P波间隔进行形态分析以产生P波模板。类似地分析随后的间隔，并将结果与模板进行比较。与模板不相似表明心房捕获的丧失，并且达到了最小的起搏能量。

3. 发明授权

US5476486A Automatic atrial pacing pulse threshold determination utilizing an external programmer and a V-sense electrode 失效
标题翻译：使用外部编程器和V检测电极进行自动心房起搏脉冲阈值测定
公开(公告)号：US5476486A
公开(公告)日：1995-12-19
申请号：US205795
申请日：1994-03-04
申请人： Richard M. T. Lu , Bruce M. Steinhaus , Peter A. Crosby
发明人： Richard M. T. Lu , Bruce M. Steinhaus , Peter A. Crosby
IPC分类号： A61N1/37 , A61N1/36
CPC分类号： A61N1/371 , A61N1/3714
摘要： A clinical programming system is disclosed for use with an implanted cardiac pacemaker to automatically determine the minimum pacing energy which is necessary to evoke an atrial depolarization. The system utilizes a series of pacing pulses of progressively decreasing energies to stimulate the atrium and detects following R-waves. The absence of an R-wave indicates the loss of atrial capture.
摘要翻译：一种临床编程系统被公开用于与植入式心脏起搏器一起使用以自动确定唤起心房去极化所必需的最小起搏能量。该系统利用一系列逐步降低能量的起搏脉冲来刺激心房并检测以下R波。没有R波表明心房捕获的丧失。

4. 发明授权

US5184615A Apparatus and method for detecting abnormal cardiac rhythms using evoked potential measurements in an arrhythmia control system 失效
标题翻译：在心律失常控制系统中使用诱发电位测量来检测异常心律的装置和方法
公开(公告)号：US5184615A
公开(公告)日：1993-02-09
申请号：US667316
申请日：1991-03-08
申请人： Tibor A. Nappholz , Albert K. Dawson , Richard M. T. Lu , Bruce M. Steinhaus
发明人： Tibor A. Nappholz , Albert K. Dawson , Richard M. T. Lu , Bruce M. Steinhaus
IPC分类号： A61N1/362 , A61N1/37
CPC分类号： A61N1/3622 , A61N1/3716
摘要： In an implantable antiarryhythmia pacemaker, an automatic cardiac arrhythmia detection and classification monitoring apparatus and method for measuring stimulated intracardiac electrogram potentials, deriving therefrom a paced depolarization integral (PDI), analyzing time-based changes in the PDI, detecting and classifying harmful cardiac rhythms while distinguishing harmful from benign tachycardias, and automatically establishing and initiating an appropriate therapy, if necessary, to revert the arrhythmia condition.
摘要翻译：在可植入的抗心律失常起搏器中，一种自动心律失常检测和分类监测装置和方法，用于测量刺激的心内电描绘电位，从中得出节奏去极化积分（PDI），分析PDI中的基于时间的变化，检测和分类有害的心律，同时区分有害的良性心动过速，并在必要时自动建立和启动适当的治疗以恢复心律失常状态。

5. 发明授权

US5188117A Notch filter noise rejection system in a cardiac control device 失效
标题翻译：心脏控制装置中的陷波滤波器噪声抑制系统
公开(公告)号：US5188117A
公开(公告)日：1993-02-23
申请号：US782586
申请日：1991-10-25
申请人： Bruce M. Steinhaus , Richard M. T. Lu
发明人： Bruce M. Steinhaus , Richard M. T. Lu
IPC分类号： A61B5/00 , A61N1/37 , G06F17/00 , H03H11/04 , H03M3/02
CPC分类号： H03M3/02 , A61B5/0006 , A61B5/7203 , A61N1/3704 , H03H11/04
摘要： A physiological event signal sensing system in a cardiac control or monitoring device for detecting spontaneous cardiac electrical events which may be obscured by continuous or burst EMI line frequency noise. The noise rejecting sensing system of this invention senses and samples cardiac signals which may include a noise component which is produced by power line interference in addition to a physiological signal component. The sampling frequency is selected to be an integer multiple of at least one common power line frequency. The system notch filters the cardiac signal to remove line frequency components, using either or both lowpass and highpass notch filtering coefficients, then limits the filtered output to the amplitude of the corresponding filter input to remove filter output signals caused by the sudden termination of line frequency noise which is characteristic of burst noise.
摘要翻译：心脏控制或监测装置中的生理事件信号感测系统，用于检测可能被连续或突发的EMI线路频率噪声遮蔽的自发性心脏电气事件。本发明的噪声抑制感测系统感测和采样心脏信号，心脏信号可以包括除了生理信号分量之外由电力线干扰产生的噪声分量。采样频率被选择为至少一个公共电力线频率的整数倍。系统陷波滤波心脏信号以去除线路频率分量，使用低通和高通陷波滤波系数中的一个或两者，然后将滤波输出限制为相应滤波器输入的幅度，以消除由线路频率突然终止引起的滤波器输出信号噪声是突发噪声的特征。

6. 发明授权

US5181511A Apparatus and method for antitachycardia pacing using a virtual electrode 失效
标题翻译：使用虚拟电极进行抗心动过速起搏的装置和方法
公开(公告)号：US5181511A
公开(公告)日：1993-01-26
申请号：US780753
申请日：1991-10-21
申请人： Peter Nickolls , Richard M. T. Lu , Kenneth A. Collins , Roy M. McCulloch , Lucy M. Cheatle , Brian Cleland
发明人： Peter Nickolls , Richard M. T. Lu , Kenneth A. Collins , Roy M. McCulloch , Lucy M. Cheatle , Brian Cleland
IPC分类号： A61N1/05 , A61N1/362 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/056 , A61N1/3622 , A61N1/3918
摘要： An implantable device and method for treating cardiac arrhythmias in a patient's heart are disclosed. A source of antitachycardia pacing therapy and an electrode system including at least three electrodes for delivering the antitachycardia pacing therapy to the heart are provided. Circuitry and software for detecting a tachycardia having a site of focus in the heart and for determining the relative distances of the electrodes from the focus site are also provided. The three or more electrodes are connected to the source of antitachycardia pacing therapy based on the relative distances determined and in such a manner as to create a virtual electrode at the focus site upon delivery of the therapy to the heart.

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