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1. 发明授权

US07215999B1 Battery charge indicator for implantable pacemakers and defibrillators 有权
标题翻译：用于植入式起搏器和除颤器的电池充电指示器
公开(公告)号：US07215999B1
公开(公告)日：2007-05-08
申请号：US10636724
申请日：2003-08-06
申请人： Reza Shahandeh , George I. Isaac
发明人： Reza Shahandeh , George I. Isaac
IPC分类号： A61N1/00
CPC分类号： A61N1/3708 , G01R31/3624 , G01R31/3648
摘要： Current usage from a battery in an implantable cardiac device is tracked. The apparatus includes a battery current sensor having multiple current ranges. The current sensor produces a first signal representative of current drawn from a battery. A current range selector selects a current range for the battery current sensor and produces a second signal representative of the current range. An accumulator accumulates the first signal based on the second signal over time to generate an output signal representing usage of the battery.
摘要翻译：跟踪可植入式心脏装置中的电池的当前使用情况。该装置包括具有多个电流范围的电池电流传感器。电流传感器产生代表从电池吸取的电流的第一信号。电流量程选择器选择电池电流传感器的电流范围，并产生代表当前范围的第二信号。累加器根据第二信号随时间积累第一信号以产生表示电池使用的输出信号。

2. 发明授权

US08209005B1 System and method for reducing pain in a high-voltage lead impedance check procedure using DC voltage or current in an implantable medical device 有权
标题翻译：用于在可植入医疗装置中使用直流电压或电流降低高压引线阻抗检查程序中疼痛的系统和方法
公开(公告)号：US08209005B1
公开(公告)日：2012-06-26
申请号：US11555183
申请日：2006-10-31
申请人： J. Christopher Moulder , George I. Isaac , Sergiu Silvian
发明人： J. Christopher Moulder , George I. Isaac , Sergiu Silvian
IPC分类号： A61B5/05
CPC分类号： A61N1/3925
摘要： Constant voltage or current is applied to high-voltage leads to determine impedance across medical device leads. Thyristors are used for upper switching components in an H-bridge. Current is sourced into a thyristor's gate from a ground-referenced source. This current then passes from the gate to the cathode and out to the patient. By keeping the current sufficiently low, the thyristors will not conduct from the anode to the cathode. Current passes through the thyristor, lead and patient and is sensed as it returns from the other lead. The sensed current is used to regulate the injected current. Pulses of constant current on the order of tens of milliamperes can be injected and the resulting voltage can be measured. Alternatively, a constant voltage can be applied and the resulting current can be measured to determine lead impedance.
摘要翻译：对高压引线施加恒定电压或电流，以确定医疗器械引线上的阻抗。晶闸管用于H桥中的上部开关元件。电流源自地参考源的晶闸管门。该电流然后从门传递到阴极并输出到患者身上。通过保持电流足够低，晶闸管将不会从阳极传导到阴极。电流通过晶闸管，导线和患者，并在从另一导线返回时被感测。感应电流用于调节注入电流。可以注入几十毫安量级的恒定电流的脉冲，并且可以测量所得到的电压。或者，可以施加恒定电压，并且可以测量所得到的电流以确定导线阻抗。

3. 发明申请

US20110112599A1 MRI SIGNAL FILTERING FOR IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：用于可植入医疗器械的MRI信号滤波
公开(公告)号：US20110112599A1
公开(公告)日：2011-05-12
申请号：US12617532
申请日：2009-11-12
申请人： Zin Zhang , J. Christopher Moulder , George I. Isaac , Gabriel A. Mouchawar , Peter Boileau , Ingmar Viohl
发明人： Zin Zhang , J. Christopher Moulder , George I. Isaac , Gabriel A. Mouchawar , Peter Boileau , Ingmar Viohl
IPC分类号： A61N1/08
CPC分类号： G01R33/288 , A61N1/36521 , A61N1/3718 , A61N1/3754 , G01R33/3685
摘要： A filtering scheme for an implantable medical device mitigates potentially adverse effects that may be caused by MRI-induced signals. In some aspects filtering is provided to attenuate MRI-induced signals on an implanted cardiac lead that is coupled to an implanted device. In some aspects the filter may be configured to complement a capacitor circuit (e.g., a feedthrough capacitor) that reduces the amount of EMI that enters the implanted device via the cardiac lead. In some implementations the filter consists of a LC tank circuit and a series LC circuit, where the LC tank circuit is in series with the cardiac lead and a cardiac stimulation circuit and the series LC circuit is in a shunt configuration across the cardiac stimulation circuit.
摘要翻译：用于可植入医疗装置的过滤方案减轻了可能由MRI诱导的信号引起的潜在的不利影响。在一些方面，提供过滤以减少与植入装置耦合的植入心脏引线上的MRI诱导信号。在一些方面，滤波器可以被配置为补充通过心脏引线减少进入植入装置的EMI量的电容器电路（例如，馈通电容器）。在一些实施方式中，滤波器由LC谐振电路和串联LC电路组成，其中LC谐振电路与心脏引线和心脏刺激电路串联，并且串联LC电路处于穿过心脏刺激电路的分流配置。

4. 发明授权

US06937894B1 Method of recharging battery for an implantable medical device 失效
标题翻译：为可植入医疗器械充电电池的方法
公开(公告)号：US06937894B1
公开(公告)日：2005-08-30
申请号：US10045844
申请日：2001-11-08
申请人： George I. Isaac , Jorge N. Amely-Velez , Gabriel A. Mouchawar
发明人： George I. Isaac , Jorge N. Amely-Velez , Gabriel A. Mouchawar
IPC分类号： A61N1/378
CPC分类号： A61N1/3787
摘要： A method of operating an implantable medical device containing a Lithium Silver Vanadium Oxide battery. In response to a detected need for therapy, a current flow is delivered from the battery to a charge storage device. After the battery is at least partly depleted by one or more such deliveries of current or other power consumption, the battery is recharged. The recharging may be initiated in response to a selected time threshold, a selected number of current flow delivery events, a selected voltage level, an excess charge time duration, or other operating characteristics. A limited number of recharging cycles may be provided if the charging is done under controlled conditions with respect to charge current and voltage.
摘要翻译：一种操作含有锂银氧化钒电池的可植入医疗装置的方法。响应于检测到的治疗需要，电流从电池传送到电荷存储装置。在电池至少部分耗尽当前或其他功率消耗的一个或多个这样的传送之后，电池被再充电。可以响应于所选择的时间阈值，所选数量的当前流量递送事件，所选择的电压电平，超量充电时间持续时间或其他操作特性来启动充电。如果在相对于充电电流和电压的受控条件下进行充电，则可以提供有限数量的充电循环。

5. 发明授权

US06687543B1 Implantable cardiac stimulation device having reduced shelf current consumption and method 有权
标题翻译：植入式心脏刺激装置具有降低的电流消耗和方法
公开(公告)号：US06687543B1
公开(公告)日：2004-02-03
申请号：US09876725
申请日：2001-06-06
申请人： George I. Isaac , Alan B. Vogel
发明人： George I. Isaac , Alan B. Vogel
IPC分类号： A61N108
CPC分类号： A61N1/08 , A61N1/3956
摘要： A processor controlled implantable cardiac stimulation device may be placed into a shelf mode for extending the shelf life of the device. The device includes a real time clock circuit, a watch dog timer circuit having a duty cycle, a telemetry circuit capable of operation in either an active mode or a standby mode, and ancillary circuits that sense cardiac activity and provides stimulation pulses to a heart. The device includes a power source for providing power to all of the circuits of the device and a shelf mode circuit that places the device into the shelf mode. The shelf mode circuit disables power to the ancillary circuits, decreases the duty cycle of the watch dog timer, sets the processor into a static state, and sets the telemetry circuit to the standby mode. The shelf mode circuit places the device into the shelf mode in response to shelf mode commands received by the telemetry circuit to set the device from an active powered mode to the shelf mode.
摘要翻译：处理器控制的可植入心脏刺激装置可以放置在搁架模式中，以延长装置的保质期。该装置包括实时时钟电路，具有占空比的看门狗定时器电路，能够以活动模式或待机模式操作的遥测电路，以及感测心脏活动并向心脏提供刺激脉冲的辅助电路。该设备包括用于向设备的所有电路提供电力的电源和将设备置于搁置模式的搁板模式电路。搁板模式电路禁用辅助电路供电，降低看门狗定时器的占空比，将处理器设置为静态，并将遥测电路设置为待机模式。响应于由遥测电路接收到的搁板模式命令将设备从有源供电模式设置到搁板模式，搁板模式电路将设备置于搁板模式。

6. 发明授权

US08886319B2 MRI signal filtering for implantable medical device 有权
标题翻译：可植入医疗器械的MRI信号滤波
公开(公告)号：US08886319B2
公开(公告)日：2014-11-11
申请号：US12617532
申请日：2009-11-12
申请人： Jin Zhang , J. Christopher Moulder , George I. Isaac , Gabriel A. Mouchawar , Peter Boileau , Ingmar Viohl
发明人： Jin Zhang , J. Christopher Moulder , George I. Isaac , Gabriel A. Mouchawar , Peter Boileau , Ingmar Viohl
IPC分类号： A61N1/08 , G01R33/28 , A61N1/37 , A61N1/375 , A61N1/365 , G01R33/36
CPC分类号： G01R33/288 , A61N1/36521 , A61N1/3718 , A61N1/3754 , G01R33/3685
摘要： A filtering scheme for an implantable medical device mitigates potentially adverse effects that may be caused by MRI-induced signals. In some aspects filtering is provided to attenuate MRI-induced signals on an implanted cardiac lead that is coupled to an implanted device. In some aspects the filter may be configured to complement a capacitor circuit (e.g., a feedthrough capacitor) that reduces the amount of EMI that enters the implanted device via the cardiac lead. In some implementations the filter consists of a LC tank circuit and a series LC circuit, where the LC tank circuit is in series with the cardiac lead and a cardiac stimulation circuit and the series LC circuit is in a shunt configuration across the cardiac stimulation circuit.
摘要翻译：用于可植入医疗装置的过滤方案减轻了可能由MRI诱导的信号引起的潜在的不利影响。在一些方面，提供过滤以减少与植入装置耦合的植入心脏引线上的MRI诱导信号。在一些方面，滤波器可以被配置为补充通过心脏引线减少进入植入装置的EMI量的电容器电路（例如，馈通电容器）。在一些实施方式中，滤波器由LC谐振电路和串联LC电路组成，其中LC谐振电路与心脏引线和心脏刺激电路串联，并且串联LC电路处于穿过心脏刺激电路的分流配置。

7. 发明授权

US06658294B1 Implantable cardiac device having an impedance monitoring circuit and method 失效
标题翻译：具有阻抗监测电路和方法的可植入心脏装置
公开(公告)号：US06658294B1
公开(公告)日：2003-12-02
申请号：US09943145
申请日：2001-08-29
申请人： Ali Enayat Zadeh , Dro Darbidian , George I. Isaac
发明人： Ali Enayat Zadeh , Dro Darbidian , George I. Isaac
IPC分类号： A61N118
CPC分类号： A61N1/3925 , A61N1/3686 , A61N1/37 , A61N2001/083
摘要： A circuit within an implantable cardiac stimulation device monitors impedance of an electrode configuration including first and second electrodes in electrical contact with a heart. The circuit is within the implantable cardiac stimulation device which applies stimulation pulses having a current and a voltage magnitude across the electrode configuration. The circuit that monitors impedance of an electrode configuration provides an impedance digital output proportional to the ratio of a stimulation pulse voltage and current.
摘要翻译：可植入心脏刺激装置内的电路监测包括与心脏电接触的第一和第二电极的电极配置的阻抗。该电路在可植入的心脏刺激装置内，其施加在电极构型上具有电流和电压幅度的刺激脉冲。监测电极配置阻抗的电路提供与刺激脉冲电压和电流的比例成比例的阻抗数字输出。

8. 发明授权

US06553259B2 System and method of performing automatic capture in an implantable cardiac stimulation device 有权
公开(公告)号：US06553259B2
公开(公告)日：2003-04-22
申请号：US09810929
申请日：2001-03-14
申请人： Gabriel A. Mouchawar , Jorge N. Amely-Velez , George I. Isaac , Steven W. Badelt
发明人： Gabriel A. Mouchawar , Jorge N. Amely-Velez , George I. Isaac , Steven W. Badelt
IPC分类号： A61N1362
CPC分类号： A61N1/3712
摘要： An implantable cardiac stimulation device possessing pacing, cardioversion and defibrillation functions and automatic capture capabilities, for automatically verifying capture during stimulation operations and, as necessary, automatically delivering back-up stimulation pulses when capture is lost, and subsequently adjusting the stimulation energy to a level safely above that needed to achieve capture. The stimulation device utilizes a method for maintaining capture by means of a capture search algorithm, so that whenever loss of capture is detected, it re-determines the minimum stimulation energy required to achieve capture. Another aspect of the stimulation device is the automatic threshold testing which is invoked to determine the minimum stimulation pulse energy needed to ensure capture. When the automatic capture function is enabled, the stimulation device initiates a stimulation refractory period, upon the expiration of which, the stimulation device sets a sensing threshold to a predetermined level and then either maintaining this level fixed or causing it to decay, during an alert interval. Concurrently, the stimulation device verifies capture during the alert interval.

9. 发明申请

US20110245888A1 MEDICAL DEVICE WITH CHARGE LEAKAGE DETECTION 审中-公开
标题翻译：具有电荷泄漏检测的医疗设备
公开(公告)号：US20110245888A1
公开(公告)日：2011-10-06
申请号：US12754491
申请日：2010-04-05
申请人： Steven W. Badelt , Gabriel A. Mouchawar , George I. Isaac , Neal Forss , Lyle Frank Weaver
发明人： Steven W. Badelt , Gabriel A. Mouchawar , George I. Isaac , Neal Forss , Lyle Frank Weaver
IPC分类号： A61N1/39
CPC分类号： A61N1/3975 , A61N1/3931 , A61N1/3956 , A61N1/3981 , G01R19/0092 , H01G9/14 , H03K17/082
摘要： A medical device (implantable or external) is provided that comprises a power source, a charge storage member, a terminal connector, a switch network, a controller and a leak detection module. The charge storage member is configured to receive and store energy from the power source. The terminal connector is configured to be coupled to a lead to be implanted in a patient proximate to tissue of interest. The switch network is electrically disposed between the charge storage member and the terminal connector. The switch network changes between open and closed states to disconnect and connect the charge storage member and the terminal connector. The controller controls storage of energy in the charge storage member and delivery of stimulating pulses from the charge storage member to the lead coupled to the terminal connector. The leak detection module obtains a leakage measurement by sensing at least one of i) a voltage potential of the charge storage member and ii) current flow from the charge storage member. The leak detection module compares the leakage measurement to a leakage threshold to determine when the leakage measurement satisfies the leakage threshold.
摘要翻译：提供了包括电源，电荷存储构件，端子连接器，开关网络，控制器和泄漏检测模块的医疗设备（可植入或外部）。电荷存储部件被配置为从电源接收和存储能量。端子连接器被配置为耦合到待植入接近感兴趣组织的患者的导线。开关网络电气地设置在电荷存储部件和端子连接器之间。开关网络在打开和关闭状态之间变化，以断开并连接电荷存储部件和端子连接器。所述控制器控制所述电荷存储部件中的能量存储和从所述电荷存储部件向耦合到所述端子连接器的引线的刺激脉冲的传送。泄漏检测模块通过感测i）电荷存储构件的电压电位和ii）来自电荷存储构件的电流流动中的至少一个来获得泄漏测量。泄漏检测模块将泄漏测量与泄漏阈值进行比较，以确定泄漏测量何时满足泄漏阈值。

10. 发明授权

US07197360B1 Methods and systems for using an inductor to increase capacitor reformation efficiency in an implantable cardiac device (ICD) 有权
标题翻译：使用电感提高可植入式心脏装置（ICD）中的电容器重组效率的方法和系统
公开(公告)号：US07197360B1
公开(公告)日：2007-03-27
申请号：US11035348
申请日：2005-01-12
申请人： J. Christopher Moulder , Joseph Beauvais , George I. Isaac , Gabriel A. Mouchawar
发明人： J. Christopher Moulder , Joseph Beauvais , George I. Isaac , Gabriel A. Mouchawar
IPC分类号： A61N1/00
CPC分类号： A61N1/3956
摘要： Methods and systems for increasing capacitor reformation efficiency in an implantable cardiac device (ICD) are presented. In one embodiment, a method and system provide for: (1) fully charging a first capacitor, (2) transferring energy from the first capacitor to an inductor, (3) transferring energy from the inductor to the second capacitor, and (4) completing charging of the second capacitor. In another embodiment, a method and system provide for: (1) fully charging a first capacitor, (2) sharing energy from the first capacitor with a second capacitor, and (3) completing charging of the second capacitor. In yet another embodiment, a method and system provide for: (1) fully charging a first capacitor, (2) sharing energy from the first capacitor with a second capacitor, (3) transferring remaining energy from the first capacitor to an inductor, (4) transferring energy from the inductor to the second capacitor, and (5) completing charging of the second capacitor.
摘要翻译：提出了用于增加可植入心脏装置（ICD）中的电容器重组效率的方法和系统。在一个实施例中，一种方法和系统提供：（1）完全充电第一电容器，（2）将能量从第一电容器传递到电感器，（3）将能量从电感器传递到第二电容器;以及（4）完成第二电容器的充电。在另一个实施例中，一种方法和系统提供：（1）对第一电容器充分充电，（2）从第一电容器与第二电容器共享能量，以及（3）完成第二电容器的充电。在另一个实施例中，一种方法和系统提供：（1）对第一电容器进行完全充电，（2）从第一电容器与第二电容器共享能量，（3）将剩余能量从第一电容器转移到电感器（ 4）将电能从电感器传递到第二电容器，（5）完成第二电容器的充电。

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