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1. 发明授权

US5690892A Cassette for use with automated specimen handling system 失效
标题翻译：用于自动化样品处理系统的纸盒
公开(公告)号：US5690892A
公开(公告)日：1997-11-25
申请号：US528791
申请日：1995-09-15
申请人： Egan Babler , Richard A. Domanik , Peter G. Gombrich , William J. Mayer
发明人： Egan Babler , Richard A. Domanik , Peter G. Gombrich , William J. Mayer
IPC分类号： G01N35/00 , G01N35/04
CPC分类号： G01N35/00029 , G01N2035/00039 , G01N2035/00089 , Y10T436/11 , Y10T436/113332 , Y10T436/114165
摘要： A portable specimen transporting cassette for use with an automated specimen handling system The cassette includes a body portion, an electronic programmable memory device attached to the body portion, and an electrical conductor coupled to the memory device. The body portion includes right and left opposing sidewalls, and a substantially open front face between the opposing sidewalls. A plurality of ribs compartmentalize the body portion into superimposed sections, each capable of containing a specimen. The substantially open front face permits the specimens to be inserted into and withdrawn from the cassette. The electrical conductor interfaces with the specimen handling system and permits communication between the memory device and the specimen handling system. The cassette may include two separable portions which can be separately distributed for processing of sorted specimens therein.
摘要翻译：用于自动化样品处理系统的便携式样品输送盒盒式磁带包括主体部分，附接到主体部分的电子可编程存储器件以及耦合到存储器件的电导体。主体部分包括左右相对的侧壁和相对侧壁之间的基本上敞开的前表面。多个肋将主体部分分隔成叠加的部分，每个肋可容纳样本。基本上敞开的前表面允许将样本插入盒中并从盒中取出。电导体与样品处理系统接口，并允许存储器件和样品处理系统之间的通信。盒可以包括两个可分离的部分，用于处理分选的样本。

2. 发明授权

US5963368A Specimen management system 失效
标题翻译：标本管理系统
公开(公告)号：US5963368A
公开(公告)日：1999-10-05
申请号：US926182
申请日：1997-09-09
申请人： Richard A Domanik , Peter G. Gombrich , William J. Mayer
发明人： Richard A Domanik , Peter G. Gombrich , William J. Mayer
IPC分类号： G02B21/34 , G02B21/36 , G01N21/00 , G02B21/26
CPC分类号： G02B21/34 , G02B21/365
摘要： A system for managing specimens in a clinical laboratory comprises specimens and a computer controlled instrument. Each specimen includes a biological sample and an identifier which is unique to the specimen to which it is applied. The computer controlled instrument includes a reader for automatically logging and verifying the specimen to be analyzed, and a print head for modifying the identifier to indicate whether the specimen has been analyzed and whether the sample includes any abnormalities. The print head is also used to indicate whether the specimen has been reanalyzed. Further, the print head works to print symbols adjacent the locations of the abnormalities in the sample.
摘要翻译：用于管理临床实验室标本的系统包括标本和计算机控制仪器。每个样本包括生物样本和标识符，该标识符对于其应用的样本是唯一的。计算机控制仪器包括用于自动记录和验证待分析样本的读取器，以及用于修改标识符以指示样本是否已被分析以及样本是否包含任何异常的打印头。打印头也用于指示样品是否已经重新分析。此外，打印头用于在样本中的异常位置附近打印符号。

3. 发明授权

US5930732A System for simplifying the implementation of specified functions 失效
标题翻译：用于简化指定功能实现的系统
公开(公告)号：US5930732A
公开(公告)日：1999-07-27
申请号：US529188
申请日：1995-09-15
申请人： Richard A. Domanik , Dennis W. Gruber , William J. Mayer
发明人： Richard A. Domanik , Dennis W. Gruber , William J. Mayer
IPC分类号： G02B21/36 , G05B19/10 , G06F3/033 , G05B19/045
CPC分类号： G06F3/03543 , G02B21/365 , G05B19/106 , G05B2219/23045 , G05B2219/23387
摘要： A machine, method and medium for implementing functions using an input device in a manner that enhances efficient operation of a mechanism capable of operating in at least two states. The functions are implemented via a convenient input device, such as a mouse. One or more specified actuators of the input device implement a given function when the mechanism is in a first state, while at least one of those actuators implements a different function when the mechanism is in a second state. In embodiments of the present invention contemplating that the mechanism is a microscope system, two states in which the microscope system is envisioned to operate are a scan state and a pause state. The scan state allows the microscope system to execute a pre-defined scan sequence, while the pause state allows the microscope system to pause from that sequence.
摘要翻译：一种机器，方法和介质，用于以增强能够在至少两种状态下操作的机构的有效操作的方式使用输入装置来实现功能。这些功能通过方便的输入设备（如鼠标）来实现。当机构处于第一状态时，输入装置的一个或多个指定的致动器实现给定的功能，而当机构处于第二状态时，这些致动器中的至少一个致动器执行不同的功能。在本发明的实施例中，考虑到该机构是显微镜系统，其中设想显微镜系统的两种状态是扫描状态和暂停状态。扫描状态允许显微镜系统执行预定义的扫描序列，而暂停状态允许显微镜系统从该顺序暂停。

4. 发明授权

US6151161A High-precision computer-aided microscope system 有权
标题翻译：高精度计算机辅助显微镜系统
公开(公告)号：US6151161A
公开(公告)日：2000-11-21
申请号：US174140
申请日：1998-10-16
申请人： William J. Mayer , Norman J. Pressman , Richard A. Domanik
发明人： William J. Mayer , Norman J. Pressman , Richard A. Domanik
IPC分类号： G02B21/00 , G02B21/06 , G02B21/24 , G02B21/26 , G02B21/36
CPC分类号： G02B21/362 , G02B21/24
摘要： A system for facilitating microscope-based specimen analysis is disclosed. The system includes an improved optical microscope, which may be used, in one application, to analyze cell and tissue samples from specimens obtained from patients, to facilitate inspection of suspicious materials and identification of atypical or abnormal cells and further expert review. The system includes a motorized plate, an automatic focusing sub-system, an improved light source, an improved simple plug connector for direct hookup of the microscope to an external computer, and an electronic image capturing and analyzing sub-system for automatic scanning of the sample and for electronic capture and storage of images indicative of the specimen.
摘要翻译：公开了一种促进基于显微镜的样本分析的系统。该系统包括改进的光学显微镜，其可以在一个应用中用于分析从患者获得的样本的细胞和组织样品，以便于检查可疑物质和鉴定非典型或异常细胞并进一步专家评估。该系统包括电动板，自动聚焦子系统，改进的光源，用于将显微镜直接连接到外部计算机的改进的简单插头连接器，以及用于自动扫描的外部计算机的电子图像捕获和分析子系统样品和用于电子捕获和存储指示样品的图像。

5. 发明授权

US5652143A Dual chamber blood culture bottle with break seal 失效
标题翻译：双室血培养瓶具有断裂密封
公开(公告)号：US5652143A
公开(公告)日：1997-07-29
申请号：US477656
申请日：1995-06-07
申请人： Peter P. Gombrich , Richard A. Domanik , William J. Mayer
发明人： Peter P. Gombrich , Richard A. Domanik , William J. Mayer
IPC分类号： B01L3/00 , C12M1/24 , C12M3/00 , B01L11/00
CPC分类号： B01L3/502 , C12M23/08 , C12M23/22 , C12M23/34 , C12M23/38 , C12M33/04 , B01L2400/0644
摘要： A multi-chambered blood culture device for simultaneously conducting two blood culture tests on a single blood sample. An integrated unit including a syringe port with pin extensions is provided for receiving a blood sample simultaneously into two independent sample compartments. At least two culture chambers contain growth media, one culture chamber preferably containing an aerobic growth medium and another culture chamber preferably containing an anaerobic growth medium. The device is configured to isolate the sample vials and culture chambers from contaminants of the external environment. Downward pressure on the syringe port causes the pin extensions to breache the sample compartment walls and thereby releases the blood sample from one sample compartment into one culture chamber while simultaneously releasing the blood from the other sample compartment into the other culture chamber. In the preferred embodiment, outer walls of the device are constructed of transparent plastic so as to enable visual observance of microorganism growth in the respective culture chambers.
摘要翻译：一种多室血液培养装置，用于同时对单个血液样品进行两次血培养试验。提供包括具有销延伸部的注射器端口的集成单元，用于将血液样本同时接收到两个独立的样品室中。至少两个培养室含有生长培养基，一个培养室优选含有需氧生长培养基，另一培养室优选含有厌氧生长培养基。该装置被配置为将样品瓶和培养室与外部环境的污染物隔离。注射器端口上的向下压力导致销延伸部破裂样品室壁，从而将血液样品从一个样品室释放到一个培养室中，同时将血液从另一个样品室释放到另一个培养室中。在优选实施例中，该装置的外壁由透明塑料构成，以便可以观察各个培养室中的微生物生长。

6. 发明授权

US5580786A Dual chamber blood culture bottle with syringe capture and piston assembly 失效
标题翻译：双腔血培养瓶，注射器捕捉和活塞组装
公开(公告)号：US5580786A
公开(公告)日：1996-12-03
申请号：US477655
申请日：1995-06-07
申请人： Peter P. Gombrich , Richard A. Domanik , William J. Mayer
发明人： Peter P. Gombrich , Richard A. Domanik , William J. Mayer
IPC分类号： B01L3/00 , C12M1/18 , C12M1/24 , C12M1/36
CPC分类号： B01L3/502 , C12M23/08 , C12M23/34 , C12M33/04 , B01L2400/0644
摘要： A multi-chambered blood culture device for simultaneously conducting two blood culture tests on a single blood sample. An integrated unit is provided with a syringe port and a piston assembly for receiving a specimen syringe and for enabling a predetermined quantity of blood to be injected into two sample cups. Isolated media compartments contain growth media, one preferably containing an aerobic growth medium and another preferably containing an anaerobic growth medium. Once the blood specimen is fully injected into the sample cups, the sample cups are released into the media compartments, thereby enabling the blood specimens to mix with the respective growth media for testing. Further, means may also be provided to lock the syringe into the integral device in order to facilitate efficient disposal upon completion of testing. Additionally, in the preferred embodiment, outer walls of the device are constructed of transparent plastic so as to enable visual observance of microorganism growth in the respective culture chambers.
摘要翻译：一种多室血液培养装置，用于同时对单个血液样品进行两次血培养试验。集成单元设置有注射器端口和用于接收样本注射器的活塞组件，并且用于使预定量的血液能够注射到两个样品杯中。分离的介质隔室含有生长培养基，优选含有需氧生长培养基，另一种优选含有厌氧生长培养基。一旦血液样本被完全注射到样品杯中，样品杯被释放到介质室中，从而使得血液样本与相应的生长培养基混合以进行测试。此外，还可以提供用于将注射器锁定到整体装置中的装置，以便在测试完成时促进有效的处置。此外，在优选实施例中，该装置的外壁由透明塑料构成，以便能够在各培养室内观察微生物生长。

7. 发明授权

US5573951A Dual chamber blood culture bottle with rotating inlet valve assembly 失效
标题翻译：双室血培养瓶具有旋转进气阀组件
公开(公告)号：US5573951A
公开(公告)日：1996-11-12
申请号：US475380
申请日：1995-06-07
申请人： Peter P. Gombrich , Richard A. Domanik , William J. Mayer
发明人： Peter P. Gombrich , Richard A. Domanik , William J. Mayer
IPC分类号： B01L3/00 , C12M1/18 , C12M1/24 , C12M1/36
CPC分类号： B01L3/502 , C12M23/08 , C12M23/22 , C12M23/34 , B01L2400/0644
摘要： A multi-chambered blood culture device for simultaneously conducting two blood culture tests on a single blood sample. An integrated unit is provided with rotating blood inlet valve assembly for receiving a blood sample simultaneously into two independent sample vials. Independent culture chambers contain growth media, one culture chamber preferably containing an aerobic growth medium and another culture chamber preferably containing an anaerobic growth medium. The device is configured to isolate the sample vials and culture chambers from contaminants of the external environment. By rotating the blood inlet valve assembly, blood is simultaneously released from one sample vial into one culture chamber and from the other sample vial into the other culture chamber. Outer walls of the device are preferably constructed of a transparent plastic material so as to enable visual observance of microorganism growth in the respective culture chambers.
摘要翻译：一种多室血液培养装置，用于同时对单个血液样品进行两次血培养试验。集成单元设置有旋转进血阀组件，用于将血液样本同时接收到两个独立的样品瓶中。独立培养室含有生长培养基，一个培养室优选含有需氧生长培养基，另一培养室优选含有厌氧生长培养基。该装置被配置为将样品瓶和培养室与外部环境的污染物隔离。通过旋转进血阀组件，将血液从一个样品瓶同时释放到一个培养室中，并从另一个样品瓶中释放到另一个培养室中。设备的外壁优选由透明塑料材料构成，以便能够在各个培养室中观察到微生物生长。

8. 发明授权

US6118581A Multifunctional control unit for a microscope 失效
标题翻译：用于显微镜的多功能控制单元
公开(公告)号：US6118581A
公开(公告)日：2000-09-12
申请号：US768711
申请日：1996-12-18
申请人： Richard A. Domanik , Dennis W. Gruber , Peter P. Gombrich , William J. Mayer
发明人： Richard A. Domanik , Dennis W. Gruber , Peter P. Gombrich , William J. Mayer
IPC分类号： G02B21/26 , G05B19/10 , G06F3/033 , G02B21/00
CPC分类号： G06F3/03543 , G02B21/26 , G05B19/106 , G05B2219/23045 , G05B2219/23387 , G05B2219/35451 , G05B2219/43186 , G05B2219/45182
摘要： A machine, method and medium for implementing functions using an input device in a manner that enhances efficient operation of a mechanism capable of operating in at least two states. The functions are implemented via a convenient input device, such as a mouse. One or more specified actuators of the input device implement a given function when the mechanism is in a first state, while at least one of those actuators implements a different function when the mechanism is in a second state. In embodiments of the present invention contemplating that the mechanism is a microscope system, two states in which the microscope system is envisioned to operate are a scan state and a pause state. The scan state allows the microscope system to execute a pre-defined scan sequence, while the pause state allows the microscope system to pause from that sequence.
摘要翻译：一种机器，方法和介质，用于以增强能够在至少两种状态下操作的机构的有效操作的方式使用输入装置来实现功能。这些功能通过方便的输入设备（如鼠标）来实现。当机构处于第一状态时，输入装置的一个或多个指定的致动器实现给定的功能，而当机构处于第二状态时，这些致动器中的至少一个致动器执行不同的功能。在本发明的实施例中，考虑到该机构是显微镜系统，其中设想显微镜系统的两种状态是扫描状态和暂停状态。扫描状态允许显微镜系统执行预定义的扫描序列，而暂停状态允许显微镜系统从该顺序暂停。

9. 发明授权

US5607860A Dual chamber blood culture bottle 失效
标题翻译：双室血培养瓶
公开(公告)号：US5607860A
公开(公告)日：1997-03-04
申请号：US477657
申请日：1995-06-07
申请人： Peter P. Gombrich , Richard A. Domanik , William J. Mayer
发明人： Peter P. Gombrich , Richard A. Domanik , William J. Mayer
IPC分类号： B01L3/00 , C12M1/18 , C12M1/24 , C12M3/00
CPC分类号： B01L3/502 , C12M23/08 , C12M23/22 , C12M23/34 , C12M23/38 , C12M33/04 , B01L2400/0644
摘要： A multi-chambered blood culture device for simultaneously conducting two blood culture tests on a single blood sample. An integrated unit is provided for receiving a blood sample simultaneously into two independent sample vials. Independent culture chambers contain growth media, one culture chamber preferably containing an aerobic growth medium and another culture chamber preferably containing an anaerobic growth medium. The device is configured to isolate the sample vials and culture chambers from contaminants of the external environment. Further, means are provided for releasing the blood from one sample vial into one culture chamber while simultaneously releasing the blood from the other sample vial into the other culture chamber. In the preferred embodiment, outer walls of the device are constructed of transparent plastic so as to enable visual observance of microorganism growth in the respective culture chambers.
摘要翻译：一种多室血液培养装置，用于同时对单个血液样品进行两次血培养试验。提供了一个集成单元，用于将血液样本同时接收到两个独立的样品瓶中。独立培养室含有生长培养基，一个培养室优选含有需氧生长培养基，另一培养室优选含有厌氧生长培养基。该装置被配置为将样品瓶和培养室与外界环境的污染物隔离。此外，提供了用于将血液从一个样品瓶释放到一个培养室中同时将血液从另一个样品瓶释放到另一培养室中的装置。在优选实施例中，该装置的外壁由透明塑料构成，以便可以观察各个培养室中的微生物生长。

10. 发明授权

US07807476B2 Vial system and method for processing liquid-based specimens 有权
公开(公告)号：US07807476B2
公开(公告)日：2010-10-05
申请号：US12732078
申请日：2010-03-25
申请人： Norman J. Pressman , William J. Mayer
发明人： Norman J. Pressman , William J. Mayer
IPC分类号： G01N1/18
CPC分类号： B01D61/18 , B01D61/22 , B01D63/08 , B01D65/08 , B01D2321/2041 , B01F7/00583 , B01F7/1695 , B01F13/002 , B01F13/04 , B01F13/045 , B01L3/502 , B01L3/50825 , B01L2300/042 , B01L2300/046 , B01L2300/0681 , B01L2400/049 , B65B7/161 , G01N1/2813 , G01N1/4077 , G01N35/00 , G01N35/00029 , G01N35/0099 , G01N35/021 , G01N35/1016 , G01N2001/1025 , G01N2001/2826 , G01N2035/00089 , G01N2035/00138 , G01N2035/0405 , G01N2035/0427 , G01N2035/0441 , G01N2035/0443 , G01N2035/0458 , G01N2035/0462 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： A vial-based system and method for handling and processing specimens of particulate matter-containing liquid directly in the vial. A processing assembly, which includes a stirrer and a particulate matter separation chamber, is releasably coupled to the inside of the vial cover. The processing assembly remains with the cover when the vial is opened to insert a specimen therein. Application of a particular external force to the closed vial detaches the processing assembly from the cover so that it remains in the vial, for access by automated or manual laboratory equipment, when the cover is subsequently removed.

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