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1. 发明申请

US20100099993A1 METHODS AND APPARATUS FOR DETERMINING CARDIAC OUTPUT AND LEFT ATRIAL PRESSURE 有权
标题翻译：用于确定心脏输出和左心室压力的方法和装置
公开(公告)号：US20100099993A1
公开(公告)日：2010-04-22
申请号：US12646362
申请日：2009-12-23
申请人： Richard J. COHEN , Ramakrishna Mukkamala
发明人： Richard J. COHEN , Ramakrishna Mukkamala
IPC分类号： A61B5/021 , A61B5/02
CPC分类号： A61B5/029 , A61B5/02028 , A61B5/02116 , A61B5/0215 , A61B5/7239 , A61B2560/0223
摘要： Method and apparatus are introduced for determining proportional cardiac output (CO), absolute left atrial pressure (LAP), and/or other important hemodynamic variables from a contour of a circulatory pressure waveform or related signal. Certain embodiments of the invention provided herein include the mathematical analysis of a pulmonary artery pressure (PAP) waveform or a right ventricular pressure (RVP) waveform in order to determine beat-to-beat or time-averaged proportional CO, proportional pulmonary vascular resistance (PVR), and/or LAP. The invention permits continuous and automatic monitoring of critical hemodynamic variables with a level of invasiveness suitable for routine clinical application. The invention may be utilized, for example, to continuously monitor critically ill patients with pulmonary artery catheters installed and chronically monitor heart failure patients instrumented with implanted devices for measuring RVP.
摘要翻译：引入方法和装置，用于根据循环压力波形或相关信号的轮廓确定比例心输出量（CO），绝对左心房压力（LAP）和/或其他重要血液动力学变量。本文提供的本发明的某些实施方案包括肺动脉压力（PAP）波形或右心室压力（RVP）波形的数学分析，以便确定搏动搏动或时间平均比例CO，比例肺血管阻力（ PVR）和/或LAP。本发明允许以适合常规临床应用的侵入水平连续和自动监测关键血液动力学变量。本发明可以用于例如连续监测安装的肺动脉导管的危重病人，并长期监测用植入装置测量RVP的心力衰竭患者。

2. 发明授权

US07815578B2 Methods and apparatus for determining cardiac output 有权
标题翻译：用于确定心输出量的方法和装置
公开(公告)号：US07815578B2
公开(公告)日：2010-10-19
申请号：US10667956
申请日：2003-09-22
申请人： Richard J. Cohen , Ramakrishna Mukkamala , Derin A. Sherman
发明人： Richard J. Cohen , Ramakrishna Mukkamala , Derin A. Sherman
IPC分类号： A61B5/02
CPC分类号： A61B5/02007 , A61B5/02255 , A61B5/029 , A61B5/0456 , A61B5/726
摘要： The present invention provides methods and apparatus for determining a dynamical property of the systemic or pulmonary arterial tree using long time scale information, i.e., information obtained from measurements over time scales greater than a single cardiac cycle. In one aspect, the invention provides a method and apparatus for monitoring cardiac output (CO) from a single blood pressure signal measurement obtained at any site in the systemic or pulmonary arterial tree or from any related measurement including, for example, fingertip photoplethysmography.According to the method the time constant of the arterial tree, defined to be the product of the total peripheral resistance (TPR) and the nearly constant arterial compliance, is determined by analyzing the long time scale variations (greater than a single cardiac cycle) in any of these blood pressure signals. Then, according to Ohm's law, a value proportional to CO may be determined from the ratio of the blood pressure signal to the estimated time constant. The proportional CO values derived from this method may be calibrated to absolute CO, if desired, with a single, absolute measure of CO (e.g., thermodilution). The present invention may be applied to invasive radial arterial blood pressure or pulmonary arterial blood pressure signals which are routinely measured in intensive care units and surgical suites or to noninvasively measured peripheral arterial blood pressure signals or related noninvasively measured signals in order to facilitate the clinical monitoring of CO as well as TPR.
摘要翻译：本发明提供了使用长时间尺度信息（即从大于单个心动周期的时间尺度的测量获得的信息）来确定全身或肺动脉树的动力特性的方法和装置。一方面，本发明提供一种用于从在全身或肺动脉树中的任何位置处获得的单个血压信号测量值或任何相关测量（包括例如指尖光体积描记术）来监测心输出量（CO）的方法和装置。根据该方法，通过分析长时间尺度变化（大于单个心动周期）来确定被定义为总外周阻力（TPR）和几乎恒定的动脉顺应性的乘积的动脉树的时间常数任何这些血压信号。然后，根据欧姆定律，可以根据血压信号与估计的时间常数的比率确定与CO成比例的值。如果需要，从该方法得到的比例CO值可以通过CO的单一绝对测量（例如，热稀释）校准为绝对CO。本发明可以应用于在重症监护病房和手术套件中常规测量的侵入性桡动脉血压或肺动脉血压信号，或应用于非侵入性测量的外周动脉血压信号或相关非侵入性测量信号，以便于临床监测的CO以及TPR。

3. 发明授权

US07666144B2 Methods and apparatus for determining cardiac output and left atrial pressure 有权
标题翻译：用于测定心输出量和左心房压力的方法和装置
公开(公告)号：US07666144B2
公开(公告)日：2010-02-23
申请号：US11358379
申请日：2006-02-21
申请人： Richard J. Cohen , Ramakrishna Mukkamala
发明人： Richard J. Cohen , Ramakrishna Mukkamala
IPC分类号： A61B5/02
CPC分类号： A61B5/029 , A61B5/02028 , A61B5/02116 , A61B5/0215 , A61B5/7239 , A61B2560/0223
摘要： Method and apparatus are introduced for determining proportional cardiac output (CO), absolute left atrial pressure (LAP), and/or other important hemodynamic variables from a contour of a circulatory pressure waveform or related signal. Certain embodiments of the invention provided herein include the mathematical analysis of a pulmonary artery pressure (PAP) waveform or a right ventricular pressure (RVP) waveform in order to determine beat-to-beat or time-averaged proportional CO, proportional pulmonary vascular resistance (PVR), and/or LAP. The invention permits continuous and automatic monitoring of critical hemodynamic variables with a level of invasiveness suitable for routine clinical application. The invention may be utilized, for example, to continuously monitor critically ill patients with pulmonary artery catheters installed and chronically monitor heart failure patients instrumented with implanted devices for measuring RVP.
摘要翻译：引入方法和装置，用于根据循环压力波形或相关信号的轮廓确定比例心输出量（CO），绝对左心房压力（LAP）和/或其他重要血液动力学变量。本文提供的本发明的某些实施方案包括肺动脉压力（PAP）波形或右心室压力（RVP）波形的数学分析，以便确定搏动搏动或时间平均比例CO，比例肺血管阻力（ PVR）和/或LAP。本发明允许以适合常规临床应用的侵入水平连续和自动监测关键血液动力学变量。本发明可以用于例如连续监测安装的肺动脉导管的危重病人，并长期监测用植入装置测量RVP的心力衰竭患者。

4. 发明授权

US09289133B2 Methods and apparatus for determining cardiac output 有权
标题翻译：用于确定心输出量的方法和装置
公开(公告)号：US09289133B2
公开(公告)日：2016-03-22
申请号：US12903915
申请日：2010-10-13
申请人： Richard J. Cohen , Ramakrishna Mukkamala , Derin A. Sherman
发明人： Richard J. Cohen , Ramakrishna Mukkamala , Derin A. Sherman
IPC分类号： A61B5/021 , A61B5/02 , A61B5/0402 , A61B5/029 , A61B5/0225 , A61B5/0456 , A61B5/00
CPC分类号： A61B5/02007 , A61B5/02255 , A61B5/029 , A61B5/0456 , A61B5/726
摘要： The present invention provides methods and apparatus for determining a dynamical property of the systemic or pulmonary arterial tree using long time scale information, i.e., information obtained from measurements over time scales greater than a single cardiac cycle. In one aspect, the invention provides a method and apparatus for monitoring cardiac output (CO) from a single blood pressure signal measurement obtained at any site in the systemic or pulmonary arterial tree or from any related measurement including, for example, fingertip photoplethysmography.According to the method the time constant of the arterial tree, defined to be the product of the total peripheral resistance (TPR) and the nearly constant arterial compliance, is determined by analyzing the long time scale variations (greater than a single cardiac cycle) in any of these blood pressure signals. Then, according to Ohm's law, a value proportional to CO may be determined from the ratio of the blood pressure signal to the estimated time constant. The proportional CO values derived from this method may be calibrated to absolute CO, if desired, with a single, absolute measure of CO (e.g., thermodilution). The present invention may be applied to invasive radial arterial blood pressure or pulmonary arterial blood pressure signals which are routinely measured in intensive care units and surgical suites or to noninvasively measured peripheral arterial blood pressure signals or related noninvasively measured signals in order to facilitate the clinical monitoring of CO as well as TPR.
摘要翻译：本发明提供了使用长时间尺度信息（即从大于单个心动周期的时间尺度的测量获得的信息）来确定全身或肺动脉树的动力特性的方法和装置。一方面，本发明提供一种用于从在全身或肺动脉树中的任何位置处获得的单个血压信号测量值或任何相关测量（包括例如指尖光体积描记术）来监测心输出量（CO）的方法和装置。根据该方法，通过分析长时间尺度变化（大于单个心动周期）来确定被定义为总外周阻力（TPR）和几乎恒定的动脉顺应性的乘积的动脉树的时间常数任何这些血压信号。然后，根据欧姆定律，可以根据血压信号与估计的时间常数的比率确定与CO成比例的值。如果需要，从该方法得到的比例CO值可以通过CO的单一绝对测量（例如，热稀释）校准为绝对CO。本发明可以应用于在重症监护病房和手术套件中常规测量的侵入性桡动脉血压或肺动脉血压信号，或应用于非侵入性测量的外周动脉血压信号或相关非侵入性测量信号，以便于临床监测的CO以及TPR。

5. 发明申请

US20070197921A1 Methods and apparatus for determining cardiac output and left atrial pressure 有权
标题翻译：用于测定心输出量和左心房压力的方法和装置
公开(公告)号：US20070197921A1
公开(公告)日：2007-08-23
申请号：US11358379
申请日：2006-02-21
申请人： Richard J. Cohen , Ramakrishna Mukkamala
发明人： Richard J. Cohen , Ramakrishna Mukkamala
IPC分类号： A61B5/02
CPC分类号： A61B5/029 , A61B5/02028 , A61B5/02116 , A61B5/0215 , A61B5/7239 , A61B2560/0223
摘要： Method and apparatus are introduced for determining proportional cardiac output (CO), absolute left atrial pressure (LAP), and/or other important hemodynamic variables from a contour of a circulatory pressure waveform or related signal. Certain embodiments of the invention provided herein include the mathematical analysis of a pulmonary artery pressure (PAP) waveform or a right ventricular pressure (RVP) waveform in order to determine beat-to-beat or time-averaged proportional CO, proportional pulmonary vascular resistance (PVR), and/or LAP. The invention permits continuous and automatic monitoring of critical hemodynamic variables with a level of invasiveness suitable for routine clinical application. The invention may be utilized, for example, to continuously monitor critically ill patients with pulmonary artery catheters installed and chronically monitor heart failure patients instrumented with implanted devices for measuring RVP.
摘要翻译：引入方法和装置，用于根据循环压力波形或相关信号的轮廓确定比例心输出量（CO），绝对左心房压力（LAP）和/或其他重要血液动力学变量。本文提供的本发明的某些实施方案包括肺动脉压力（PAP）波形或右心室压力（RVP）波形的数学分析，以便确定搏动搏动或时间平均比例CO，比例肺血管阻力（ PVR）和/或LAP。本发明允许以适合常规临床应用的侵入水平连续和自动监测关键血液动力学变量。本发明可以用于例如连续监测安装的肺动脉导管的危重病人，并长期监测用植入装置测量RVP的心力衰竭患者。

6. 发明申请

US20110034813A1 METHODS AND APPARATUS FOR DETERMINING CARDIAC OUTPUT 有权
标题翻译：用于测定心脏输出量的方法和装置
公开(公告)号：US20110034813A1
公开(公告)日：2011-02-10
申请号：US12903915
申请日：2010-10-13
申请人： Richard J. Cohen , Ramakrishna Mukkamala , Derin A. Sherman
发明人： Richard J. Cohen , Ramakrishna Mukkamala , Derin A. Sherman
IPC分类号： A61B5/021 , A61B5/0402 , A61B5/02
CPC分类号： A61B5/02007 , A61B5/02255 , A61B5/029 , A61B5/0456 , A61B5/726
摘要： The present invention provides methods and apparatus for determining a dynamical property of the systemic or pulmonary arterial tree using long time scale information, i.e., information obtained from measurements over time scales greater than a single cardiac cycle. In one aspect, the invention provides a method and apparatus for monitoring cardiac output (CO) from a single blood pressure signal measurement obtained at any site in the systemic or pulmonary arterial tree or from any related measurement including, for example, fingertip photoplethysmography.According to the method the time constant of the arterial tree, defined to be the product of the total peripheral resistance (TPR) and the nearly constant arterial compliance, is determined by analyzing the long time scale variations (greater than a single cardiac cycle) in any of these blood pressure signals. Then, according to Ohm's law, a value proportional to CO may be determined from the ratio of the blood pressure signal to the estimated time constant. The proportional CO values derived from this method may be calibrated to absolute CO, if desired, with a single, absolute measure of CO (e.g., thermodilution). The present invention may be applied to invasive radial arterial blood pressure or pulmonary arterial blood pressure signals which are routinely measured in intensive care units and surgical suites or to noninvasively measured peripheral arterial blood pressure signals or related noninvasively measured signals in order to facilitate the clinical monitoring of CO as well as TPR.
摘要翻译：本发明提供了使用长时间尺度信息（即从大于单个心动周期的时间尺度的测量获得的信息）来确定全身或肺动脉树的动力特性的方法和装置。一方面，本发明提供一种用于从在全身或肺动脉树中的任何位置处获得的单个血压信号测量值或任何相关测量（包括例如指尖光体积描记术）来监测心输出量（CO）的方法和装置。根据该方法，通过分析长时间尺度变化（大于单个心动周期）来确定被定义为总外周阻力（TPR）和几乎恒定的动脉顺应性的乘积的动脉树的时间常数任何这些血压信号。然后，根据欧姆定律，可以根据血压信号与估计的时间常数的比率确定与CO成比例的值。如果需要，从该方法得到的比例CO值可以通过CO的单一绝对测量（例如，热稀释）校准为绝对CO。本发明可以应用于在重症监护病房和手术套件中常规测量的侵入性桡动脉血压或肺动脉血压信号，或应用于非侵入性测量的外周动脉血压信号或相关非侵入性测量信号，以便于临床监测的CO以及TPR。

7. 发明申请

US20090131804A1 Method And Apparatus For Determining Central Aortic Pressure Waveform 有权
标题翻译：用于确定中央主动脉压波形的方法和装置
公开(公告)号：US20090131804A1
公开(公告)日：2009-05-21
申请号：US12225141
申请日：2007-03-15
申请人： Ramakrishna Mukkamala , Gokul Swamy , Qi Ling , Tongtong Li
发明人： Ramakrishna Mukkamala , Gokul Swamy , Qi Ling , Tongtong Li
IPC分类号： A61B5/021
CPC分类号： A61B5/7278 , A61B5/021 , A61B5/02108 , A61B5/7225 , A61B5/7246 , A61B5/7257 , A61B5/7264
摘要： A method is provided for determining a central aortic pressure waveform. The method includes: measuring two or more peripheral artery pressure waveforms; analyzing the signals so as to extract common features in the measured waveforms; and determining an absolute central aortic pressure waveform based on the common features.
摘要翻译：提供了一种用于确定中心主动脉压力波形的方法。该方法包括：测量两个或更多个外周动脉压力波形; 分析信号以提取测量波形中的共同特征; 并基于共同特征确定绝对中心主动脉压力波形。

8. 发明授权

US10349838B2 Methods and apparatus for determining arterial pulse wave velocity 有权
公开(公告)号：US10349838B2
公开(公告)日：2019-07-16
申请号：US13816427
申请日：2011-08-12
申请人： Ramakrishna Mukkamala , Da Xu , Guanqun Zhang , Mingwu Gao , Mohsen Moslehpour
发明人： Ramakrishna Mukkamala , Da Xu , Guanqun Zhang , Mingwu Gao , Mohsen Moslehpour
IPC分类号： A61B5/021 , A61B5/0285 , A61B5/029 , A61B5/00
摘要： Methods are presented for determining pulse transit time (PTT) and/or pulse wave velocity (PWV) of a subject by application of parametric system identification to proximal and distal arterial waveforms. The two waveforms are measured from the subject. A system is defined that relates the proximal arterial waveform to the distal arterial waveform (or vice versa) in terms of the unknown parameters of a parametric mathematical model. The model parameters are determined from the measured waveforms using system identification. PTT between the proximal and distal arterial sites is then determined from the system model. PWV may also be determined by dividing the distance between measurement sites (D) by PTT.

9. 发明申请

US20090112113A1 METHOD AND APPARATUS FOR DETERMINING EJECTION FRACTION 有权
标题翻译：用于确定喷射分级的方法和装置
公开(公告)号：US20090112113A1
公开(公告)日：2009-04-30
申请号：US12225133
申请日：2007-03-15
申请人： Ramakrishna Mukkamala
发明人： Ramakrishna Mukkamala
IPC分类号： A61B5/029
CPC分类号： A61B5/029 , A61B5/021 , A61B5/02108
摘要： A method is provided for determining ejection fraction. The method includes: measuring a physiologic signal indicative of blood pressure; analyzing the physiologic signal at more than one time instance so as to extract information present in its temporal variations; and determining ejection fraction based in part on the extracted information
摘要翻译：提供了一种用于确定射血分数的方法。该方法包括：测量指示血压的生理信号; 在多于一个时间的情况下分析生理信号，以提取其时间变化中存在的信息; 并且部分地基于所提取的信息确定射血分数

10. 发明授权

US10251566B2 Methods and apparatus for determining a central aortic pressure waveform from a peripheral artery pressure waveform 有权
公开(公告)号：US10251566B2
公开(公告)日：2019-04-09
申请号：US12993544
申请日：2009-05-27
申请人： Ramakrishna Mukkamala , Gokul Swamy , Nicholas Bari Olivier
发明人： Ramakrishna Mukkamala , Gokul Swamy , Nicholas Bari Olivier
IPC分类号： A61B5/021 , A61B5/029
摘要： A method is provided for determining a central aortic pressure (AP) wave-form for a subject. The method includes measuring a peripheral artery pressure (PAP) waveform from the subject, employing a distributed model to define a pressure-to-pressure transfer function relating PAP to AP and a pressure-to-flow transfer function relating PAP to a central arterial flow in terms of the same unknown parameters, estimating the unknown parameters by finding the pressure-to-flow transfer function, which when applied to the measured PAP waveform, minimizes the magnitude of the central arterial flow waveform during diastole, and applying the pressure-to-pressure transfer function with the estimated parameters to determine an AP waveform for the subject.

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