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1. 发明授权

US06629987B1 Catheter positioning systems 失效
标题翻译：导管定位系统
公开(公告)号：US06629987B1
公开(公告)日：2003-10-07
申请号：US09364520
申请日：1999-07-30
申请人： Richard A. Gambale , Stephen J. Forcucci , Chirag B. Shah , Michael F. Weiser , Sean Forde
发明人： Richard A. Gambale , Stephen J. Forcucci , Chirag B. Shah , Michael F. Weiser , Sean Forde
IPC分类号： A61M2900
CPC分类号： A61M25/04 , A61B2017/3488 , A61M25/0084 , A61M2025/0087
摘要： The present invention provides a catheter positioning system which serves to control and stabilize a distal end of a catheter at a treatment site within a patient so that a medical procedure can be performed with accuracy. Generally, the positioning system operates by providing a deformable mechanical members at the distal end of the catheter which can be operated from the proximal end of the catheter to extend radially outward to engage surrounding tissue adjacent to treatment site. In one embodiment of the invention a flexible superstructure comprising the plurality of flexible veins extending longitudinally along the distal end of the catheter can be deformed to bow radially outward to engage surrounding tissue. The distal tip of the catheter joined to one of the veins was correspondingly displaced or rotated angularly as the veins bow outward. In another embodiment radially projecting fingers are joined to the distal end of the catheter, which remain retracted during navigation of the catheter to the treatment site then are extended outward to penetrate the tissue and secure the catheter at the treatment site upon being actuated from the proximal end of the catheter by a physician. Methods of positioning a catheter are also disclosed. The inventive device and method are particularly useful in catheter based procedures carried out in large body lumens or in cavities of body organs. In particular, the invention may be useful in delivering implants percutaneously through the left ventricle into the myocardium of the heart.
摘要翻译：本发明提供了一种导管定位系统，其用于控制和稳定患者内的治疗部位处的导管的远端，使得可以精确地执行医疗程序。通常，定位系统通过在导管的远端处提供可变形的机械构件来操作，该可变形机械构件可以从导管的近端操作以径向向外延伸以接合邻近治疗部位的周围组织。在本发明的一个实施例中，包括沿着导管的远端纵向延伸的多个柔性静脉的柔性上部结构可以变形以径向向外弯曲以接合周围的组织。当静脉向外弯曲时，连接到静脉中的一个静脉的导管的远端相应地位移或旋转。在另一个实施例中，径向突出的指状物连接到导管的远端，导管的远端在导管导航到治疗部位期间保持缩回，然后向外延伸以穿透组织，并且在从近端致动时将导管固定在治疗部位导管的末端由医师。还公开了定位导管的方法。本发明的装置和方法特别适用于在大体腔或身体器官腔中进行的基于导管的程序。特别地，本发明可用于将植入物通过左心室经皮穿入心脏心肌。

2. 发明授权

US06331185B1 Flexible vascular inducing implants 失效
公开(公告)号：US06331185B1
公开(公告)日：2001-12-18
申请号：US09164163
申请日：1998-09-30
申请人： Richard A. Gambale , Stephen J. Forcucci , Michael F. Weiser , Richard T. Choh , Sean Forde
发明人： Richard A. Gambale , Stephen J. Forcucci , Michael F. Weiser , Richard T. Choh , Sean Forde
IPC分类号： A61F206
摘要： Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to be flexible so that they compress and expand with corresponding movement of the surrounding tissue into which they are implanted. The flow of blood into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth, a healing process that leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.

3. 发明授权

US07232421B1 Agent delivery systems 失效
标题翻译：代理运送系统
公开(公告)号：US07232421B1
公开(公告)日：2007-06-19
申请号：US09743726
申请日：2000-05-12
申请人： Richard A. Gambale , Chirag B. Shah , Michael F. Weiser , Stephen J. Forcucci , Sean Forde
发明人： Richard A. Gambale , Chirag B. Shah , Michael F. Weiser , Stephen J. Forcucci , Sean Forde
IPC分类号： A61M31/00
CPC分类号： A61M37/0069 , A61B17/3468 , A61B2017/00247 , A61B2018/00392
摘要： The present invention provides a system for delivering a therapeutic agent into tissue in combination with an implant device (2). Preferably the therapeutic substance is contained within a pellet form (14) that is deliverable into the interior of the device (2) after it has been implanted. In a preferred embodiment the implant device (2) comprises a flexible coiled spring body, the coils (4) of which have the proper diameter and spacing to contain the pellet (14) within the interior of the device (2) to contact the therapeutic agent. In treatment of ischemic tissue such as that of the myocardium of the heart, the mechanical irritation of the tissue caused by the implanted device (2) can help to provide an angiogenic effect. Additionally, the cavity (18) provided by the interior of the device (2) permits blood to pool around the pellet (14) and mix with the therapeutic agent. Several delivery systems have provided for delivering the implant and pellet (14) sequentially or simultaneously.
摘要翻译：本发明提供了一种用于将治疗剂与植入装置（2）组合递送到组织中的系统。优选地，治疗物质包含在颗粒形式（14）中，其在植入之后可输送到装置（2）的内部。在优选实施例中，植入装置（2）包括柔性螺旋弹簧体，其线圈（4）具有适当的直径和间隔，以在装置（2）内部容纳颗粒（14）以接触治疗代理商在诸如心脏心肌的缺血组织的治疗中，由植入装置（2）引起的组织的机械刺激可以有助于提供血管生成作用。此外，由装置（2）的内部提供的空腔（18）允许血液围绕丸粒（14）聚集并与治疗剂混合。已经提供了几个递送系统来顺序地或同时地递送植入物和颗粒（14）。

4. 发明授权

US06432126B1 Flexible vascular inducing implants 失效
公开(公告)号：US06432126B1
公开(公告)日：2002-08-13
申请号：US09164163
申请日：1998-09-30
申请人： Richard A. Gambale , Stephen J. Forcucci , Michael F. Weiser , Richard T. Choh , Sean Forde
发明人： Richard A. Gambale , Stephen J. Forcucci , Michael F. Weiser , Richard T. Choh , Sean Forde
IPC分类号： A61F206
CPC分类号： A61F2/94 , A61F2/2493 , A61F2230/0091 , A61F2250/0067
摘要： Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to be flexible so that they compress and expand with corresponding movement of the surrounding tissue into which they are implanted. The flow of blood into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth, a healing process that leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.

5. 发明授权

US06986784B1 Implant anchor systems 失效
标题翻译：植入锚系统
公开(公告)号：US06986784B1
公开(公告)日：2006-01-17
申请号：US09743695
申请日：2000-05-12
申请人： Michael F. Weiser , Richard A. Gambale , Stephen J. Forcucci , Sean Forde , Kellywan Kan
发明人： Michael F. Weiser , Richard A. Gambale , Stephen J. Forcucci , Sean Forde , Kellywan Kan
IPC分类号： A61F2/06
CPC分类号： A61F2/2493 , A61F2/88 , A61F2002/8486 , A61F2220/0008 , A61F2220/0016 , A61F2230/005 , A61F2250/0029 , A61F2250/0036
摘要： The present invention provides anchoring mechanisms for tissue implants. The anchors are integrated as part of the structure of the implant and serve to resist migration of the implant from highly dynamic muscle tissue such as the myocardium of the heart. In implant devices configured as a flexible coil, various attributes of the coil may be altered to increase the anchoring capability of the device. The flexibility of the device may be increased to resist migration by changing the coil filament thickness, pitch or filament material. Alternatively, the end coil may be altered to have a broader cross-sectional profile in engagement with the tissue or may include an anchoring barb. Additionally, methods of implanting a tissue implant device are provided.
摘要翻译：本发明提供了用于组织植入物的锚定机构。锚固件被整合为植入物的结构的一部分，并且用于抵抗植入物从高度动态的肌肉组织（例如心脏的心肌）的迁移。在配置为柔性线圈的植入装置中，可以改变线圈的各种属性以增加装置的锚定能力。通过改变线圈长度，节距或细丝材料，可以提高器件的灵活性以抵抗迁移。或者，可以改变端部线圈以具有与组织接合的更宽的横截面轮廓，或者可以包括锚定倒钩。另外，提供植入组织植入装置的方法。

6. 发明授权

US06949117B2 Vascular inducing implants 失效
标题翻译：血管诱导植入物
公开(公告)号：US06949117B2
公开(公告)日：2005-09-27
申请号：US10767550
申请日：2004-01-29
申请人： Richard A. Gambale , Stephen J. Forcucci , Michael F. Weiser , Richard T. Choh , Sean Forde
发明人： Richard A. Gambale , Stephen J. Forcucci , Michael F. Weiser , Richard T. Choh , Sean Forde
IPC分类号： A61B17/00 , A61F2/00 , A61F2/02 , A61F2/06 , A61F2/94 , A61M37/00 , A61M31/00
CPC分类号： A61F2/94 , A61B17/00234 , A61B2017/00243 , A61F2/06 , A61F2/2493 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0076 , A61F2230/0091 , A61F2250/0067
摘要： Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to have a first configuration having a low profile and an expanded, second configuration having a large profile. The implants are delivered to the ischemic tissue location in the first configuration, implanted then expanded to the second configuration. The expanded implants maintain a stress on the surrounding tissue, irritating and slightly injuring the tissue to provoke an injury response that results in angiogenesis. The flow of blood from the surrounding tissue into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth. This healing process leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.
摘要翻译：提供了用于促进缺血组织中血管生成的植入物和相关递送系统。植入物可以经皮，胸部或手术递送，并且特别适合于植入心脏的心肌。植入物配置成具有低轮廓的第一构造和具有大轮廓的扩展的第二构型。植入物在第一构型中被递送到缺血组织位置，然后植入然后扩展到第二构型。膨胀的植入物对周围组织施加压力，刺激和轻微损伤组织以引起导致血管发生的损伤反应。从周围组织到植入物的血液流动以及植入物中和周围的血液的汇集导致血栓形成和纤维蛋白生长。这种愈合过程导致植入物周围的组织中的血管生成。此外，植入物可能含有血管生成物质或血栓，预先加载或在植入后注射以帮助起始血管发生。

7. 发明授权

US06855160B1 Implant and agent delivery device 失效
标题翻译：植入物和药剂输送装置
公开(公告)号：US06855160B1
公开(公告)日：2005-02-15
申请号：US10048694
申请日：2000-08-03
申请人： Richard A. Gambale , Stephen J. Forcucci , Michael F. Weiser , Sean Forde
发明人： Richard A. Gambale , Stephen J. Forcucci , Michael F. Weiser , Sean Forde
IPC分类号： A61F2/00 , A61F2/02 , A61F2/06 , A61F2/88 , A61F11/00
CPC分类号： A61F2/88 , A61F2/06 , A61F2/2493 , A61F2220/0016 , A61F2250/0067
摘要： The present invention provides a system for delivering a therapeutic agent in combination with an implanted device to maximize a therapeutic benefit offered by each. Preferably, the therapeutic agent is contained within a solid matrix form such as a pellet or gel to facilitate its handling, and to regulate its rate of dissipation into the tissue after delivery. The implant device is specially configured to receive retain the matrix but permit blood to interact with the matrix so that the agent can be released to the blood in, around the device, and the surrounding tissue. A delivery system comprises an implant delivery device having an obturator capable of piercing the tissue and an agent matrix delivery device to place a matrix form, such as a pellet, into the interior of the implant after it has been implanted. Preferably, the implant delivery device and the matrix delivery device are contained in one apparatus to facilitate delivery of the pellet into the embedded implant. The present invention is useful for treating tissue in any area of the body, especially ischemic tissue experiencing reduced blood flow. The present devices and methods are especially useful for treatment of ischemia of the myocardium. In treatment of the myocardium, the present implant device and matrix combination may be delivered surgically through the epicardium of the heart.
摘要翻译：本发明提供了一种用于与植入装置组合递送治疗剂的系统，以最大化由每一种提供的治疗益处。优选地，治疗剂包含在固体基质形式例如丸粒或凝胶中以便于其处理，并调节其在输送后向组织中的耗散速率。植入装置被特别构造成接收保留基质，但允许血液与基质相互作用，使得试剂可以释放到装置周围的血液和周围组织中。递送系统包括植入物递送装置，其具有能够刺穿组织的填塞物和药剂基质递送装置，以便在移植植入物的内部之后将诸如颗粒的基质形式放置在植入物的内部。优选地，植入物递送装置和基质递送装置包含在一个装置中以便于将颗粒递送到嵌入的植入物中。本发明可用于治疗身体的任何区域中的组织，特别是经历血流减少的缺血组织。本发明的装置和方法对于治疗心肌缺血特别有用。在心肌的治疗中，本发明的植入装置和基质组合可以通过心脏的心外膜手术递送。

8. 发明授权

US06802858B2 Vascular inducing implants 失效
公开(公告)号：US06802858B2
公开(公告)日：2004-10-12
申请号：US09774320
申请日：2001-01-31
申请人： Richard A. Gambale , Stephen J. Forcucci , Michael F. Weiser , Richard T. Choh , Sean Forde
发明人： Richard A. Gambale , Stephen J. Forcucci , Michael F. Weiser , Richard T. Choh , Sean Forde
IPC分类号： A61F206
CPC分类号： A61F2/94 , A61B17/00234 , A61B2017/00243 , A61F2/06 , A61F2/2493 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0076 , A61F2230/0091 , A61F2250/0067
摘要： Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to have a first configuration having a low profile and an expanded, second configuration having a large profile. The implants are delivered to the ischemic tissue location in the first configuration, implanted then expanded to the second configuration. The expanded implants maintain a stress on the surrounding tissue, irritating and slightly injuring the tissue to provoke an injury response that results in angiogenesis. The flow of blood from the surrounding tissue into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth. This healing process leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.

9. 发明授权

US06786929B2 Flexible vascular inducing implants and methods 失效
标题翻译：灵活的血管诱导植入物和方法
公开(公告)号：US06786929B2
公开(公告)日：2004-09-07
申请号：US09990644
申请日：2001-11-21
申请人： Richard A. Gambale , Stephen J. Forcucci , Michael F. Weiser , Richard T. Choh , Sean Forde
发明人： Richard A. Gambale , Stephen J. Forcucci , Michael F. Weiser , Richard T. Choh , Sean Forde
IPC分类号： A61F202
CPC分类号： A61F2/94 , A61F2/2493 , A61F2230/0091 , A61F2250/0067
摘要： Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to be flexible so that they compress and expand with corresponding movement of the surrounding tissue into which they are implanted. The flow of blood into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth, a healing process that leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.
摘要翻译：提供了用于促进缺血组织中血管生成的植入物和相关递送系统。植入物可以经皮，胸部或手术递送，并且特别适合于植入心脏心肌。植入物被构造成具有柔性的，使得它们随着植入其中的周围组织的相应运动而压缩和扩张。血液进入植入物的流动以及血液在植入物中和周围的汇集导致血栓形成和纤维蛋白生长，这是导致植入物周围组织血管生成的愈合过程。此外，植入物可能含有血管生成物质或血栓，预先加载或在植入后注射以帮助起始血管发生。

10. 发明授权

US06709425B2 Vascular inducing implants 失效
标题翻译：血管诱导植入物
公开(公告)号：US06709425B2
公开(公告)日：2004-03-23
申请号：US09774319
申请日：2001-01-31
申请人： Richard A. Gambale , Stephen J. Forcucci , Michael F. Weiser , Richard T. Choh , Sean Forde
发明人： Richard A. Gambale , Stephen J. Forcucci , Michael F. Weiser , Richard T. Choh , Sean Forde
IPC分类号： A61M3100
CPC分类号： A61F2/94 , A61B17/00234 , A61B2017/00243 , A61F2/06 , A61F2/2493 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0076 , A61F2230/0091 , A61F2250/0067
摘要： Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to have a first configuration having a low profile and an expanded, second configuration having a large profile. The implants are delivered to the ischemic tissue location in the first configuration, implanted then expanded to the second configuration. The expanded implants maintain a stress on the surrounding tissue, irritating and slightly injuring the tissue to provoke an injury response that results in angiogenesis. The flow of blood from the surrounding tissue into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth. This healing process leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.
摘要翻译：提供了用于促进缺血组织中血管生成的植入物和相关递送系统。植入物可以经皮，胸部或手术递送，并且特别适合于植入心脏的心肌。植入物配置成具有低轮廓的第一构造和具有大轮廓的扩展的第二构型。植入物在第一构型中被递送到缺血组织位置，然后植入然后扩展到第二构型。膨胀的植入物对周围组织施加压力，刺激和轻微损伤组织以引起导致血管发生的损伤反应。从周围组织到植入物的血液流动以及植入物中和周围的血液的汇集导致血栓形成和纤维蛋白生长。这种愈合过程导致植入物周围的组织中的血管生成。此外，植入物可能含有血管生成物质或血栓，预先加载或在植入后注射以帮助起始血管发生。

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