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1. 发明授权

US07632685B2 Method of predicting the onset of sepsis in SIRS-positive individuals using mass spectrometry 有权
标题翻译：使用质谱法预测SIRS阳性个体败血症发病的方法
公开(公告)号：US07632685B2
公开(公告)日：2009-12-15
申请号：US11647689
申请日：2006-12-28
申请人： Richard M. Ivey , Thomas M. Gentle, Jr. , Richard L. Moore , Michael L. Towns , Nicholas Bachur, Jr. , Robert W. Rosenstein , James G. Nadeau , Paul E. Goldenbaum , Song Shi , Donald Copertino , James Garrett , Gregory Tice , Gary Siuzdak , Elizabeth Want , Zhouxin Shen
发明人： Richard M. Ivey , Thomas M. Gentle, Jr. , Richard L. Moore , Michael L. Towns , Nicholas Bachur, Jr. , Robert W. Rosenstein , James G. Nadeau , Paul E. Goldenbaum , Song Shi , Donald Copertino , James Garrett , Gregory Tice , Gary Siuzdak , Elizabeth Want , Zhouxin Shen
IPC分类号： G01N24/00
CPC分类号： G01N33/6848 , C12Q1/6883 , G01N33/6803 , G01N2800/26 , Y10T436/24
摘要： Mass spectrometry techniques for determining the status of sepsis in an individual are provided. A biomarker profile resolved from a biological sample, taken from the individual, using a mass spectrometry technique is compared to a reference biomarker profile. A single such comparison classifies the individual as belonging to or not belonging to a reference population. The individual's biomarker profile and the reference biomarker profile comprise a plurality of ions each having a mass-to-charge ratio of about 100 Daltons to about 1000 Daltons. The plurality of ions can be detected by electrospray ionization mass spectrometry in positive mode. The comparison uses a decision rule, such as a classification tree, that determines the status of sepsis in the individual without requiring knowledge of the identity of the biomarkers in the biomarker profile from the individual and without requiring knowledge of the identity of the biomarkers in the reference biomarker profile.
摘要翻译：提供了用于确定个体败血症状态的质谱技术。将使用质谱技术从个体获取的生物样品分解的生物标志物谱与参考生物标志物谱进行比较。单个这样的比较将个体归类为属于或不属于参考群体。个体的生物标志物概况和参考生物标志物谱包括多个离子，其各自具有约100道尔顿至约1000道尔顿的质荷比。可以通过电喷雾电离质谱法以正模式检测多个离子。比较使用决定规则，例如分类树，其确定个体中败血症的状态，而不需要知道来自个体的生物标志物概况中的生物标志物的身份，并且不需要知道生物标志物的身份参考生物标志物概况。

2. 发明授权

US07645613B2 Mass spectrometry techniques for determining the status of sepsis in an individual 有权
标题翻译：用于确定个体败血症状态的质谱技术
公开(公告)号：US07645613B2
公开(公告)日：2010-01-12
申请号：US11647688
申请日：2006-12-28
申请人： Richard M. Ivey , Thomas M. Gentle, Jr. , Richard L. Moore , Michael L. Towns , Gary Siuzdak , Elizabeth J. Want , Zhouxin Shen , Nicholas Bachur, Jr. , Robert W. Rosenstein , James G. Nadeau , Paul E. Goldenbaum , Song Shi , Donald Copertino , James Garrett , Gregory Tice
发明人： Richard M. Ivey , Thomas M. Gentle, Jr. , Richard L. Moore , Michael L. Towns , Gary Siuzdak , Elizabeth J. Want , Zhouxin Shen , Nicholas Bachur, Jr. , Robert W. Rosenstein , James G. Nadeau , Paul E. Goldenbaum , Song Shi , Donald Copertino , James Garrett , Gregory Tice
IPC分类号： G01N24/00
CPC分类号： G01N33/6848 , C12Q1/6883 , G01N33/6803 , G01N2800/26 , Y10T436/24
摘要： Mass spectrometry techniques for determining the status of sepsis in an individual are provided. A biomarker profile resolved from a biological sample, taken from the individual, using a mass spectrometry technique is compared to a reference biomarker profile. A single such comparison classifies the individual as belonging to or not belonging to a reference population. The individual's biomarker profile and the reference biomarker profile comprise a plurality of ions each having a mass-to-charge ratio of about 100 Daltons to about 1000 Daltons. The plurality of ions can be detected by electrospray ionization mass spectrometry in positive mode. The comparison uses a decision rule, such as a classification tree, that determines the status of sepsis in the individual without requiring knowledge of the identity of the biomarkers in the biomarker profile from the individual and without requiring knowledge of the identity of the biomarkers in the reference biomarker profile.
摘要翻译：提供了用于确定个体败血症状态的质谱技术。将使用质谱技术从个体获取的生物样品分解的生物标志物谱与参考生物标志物谱进行比较。单个这样的比较将个体归类为属于或不属于参考群体。个体的生物标志物概况和参考生物标志物谱包括多个离子，其各自具有约100道尔顿至约1000道尔顿的质荷比。可以通过电喷雾电离质谱法以正模式检测多个离子。比较使用决定规则，例如分类树，其确定个体中败血症的状态，而不需要知道来自个体的生物标志物概况中的生物标志物的身份，并且不需要知道生物标志物的身份参考生物标志物概况。

3. 发明申请

US20070184512A1 Mass spectrometry techniques for determining the status of sepsis in an individual 有权
标题翻译：用于确定个体败血症状态的质谱技术
公开(公告)号：US20070184512A1
公开(公告)日：2007-08-09
申请号：US11647688
申请日：2006-12-28
申请人： Richard M. Ivey , Thomas M. Gentle , Richard L. Moore , Michael L. Towns , Nicholas Bachur , Robert W. Rosenstein , James G. Nadeau , Paul E. Goldenbaum , Song Shi , Donald Copertino , James Garrett , Gregory Tice , Gary Siuzdak , Elizabeth Want , Zhouxin Shen
发明人： Richard M. Ivey , Thomas M. Gentle , Richard L. Moore , Michael L. Towns , Nicholas Bachur , Robert W. Rosenstein , James G. Nadeau , Paul E. Goldenbaum , Song Shi , Donald Copertino , James Garrett , Gregory Tice , Gary Siuzdak , Elizabeth Want , Zhouxin Shen
IPC分类号： C12Q1/37 , G06F19/00
CPC分类号： G01N33/6848 , C12Q1/6883 , G01N33/6803 , G01N2800/26 , Y10T436/24
摘要： Mass spectrometry techniques for determining the status of sepsis in an individual are provided. A biomarker profile resolved from a biological sample, taken from the individual, using a mass spectrometry technique is compared to a reference biomarker profile. A single such comparison classifies the individual as belonging to or not belonging to a reference population. The individual's biomarker profile and the reference biomarker profile comprise a plurality of ions each having a mass-to-charge ratio of about 100 Daltons to about 1000 Daltons. The plurality of ions can be detected by electrospray ionization mass spectrometry in positive mode. The comparison uses a decision rule, such as a classification tree, that determines the status of sepsis in the individual without requiring knowledge of the identity of the biomarkers in the biomarker profile from the individual and without requiring knowledge of the identity of the biomarkers in the reference biomarker profile.
摘要翻译：提供了用于确定个体败血症状态的质谱技术。将使用质谱技术从个体获取的生物样品分解的生物标志物谱与参考生物标志物谱进行比较。单个这样的比较将个体归类为属于或不属于参考群体。个体的生物标志物概况和参考生物标志物谱包括多个离子，其各自具有约100道尔顿至约1000道尔顿的质荷比。可以通过电喷雾电离质谱法以正模式检测多个离子。比较使用决定规则，例如分类树，其确定个体中败血症的状态，而不需要知道来自个体的生物标志物概况中的生物标志物的身份，并且不需要知道生物标志物的身份参考生物标志物概况。

4. 发明授权

US07645573B2 Diagnosis of sepsis or SIRS using biomarker profiles 有权
标题翻译：使用生物标志物图谱诊断败血症或SIRS
公开(公告)号：US07645573B2
公开(公告)日：2010-01-12
申请号：US10704666
申请日：2003-11-12
申请人： Richard M. Ivey , Thomas M. Gentle, Jr. , Richard L. Moore , Michael L. Towns , Nicholas Bachur, Jr. , Robert W. Rosenstein , Paul E. Goldenbaum , Song Shi , Donald Copertino , James Garrett , Gregory Tice
发明人： Richard M. Ivey , Thomas M. Gentle, Jr. , Richard L. Moore , Michael L. Towns , Nicholas Bachur, Jr. , Robert W. Rosenstein , Paul E. Goldenbaum , Song Shi , Donald Copertino , James Garrett , Gregory Tice
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q1/6837 , C12Q1/686 , C12Q2600/158 , G01N33/6893 , G01N2800/26
摘要： The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished using a molecular diagnostics approach, involving comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population who develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated at the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms. Further, because the biomarker expression is assayed for its profile, identification of the particular biomarkers is unnecessary. The comparison of an individual's biomarker profile to biomarker profiles of appropriate reference populations likewise can be used to diagnose SIRS in the individual.
摘要翻译：败血症的早期预测或诊断有利地允许在疾病快速进展到初始阶段之前的临床干预到更严重的阶段，例如与高死亡率相关的更严重的败血症或败血性休克。使用分子诊断方法实现早期预测或诊断，包括将个体的生物标志物表达谱与从一个或多个对照或参考群体获得的概况进行比较，其可包括发生败血症的群体。识别个体生物标志物特征的特征是脓毒症发作的特征，允许临床医生在单个时间点从个体分离的体液诊断败血症的发作。因此，避免在一段时间内监测患者的必要性，有利地允许在严重症状发作之前进行临床干预。此外，因为生物标志物的表达被测定其特征，所以特定生物标志物的鉴定是不必要的。个体的生物标记谱与适当参考群的生物标志物概况的比较同样可以用于诊断个体中的SIRS。

5. 发明申请

US20080138832A1 Diagnosis of sepsis or SIRS using biomarker profiles 审中-公开
标题翻译：使用生物标志物图谱诊断败血症或SIRS
公开(公告)号：US20080138832A1
公开(公告)日：2008-06-12
申请号：US11904282
申请日：2007-09-25
申请人： Richard M. Ivey , Thomas M. Gentle , Richard L. Moore , Michael L. Towns , Nicholas Bachur , Robert W. Rosenstein , James G. Nadeau , Paul E. Goldenbaum , Song Shi , Donald Copertino , James Garrett , Gregory Tice
发明人： Richard M. Ivey , Thomas M. Gentle , Richard L. Moore , Michael L. Towns , Nicholas Bachur , Robert W. Rosenstein , James G. Nadeau , Paul E. Goldenbaum , Song Shi , Donald Copertino , James Garrett , Gregory Tice
IPC分类号： G01N33/53 , C12Q1/02 , G01N33/00
CPC分类号： G01N33/6803 , C12Q1/6837 , C12Q1/686 , C12Q1/6883 , C12Q2600/158 , G01N2800/26
摘要： The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished by comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated from the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis. Further, because the biomarker expression is assayed for its profile, identification of the particular biomarkers is unnecessary. The comparison of an individual's biomarker profile to biomarker profiles of appropriate reference populations likewise can be used to diagnose SIRS in the individual.
摘要翻译：败血症的早期预测或诊断有利地允许在疾病快速进展到初始阶段之前的临床干预到更严重的阶段，例如与高死亡率相关的更严重的败血症或败血性休克。通过将个体的生物标志物表达谱与从一个或多个对照或参考群体获得的概况进行比较来实现早期预测或诊断，其可包括发生败血症的群体。识别个体生物标志物特征的特征是脓毒症发作的特征允许临床医生在单个时间点诊断从个体分离的体液的败血症发作。因此，避免在一段时间内监测患者的必要性，有利地允许在脓毒症严重症状发作之前进行临床干预。此外，因为生物标志物的表达被测定其特征，所以特定生物标志物的鉴定是不必要的。个体的生物标记谱与适当参考群的生物标志物概况的比较同样可以用于诊断个体中的SIRS。

6. 发明申请

US20140302533A1 ADVANCED DETECTION OF SEPSIS 有权
标题翻译：高级检测SEPSIS
公开(公告)号：US20140302533A1
公开(公告)日：2014-10-09
申请号：US14203367
申请日：2014-03-10
申请人： Song Shi , Richard L. Moore , James Garrett
发明人： Song Shi , Richard L. Moore , James Garrett
IPC分类号： G01N33/74
CPC分类号： C12Q1/6881 , C12Q2600/158 , G01N33/74 , G01N33/92 , G01N2333/90209 , G01N2333/91051 , G01N2800/26
摘要： The present invention relates to methods, monitors and systems, useful, for example, for advanced detection of sepsis in a subject.
摘要翻译：本发明涉及可用于例如用于对象中败血症的高级检测的方法，监测器和系统。

7. 发明授权

US08669113B2 Advanced detection of sepsis 有权
标题翻译：脓毒症的先进检测
公开(公告)号：US08669113B2
公开(公告)日：2014-03-11
申请号：US12935727
申请日：2009-04-02
申请人： Song Shi , Richard L. Moore , James Garrett
发明人： Song Shi , Richard L. Moore , James Garrett
IPC分类号： G01N33/00
CPC分类号： C12Q1/6881 , C12Q2600/158 , G01N33/74 , G01N33/92 , G01N2333/90209 , G01N2333/91051 , G01N2800/26
摘要： The present invention relates to methods, monitors and systems measuring lysophosphatidylcholine, its derivatives and/or procalcitonin as well as at least one clinical marker (e.g. temperature or respiration rate) and/or at least one biomarker for the early detection of sepsis in a subject.
摘要翻译：本发明涉及测量溶血卵磷脂，其衍生物和/或降钙素原的方法，监测器和系统以及至少一种临床标志物（例如温度或呼吸速率）和/或至少一种用于早期检测受试者败血症的生物标志物。

8. 发明申请

US20110118569A1 Advanced Detection of Sepsis 有权
标题翻译：脓毒症高级检测
公开(公告)号：US20110118569A1
公开(公告)日：2011-05-19
申请号：US12935727
申请日：2009-04-02
申请人： Song Shi , Richard L. Moore , James Garrett
发明人： Song Shi , Richard L. Moore , James Garrett
IPC分类号： G01N33/53 , C12Q1/02 , C12Q1/68 , C12M1/34 , A61B5/00 , G01N27/447
CPC分类号： C12Q1/6881 , C12Q2600/158 , G01N33/74 , G01N33/92 , G01N2333/90209 , G01N2333/91051 , G01N2800/26
摘要： The present invention relates to methods, monitors and systems measuring lysophosphatidylcholine, its derivatives and/or procalcitonin as well as at least one clinical marker (e.g. temperature or respiration rate) and/or at least one biomarker for the early detection of sepsis in a subject.
摘要翻译：本发明涉及测量溶血卵磷脂，其衍生物和/或降钙素原的方法，监测器和系统以及至少一种临床标志物（例如温度或呼吸速率）和/或至少一种用于早期检测受试者败血症的生物标志物。

9. 发明申请

US20090104605A1 DIAGNOSIS OF SEPSIS 审中-公开
标题翻译： SEPSIS诊断
公开(公告)号：US20090104605A1
公开(公告)日：2009-04-23
申请号：US12098398
申请日：2008-04-04
申请人： Gary Siuzdak , William A. Nussbaumer , Craig C. Whiteford , Richard L. Moore
发明人： Gary Siuzdak , William A. Nussbaumer , Craig C. Whiteford , Richard L. Moore
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/567 , G06G7/60
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2800/26 , G16B25/00 , Y02A90/26
摘要： Methods and apparatus for predicting the development of sepsis in a subject at risk for developing sepsis are provided. Features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods and apparatus for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. A plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods and apparatus for diagnosing sepsis in a subject are provided. A plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.
摘要翻译：提供了用于预测罹患败血症风险的受试者脓毒症发展的方法和装置。评估受试者生物标志物特征。如果这些特征满足特定的值集合，主体可能会发展为败血症。提供了一种用于预测脓毒症发展阶段罹患脓毒症发展阶段的方法和装置。评估对象的生物标志物轮廓中的多个特征。如果这些特征值满足特定的值集合，受试者可能具有脓毒症的阶段。提供了用于诊断受试者败血症的方法和装置。评估对象的生物标志物轮廓中的多个特征。当多个特征满足特定值集合时，受试者可能发展为败血症。

10. 发明授权

US6038813A Method and apparatus for controlling root growth 失效
标题翻译：控制根生长的方法和装置
公开(公告)号：US6038813A
公开(公告)日：2000-03-21
申请号：US803084
申请日：1997-02-20
申请人： Richard L. Moore , Michael G. Robson , Warren E. Lockeby, Jr. , Billy E. Kaylor
发明人： Richard L. Moore , Michael G. Robson , Warren E. Lockeby, Jr. , Billy E. Kaylor
IPC分类号： A01G9/10 , A01G23/04
CPC分类号： A01G9/10 , Y10S47/901
摘要： A first outer container is formed with a side wall and a bottom wall. The bottom of the first container has a support structure or raised area to define a water reservoir in the bottom of the container. An overflow drain is provided in the container and preferably in the raised area to limit the depth of the water reservoir. A second inner container including a drain hole and having a live plant is placed in the first container at or above the water level in the first container. The water in the first container has a depth to inhibit excessive root growth from the drain hole of the second container. Roots which grow through the drain of the second inner container contact the standing water in the reservoir and die and rot at the point where the roots contact the water to limit growth in the first container. The water in the first container is particularly effective in controlling root growth from the inner container through the drain holes in the first outer container.
摘要翻译：第一外容器形成有侧壁和底壁。第一容器的底部具有支撑结构或凸起区域，以在容器底部限定一个储水器。在容器中优选地在升高的区域中设置溢流排水口以限制储水器的深度。包括排水孔并具有活植物的第二内容器在第一容器中的水位处或上方放置在第一容器中。第一容器中的水具有抑制从第二容器的排水孔过度生根的深度。通过第二内部容器的排水沟生长的根接触储存器中的直立水，并在根接触水的位置处死亡并腐烂，以限制第一容器中的生长。第一容器中的水特别有效地控制从内容器通过第一外容器中的排放孔的根生长。

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