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    • 7. 发明授权
    • Condensed 4-aminopyridines with antirheumatic activity
    • 具有抗风湿活性的冷凝的4-氨基吡啶
    • US5780482A
    • 1998-07-14
    • US564154
    • 1995-12-21
    • Bernard John ArmitageBruce William LeslieThomas Kerr MillerChristopher Morley
    • Bernard John ArmitageBruce William LeslieThomas Kerr MillerChristopher Morley
    • C07H15/203A61K31/435A61K31/445A61K31/495A61K31/535A61K31/70A61K31/7028A61K31/7034A61P29/00C07D471/04C07H15/26
    • C07D471/04C07H15/26
    • Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof in which one of A or B represents N and the other represents N or C--R.sub.3 ; R.sub.1 represents hydrogen, halo, alkyl, hydroxy, carboxyalkenyl, alkoxycarbonylalkenyl, hydroxyalkyl, carboxyalkyl, alkoxycarbonylalkyl, alkoxy, halogenated alkyl, carboxy, alkoxycarbonyl, alkanoylamino or carbamoylalkenyl; R.sub.2 represents hydrogen, alkyl, halo, alkoxy, hydroxy, alkanoyloxy, or phenoxy; R.sub.3 represents hydrogen or alkyl; R.sub.4 represents hydrogen, halo, alkoxycarbonyl, cyano, benzyloxycarbonyl, alkanoyl, benzoyl, alkyl, carboxy, alkylthio or carbamoyl; R.sub.5 represents hydrogen or alkyl; R.sub.9 represents hydrogen or alkyl; R.sub.10 represents phenyl, pyridyl or pyrimidinyl substituted by OR.sub.6 and optionally further substituted wherein R.sub.6 represents hydrogen, alkyl, alkoxycarbonyl or carbamoyl, alicyclic hydrocarbon, phenyl, cycloalkylalkyl, arylalkyl or pyridyl; or when R.sub.10 represents phenyl, OR.sub.6 represents a monosaccharide group or a disaccharide group; which are antirheumatic agents. Compositions containing these compounds and processes to prepare them are also disclosed.
    • PCT No.PCT / EP94 / 01923 Sec。 371 1995年12月21日第 102(e)日期1995年12月21日PCT提交1994年6月10日PCT公布。 第WO95 / 00511号公报 日期:1月5日,I式I化合物及其药学上可接受的盐,其中A或B中的一个为N,另一个为N或C-R 3; 羧基,烷氧基羰基烷基,烷氧基,卤代烷基,羧基,烷氧基羰基,烷酰基氨基或氨基甲酰基烯基; R 1表示氢,卤素,烷基,羟基,羧基烯基,烷氧基羰基, R2代表氢,烷基,卤素,烷氧基,羟基,烷酰氧基或苯氧基; R3表示氢或烷基; R4代表氢,卤素,烷氧基羰基,氰基,苄氧基羰基,烷酰基,苯甲酰基,烷基,羧基,烷硫基或氨基甲酰基; R5代表氢或烷基; R9代表氢或烷基; R 10表示被OR 6取代的苯基,吡啶基或嘧啶基,任选进一步取代,其中R 6表示氢,烷基,烷氧基羰基或氨基甲酰基,脂环族烃,苯基,环烷基烷基,芳基烷基或吡啶基。 或当R 10表示苯基时,OR 6表示单糖基或二糖基; 它们是抗风湿剂。 还公开了含有这些化合物的组合物和其制备方法。
    • 8. 发明申请
    • Wearable biofeedback system
    • 耐磨生物反馈系统
    • US20120229270A1
    • 2012-09-13
    • US12932936
    • 2011-03-11
    • Christopher MorleyNeil D. Blank
    • Christopher MorleyNeil D. Blank
    • G08B1/08
    • A61B5/6806A61B5/0002A61B5/02416A61B5/0533A61B5/14551A61B5/74A61B6/585
    • A wearable biofeedback device is provided. The device preferably includes a glove structure and external display device. The glove has at least one sheath for receiving a digit. The glove and sheath include dorsal and palmer surfaces. The palmer surfaces include at least one sensor for acquiring a bio-signal. The dorsal surface includes a compartment for containing an electronics control module. The electronics module is contained in the compartment, and is in communication with the sensor. A circuit system, accommodated in the electronics module, includes an analog to digital converter, a processor for performing an analysis and translation of the digitized bio-signals into a biometric measurement data, a battery, and a wirelessly transmission module for performing wirelessly transmission to the external device. The external device is wirelessly communicated with the glove through the wireless transmission module, and is adapted to display the biometric measurement data in an audio or visual display.
    • 提供了一种可佩戴的生物反馈装置。 该装置优选地包括手套结构和外部显示装置。 手套具有至少一个用于接收数字的护套。 手套和皮套包括背面和棕色表面。 平坦表面包括至少一个用于获取生物信号的传感器。 背面包括用于容纳电子控制模块的隔室。 电子模块包含在隔室中,并与传感器通信。 容纳在电子模块中的电路系统包括模数转换器,用于将数字化生物信号分析和转换成生物测量数据,电池和无线传输模块的处理器,用于执行无线传输 外部设备。 外部设备通过无线传输模块与手套无线地通信,并且适于在音频或视觉显示器中显示生物测量数据。