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1. 发明授权

US08992570B2 Suture clips, delivery devices and methods 有权
标题翻译：缝合夹，输送装置和方法
公开(公告)号：US08992570B2
公开(公告)日：2015-03-31
申请号：US11604944
申请日：2006-11-28
申请人： Richard A. Gambale , Michael F. Weiser , Edward Carlton Page , Alexander Kolnick
发明人： Richard A. Gambale , Michael F. Weiser , Edward Carlton Page , Alexander Kolnick
IPC分类号： A61B17/04
CPC分类号： A61B17/0487 , A61B17/0467 , A61B17/0469 , A61B2017/0417 , A61B2017/0424 , A61B2017/0445 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0459 , A61B2017/0464 , A61B2017/0488 , A61B2017/0496 , Y10T24/3969
摘要： Suture clips and suture clip loading, delivery, locking and severing devices in both catheter and endoscopic embodiments are disclosed that permit the delivery and application of suture clips directly in contact with or in close approximation to sutured tissue. The catheter or endoscopic versions incorporate a collet cage with a plurality of flexible collet fingers that captivate a suture clip ring and a suture clip plug for assembly with a suture. An outer sliding sleeve constrains the collet fingers when distally advanced to minimize potential trauma during delivery and assembly of the suture clip in close proximity to the stitched tissue. Proximal retraction of the sliding sleeve coupled with the distal advancement of a pusher against cam surfaces on the inner walls of the collet fingers causes the collet fingers to open. The catheter is designed to hold and assemble the suture clip in a first position and release the suture clip and sever the suture ends proximal to the suture clip in a second position. Single pusher two-step embodiments and double pusher three-step embodiments are disclosed. Suture clip designs with plugs having heads for use with the suture clip delivery catheter are also disclosed. A suture clip loading device for loading suture clip components into the delivery system as well as a threader for threading sutures into the suture clip systems are also disclosed. A method of loading, delivering and deploying suture clips is further disclosed.
摘要翻译：公开了导管和内窥镜实施例中的缝合夹和缝合夹装载，递送，锁定和切断装置，其允许缝合夹直接与缝合组织接触或接近近似地递送和施加。导管或内窥镜版本包括具有多个柔性夹头的夹头保持器，其夹持缝合夹环和缝合夹塞以与缝合线组装。外滑动套筒在向远侧前进时约束夹头，以最小化缝合夹在紧靠缝合组织的递送和组装期间的潜在创伤。与推动器的远端前进部联接的滑动套筒的近端缩回抵靠夹头指状物的内壁上的凸轮表面使得夹头指状物打开。导管被设计成将缝合夹保持并组装在第一位置，并释放缝合夹并在第二位置将缝合线端部切割成缝合线夹。公开了单推杆两步实施例和双推动器三步实施例。还公开了具有插头的缝合夹设计，其具有用于缝合夹输送导管的头部。还公开了一种用于将缝合夹组件加载到输送系统中的缝线夹装载装置以及用于将缝线穿入缝合夹系统的穿线器。进一步公开了一种加载，递送和部署缝合夹的方法。

2. 发明授权

US07993368B2 Suture clips, delivery devices and methods 有权
标题翻译：缝合夹，输送装置和方法
公开(公告)号：US07993368B2
公开(公告)日：2011-08-09
申请号：US10220413
申请日：2001-03-05
申请人： Richard A. Gambale , Michael F. Weiser , Edward Carlton Page , Alexander Kolnick
发明人： Richard A. Gambale , Michael F. Weiser , Edward Carlton Page , Alexander Kolnick
IPC分类号： A61B17/04 , A44B17/00
CPC分类号： A61B17/0487 , A61B17/0467 , A61B17/0469 , A61B2017/0417 , A61B2017/0424 , A61B2017/0445 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0459 , A61B2017/0464 , A61B2017/0488 , A61B2017/0496 , Y10T24/3969
摘要： Provided herein are suture clips that include a plug, a ring, and a shaft. Also provided is a catheter that includes a collet cage with a plurality of flexible collet fingers that engage a suture clip ring and a suture clip plug for assembly with a suture. The catheter is designed to hold and assemble the suture clip in a first position and release the suture clip and sever the suture ends proximal to the suture clip in a second position.
摘要翻译：本文提供了包括塞子，环和轴的缝合夹。还提供了一种导管，其包括具有与缝合夹环接合的多个柔性夹头的夹头保持器和用于与缝合线组装的缝合夹塞。导管被设计成将缝合夹保持并组装在第一位置，并释放缝合夹并在第二位置将缝合线端部切割成缝合线夹。

3. 发明授权

US06629987B1 Catheter positioning systems 失效
标题翻译：导管定位系统
公开(公告)号：US06629987B1
公开(公告)日：2003-10-07
申请号：US09364520
申请日：1999-07-30
申请人： Richard A. Gambale , Stephen J. Forcucci , Chirag B. Shah , Michael F. Weiser , Sean Forde
发明人： Richard A. Gambale , Stephen J. Forcucci , Chirag B. Shah , Michael F. Weiser , Sean Forde
IPC分类号： A61M2900
CPC分类号： A61M25/04 , A61B2017/3488 , A61M25/0084 , A61M2025/0087
摘要： The present invention provides a catheter positioning system which serves to control and stabilize a distal end of a catheter at a treatment site within a patient so that a medical procedure can be performed with accuracy. Generally, the positioning system operates by providing a deformable mechanical members at the distal end of the catheter which can be operated from the proximal end of the catheter to extend radially outward to engage surrounding tissue adjacent to treatment site. In one embodiment of the invention a flexible superstructure comprising the plurality of flexible veins extending longitudinally along the distal end of the catheter can be deformed to bow radially outward to engage surrounding tissue. The distal tip of the catheter joined to one of the veins was correspondingly displaced or rotated angularly as the veins bow outward. In another embodiment radially projecting fingers are joined to the distal end of the catheter, which remain retracted during navigation of the catheter to the treatment site then are extended outward to penetrate the tissue and secure the catheter at the treatment site upon being actuated from the proximal end of the catheter by a physician. Methods of positioning a catheter are also disclosed. The inventive device and method are particularly useful in catheter based procedures carried out in large body lumens or in cavities of body organs. In particular, the invention may be useful in delivering implants percutaneously through the left ventricle into the myocardium of the heart.
摘要翻译：本发明提供了一种导管定位系统，其用于控制和稳定患者内的治疗部位处的导管的远端，使得可以精确地执行医疗程序。通常，定位系统通过在导管的远端处提供可变形的机械构件来操作，该可变形机械构件可以从导管的近端操作以径向向外延伸以接合邻近治疗部位的周围组织。在本发明的一个实施例中，包括沿着导管的远端纵向延伸的多个柔性静脉的柔性上部结构可以变形以径向向外弯曲以接合周围的组织。当静脉向外弯曲时，连接到静脉中的一个静脉的导管的远端相应地位移或旋转。在另一个实施例中，径向突出的指状物连接到导管的远端，导管的远端在导管导航到治疗部位期间保持缩回，然后向外延伸以穿透组织，并且在从近端致动时将导管固定在治疗部位导管的末端由医师。还公开了定位导管的方法。本发明的装置和方法特别适用于在大体腔或身体器官腔中进行的基于导管的程序。特别地，本发明可用于将植入物通过左心室经皮穿入心脏心肌。

4. 发明授权

US06331185B1 Flexible vascular inducing implants 失效
公开(公告)号：US06331185B1
公开(公告)日：2001-12-18
申请号：US09164163
申请日：1998-09-30
申请人： Richard A. Gambale , Stephen J. Forcucci , Michael F. Weiser , Richard T. Choh , Sean Forde
发明人： Richard A. Gambale , Stephen J. Forcucci , Michael F. Weiser , Richard T. Choh , Sean Forde
IPC分类号： A61F206
摘要： Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to be flexible so that they compress and expand with corresponding movement of the surrounding tissue into which they are implanted. The flow of blood into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth, a healing process that leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.

5. 发明授权

US08100920B2 Endoscopic tissue apposition device with multiple suction ports 有权
标题翻译：具有多个吸入口的内窥镜组织安置装置
公开(公告)号：US08100920B2
公开(公告)日：2012-01-24
申请号：US12146637
申请日：2008-06-26
申请人： Richard A. Gambale , Michael F. Weiser , Edward C. Page , Peter J. Lukin
发明人： Richard A. Gambale , Michael F. Weiser , Edward C. Page , Peter J. Lukin
IPC分类号： A61B17/10 , A61B17/04
CPC分类号： A61B17/0401 , A61B17/00234 , A61B17/0469 , A61B17/0482 , A61B17/0625 , A61B17/068 , A61B17/08 , A61B18/1492 , A61B18/22 , A61B2017/00827 , A61B2017/0409 , A61B2017/0417 , A61B2017/0458 , A61B2017/047 , A61B2017/0472 , A61B2017/061 , A61B2017/081 , A61B2017/306 , A61B2018/00291
摘要： The present invention relates to an improved endoscopic tissue apposition device having multiple suction ports. The invention permits multiple folds of tissue to be captured in the suction ports with a single positioning of the device and attached together by a tissue securement mechanism such as a suture, staple or other form of tissue bonding. The improvement reduces the number of intubations required during an endoscopic procedure to suture tissue or join areas of tissue together. The suction ports may be arranged in a variety of configurations on the apposition device to best suit the desired resulting tissue orientation. The inventive tissue apposition device may also incorporate tissue abrasion means to activate the healing process on surfaces of tissue areas that are to be joined by operation of the device to promote a more secure attachment by permanent tissue bonding.
摘要翻译：本发明涉及具有多个吸入口的改进的内窥镜组织接合装置。本发明允许组织的多个折叠在装置的单个定位中被捕获在吸入口中，并通过组织固定机构（例如缝合线，钉或其它形式的组织结合）附接在一起。该改进减少了在内窥镜过程中将缝合组织或将组织区域连接在一起的插管数量。吸入口可以以配置装置中的各种构造布置，以最适合所需的组织取向。本发明的组织接合装置还可以包括组织磨损装置，以通过装置的操作来激活要连接的组织区域的表面上的愈合过程，以通过永久性组织结合来促进更安全的附接。

6. 发明申请

US20080262516A1 ENDOSCOPIC TISSUE APPOSITION DEVICE WITH MULTIPLE SUCTION PORTS 有权
标题翻译：具有多个吸气口的内窥镜组织检查装置
公开(公告)号：US20080262516A1
公开(公告)日：2008-10-23
申请号：US12146637
申请日：2008-06-26
申请人： Richard A. Gambale , Michael F. Weiser , Edward C. Page , Peter J. Lukin
发明人： Richard A. Gambale , Michael F. Weiser , Edward C. Page , Peter J. Lukin
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B17/00234 , A61B17/0469 , A61B17/0482 , A61B17/0625 , A61B17/068 , A61B17/08 , A61B18/1492 , A61B18/22 , A61B2017/00827 , A61B2017/0409 , A61B2017/0417 , A61B2017/0458 , A61B2017/047 , A61B2017/0472 , A61B2017/061 , A61B2017/081 , A61B2017/306 , A61B2018/00291
摘要： The present invention relates to an improved endoscopic tissue apposition device having multiple suction ports. The invention permits multiple folds of tissue to be captured in the suction ports with a single positioning of the device and attached together by a tissue securement mechanism such as a suture, staple or other form of tissue bonding. The improvement reduces the number of intubations required during an endoscopic procedure to suture tissue or join areas of tissue together. The suction ports may be arranged in a variety of configurations on the apposition device to best suit the desired resulting tissue orientation. The inventive tissue apposition device may also incorporate tissue abrasion means to activate the healing process on surfaces of tissue areas that are to be joined by operation of the device to promote a more secure attachment by permanent tissue bonding.
摘要翻译：本发明涉及具有多个吸入口的改进的内窥镜组织接合装置。本发明允许组织的多个折叠在装置的单个定位中被捕获在吸入口中，并通过组织固定机构（例如缝合线，钉或其它形式的组织结合）附接在一起。该改进减少了在内窥镜过程中将缝合组织或将组织区域连接在一起的插管数量。吸入口可以以配置装置中的各种构造布置，以最适合所需的组织取向。本发明的组织接合装置还可以包括组织磨损装置，以通过装置的操作来激活要连接的组织区域的表面上的愈合过程，以通过永久性组织结合来促进更安全的附接。

7. 发明授权

US06432126B1 Flexible vascular inducing implants 失效
公开(公告)号：US06432126B1
公开(公告)日：2002-08-13
申请号：US09164163
申请日：1998-09-30
申请人： Richard A. Gambale , Stephen J. Forcucci , Michael F. Weiser , Richard T. Choh , Sean Forde
发明人： Richard A. Gambale , Stephen J. Forcucci , Michael F. Weiser , Richard T. Choh , Sean Forde
IPC分类号： A61F206
CPC分类号： A61F2/94 , A61F2/2493 , A61F2230/0091 , A61F2250/0067
摘要： Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to be flexible so that they compress and expand with corresponding movement of the surrounding tissue into which they are implanted. The flow of blood into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth, a healing process that leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.

8. 发明授权

US08152821B2 Endoscopic tissue apposition device with multiple suction ports 有权
公开(公告)号：US08152821B2
公开(公告)日：2012-04-10
申请号：US12070809
申请日：2008-02-21
申请人： Richard A. Gambale , Michael F. Weiser , Edward C. Page , Peter J. Lukin
发明人： Richard A. Gambale , Michael F. Weiser , Edward C. Page , Peter J. Lukin
IPC分类号： A61B17/10 , A61B17/04
CPC分类号： A61B17/0401 , A61B17/00234 , A61B17/0469 , A61B17/0482 , A61B17/0625 , A61B17/068 , A61B17/08 , A61B18/1492 , A61B18/22 , A61B2017/00827 , A61B2017/0409 , A61B2017/0417 , A61B2017/0458 , A61B2017/047 , A61B2017/0472 , A61B2017/061 , A61B2017/081 , A61B2017/306 , A61B2018/00291
摘要： The present invention relates to an improved endoscopic tissue apposition device having multiple suction ports. The invention permits multiple folds of tissue to be captured in the suction ports with a single positioning of the device and attached together by a tissue securement mechanism such as a suture, staple or other form of tissue bonding. The improvement reduces the number of intubations required during an endoscopic procedure to suture tissue or join areas of tissue together. The suction ports may be arranged in a variety of configurations on the apposition device to best suit the desired resulting tissue orientation. The inventive tissue apposition device may also incorporate tissue abrasion means to activate the healing process on surfaces of tissue areas that are to be joined by operation of the device to promote a more secure attachment by permanent tissue bonding.

9. 发明授权

US07399304B2 Endoscopic tissue apposition device with multiple suction ports 有权
标题翻译：具有多个吸入口的内窥镜组织安置装置
公开(公告)号：US07399304B2
公开(公告)日：2008-07-15
申请号：US10220379
申请日：2001-03-02
申请人： Richard A. Gambale , Michael F. Weiser , Edward C. Page , Peter J. Lukin
发明人： Richard A. Gambale , Michael F. Weiser , Edward C. Page , Peter J. Lukin
IPC分类号： A61B17/10 , A61B17/04 , A61B18/18
CPC分类号： A61B17/0401 , A61B17/00234 , A61B17/0469 , A61B17/0482 , A61B17/0625 , A61B17/068 , A61B17/08 , A61B18/1492 , A61B18/22 , A61B2017/00827 , A61B2017/0409 , A61B2017/0417 , A61B2017/0458 , A61B2017/047 , A61B2017/0472 , A61B2017/061 , A61B2017/081 , A61B2017/306 , A61B2018/00291
摘要： An improved endoscopic tissue apposition device (50) having multiple suction ports (86) permits multiple folds of tissue to be captured in the suction ports (86) with a single positioning of the device (50) and attached together by a tissue securement mechanism such as a suture (14), staple or other form of tissue bonding. The improvement reduces the number of intubations required during an endoscopic procedure to suture tissue or join areas of tissue together. The suction ports (86) may be arranged in a variety of configurations on the apposition device (50) to best suit the desired resulting tissue orientation. The tissue apposition device (50) may also incorporate tissue abrasion means (852) to activate the healing process on surfaces of tissue areas that are to be joined by operation of the device to promote a more secure attachment by permanent tissue bonding.
摘要翻译：具有多个吸入口（86）的改进的内窥镜组织安置装置（50）允许组织的多个折叠通过装置（50）的单个定位被捕获在吸入口（86）中，并且通过组织固定机构作为缝合线（14），钉或其他形式的组织粘合。该改进减少了在内窥镜过程中将缝合组织或将组织区域连接在一起的插管数量。吸入口（86）可以以各种配置布置在接合装置（50）上，以最适合所需的组织取向。组织安置装置（50）还可以包括组织磨损装置（852），以通过装置的操作来激活要连接的组织区域的表面上的愈合过程，以通过永久性组织粘合促进更安全的附接。

10. 发明授权

US07232421B1 Agent delivery systems 失效
标题翻译：代理运送系统
公开(公告)号：US07232421B1
公开(公告)日：2007-06-19
申请号：US09743726
申请日：2000-05-12
申请人： Richard A. Gambale , Chirag B. Shah , Michael F. Weiser , Stephen J. Forcucci , Sean Forde
发明人： Richard A. Gambale , Chirag B. Shah , Michael F. Weiser , Stephen J. Forcucci , Sean Forde
IPC分类号： A61M31/00
CPC分类号： A61M37/0069 , A61B17/3468 , A61B2017/00247 , A61B2018/00392
摘要： The present invention provides a system for delivering a therapeutic agent into tissue in combination with an implant device (2). Preferably the therapeutic substance is contained within a pellet form (14) that is deliverable into the interior of the device (2) after it has been implanted. In a preferred embodiment the implant device (2) comprises a flexible coiled spring body, the coils (4) of which have the proper diameter and spacing to contain the pellet (14) within the interior of the device (2) to contact the therapeutic agent. In treatment of ischemic tissue such as that of the myocardium of the heart, the mechanical irritation of the tissue caused by the implanted device (2) can help to provide an angiogenic effect. Additionally, the cavity (18) provided by the interior of the device (2) permits blood to pool around the pellet (14) and mix with the therapeutic agent. Several delivery systems have provided for delivering the implant and pellet (14) sequentially or simultaneously.
摘要翻译：本发明提供了一种用于将治疗剂与植入装置（2）组合递送到组织中的系统。优选地，治疗物质包含在颗粒形式（14）中，其在植入之后可输送到装置（2）的内部。在优选实施例中，植入装置（2）包括柔性螺旋弹簧体，其线圈（4）具有适当的直径和间隔，以在装置（2）内部容纳颗粒（14）以接触治疗代理商在诸如心脏心肌的缺血组织的治疗中，由植入装置（2）引起的组织的机械刺激可以有助于提供血管生成作用。此外，由装置（2）的内部提供的空腔（18）允许血液围绕丸粒（14）聚集并与治疗剂混合。已经提供了几个递送系统来顺序地或同时地递送植入物和颗粒（14）。

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