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1. 发明授权

US07858359B2 Method for tapping the immunological repertoire 失效
标题翻译：攻击免疫学曲目的方法
公开(公告)号：US07858359B2
公开(公告)日：2010-12-28
申请号：US11558384
申请日：2006-11-09
申请人： William D. Huse , Gregory P. Winter , Lutz Riechmann , Joseph A. Sorge , Richard A. Lerner
发明人： William D. Huse , Gregory P. Winter , Lutz Riechmann , Joseph A. Sorge , Richard A. Lerner
IPC分类号： C12N1/21
CPC分类号： C07K16/00 , A61K38/00 , C07K16/468 , C07K2317/56
摘要： The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
摘要翻译：本发明涉及从免疫基因库中分离编码具有结合预选配体的能力的受体的基因的方法。还考虑了通过该方法分离的基因产生的受体，特别是催化受体。

2. 发明授权

US08338107B2 Method for producing polymers having a preselected activity 失效
标题翻译：具有预选活性的聚合物的制备方法
公开(公告)号：US08338107B2
公开(公告)日：2012-12-25
申请号：US11560769
申请日：2006-11-16
申请人： William D. Huse , Gregory P. Winter , Lutz Riechmann , Joseph A. Sorge , Richard A. Lerner
发明人： William D. Huse , Gregory P. Winter , Lutz Riechmann , Joseph A. Sorge , Richard A. Lerner
IPC分类号： C12Q1/68
CPC分类号： C07K16/005 , A61K38/00 , C07K16/00 , C07K16/44 , C07K16/468 , C07K2317/55 , C07K2317/56
摘要： The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
摘要翻译：本发明涉及从免疫基因库中分离编码具有结合预选配体的能力的受体的基因的方法。还考虑了通过该方法分离的基因产生的受体，特别是催化受体。

3. 发明授权

US07189841B2 Method for tapping the immunological repertoire 失效
标题翻译：攻击免疫学曲目的方法
公开(公告)号：US07189841B2
公开(公告)日：2007-03-13
申请号：US10910463
申请日：2004-08-02
申请人： Richard A. Lerner , Joseph A. Sorge , Gregory P. Winter , Lutz Riechmann
发明人： Richard A. Lerner , Joseph A. Sorge , Gregory P. Winter , Lutz Riechmann
IPC分类号： C07H21/04
CPC分类号： C07K16/005 , C07K16/00 , C07K16/44 , C07K2317/21 , C07K2317/55 , C07K2317/569 , C07K2317/622 , C12Q1/6876
摘要： The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
摘要翻译：本发明涉及从免疫基因库中分离编码具有结合预选配体的能力的受体的基因的方法。还考虑了通过该方法分离的基因产生的受体，特别是催化受体。

4. 发明授权

US06680192B1 Method for producing polymers having a preselected activity 失效
标题翻译：具有预选活性的聚合物的制备方法
公开(公告)号：US06680192B1
公开(公告)日：2004-01-20
申请号：US09726653
申请日：2000-11-28
申请人： Richard A. Lerner , Joseph A. Sorge
发明人： Richard A. Lerner , Joseph A. Sorge
IPC分类号： C12N121
CPC分类号： C07K16/00 , A61K38/00 , C07K16/468 , C07K2317/56
摘要： The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
摘要翻译：本发明涉及从免疫基因库中分离编码具有结合预选配体的能力的受体的基因的方法。还考虑了通过该方法分离的基因产生的受体，特别是催化受体。

5. 发明授权

US06969586B1 Method for tapping the immunological repertoire 失效
标题翻译：攻击免疫学曲目的方法
公开(公告)号：US06969586B1
公开(公告)日：2005-11-29
申请号：US09726649
申请日：2000-11-28
申请人： Richard A. Lerner , Joseph A. Sorge , Gregory P. Winter , Lutz Riechmann
发明人： Richard A. Lerner , Joseph A. Sorge , Gregory P. Winter , Lutz Riechmann
IPC分类号： C07K16/00 , C07K16/44 , C12Q1/68
CPC分类号： C07K16/005 , C07K16/00 , C07K16/44 , C07K2317/21 , C07K2317/55 , C07K2317/569 , C07K2317/622 , C12Q1/6876
摘要： The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
摘要翻译：本发明涉及从免疫基因库中分离编码具有结合预选配体的能力的受体的基因的方法。还考虑了通过该方法分离的基因产生的受体，特别是催化受体。

6. 发明授权

US06291161B1 Method for tapping the immunological repertiore 失效
标题翻译：攻击免疫反应的方法
公开(公告)号：US06291161B1
公开(公告)日：2001-09-18
申请号：US07941762
申请日：1992-09-04
申请人： Richard A. Lerner , Joseph A. Sorge , Gregory P. Winter , Lutz Riechmann
发明人： Richard A. Lerner , Joseph A. Sorge , Gregory P. Winter , Lutz Riechmann
IPC分类号： C12Q168
CPC分类号： C07K16/468 , A61K38/00 , C07K16/00 , C07K2317/56
摘要： The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
摘要翻译：本发明涉及从免疫基因库中分离编码具有结合预选配体的能力的受体的基因的方法。还考虑了通过该方法分离的基因产生的受体，特别是催化受体。

7. 发明授权

US06291160B1 Method for producing polymers having a preselected activity 失效
公开(公告)号：US06291160B1
公开(公告)日：2001-09-18
申请号：US07941761
申请日：1992-11-25
申请人： Richard A. Lerner , Joseph A. Sorge
发明人： Richard A. Lerner , Joseph A. Sorge
IPC分类号： C12Q168
CPC分类号： C07K16/00 , A61K38/00 , C07K16/468 , C07K2317/56
摘要： The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.

8. 发明授权

US06291159B1 Method for producing polymers having a preselected activity 失效
标题翻译：具有预选活性的聚合物的制备方法
公开(公告)号：US06291159B1
公开(公告)日：2001-09-18
申请号：US07933959
申请日：1992-08-21
申请人： Gregory P. Winter , Lutz Riechmann , William D. Huse , Joseph A. Sorge , Richard A. Lerner
发明人： Gregory P. Winter , Lutz Riechmann , William D. Huse , Joseph A. Sorge , Richard A. Lerner
IPC分类号： C12Q168
CPC分类号： C07K16/005 , A61K38/00 , C07K16/00 , C07K16/44 , C07K16/468 , C07K2317/55 , C07K2317/56
摘要： The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
摘要翻译：本发明涉及从免疫基因库中分离编码具有结合预选配体的能力的受体的基因的方法。还考虑了通过该方法分离的基因产生的受体，特别是催化受体。

9. 发明授权

US06291158B1 Method for tapping the immunological repertoire 失效
标题翻译：攻击免疫学曲目的方法
公开(公告)号：US06291158B1
公开(公告)日：2001-09-18
申请号：US07933958
申请日：1992-08-21
申请人： Gregory P. Winter , Lutz Riechmann , William D. Huse , Joseph A. Sorge , Richard A. Lerner
发明人： Gregory P. Winter , Lutz Riechmann , William D. Huse , Joseph A. Sorge , Richard A. Lerner
IPC分类号： C12Q168
CPC分类号： C07K16/00 , A61K38/00 , C07K16/468 , C07K2317/56
摘要： The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
摘要翻译：本发明涉及从免疫基因库中分离编码具有结合预选配体的能力的受体的基因的方法。还考虑了通过该方法分离的基因产生的受体，特别是催化受体。

10. 发明授权

US08383343B2 Methods of enriching for and identifying polymorphisms 有权
标题翻译：富集和鉴定多态性的方法
公开(公告)号：US08383343B2
公开(公告)日：2013-02-26
申请号：US10391090
申请日：2003-03-18
申请人： Joseph A. Sorge
发明人： Joseph A. Sorge
IPC分类号： C12Q1/68
CPC分类号： C12N15/1072 , C12Q1/6827 , C12Q1/6869 , C12Q2565/519 , C12Q2565/531 , C12Q2533/101 , C12Q2522/101
摘要： The invention encompasses methods for enriching for and identifying a polymorphism within a nucleic acid sample either by separating a subset of a nucleic acid sample or by selectively replicating a subset of a nucleic acid sample such that the polymorphism is contained within a nucleic acid population with reduced complexity, and then identifying the polymorphism within the enriched nucleic acid sample. Methods also are disclosed for enriching for and identifying a polymorphism by contacting a nucleic acid sample that includes a subset of nucleic acid molecules having a sequence that binds to a sequence-specific binding activity with a molecule having a sequence-specific binding activity under conditions which permit specific binding, such that the subset of nucleic acid molecules bound to the activity is enriched for nucleic acid molecules having the sequence recognized by the sequence-specific binding activity, and detecting a polymorphism with respect to a reference sequence in the subset of nucleic acid molecules.
摘要翻译：本发明包括用于通过分离核酸样品的子集或通过选择性复制核酸样品的子集来使得核酸样品中的多态性富集和鉴定核酸样品中的多态性的方法，使得多态性包含在具有降低的核酸群体的核酸群体内复杂性，然后鉴定富集的核酸样品内的多态性。公开了通过使包含具有与序列特异性结合活性结合的序列的核酸分子的子集与具有序列特异性结合活性的分子的核酸样品接触的方法来丰富和鉴定多态性的方法，允许特异性结合，使得与活性结合的核酸分子的子集富含具有由序列特异性结合活性识别的序列的核酸分子，并且检测核酸子集中的参考序列的多态性分子。

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