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1. 发明授权

US09591984B2 Alternans and pharmacological agents 有权
标题翻译：替代品和药理剂
公开(公告)号：US09591984B2
公开(公告)日：2017-03-14
申请号：US12630718
申请日：2009-12-03
申请人： Richard J. Cohen , Ali Haghighi-Mood
发明人： Richard J. Cohen , Ali Haghighi-Mood
IPC分类号： A61B5/0452 , A61B5/00
CPC分类号： A61B5/0452 , A61B5/7203
摘要： First cardiac signal data generated from measured heart beats of a subject is received. Characteristics of alternans occurring in the received first cardiac signal data are determined. Second cardiac signal data generated from measured heart beats of the subject after a change relating to an administration of a pharmacological agent is received. Characteristics of alternans occurring in the received second cardiac signal data are determined. The characteristics of alternans occurring in the received first cardiac signal data are compared with the characteristics of alternans occurring in the received second cardiac signal data.
摘要翻译：接收从受检者的测量心跳产生的第一心脏信号数据。确定在接收到的第一心脏信号数据中发生的交替发生的特征。在接受与药物剂的施用有关的变化之后，从被测物的测量心跳产生的第二心脏信号数据被接收。确定在所接收的第二心脏信号数据中发生的交替发生的特征。在接收的第一心脏信号数据中发生的交替发生的特征与在所接收的第二心脏信号数据中发生的交替发生的特征进行比较。

2. 发明申请

US20110034813A1 METHODS AND APPARATUS FOR DETERMINING CARDIAC OUTPUT 有权
标题翻译：用于测定心脏输出量的方法和装置
公开(公告)号：US20110034813A1
公开(公告)日：2011-02-10
申请号：US12903915
申请日：2010-10-13
申请人： Richard J. Cohen , Ramakrishna Mukkamala , Derin A. Sherman
发明人： Richard J. Cohen , Ramakrishna Mukkamala , Derin A. Sherman
IPC分类号： A61B5/021 , A61B5/0402 , A61B5/02
CPC分类号： A61B5/02007 , A61B5/02255 , A61B5/029 , A61B5/0456 , A61B5/726
摘要： The present invention provides methods and apparatus for determining a dynamical property of the systemic or pulmonary arterial tree using long time scale information, i.e., information obtained from measurements over time scales greater than a single cardiac cycle. In one aspect, the invention provides a method and apparatus for monitoring cardiac output (CO) from a single blood pressure signal measurement obtained at any site in the systemic or pulmonary arterial tree or from any related measurement including, for example, fingertip photoplethysmography.According to the method the time constant of the arterial tree, defined to be the product of the total peripheral resistance (TPR) and the nearly constant arterial compliance, is determined by analyzing the long time scale variations (greater than a single cardiac cycle) in any of these blood pressure signals. Then, according to Ohm's law, a value proportional to CO may be determined from the ratio of the blood pressure signal to the estimated time constant. The proportional CO values derived from this method may be calibrated to absolute CO, if desired, with a single, absolute measure of CO (e.g., thermodilution). The present invention may be applied to invasive radial arterial blood pressure or pulmonary arterial blood pressure signals which are routinely measured in intensive care units and surgical suites or to noninvasively measured peripheral arterial blood pressure signals or related noninvasively measured signals in order to facilitate the clinical monitoring of CO as well as TPR.
摘要翻译：本发明提供了使用长时间尺度信息（即从大于单个心动周期的时间尺度的测量获得的信息）来确定全身或肺动脉树的动力特性的方法和装置。一方面，本发明提供一种用于从在全身或肺动脉树中的任何位置处获得的单个血压信号测量值或任何相关测量（包括例如指尖光体积描记术）来监测心输出量（CO）的方法和装置。根据该方法，通过分析长时间尺度变化（大于单个心动周期）来确定被定义为总外周阻力（TPR）和几乎恒定的动脉顺应性的乘积的动脉树的时间常数任何这些血压信号。然后，根据欧姆定律，可以根据血压信号与估计的时间常数的比率确定与CO成比例的值。如果需要，从该方法得到的比例CO值可以通过CO的单一绝对测量（例如，热稀释）校准为绝对CO。本发明可以应用于在重症监护病房和手术套件中常规测量的侵入性桡动脉血压或肺动脉血压信号，或应用于非侵入性测量的外周动脉血压信号或相关非侵入性测量信号，以便于临床监测的CO以及TPR。

3. 发明授权

US07792563B2 Method and apparatus for the guided ablative therapy of fast ventricular arrhythmia 有权
标题翻译：用于快速室性心律失常的引导性烧蚀治疗的方法和装置
公开(公告)号：US07792563B2
公开(公告)日：2010-09-07
申请号：US11376994
申请日：2006-03-16
申请人： Richard J. Cohen , Maya Barley
发明人： Richard J. Cohen , Maya Barley
IPC分类号： A61B5/04
CPC分类号： A61B5/04 , A61B18/1492 , A61B2018/00351 , A61B2018/00839 , A61N1/362
摘要： Method and apparatus for guiding ablative therapy of abnormal biological electrical excitation. The excitation from the previous excitatory wave is significant at the beginning of the next excitation. In particular, it is designed for treatment of fast cardiac arrhythmias. Electrical signals are acquired from recording electrodes, and an inverse dipole method is used to identify the site of origin of an arrhythmia. The location of the tip of an ablation catheter is similarly localized from signals acquired from the recording electrodes while electrical pacing energy is delivered to the tip of the catheter close to or in contact with the cardiac tissue. The catheter tip is then guided to the site of origin of the arrhythmia, and ablative radio frequency energy is delivered to its tip to ablate the site.
摘要翻译：引导异常生物电激发的消融治疗的方法和装置。来自先前兴奋波的激发在下次激发开始时是显着的。特别地，它被设计用于治疗快速心律失常。从记录电极获取电信号，使用反偶极方法来识别心律不齐的起源部位。消融导管的尖端的位置类似地从从记录电极获取的信号定位，而电起搏能量被传送到靠近或与心脏组织接触的导管的尖端。然后将导管尖端引导到心律失常的原点，并将消融射频能量输送到其尖端以烧蚀部位。

4. 发明申请

US20100145204A1 ALTERNANS AND PHARMACOLOGICAL AGENTS 有权
标题翻译： ALTERNANS和药物代理
公开(公告)号：US20100145204A1
公开(公告)日：2010-06-10
申请号：US12630718
申请日：2009-12-03
申请人： Richard J. Cohen , Ali Haghighi-Mood
发明人： Richard J. Cohen , Ali Haghighi-Mood
IPC分类号： A61B5/0472
CPC分类号： A61B5/0452 , A61B5/7203
摘要： First cardiac signal data generated from measured heart beats of a subject is received. Characteristics of alternans occurring in the received first cardiac signal data are determined. Second cardiac signal data generated from measured heart beats of the subject after a change relating to an administration of a pharmacological agent is received. Characteristics of alternans occurring in the received second cardiac signal data are determined. The characteristics of alternans occurring in the received first cardiac signal data are compared with the characteristics of alternans occurring in the received second cardiac signal data.
摘要翻译：接收从受检者的测量心跳产生的第一心脏信号数据。确定在接收到的第一心脏信号数据中发生的交替发生的特征。在接受与药物剂的施用有关的变化之后，从被测物的测量心跳产生的第二心脏信号数据被接收。确定在所接收的第二心脏信号数据中发生的交替发生的特征。在接收的第一心脏信号数据中发生的交替发生的特征与在所接收的第二心脏信号数据中发生的交替发生的特征进行比较。

5. 发明授权

US5891045A Method and system for obtaining a localized cardiac measure 失效
标题翻译：用于获得局部心脏测量的方法和系统
公开(公告)号：US5891045A
公开(公告)日：1999-04-06
申请号：US896012
申请日：1997-07-17
申请人： Paul Albrecht , Jeffrey M. Arnold , Richard J. Cohen , Paul Lander
发明人： Paul Albrecht , Jeffrey M. Arnold , Richard J. Cohen , Paul Lander
IPC分类号： A61B5/0452 , A61B5/0408 , A61B5/05 , A61B5/0402
CPC分类号： A61B5/0452 , A61B5/04085 , A61B5/05
摘要： A localized cardiac measure, such as a localized measure of myocardial ischemia, is obtained by applying sensors to a subject, where the sensors are configured to produce electrical signals representative of cardiac activity of the subject. The subject's heart is then physiologically stressed by, for example, exercise stress testing, and electrical signals are received from at least two of the sensors. The received signals then are processed to obtain a localized cardiac measure.
摘要翻译：通过将传感器应用于受试者来获得局部心脏测量，例如心肌缺血的局部测量，其中传感器被配置为产生代表受试者的心脏活动的电信号。然后通过例如运动压力测试对受试者的心脏产生生理压力，并且从至少两个传感器接收电信号。然后处理所接收的信号以获得局部心脏测量。

6. 发明授权

US5713367A Measuring and assessing cardiac electrical stability 失效
标题翻译：测量和评估心脏电气稳定性
公开(公告)号：US5713367A
公开(公告)日：1998-02-03
申请号：US379375
申请日：1995-01-26
申请人： Jeffrey M. Arnold , Paul Albrecht , Kevin S. Librett , Richard J. Cohen
发明人： Jeffrey M. Arnold , Paul Albrecht , Kevin S. Librett , Richard J. Cohen
IPC分类号： A61B5/0408 , A61B5/0452 , A61B5/053 , A61B5/22 , G06F17/00
CPC分类号： A61B5/0535 , A61B5/0408 , A61B5/04085 , A61B5/0452 , A61B5/222 , A61B5/4884 , A61B5/7203 , A61B5/7207 , A61B5/721 , Y10S128/901
摘要： The alternans pattern of cycle-to-cycle variability in physiologic waveforms is assessed by applying transducers to a subject, recording physiologic signals, and analyzing the alternans pattern of variation in waveform morphology. Preferred embodiments include methods and apparatus for measuring and assessing alternans in the presence of physiologic stress, such as exercise, in order to induce or increase the amplitude of the alternans, improvements in signal processing to improve the sensitivity and specificity of the analysis, improvements to provide real-time analysis and feedback to the operator conducting the recording of physiologic signals, reduction in the effect of intercycle interval variability on waveform variability, reduction in the effects of respiration on the alternans measurement, improved means for determining the statistical significance of the alternans measurement, handling of abnormal beats such as atrial and ventricular premature beats, choosing of data epochs over which to perform the alternans measurement, using multiple electrodes to improve the accuracy of the alternans measurement, and combining measurement of alternans with other cardiovascular diagnostic tests to facilitate and improve the combined diagnostic capability.
摘要翻译：通过对受试者应用传感器，记录生理信号和分析波形形态变化的交替模式来评估生理波形中周期与周期变异性的交替模式。优选的实施方案包括用于测量和评估存在生理应激（诸如运动）的交替量的方法和装置，以便诱导或增加交替量的幅度，改进信号处理以提高分析的灵敏度和特异性，改善为进行生理信号记录的操作员提供实时分析和反馈，减少周期间隔变化对波形变化的影响，减少呼吸对交替量测量的影响，改进确定交替量的统计学意义的手段测量，异常搏动的处理，例如心房和心室早搏，选择进行交替测量的数据时期，使用多个电极来提高交替量测量的准确度，以及将交替量测量与其他心血管诊断测试相结合以促进和imp 结合诊断能力。

7. 发明授权

US4164558A Method for optimizing reagents for agglutination reactions 失效
标题翻译：优化凝集反应试剂的方法
公开(公告)号：US4164558A
公开(公告)日：1979-08-14
申请号：US743678
申请日：1976-11-22
申请人： Gustav K. von Schulthess , Richard J. Cohen , George B. Benedek
发明人： Gustav K. von Schulthess , Richard J. Cohen , George B. Benedek
IPC分类号： G01N33/543 , G01N31/00 , G01N33/16
CPC分类号： G01N33/54393 , Y10S435/962
摘要： A method and compositions are provided to effect optimization of methods for determining concentrations of antibodies or antigens. Particles coated with an antigen or an antibody are suspended in an aqueous medium where pH and ionic strength are controlled so that the coulomb effect and the van der Waals forces on and exerted by the particles are balanced.
摘要翻译：提供了一种方法和组合物来实现用于确定抗体或抗原浓度的方法的优化。用抗原或抗体包被的颗粒悬浮在水性介质中，其中控制pH和离子强度，使得颗粒的库伦效应和范德华力受到平衡。

8. 发明授权

US09289133B2 Methods and apparatus for determining cardiac output 有权
标题翻译：用于确定心输出量的方法和装置
公开(公告)号：US09289133B2
公开(公告)日：2016-03-22
申请号：US12903915
申请日：2010-10-13
申请人： Richard J. Cohen , Ramakrishna Mukkamala , Derin A. Sherman
发明人： Richard J. Cohen , Ramakrishna Mukkamala , Derin A. Sherman
IPC分类号： A61B5/021 , A61B5/02 , A61B5/0402 , A61B5/029 , A61B5/0225 , A61B5/0456 , A61B5/00
CPC分类号： A61B5/02007 , A61B5/02255 , A61B5/029 , A61B5/0456 , A61B5/726
摘要： The present invention provides methods and apparatus for determining a dynamical property of the systemic or pulmonary arterial tree using long time scale information, i.e., information obtained from measurements over time scales greater than a single cardiac cycle. In one aspect, the invention provides a method and apparatus for monitoring cardiac output (CO) from a single blood pressure signal measurement obtained at any site in the systemic or pulmonary arterial tree or from any related measurement including, for example, fingertip photoplethysmography.According to the method the time constant of the arterial tree, defined to be the product of the total peripheral resistance (TPR) and the nearly constant arterial compliance, is determined by analyzing the long time scale variations (greater than a single cardiac cycle) in any of these blood pressure signals. Then, according to Ohm's law, a value proportional to CO may be determined from the ratio of the blood pressure signal to the estimated time constant. The proportional CO values derived from this method may be calibrated to absolute CO, if desired, with a single, absolute measure of CO (e.g., thermodilution). The present invention may be applied to invasive radial arterial blood pressure or pulmonary arterial blood pressure signals which are routinely measured in intensive care units and surgical suites or to noninvasively measured peripheral arterial blood pressure signals or related noninvasively measured signals in order to facilitate the clinical monitoring of CO as well as TPR.
摘要翻译：本发明提供了使用长时间尺度信息（即从大于单个心动周期的时间尺度的测量获得的信息）来确定全身或肺动脉树的动力特性的方法和装置。一方面，本发明提供一种用于从在全身或肺动脉树中的任何位置处获得的单个血压信号测量值或任何相关测量（包括例如指尖光体积描记术）来监测心输出量（CO）的方法和装置。根据该方法，通过分析长时间尺度变化（大于单个心动周期）来确定被定义为总外周阻力（TPR）和几乎恒定的动脉顺应性的乘积的动脉树的时间常数任何这些血压信号。然后，根据欧姆定律，可以根据血压信号与估计的时间常数的比率确定与CO成比例的值。如果需要，从该方法得到的比例CO值可以通过CO的单一绝对测量（例如，热稀释）校准为绝对CO。本发明可以应用于在重症监护病房和手术套件中常规测量的侵入性桡动脉血压或肺动脉血压信号，或应用于非侵入性测量的外周动脉血压信号或相关非侵入性测量信号，以便于临床监测的CO以及TPR。

9. 发明申请

US20130013013A1 METHOD AND APPARATUS FOR TREATMENT OF CARDIAC TACHYARRHYTHMIAS 失效
标题翻译：治疗心律失常症的方法和装置
公开(公告)号：US20130013013A1
公开(公告)日：2013-01-10
申请号：US13492191
申请日：2012-06-08
申请人： Antonis A. Armoundas , Richard J. Cohen
发明人： Antonis A. Armoundas , Richard J. Cohen
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/3621 , A61N1/3702 , A61N1/3925 , A61N1/3962
摘要： Method and apparatus for preventing heart rhythm disturbances by recording cardiac electrical activity, measuring beat-to-beat variability in the morphology of electrocardiographic waveforms, and using the measured beat-to-beat variability to control the delivery of electrical impulses to the heart during the absolute refractory period.
摘要翻译：通过记录心脏电活动来预防心律紊乱的方法和装置，测量心电图波形形态中的搏动间差异变化，以及使用测量的搏动到搏动变异性来控制在心电图期间向心脏递送电脉冲绝对不应期

10. 发明授权

US08249704B2 Method and apparatus for treatment of cardiac tachyarrhythmias 失效
标题翻译：用于治疗心脏性快速性心律失常的方法和装置
公开(公告)号：US08249704B2
公开(公告)日：2012-08-21
申请号：US11493466
申请日：2006-07-26
申请人： Antonis A. Armoundas , Richard J. Cohen
发明人： Antonis A. Armoundas , Richard J. Cohen
IPC分类号： A61N1/00
CPC分类号： A61N1/3621 , A61N1/3702 , A61N1/3925 , A61N1/3962
摘要： Method and apparatus for preventing heart rhythm disturbances by recording cardiac electrical activity, measuring beat-to-beat variability in the morphology of electrocardiographic waveforms, and using the measured beat-to-beat variability to control the delivery of electrical impulses to the heart during the absolute refractory period.
摘要翻译：通过记录心脏电活动来预防心律紊乱的方法和装置，测量心电图波形形态中的搏动间差异变化，以及使用测量的搏动到搏动变异性来控制在心电图期间向心脏递送电脉冲绝对不应期

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