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1. 发明申请

US20070250142A1 Atomic Layer Deposition Coatings for Implantable Medical Devices 审中-公开
标题翻译：用于可植入医疗器械的原子层沉积涂层
公开(公告)号：US20070250142A1
公开(公告)日：2007-10-25
申请号：US11278020
申请日：2006-03-30
申请人： Richard Francis , Naim Istephanous , Eric Bonde , Michael Schugt , Richard O'Brien
发明人： Richard Francis , Naim Istephanous , Eric Bonde , Michael Schugt , Richard O'Brien
IPC分类号： A61N1/00
CPC分类号： A61L31/082 , C23C16/45525 , C23C16/45555
摘要： Implantable medical devices with coatings formed by atomic layer deposition and methods of applying such coatings to implantable medical devices are disclosed. The medical devices may include electrical feedthroughs and media exposed integrated circuits and/or transducer systems, as well as others. The coatings may improve, among other things, hermeticity, biocompatibility, biostability, surface characteristics, and electrical properties.
摘要翻译：公开了具有通过原子层沉积形成的涂层的可植入医疗装置以及将这种涂层施加到可植入医疗装置的方法。医疗设备可以包括电馈通和媒体曝光的集成电路和/或换能器系统以及其他。除其他之外，涂层可以改善气密性，生物相容性，生物稳定性，表面特性和电性能。

2. 发明申请

US20060247539A1 Implantable capacitive pressure sensor system and method 有权
标题翻译：可植入电容式压力传感器系统及方法
公开(公告)号：US20060247539A1
公开(公告)日：2006-11-02
申请号：US11116804
申请日：2005-04-28
申请人： Michael Schugt , Keith Miesel , Jeremy Burdon , Eric Bonde
发明人： Michael Schugt , Keith Miesel , Jeremy Burdon , Eric Bonde
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , H01L2224/48227 , H01L2924/15192
摘要： Embodiments of the invention provide systems and methods for an implantable capacitive pressure sensor. Some embodiments of the invention include a capacitive pressure sensor capsule comprising a substrate, a conductive plate functionally coupled to the substrate, a conductive diaphragm spaced from the conductive plate and functionally coupled to the substrate, a lid hermetically sealed against the substrate, and pressure sensing circuitry disposed within a volume generally defined by the lid and the substrate. Embodiments of the invention also include a lead provided with an implantable pressure sensor capsule and a method of manufacturing a capacitive pressure sensor capsule.
摘要翻译：本发明的实施例提供了一种用于可植入电容式压力传感器的系统和方法。本发明的一些实施例包括电容式压力传感器胶囊，其包括基底，功能性地连接到基底的导电板，与导电板隔开并功能耦合到基底的导电隔膜，密封地密封在基底上的盖，以及压力感测设置在通常由盖和基板限定的体积内的电路。本发明的实施例还包括具有可植入压力传感器胶囊的引线和制造电容式压力传感器胶囊的方法。

3. 发明申请

US20070255366A1 IMPLANTABLE MEDICAL ELECTRICAL STIMULATION LEAD FIXATION METHOD AND APPARATUS 有权
标题翻译：可植入电刺激引线固定方法和装置
公开(公告)号：US20070255366A1
公开(公告)日：2007-11-01
申请号：US11380499
申请日：2006-04-27
申请人： Martin Gerber , Eric Bonde
发明人： Martin Gerber , Eric Bonde
IPC分类号： A61N1/00
CPC分类号： A61N1/0558 , A61N1/36007 , A61N1/36071
摘要： An implantable medical electrical lead for electrical stimulation of body tissue that includes at least one shape memory polymer portion that has a first configuration and a second configuration, wherein the second configuration is obtained upon exposure of the shape memory polymer portion to a transition stimulus, and wherein the second configuration of the modifiable portion exhibits a greater resistance to movement of the lead within the body tissue than does the first configuration; and at least one electrode configured to provide electrical stimulation of body tissue, wherein the lead has a proximal end and a distal end. Systems and kits as well as methods of utilizing the leads of the invention are also included.
摘要翻译：一种用于对身体组织进行电刺激的可植入医用电导线，其包括至少一个形状记忆聚合物部分，该部分具有第一构型和第二构型，其中第二构型是在将形状记忆聚合物部分暴露于转变刺激物时得到的，其中所述可修改部分的所述第二配置对所述主体组织内的所述引线的移动性比所述第一构造表现出更大的阻力; 以及构造成提供对身体组织的电刺激的至少一个电极，其中所述引线具有近端和远端。还包括系统和试剂盒以及利用本发明的引线的方法。

4. 发明申请

US20070255295A1 Sutureless implantable medical device fixation 有权
标题翻译：无缝线植入式医疗器械固定
公开(公告)号：US20070255295A1
公开(公告)日：2007-11-01
申请号：US11413071
申请日：2006-04-27
申请人： Warren Starkebaum , Daniel Stetson , Eric Bonde
发明人： Warren Starkebaum , Daniel Stetson , Eric Bonde
IPC分类号： A61B17/10
CPC分类号： A61N1/05 , A61N1/0534 , A61N1/0551 , A61N1/0573 , A61N1/0587
摘要： A device comprises a medical implant and an actively deployable clip attached to the medical implant that operates to restrict movement of the medical implant once the actively deployable clip is deployed within a body of a patient. In some embodiments, the medical implant is an electrical lead for electrical stimulation. The actively deployable clip is operable to fixate the medical implant to a body tissue once deployed, such that the actively deployable clip performs a similar function to a suture. In this manner, embodiments of the invention may provide a medical implant that requires few or even no sutures to properly fixate the implant within the patient.
摘要翻译：一种装置包括医疗植入物和附接到医疗植入物的可主动展开的夹子，其操作以在将可主动展开的夹子部署在患者的身体内时限制医疗植入物的运动。在一些实施例中，医疗植入物是用于电刺激的电引线。可主动展开的夹子可操作以将医疗植入物固定到身体组织一旦被部署，使得可主动展开的夹子执行与缝合线类似的功能。以这种方式，本发明的实施例可以提供一种医疗植入物，其需要很少或甚至没有缝合线来将植入物适当地固定在患者体内。

5. 发明授权

US07846095B2 Atraumatic sensor lead assemblies 有权
标题翻译：无创传感器引线组件
公开(公告)号：US07846095B2
公开(公告)日：2010-12-07
申请号：US10919685
申请日：2004-08-17
申请人： Mark A. Christopherson , Nancy Perry Pool , John L. Sommer , Eric Bonde
发明人： Mark A. Christopherson , Nancy Perry Pool , John L. Sommer , Eric Bonde
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61N1/05 , A61N1/056
摘要： The invention is directed to lead configurations for sensors that allow for less invasive sensor replacement procedures. In one configuration, a sensor lead assembly includes an outer lead body and an inner lead including a sensor such as an electrochemical glucose sensor. The inner lead can be positioned in an inner conduit of the outer lead body. The outer lead body may be substantially permanently implanted in the patient, and the inner lead can be implanted through the inner conduit of the outer lead body. Once the sensor of the inner lead has worn out or otherwise exhausted its useful life, the inner lead can be removed, and a new inner lead can be implanted in place of the old inner lead.
摘要翻译：本发明涉及允许较少侵入性的传感器更换程序的传感器的引线配置。在一种配置中，传感器引线组件包括外引线体和包括诸如电化学葡萄糖传感器的传感器的内引线。内引线可以定位在外引线体的内导管中。外引线体可以基本上永久地植入患者体内，并且内引线可以通过外引线体的内导管植入。一旦内部引线的传感器已经磨损或以其他方式耗尽其使用寿命，内部引线可以被去除，并且可以将新的内部引线植入代替旧的内部引线。

6. 发明申请

US20070255364A1 IMPLANTABLE MEDICAL ELECTRICAL STIMULATION LEAD FIXATION METHOD AND APPARATUS 有权
标题翻译：可植入电刺激引线固定方法和装置
公开(公告)号：US20070255364A1
公开(公告)日：2007-11-01
申请号：US11380458
申请日：2006-04-27
申请人： Martin Gerber , Eric Bonde
发明人： Martin Gerber , Eric Bonde
IPC分类号： A61N1/00
CPC分类号： A61N1/0534 , A61N1/0558
摘要： The invention includes an implantable medical electrical lead for electrical stimulation of body tissue that includes at least one modifiable portion that exhibits a first configuration when exposed to a first temperature and a second configuration when exposed to a second temperature, wherein the second configuration of the modifiable portion exhibits a greater resistance to movement of the lead within the body tissue than does the first configuration, and the second temperature is higher than the first temperature; and at least one electrode configured to provide electrical stimulation of body tissue, wherein the lead has a proximal end and a distal end. Systems including leads of the invention and methods of implanting leads of the invention are also included.
摘要翻译：本发明包括用于电刺激身体组织的可植入医用电线，其包括当暴露于第二温度时暴露于第一温度和第二构型时呈现第一构型的至少一个可修改部分，其中可修改的第二配置部分表现出比第一构型更强的铅在身体组织内的运动阻力，第二温度高于第一温度; 以及构造成提供对身体组织的电刺激的至少一个电极，其中所述引线具有近端和远端。还包括包括本发明的引线和植入引线的本发明的方法的系统。

7. 发明授权

US07239916B2 Method and apparatus for automatic implantable medical lead recognition and configuration 有权
标题翻译：用于自动植入式医疗导线识别和配置的方法和装置
公开(公告)号：US07239916B2
公开(公告)日：2007-07-03
申请号：US10714123
申请日：2003-11-14
申请人： David L. Thompson , Steven D. Goedeke , Gregory J. Haubrich , Ryan Cobian , Eric Bonde , John L. Sommer , Jonathan Werder , Nels Nerison , Eric V. Blaha
发明人： David L. Thompson , Steven D. Goedeke , Gregory J. Haubrich , Ryan Cobian , Eric Bonde , John L. Sommer , Jonathan Werder , Nels Nerison , Eric V. Blaha
IPC分类号： A61N1/362
CPC分类号： A61N1/37252 , A61B5/0031 , A61B2560/0219 , A61N1/025 , A61N1/05 , A61N1/37223 , A61N1/3752 , A61N2001/0585
摘要： An automated identification and configuration system for use with an implantable medical device (IMD) is disclosed. The system includes a first communication circuit that is attached to, or otherwise carried by, a detachable component associated with the IMD such as a medical lead. The communication circuit stores data such as model numbers, serial numbers, technical data, and/or calibration information that describes the additional component. This information may be transferred by the first communications circuit to a second communications circuit that is external to the additional component. This transferred data can be used to automatically configure the internal circuitry and connection functions of the IMD to properly interface with, and support, the additional component. For example, the data can be used to automatically adjust amplifier gains or other sensor circuitry, or to configure a connector block to properly couple to the component. The data may further be entered into a patient record on an external programmer, or may be transferred to a central storage location to be generally accessible to health care providers. In one embodiment, the first communication circuit is a passive RF transponder. This first communication circuit may include a receiver as well as a transmitter to allow the circuit to programmably receive data at the time of component manufacture.
摘要翻译：公开了一种用于可植入医疗装置（IMD）的自动识别和配置系统。该系统包括第一通信电路，其连接到与IMD相关联的可拆卸部件（例如医疗引线）或由其携带。通信电路存储诸如型号，序列号，技术数据和/或描述附加组件的校准信息的数据。该信息可以由第一通信电路传送到附加组件外部的第二通信电路。该传输的数据可用于自动配置IMD的内部电路和连接功能，以正确地连接和支持附加组件。例如，数据可用于自动调整放大器增益或其他传感器电路，或配置连接器块以正确耦合到组件。数据可以进一步输入到外部编程器上的病人记录中，或者可以被传送到中央存储位置，以便卫生保健提供者通常可访问。在一个实施例中，第一通信电路是无源RF应答器。该第一通信电路可以包括接收器以及发射器，以允许电路在组件制造时可编程地接收数据。

8. 发明申请

US20070100355A1 Method and device for controlling bulking agent depth in tissue 审中-公开
标题翻译：控制组织中膨化剂深度的方法和装置
公开(公告)号：US20070100355A1
公开(公告)日：2007-05-03
申请号：US11260828
申请日：2005-10-27
申请人： Eric Bonde , Carole Tronnes , Yelena Tropsha , Lisa Draper
发明人： Eric Bonde , Carole Tronnes , Yelena Tropsha , Lisa Draper
IPC分类号： A61B17/34 , A61B17/94
CPC分类号： A61B17/12022 , A61B17/12099 , A61B17/12136 , A61B17/12181 , A61B17/3468 , A61B2017/00296 , A61B2017/00827 , A61B2017/306 , A61B2090/034 , A61F2/04 , A61F2002/044
摘要： The invention includes a delivery device for introducing a prosthesis beneath a tissue surface that includes an elongate body having a proximal end and a distal end, an opening on the elongate body, which is at least partially covered by a mesh, and a deployment lumen extending through the body that has a longitudinal axis and a distal end, wherein the distal end of the deployment lumen is positioned proximal of the opening. Also included are delivery systems and kits that include delivery devices of the invention. Further, an overtube for receiving an endoscope, that includes an elongate, flexible tubular body, having a proximal end and a distal end and a longitudinal axis, at least one lumen extending therethrough for receiving an endoscope, an opening on the body, in communication with the lumen, and a tissue limiting surface within the body aligned with the opening, formed at least in part by a mesh. Methods of using the devices, and kits are also included in the invention.
摘要翻译：本发明包括用于将假体引入组织表面下方的递送装置，其包括具有近端和远端的细长主体，细长主体上的至少部分地被网状覆盖的开口，以及展开腔通过具有纵向轴线和远端的主体，其中展开腔的远端位于开口的近侧。还包括包括本发明的递送装置的递送系统和套件。此外，用于接收内窥镜的外套管，其包括细长的柔性管状体，其具有近端和远端和纵向轴线，延伸穿过其中的至少一个内腔，用于接纳内窥镜，在身体上的开口与内腔对齐，以及与开口对齐的体内的组织限制表面，至少部分地由网状物形成。使用装置和试剂盒的方法也包括在本发明中。

9. 发明申请

US20070261115A1 IMPLANTABLE MEDICAL ELECTRICAL STIMULATION LEAD FIXATION METHOD AND APPARATUS 有权
标题翻译：可植入电刺激引线固定方法和装置
公开(公告)号：US20070261115A1
公开(公告)日：2007-11-08
申请号：US11380493
申请日：2006-04-27
申请人： Martin Gerber , Eric Bonde
发明人： Martin Gerber , Eric Bonde
IPC分类号： G06F12/14
CPC分类号： A61N1/0558 , A61N1/0534 , G06F19/00 , G16H40/63
摘要： The invention includes a implantable medical electrical lead for electrical stimulation of body tissue that includes at least one electrode; a lead body; and at least one modifiable portion, wherein the at least one modifiable portion has a first configuration and a second configuration, wherein the first configuration exists when axial tension is exerted on the at least one modifiable portion, and wherein the second configuration exhibits a greater resistance to movement of the lead within the body tissue than does the first configuration. Kits, and systems and methods of using the lead are also included.
摘要翻译：本发明包括用于电刺激身体组织的可植入医用电线，其包括至少一个电极; 铅体; 以及至少一个可修改部分，其中所述至少一个可修改部分具有第一构造和第二构造，其中当所述至少一个可修改部分上施加轴向张力时存在所述第一构型，并且其中所述第二构型具有较大的阻力使得铅在身体组织内的移动比第一构型。套件以及使用铅的系统和方法也包括在内。

10. 发明申请

US20070255371A1 System and method for electrically probing and providing medical electrical stimulation 有权
标题翻译：电探测和提供医疗电刺激的系统和方法
公开(公告)号：US20070255371A1
公开(公告)日：2007-11-01
申请号：US11413310
申请日：2006-04-28
申请人： Eric Bonde , Eric Stetz , Carole Tronnes
发明人： Eric Bonde , Eric Stetz , Carole Tronnes
IPC分类号： A61N1/00
CPC分类号： A61N1/0551
摘要： A system for providing medical electrical stimulation including a lead assembly and a cannula. The lead assembly includes a lead body and a needle tip. The lead body has a distal section and a proximal section. The needle tip is formed of an electrically conductive material and is connected to the distal section of the lead body. The lead body is slidably disposed within a cannula lumen, with a distal end of the cannula being selectively connected to an abutment surface of the needle tip such that the needle tip extends distal the cannula to define a needle probe. With this construction, the lead assembly can be delivered to a desired implantation site via manipulation of the cannula and/or energization of the needle tip, and the cannula can be removed from the lead body without requiring movement of the needle tip.
摘要翻译：一种用于提供医疗电刺激的系统，包括引线组件和套管。引线组件包括引线体和针尖。引线体具有远侧部分和近端部分。针尖由导电材料形成并且连接到引线主体的远端部分。引导体可滑动地设置在套管腔内，套管的远端选择性地连接到针尖的邻接表面，使得针尖延伸到套管的远端以限定针头探针。利用这种结构，引导组件可以通过插管的操作和/或针尖的通电而被输送到期望的植入位置，并且可以不用移动针尖从导线主体移除套管。

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