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1. 发明授权

US07585412B2 Specialized hollow fiber membranes for plasmapheresis and ultrafiltration 失效
标题翻译：专用中空纤维膜用于血浆置换和超滤
公开(公告)号：US07585412B2
公开(公告)日：2009-09-08
申请号：US11404415
申请日：2006-04-14
申请人： Reynolds G. Gorsuch , Henry Grage , Harold H. Handley, Jr. , Harold W. Peters , Jacob C. Kearns
发明人： Reynolds G. Gorsuch , Henry Grage , Harold H. Handley, Jr. , Harold W. Peters , Jacob C. Kearns
IPC分类号： B01D69/06 , B01D71/66 , B01D63/02
CPC分类号： B01D69/08 , A61M1/1678 , B01D67/0088 , B01D67/0093 , B01D69/02 , B01D69/141
摘要： A plasmapheresis and/or ultrafiltration membrane comprises elongated hollow fibers each fiber having an interior lumen extending along the fiber length, the fiber wall having a plurality of zones between the inner and outer wall surfaces, each of the zones having a mass density different than the mass density of an adjacent zone. The fiber wall is characterized by having a lower mass density zone at the inner wall surface and a higher mass density zone at the outer wall surface. The fiber is further characterized by having an average elongation breaking force strength of at least about 0.2 lbs. and an average elongation of at least about 45%.
摘要翻译：血浆置换术和/或超滤膜包括细长的中空纤维，每个纤维具有沿着纤维长度延伸的内腔，所述纤维壁在内壁和外壁表面之间具有多个区域，每个区域的质量密度不同于相邻区域的质量密度。纤维壁的特征在于在内壁表面具有较低的质量密度区域，并且在外壁表面具有较高的质量密度区域。纤维的特征还在于具有至少约0.2磅的平均伸长断裂力强度。平均伸长率至少约45％。

2. 发明授权

US07476210B2 Apparatus and method for in-vivo plasmapheresis using periodic backflush containing anticoagulant 失效
标题翻译：使用含有抗凝血剂的定期反冲剂的体内血浆置换术的装置和方法
公开(公告)号：US07476210B2
公开(公告)日：2009-01-13
申请号：US11320866
申请日：2005-12-29
申请人： Reynolds G. Gorsuch , Tommy Gene Cooper , Harold H. Handley, Jr. , Harold W. Peters
发明人： Reynolds G. Gorsuch , Tommy Gene Cooper , Harold H. Handley, Jr. , Harold W. Peters
IPC分类号： A61M37/00
CPC分类号： A61M1/3672 , A61M1/3661 , A61M25/0068 , A61M25/0082 , A61M2025/0031 , A61M2025/0037
摘要： Method for in-vivo plasmapheresis utilizing a plurality of elongated hollow microporous filter fibers periodically interrupt diffusion of blood plasma from a patient, and, for a selected time, directing backflush fluid into the fibers at a pressure and interval sufficient to cleanse the fiber pores, after which plasma diffusion is resumed. The backflush fluid, preferably a normal saline solution, may contain an anticoagulant such as heparin, citrate or NO donor in suitable concentration for systemic anti-coagulation or for treating the fiber for thromboresistance.
摘要翻译：使用多个细长中空微孔过滤纤维的体内血浆置换术的方法周期性地中断来自患者的血浆扩散，并且在选定的时间内，将反冲洗流体以足以清洁纤维孔的压力和间隔引导到纤维中，之后等离子体扩散恢复。反冲洗液，优选生理盐水溶液，可以含有合适浓度的抗凝血剂，例如肝素，柠檬酸盐或NO供体，用于全身性抗凝或用于治疗纤维进行血栓阻力。

3. 发明授权

US07354392B2 Structurally optimized hollow fiber membranes 失效
标题翻译：结构优化的中空纤维膜
公开(公告)号：US07354392B2
公开(公告)日：2008-04-08
申请号：US10786339
申请日：2004-02-25
申请人： Reynolds G. Gorsuch , Harold W. Peters , Harold H. Handley, Jr.
发明人： Reynolds G. Gorsuch , Harold W. Peters , Harold H. Handley, Jr.
IPC分类号： A61M25/14
CPC分类号： A61M1/1678 , B01D69/08 , D01D5/247
摘要： An elongated hollow microporous fiber comprises an inner wall surface defining an interior fiber lumen, an outer wall surface, and a microporous fiber wall therebetween, the fiber wall having one or more continuous, cohesive, elongated filaments embedded in the fiber and extending lengthwise of the elongated fiber along substantially the full length of the fiber.
摘要翻译：细长的中空微孔纤维包括限定内纤维内腔，外壁表面和其间的微孔纤维壁的内壁表面，所述纤维壁具有一个或多个连续的，内聚的细长丝，其嵌入纤维中，并延伸长度方向基本上纤维全长的细长纤维。

4. 发明授权

US07267771B2 Apparatus for therapeutic apheresis 失效
标题翻译：用于治疗性血液分离术的装置
公开(公告)号：US07267771B2
公开(公告)日：2007-09-11
申请号：US11009226
申请日：2004-12-10
申请人： Reynolds G. Gorsuch , Harold W. Peters , Harold H. Handley, Jr. , Tommy Cooper
发明人： Reynolds G. Gorsuch , Harold W. Peters , Harold H. Handley, Jr. , Tommy Cooper
IPC分类号： B01D63/02 , A61M37/00 , B01D61/00
CPC分类号： A61M1/1678 , A61M1/1682 , A61M1/1684 , A61M1/1688 , A61M1/34 , A61M1/3403 , A61M1/3406 , A61M1/341 , A61M1/3431 , A61M2205/3331 , A61M2205/3334 , A61M2205/50
摘要： Apparatus for carrying out therapeutic apheresis includes a filter device for being implanted in a blood vessel for carrying out in-vivo plasma separation having one or more elongated hollow tubes and a plurality of elongated hollow microporous fibers capable of separating plasma from whole blood at pressure and blood flow within a patient's vein, a multiple lumen catheter secured to the proximal end of the filter device having one or more lumens in fluid communication with the interior of said one or more hollow tubes and a plasma return lumen, and therapeutic apheresis apparatus for removing and/or separating selected disease-related components from the separated plasma and means for directing plasma between said catheter and the selective component removal apparatus.
摘要翻译：用于进行治疗性血液分离术的装置包括：植入用于进行体内血浆分离的血管中的过滤装置，其具有一个或多个细长的中空管和能够在压力下从全血中分离血浆的多个细长的中空微孔纤维，在患者静脉内的血液流动，固定到过滤器装置的近端的多腔导管，其具有与所述一个或多个中空管的内部流体连通的一个或多个腔和等离子体返回腔，以及用于去除和/或从所分离的血浆中分离所选择的疾病相关组分，以及用于在所述导管和选择性组分去除装置之间引导血浆的装置。

5. 发明授权

US06899692B2 Plasmapheresis filter device and catheter assembly 失效
标题翻译：血浆置换过滤装置和导管组件
公开(公告)号：US06899692B2
公开(公告)日：2005-05-31
申请号：US09981783
申请日：2001-10-17
申请人： Reynolds G. Gorsuch , Harold W. Peters , Harold H. Handley, Jr.
发明人： Reynolds G. Gorsuch , Harold W. Peters , Harold H. Handley, Jr.
IPC分类号： A61M1/16 , A61M1/34 , B01D63/02
CPC分类号： B01D63/024 , A61M1/16 , A61M1/1678 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M1/3431 , A61M1/3472 , A61M1/3479 , A61M1/3486 , A61M1/3496 , A61M2205/50 , B01D63/02 , B01D2313/10
摘要： A filter device for being implanted in a blood vessel for carrying out in-vivo plasma separation comprises one or more elongated hollow tubes and a plurality of elongated hollow microporous fibers, each fiber having a first and second end secured to one or more of the elongated hollow tubes with the interior lumen of each of the fibers communicating with the interior of the one or more of the hollow tubes, and wherein the fiber wall has a higher mass density zone adjacent to the outer wall surface and a lower mass density zone adjacent to the inner wall surface.
摘要翻译：用于植入用于进行体内血浆分离的血管中的过滤装置包括一个或多个细长的中空管和多个细长的中空微孔纤维，每个纤维的第一和第二端固定到一个或多个细长的中空管，其中每个纤维的内腔与一个或多个中空管的内部连通，并且其中纤维壁具有与外壁表面相邻的较高的质量密度区域和与其相邻的较低质量密度区域内壁表面。

6. 发明申请

US20090118660A1 APPARATUS AND METHOD FOR IN-VIVO PLASMAPHERESIS USING PERIODIC BACKLUSH CONTAINING ANTICOAGULANT 失效
标题翻译：使用包含抗凝剂的周期性背部血管内皮生长因子的装置和方法
公开(公告)号：US20090118660A1
公开(公告)日：2009-05-07
申请号：US12353209
申请日：2009-01-13
申请人： Reynolds G. Gorsuch , Tommy Gene Cooper , Harold H. Handley, JR. , Harold W. Peters
发明人： Reynolds G. Gorsuch , Tommy Gene Cooper , Harold H. Handley, JR. , Harold W. Peters
IPC分类号： A61M1/34 , A61K31/727 , A61K31/195 , A61K31/132 , A61K31/18 , A61K31/42 , A61K31/155 , A61P7/02
CPC分类号： A61M1/1678 , A61M1/1682 , A61M1/1688 , A61M1/3413 , A61M2205/7554
摘要： Method for in-vivo plasmapheresis utilizing a plurality of elongated hollow microporous filter fibers periodically interrupt diffusion of blood plasma from a patient, and, for a selected time, directing backflush fluid into the fibers at a pressure and interval sufficient to cleanse the fiber pores, after which plasma diffusion is resumed. The backflush fluid, preferably a normal saline solution, may contain an anticoagulant such as heparin, citrate or NO donor in suitable concentration for systemic anti-coagulation or for treating the fiber for thromboresistance.
摘要翻译：使用多个细长中空微孔过滤纤维的体内血浆置换术的方法周期性地中断来自患者的血浆扩散，并且在选定的时间内，将反冲洗流体以足以清洁纤维孔的压力和间隔引导到纤维中，之后等离子体扩散恢复。反冲洗液，优选生理盐水溶液，可以含有合适浓度的抗凝血剂，例如肝素，柠檬酸盐或NO供体，用于全身性抗凝或用于治疗纤维进行血栓阻力。

7. 发明授权

US08070706B2 Apparatus and method for in-vivo plasmapheresis using periodic backflush containing anticoagulant 失效
标题翻译：使用含有抗凝血剂的定期反冲剂的体内血浆置换术的装置和方法
公开(公告)号：US08070706B2
公开(公告)日：2011-12-06
申请号：US12353209
申请日：2009-01-13
申请人： Reynolds G. Gorsuch , Tommy Gene Cooper , Harold H. Handley, Jr. , Harold W. Peters
发明人： Reynolds G. Gorsuch , Tommy Gene Cooper , Harold H. Handley, Jr. , Harold W. Peters
IPC分类号： A61M37/00
CPC分类号： A61M1/1678 , A61M1/1682 , A61M1/1688 , A61M1/3413 , A61M2205/7554
摘要： Method for in-vivo plasmapheresis utilizing a plurality of elongated hollow microporous filter fibers periodically interrupt diffusion of blood plasma from a patient, and, for a selected time, directing backflush fluid into the fibers at a pressure and interval sufficient to cleanse the fiber pores, after which plasma diffusion is resumed. The backflush fluid, preferably a normal saline solution, may contain an anticoagulant such as heparin, citrate or NO donor in suitable concentration for systemic anti-coagulation or for treating the fiber for thromboresistance.
摘要翻译：使用多个细长中空微孔过滤纤维的体内血浆置换术的方法周期性地中断来自患者的血浆扩散，并且在选定的时间内，将反冲洗流体以足以清洁纤维孔的压力和间隔引导到纤维中，之后等离子体扩散恢复。反冲洗液，优选生理盐水溶液，可以含有合适浓度的抗凝血剂，例如肝素，柠檬酸盐或NO供体，用于全身性抗凝或用于治疗纤维进行血栓阻力。

8. 发明授权

US07572374B2 Anticoagulant and thrombo-resistant hollow fiber membranes for in-vivo plasmapheresis and ultrafiltration 失效
标题翻译：抗凝血和抗血栓中空纤维膜，用于体内血浆置换和超滤
公开(公告)号：US07572374B2
公开(公告)日：2009-08-11
申请号：US11334994
申请日：2006-01-18
申请人： Reynolds G. Gorsuch , Harold H. Handley, Jr. , Harold W. Peters , Jacob C. Kearns
发明人： Reynolds G. Gorsuch , Harold H. Handley, Jr. , Harold W. Peters , Jacob C. Kearns
IPC分类号： B01D63/02 , B01D69/08 , B01D71/68
CPC分类号： A61M1/1678 , A61M1/34 , A61M1/3403 , A61M2205/3331 , B01D67/0016 , B01D67/0088 , B01D67/0093 , B01D69/02 , B01D69/04 , B01D69/08 , B01D69/12 , B01D69/141 , B01D71/68 , B01D2325/022
摘要： An in-vivo plasmapheresis or in-vivo ultrafiltration membrane comprises a plurality of elongated hollow microporous fibers each fiber having an outer wall, an inner wall and an interior lumen extending along the length thereof and defined by an inner wall surface, and wherein the fiber wall structure is a substantially continuous change in mass density from the outer wall to the inner wall and comprises a continuum of voids bounded by solid frames, the fiber wall having an asymmetrical pore size and asymmetrical mass density between said inner wall surface and the outer wall surface with a higher mass density adjacent to the outer wall and a lower mass density adjacent to said inner wall, and characterized by a nitric oxide donor composition capable of producing or releasing nitric oxide or inducing nitric oxide production or release in-vivo with a blood vessel, distributed on or in the fiber wall.
摘要翻译：体内血浆置换术或体内超滤膜包括多个细长的中空微孔纤维，每个纤维具有沿其长度延伸并由内壁表面限定的外壁，内壁和内腔，并且其中纤维壁结构是从外壁到内壁的质量密度的基本上连续的变化，并且包括由实心框架限定的连续的空隙，所述纤维壁在所述内壁表面和外壁之间具有不对称的孔径和不对称质量密度具有邻近外壁的较高质量密度的表面和邻近所述内壁的较低质量密度，并且其特征在于能够产生或释放一氧化氮或诱导一氧化氮在血液中产生或释放的一氧化氮供体组合物容器，分布在纤维壁上或纤维壁上。

9. 发明授权

US07481936B2 Method and apparatus for patient fluid management 失效
标题翻译：患者流体管理的方法和装置
公开(公告)号：US07481936B2
公开(公告)日：2009-01-27
申请号：US11078016
申请日：2005-03-11
申请人： Reynolds G. Gorsuch , Harold H. Handley , Harold W. Peters
发明人： Reynolds G. Gorsuch , Harold H. Handley , Harold W. Peters
IPC分类号： B01D61/14 , B01D61/18 , B01D63/02 , B01D63/04 , B01D61/00 , B01D63/00
CPC分类号： A61M1/1678 , A61M1/1682 , A61M1/34 , A61M1/3406 , A61M1/3431 , A61M1/3472 , A61M1/3479 , A61M1/3486 , A61M1/3496 , A61M2205/15 , A61M2205/50 , B01D63/02 , B01D63/024 , B01D2313/10
摘要： Patient fluid management is carried out by separating plasma from whole blood in vivo via an implantable filter device comprising one or more elongated hollow tubes and a plurality of elongated microporous fibers having an interior lumen extending along the length thereof, each fiber having a first and second end secured to the one or more elongated hollow tubes by passing plasma through the fiber wall from the outer wall surface to the inner wall surface and to the interior fiber lumen, directing the separated plasma to an ultrafiltration apparatus having a sieving coefficient cutoff between about 1×104 and about 6×104 daltons, separating plasma water and selected plasma components, from the separated plasma, and directing the treated plasma to the patient.
摘要翻译：患者液体管理是通过经由包括一个或多个细长中空管的可植入过滤器装置和具有沿着其长度延伸的内腔的多个细长微孔纤维在体内分离全血的血浆进行的，每个纤维具有第一和第二通过将等离子体通过纤维壁从外壁表面传递到内壁表面和内部纤维内腔，将分离的等离子体引导到超滤装置，其中筛分系数截止值在约1×10 4 和约6×10 4道尔顿，从分离的血浆中分离血浆水和选定的血浆成分，并将治疗的血浆引导至患者。

10. 发明授权

US06849183B2 Method and apparatus for therapeutic apheresis 失效
标题翻译：治疗性血液成像术的方法和装置
公开(公告)号：US06849183B2
公开(公告)日：2005-02-01
申请号：US10219082
申请日：2002-08-13
申请人： Reynolds G. Gorsuch , Tommy Cooper
发明人： Reynolds G. Gorsuch , Tommy Cooper
IPC分类号： A61M1/16 , A61M1/34 , B01D61/00 , C02F1/44
CPC分类号： A61M1/1678 , A61M1/1682 , A61M1/1684 , A61M1/1688 , A61M1/34 , A61M1/3403 , A61M1/3406 , A61M1/341 , A61M1/3431 , A61M2205/3331 , A61M2205/3334 , A61M2205/50
摘要： A method for carrying out therapeutic apheresis comprises separating plasma from whole blood in-vivo and removing selected disease-related components from the separated plasma. Apparatus for carrying out therapeutic apheresis includes a filter device for being implanted in a blood vessel for carrying out in-vivo plasma separation having one or more elongated hollow tubes and a plurality of elongated hollow microporous fibers capable of separating plasma from whole blood at pressure and blood flow within a patient's vein, a multiple lumen catheter secured to the proximal end of the filter device having one or more lumens in fluid communication with the interior of said one or more hollow tubes and a plasma return lumen, and therapeutic apheresis apparatus for removing and/or separating selected disease-related components from the separated plasma and means for directing plasma between said catheter and the selective component removal apparatus.
摘要翻译：用于进行治疗性血液分离术的方法包括从体内分离全血中的血浆并从分离的血浆中除去选定的疾病相关成分。用于进行治疗性血液分离术的装置包括：植入用于进行体内血浆分离的血管中的过滤装置，其具有一个或多个细长的中空管和能够在压力下从全血中分离血浆的多个细长的中空微孔纤维，在患者静脉内的血液流动，固定到过滤器装置的近端的多腔导管，其具有与所述一个或多个中空管的内部流体连通的一个或多个腔和等离子体返回腔，以及用于去除和/或从所分离的血浆中分离所选择的疾病相关组分，以及用于在所述导管和选择性组分去除装置之间引导血浆的装置。

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