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1. 发明授权

US07585412B2 Specialized hollow fiber membranes for plasmapheresis and ultrafiltration 失效
标题翻译：专用中空纤维膜用于血浆置换和超滤
公开(公告)号：US07585412B2
公开(公告)日：2009-09-08
申请号：US11404415
申请日：2006-04-14
申请人： Reynolds G. Gorsuch , Henry Grage , Harold H. Handley, Jr. , Harold W. Peters , Jacob C. Kearns
发明人： Reynolds G. Gorsuch , Henry Grage , Harold H. Handley, Jr. , Harold W. Peters , Jacob C. Kearns
IPC分类号： B01D69/06 , B01D71/66 , B01D63/02
CPC分类号： B01D69/08 , A61M1/1678 , B01D67/0088 , B01D67/0093 , B01D69/02 , B01D69/141
摘要： A plasmapheresis and/or ultrafiltration membrane comprises elongated hollow fibers each fiber having an interior lumen extending along the fiber length, the fiber wall having a plurality of zones between the inner and outer wall surfaces, each of the zones having a mass density different than the mass density of an adjacent zone. The fiber wall is characterized by having a lower mass density zone at the inner wall surface and a higher mass density zone at the outer wall surface. The fiber is further characterized by having an average elongation breaking force strength of at least about 0.2 lbs. and an average elongation of at least about 45%.
摘要翻译：血浆置换术和/或超滤膜包括细长的中空纤维，每个纤维具有沿着纤维长度延伸的内腔，所述纤维壁在内壁和外壁表面之间具有多个区域，每个区域的质量密度不同于相邻区域的质量密度。纤维壁的特征在于在内壁表面具有较低的质量密度区域，并且在外壁表面具有较高的质量密度区域。纤维的特征还在于具有至少约0.2磅的平均伸长断裂力强度。平均伸长率至少约45％。

2. 发明授权

US07195711B2 Specialized hollow fiber membranes for in-vivo plasmapheresis and ultrafiltration 失效
标题翻译：专用中空纤维膜，用于体内血浆置换和超滤
公开(公告)号：US07195711B2
公开(公告)日：2007-03-27
申请号：US10959918
申请日：2004-10-06
申请人： Reynolds G. Gorsuch , Henry Grage , Harold Handley, Jr. , Harold Peters , Jacob C. Kearns
发明人： Reynolds G. Gorsuch , Henry Grage , Harold Handley, Jr. , Harold Peters , Jacob C. Kearns
IPC分类号： B01D69/08 , B01D71/68 , B01D63/02
CPC分类号： B01D67/0016 , A61M1/1678 , A61M1/34 , A61M1/3403 , B01D69/02 , B01D69/04 , B01D69/08 , B01D69/12 , B01D71/68 , B01D2325/022
摘要： An in-vivo plasmapheresis and/or in-vivo ultrafiltration membrane comprises elongated hollow fibers each fiber having an interior lumen extending along the fiber length, the fiber wall having a plurality of zones between the inner and outer wall surfaces, each of the zones having a mass density different than the mass density of an adjacent zone. The fiber wall is characterized by having a lower mass density zone at the inner wall surface and a higher mass density zone at the outer wall surface. The fiber is further characterized by having an average elongation breaking force strength of at least about 0.2 lbs. and an average elongation of at least about 45%.
摘要翻译：体内血浆置换术和/或体内超滤膜包括细长的中空纤维，每个纤维具有沿着纤维长度延伸的内腔，纤维壁在内壁和外壁之间具有多个区域，每个区域具有质量密度不同于相邻区域的质量密度。纤维壁的特征在于在内壁表面具有较低的质量密度区域，并且在外壁表面具有较高的质量密度区域。纤维的进一步特征在于具有至少约0.2磅的平均伸长断裂力强度。平均伸长率至少约45％。

3. 发明申请

US20070093728A1 BLOOD AND INTERSTITIAL FLUID SAMPLING DEVICE 有权
标题翻译：血液和间质液体取样装置
公开(公告)号：US20070093728A1
公开(公告)日：2007-04-26
申请号：US11562496
申请日：2006-11-22
申请人： Joel Douglas , Jeffrey Roe , Ryszard Radwanski , Henry Grage , Michael Sanchez
发明人： Joel Douglas , Jeffrey Roe , Ryszard Radwanski , Henry Grage , Michael Sanchez
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/157 , A61B5/14532 , A61B5/150022 , A61B5/150076 , A61B5/150083 , A61B5/150183 , A61B5/15019 , A61B5/150213 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150343 , A61B5/150358 , A61B5/150396 , A61B5/150503 , A61B5/150946 , A61B5/150977 , A61B5/15113 , A61B5/15117 , A61B5/1513 , A61B5/15136 , A61B5/1519 , A61B5/15196
摘要： A device and method for lancing a patient, virtually simultaneously producing and collecting a small fluid sample from a body. The device comprises a blood collection system including a lancing needle (16), drive mechanism (11), kneading or vibration mechanism (25), optional suction system (7), and sample ejection mechanism. The device is preferably sized to be hand-held in one hand and operable with one hand. The device can optionally contain integral testing or analysis component (83) for receiving the sample and providing testing or analysis indication or readout for the user. A method involves piercing the skin at a rapid rate, kneading the surrounding area by ultrasonic action, piezoelectric or mechanical oscillation to stimulate the blood flow from the wound, drawing the fluid using a pumping system.
摘要翻译：用于穿刺患者的装置和方法，实际上同时从身体产生和收集小的液体样品。该装置包括采血系统，其包括穿刺针（16），驱动机构（11），揉搓或振动机构（25），可选的抽吸系统（7）和样品排出机构。该装置的尺寸优选为一只手中的手持式并且用一只手可操作。该设备可以可选地包含用于接收样品并为用户提供测试或分析指示或读出的整体测试或分析组件（83）。一种方法包括以快速的速度刺穿皮肤，通过超声波作用，压电或机械振动来捏合周围区域，以刺激来自伤口的血液流动，使用泵送系统拉伸流体。

4. 发明授权

US06802820B1 Specialized hollow fiber membranes for in-vivo plasmapheresis and ultrafiltration 失效
公开(公告)号：US06802820B1
公开(公告)日：2004-10-12
申请号：US09549131
申请日：2000-04-13
申请人： Reynolds Gorsuch , Henry Grage
发明人： Reynolds Gorsuch , Henry Grage
IPC分类号： A61M134
CPC分类号： B01D71/68 , A61M1/1678 , A61M1/34 , A61M1/3403 , A61M1/3413 , A61M1/3696 , B01D67/0011 , B01D69/02 , B01D69/08 , B01D69/12 , B01D2325/022
摘要： An in-vivo plasmapheresis and/or in-vivo ultrafiltration membrane comprises a plurality of elongated hollow fibers each fiber having an interior lumen extending along the fiber length, the fiber wall having a plurality of zones between the inner and outer wall surfaces, each of the zones having a mass density different than the mass density of an adjacent zone. The fiber wall is characterized by having a lower mass density zone at the inner wall surface and a higher mass density zone at the outer wall surface.

5. 发明申请

US20080097288A1 Disposable blood glucose sensor with internal pump 审中-公开
标题翻译：一次性血糖传感器，内置泵
公开(公告)号：US20080097288A1
公开(公告)日：2008-04-24
申请号：US11891701
申请日：2007-08-13
申请人： Paul D. Levin , Henry Grage
发明人： Paul D. Levin , Henry Grage
IPC分类号： A61M31/00 , A61B5/05
CPC分类号： A61B5/157 , A61B5/1486 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150274 , A61B5/150389 , A61B5/150503 , A61B5/15074 , A61B5/155 , A61B5/4839 , A61B5/6802 , A61B2560/0223 , A61M5/1723 , A61M2005/1726 , A61M2230/201
摘要： An apparatus and method are disclosed for automatically and periodically measuring the level of a patient's blood glucose when a patient has a catheter in a blood vessel. A wearable, disposable test unit is attached by air, fluid and electric lines to a bedside monitor. The test unit has means for measuring blood glucose. A chamber in the unit contains a pneumatic pump which draws blood into the device and then expels all but a small residual portion of blood back into the patient's blood vessel catheter. A testing area is provided adjacent the pumping chamber. A test is done either when the pumping chamber is filled with blood, or after the pumping chamber is emptied. The test cycle is repeated about every 60 seconds. Provision is made to automatically calibrate the device every few hours or whenever calibration is required.
摘要翻译：公开了一种当患者在血管中具有导管时自动和周期性地测量患者血糖水平的装置和方法。可佩戴的一次性测试单元通过空气，流体和电线连接到床头监护仪。测试单元具有测量血糖的方法。该单元中的腔室包含气动泵，其将血液吸入装置中，然后将除了少量残留部分的血液排除回到患者的血管导管中。在泵室附近提供测试区域。当泵室充满血液或者在泵腔被排空之后进行测试。测试周期大约每60秒重复一次。规定每隔几个小时自动校准设备，或需要校准时。

6. 发明申请

US20070179437A1 Method and apparatus for testing blood glucose in a reversible infusion line 失效
标题翻译：用于在可逆输液管线中测试血糖的方法和装置
公开(公告)号：US20070179437A1
公开(公告)日：2007-08-02
申请号：US11406973
申请日：2006-04-19
申请人： Henry Grage , Paul Levin
发明人： Henry Grage , Paul Levin
IPC分类号： A61M31/00 , A61B5/05 , A61B5/00
CPC分类号： A61B5/1486 , A61M5/14228
摘要： An apparatus for automatically and periodically measuring a patient's blood glucose level wherein the patient has a catheter in a blood vessel and is receiving infusion fluid through the catheter. A testing unit is provided which has a main infusion channel and, in a preferred embodiment, the testing unit includes a side channel. The side channel has a restrictive cross-sectional area compared with the main infusion channel. A glucose test chamber is formed in the side channel. First and second valves are placed adjacent the test chamber in the side channel to isolate a blood sample for testing. The isolation of the sample provides more accurate blood glucose measurements than those provided by systems of the prior art. A second embodiment of the invention has an isolatable test chamber placed in the main infusion line and no side channel is utilized.
摘要翻译：一种用于自动和周期性地测量患者血糖水平的装置，其中患者在血管中具有导管并且正在接收通过导管的输注液。提供了具有主输液通道的测试单元，并且在优选实施例中，测试单元包括侧通道。与主输液通道相比，侧通道具有限制性横截面积。在侧通道中形成葡萄糖测试室。第一和第二阀门放置在侧通道的测试室附近，以隔离血液样本进行测试。样品的分离提供比现有技术系统提供的更准确的血糖测量值。本发明的第二实施例具有放置在主输液管中的可分离的测试室，并且不使用侧通道。

7. 发明申请

US20070023353A1 Specialized hollow fiber membranes for plasmapheresis and ultrafiltration 失效
标题翻译：专用中空纤维膜用于血浆置换和超滤
公开(公告)号：US20070023353A1
公开(公告)日：2007-02-01
申请号：US11404415
申请日：2006-04-14
申请人： Reynolds Gorsuch , Henry Grage , Harold Handley , Harold Peters , Jacob Kearns
发明人： Reynolds Gorsuch , Henry Grage , Harold Handley , Harold Peters , Jacob Kearns
IPC分类号： B01D69/00
CPC分类号： B01D69/08 , A61M1/1678 , B01D67/0088 , B01D67/0093 , B01D69/02 , B01D69/141
摘要： A plasmapheresis and/or ultrafiltration membrane comprises elongated hollow fibers each fiber having an interior lumen extending along the fiber length, the fiber wall having a plurality of zones between the inner and outer wall surfaces, each of the zones having a mass density different than the mass density of an adjacent zone. The fiber wall is characterized by having a lower mass density zone at the inner wall surface and a higher mass density zone at the outer wall surface. The fiber is further characterized by having an average elongation breaking force strength of at least about 0.2 lbs. and an average elongation of at least about 45%.
摘要翻译：血浆置换术和/或超滤膜包括细长的中空纤维，每个纤维具有沿着纤维长度延伸的内腔，所述纤维壁在内壁和外壁表面之间具有多个区域，每个区域的质量密度不同于相邻区域的质量密度。纤维壁的特征在于在内壁表面具有较低的质量密度区域，并且在外壁表面具有较高的质量密度区域。纤维的进一步特征在于具有至少约0.2磅的平均伸长断裂力强度。平均伸长率至少约45％。

8. 发明申请

US20050010134A1 Blood and interstitial fluid sampling device 有权
标题翻译：血液和间质液取样装置
公开(公告)号：US20050010134A1
公开(公告)日：2005-01-13
申请号：US10835094
申请日：2004-04-29
申请人： Joel Douglas , Jeffrey Roe , Ryszard Radwanski , Henry Grage , Michael Sanchez
发明人： Joel Douglas , Jeffrey Roe , Ryszard Radwanski , Henry Grage , Michael Sanchez
IPC分类号： A61B5/00 , A61B5/15 , A61B10/00 , A61B17/00
CPC分类号： A61B10/0045 , A61B5/14532 , A61B5/150022 , A61B5/150083 , A61B5/15019 , A61B5/150198 , A61B5/150358 , A61B5/150396 , A61B5/150503 , A61B5/150984 , A61B5/15113 , A61B5/15117 , A61B5/15136 , A61B5/1519 , A61B5/15194 , A61B5/157 , A61B2010/008 , A61B2017/00765 , A61B2562/0295
摘要： A device and method for lancing a patient, virtually simultaneously producing and collecting a small fluid sample from a body. The device comprises a blood collection system including a lancing needle (16), drive mechanism (11), kneading or vibration mechanism (25), optional suction system (7), and sample ejection mechanism. The device is preferably sized to be hand-held in one hand and operable with one hand. The device can optionally contain integral testing or analysis component (83) for receiving the sample and providing testing or analysis indication or readout for the user. A method involves piercing the skin at a rapid rate, kneading the surrounding area by ultrasonic action, piezoelectric or mechanical oscillation to stimulate the blood flow from the wound, drawing the fluid using a pumping system.
摘要翻译：用于穿刺患者的装置和方法，实际上同时从身体产生和收集小的液体样品。该装置包括采血系统，其包括穿刺针（16），驱动机构（11），揉搓或振动机构（25），可选的抽吸系统（7）和样品排出机构。该装置的尺寸优选为一只手中的手持式并且用一只手可操作。该设备可以可选地包含用于接收样品并为用户提供测试或分析指示或读出的整体测试或分析组件（83）。一种方法包括以快速的速度刺穿皮肤，通过超声波作用，压电或机械振动来捏合周围区域，以刺激来自伤口的血液流动，使用泵送系统拉伸流体。

9. 发明申请

US20230015833A1 Apparatus and method for personalized hormonal diagnostics and therapy 有权
公开(公告)号：US20230015833A1
公开(公告)日：2023-01-19
申请号：US17857096
申请日：2022-07-04
申请人： Natalia Shtraizent , Henry Grage , Falk Fish
发明人： Natalia Shtraizent , Henry Grage , Falk Fish
IPC分类号： G01N33/76 , G01N33/74 , G16H70/60 , G16H10/60
摘要： A method and system for measuring hormone levels in human samples. Either actual levels can be measured, or hormone related parameters can be measured with computation extrapolating the parameters to the actual hormone level. A patient hormone level can be compared against a population database based on age, gender and other factors to determine a score for a particular hormone. A dosage of the hormone being given a patient can be automatically adjusted based on the score with optional approval of the adjustment made by a health professional. This is particularly useful in hormone replacement therapy and in-vitro fertilization.

10. 发明授权

US07367942B2 Method and apparatus for testing blood glucose in a reversible infusion line 失效
标题翻译：用于在可逆输液管线中测试血糖的方法和装置
公开(公告)号：US07367942B2
公开(公告)日：2008-05-06
申请号：US11406973
申请日：2006-04-19
申请人： Henry Grage , Paul D. Levin
发明人： Henry Grage , Paul D. Levin
IPC分类号： A61B5/00
CPC分类号： A61B5/1486 , A61M5/14228
摘要： An apparatus for automatically and periodically measuring a patient's blood glucose level wherein the patient has a catheter in a blood vessel and is receiving infusion fluid through the catheter. A testing unit is provided which has a main infusion channel and, in a preferred embodiment, the testing unit includes a side channel. The side channel has a restrictive cross-sectional area compared with the main infusion channel. A glucose test chamber is formed in the side channel. First and second valves are placed adjacent the test chamber in the side channel to isolate a blood sample for testing. The isolation of the sample provides more accurate blood glucose measurements than those provided by systems of the prior art. A second embodiment of the invention has an isolatable test chamber placed in the main infusion line and no side channel is utilized.
摘要翻译：一种用于自动和周期性地测量患者血糖水平的装置，其中患者在血管中具有导管并且正在接收通过导管的输注液。提供了具有主输液通道的测试单元，并且在优选实施例中，测试单元包括侧通道。与主输液通道相比，侧通道具有限制性横截面积。在侧通道中形成葡萄糖测试室。第一和第二阀门放置在侧通道的测试室附近，以隔离血液样本进行测试。样品的分离提供比现有技术系统提供的更准确的血糖测量值。本发明的第二实施例具有放置在主输液管中的可分离的测试室，并且不使用侧通道。

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