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1. 发明申请

US20060116392A1 Methods for treating anxiety disorders and related article of manufacture 审中-公开
标题翻译：治疗焦虑症和相关制品的方法
公开(公告)号：US20060116392A1
公开(公告)日：2006-06-01
申请号：US11144421
申请日：2005-06-03
申请人： Rene Hen , Luca Santarelli , Cristina Alberini , Maria Milekie
发明人： Rene Hen , Luca Santarelli , Cristina Alberini , Maria Milekie
IPC分类号： A61K31/4745
CPC分类号： A61K31/00 , A61K31/4745
摘要： This invention provides a method for treating a subject afflicted with an anxiety disorder whose symptoms are exacerbated by the subject's exposure to a predetermined eliciting event, which method comprises administering to the subject a therapeutically effective amount of a protein synthesis inhibitor before, during the time, and/or after the subject intentionally recalls the eliciting event. Furthermore, this invention provides a method for inhibiting in a subject the onset of an anxiety disorder in response to an anxiety disorder-causing event. Finally, this invention provides a related article of manufacture.
摘要翻译：本发明提供一种治疗患有焦虑症的受试者的方法，其症状由受试者暴露于预定的引发事件而加剧，该方法包括在受试者之前，在此期间向受试者施用治疗有效量的蛋白质合成抑制剂，和/或在该受试者有意地召回引发事件之后。此外，本发明提供了一种抑制受试者响应于焦虑障碍引起事件的焦虑症发作的方法。最后，本发明提供了相关的制造方法。

2. 发明申请

US20060078499A1 Use of hedgehog agonist to treat depression 审中-公开
标题翻译：使用刺猬激动剂治疗抑郁症
公开(公告)号：US20060078499A1
公开(公告)日：2006-04-13
申请号：US11002769
申请日：2004-12-01
申请人： Rene Hen , Luca Santarelli
发明人： Rene Hen , Luca Santarelli
IPC分类号： A61K49/00 , A61K31/7072
CPC分类号： A61K31/7072 , A61K31/00 , A61K49/0008
摘要： This invention provides methods for determining whether an agent, known to upregulate the sonic hedgehog pathway, increases brain progenitor cell division in a subject. Furthermore, this invention provides methods for treating anxiety, depression, a cognitive disorder or a neuro-degenerative disorder or inhibiting the onset of anxiety, depression or a cognitive disorder by administering to an afflicted subject a therapeutically or prophylactically effective amount of the agent known to upregulate the sonic hedgehog pathway. Finally, this invention provides methods for treating anxiety, depression, a cognitive disorder or a neuro-degenerative disorder or inhibiting the onset of anxiety, depression or a cognitive disorder by administering to an afflicted subject a therapeutically or prophylactically effective amount of Hh-Ag 1.1, Hh-Ag 1.2, Hh-Ag 1.3, or a derivative of Hh-Ag 1.1, Hh-Ag 1.2 or Hh-Ag 1.3.
摘要翻译：本发明提供用于确定已知上调声刺猬蛋白通路的药剂是否增加受试者中的脑祖细胞分裂的方法。此外，本发明提供了治疗焦虑，抑郁，认知障碍或神经退行性疾病或抑制焦虑，抑郁或认知障碍发作的方法，其通过向受影响的受试者施用治疗或预防有效量的已知的上调声刺猬通路。最后，本发明提供了治疗焦虑，抑郁，认知障碍或神经退化性疾病或抑制焦虑，抑郁或认知障碍发作的方法，通过向受影响的受试者施用治疗或预防有效量的Hh-Ag1.1 ，Hh-Ag 1.2，Hh-Ag 1.3或Hh-Ag 1.1，Hh-Ag 1.2或Hh-Ag 1.3的衍生物。

3. 发明授权

US08852930B2 In vivo gene regulation by the combination of knock-in-tetO sequence into the genome and tetracycline-controlled trans-suppressor (tTS) protein 有权
标题翻译：通过敲入tetO序列组合到基因组和四环素受控反式抑制（tTS）蛋白中的体内基因调控
公开(公告)号：US08852930B2
公开(公告)日：2014-10-07
申请号：US13577281
申请日：2011-02-08
申请人： Rene Hen , Kenji Tanaka
发明人： Rene Hen , Kenji Tanaka
IPC分类号： C12N15/00 , C12N5/00 , C07H21/00 , A01K67/027 , C12N15/85
CPC分类号： C07H21/00 , A01K67/0275 , A01K2217/072 , A01K2217/075 , A01K2217/203 , A01K2217/206 , A01K2227/105 , C12N15/85 , C12N15/8509 , C12N2800/107 , C12N2800/30 , C12N2830/003
摘要： Disclosed is a FAST (Flexible Accelerated STOP TetO-knockin) system, an efficient method for manipulating gene expression in vivo to rapidly screen animal models of disease. This invention further discloses a single gene targeting event yielding 2 distinct knockin mice—STOP-tetO and tetO knockin—which permit generation of multiple strains with variable expression patterns: 1) knockout, 2) Cre-mediated rescue; 3) tTA-mediated misexpression; 4) tTA-mediated overexpression; and 5) tTS-mediated conditional knockout/knockdown. Using the FAST system, multiple gain- and loss-of-function strains can therefore be generated on a timescale not previously achievable. These strains can then be screened for clinically-relevant abnormalities. The flexibility and broad applicability of the FAST system is demonstrated by targeting several genes encoding proteins implicated in neuropsychiatric disorders: Mlc1, Neuroligin 3, the serotonin 1A receptor, and the serotonin 1B receptor.
摘要翻译：公开了一种FAST（Flexible Accelerated STOP TetO-knockin）系统，其是在体内操纵基因表达以快速筛选动物疾病模型的有效方法。本发明进一步公开了产生2个不同敲入小鼠-STAT-tetO和tetO敲入物的单一基因靶向事件，其允许产生具有可变表达模式的多个菌株：1）敲除，2）Cre介导的营救; 3）tTA介导的错误表达; 4）tTA介导的过度表达; 和5）tTS介导的条件敲除/击倒。因此，使用FAST系统，可以在以前不能实现的时间范围内生成多个功能损失增益和损失。然后可以筛选这些菌株用于临床相关的异常。 FAST系统的灵活性和广泛适用性通过靶向编码与神经精神障碍相关的蛋白质的几种基因来证明：Mlc1，神经丝氨酸3，5-羟色胺1A受体和血清素1B受体。

4. 发明授权

US5807691A Polypeptides having serotonin receptor activity (5HT5A), nucleic acids coding for these polypeptides and uses thereof 失效
标题翻译：具有5-羟色胺受体活性的多肽（5HT5A），编码这些多肽的核酸及其用途
公开(公告)号：US5807691A
公开(公告)日：1998-09-15
申请号：US356405
申请日：1995-03-29
申请人： Nourdine Amlaiky , Ursula Boschert , Rene Hen , Jean-Luc Plassat
发明人： Nourdine Amlaiky , Ursula Boschert , Rene Hen , Jean-Luc Plassat
IPC分类号： G01N33/53 , A61K38/00 , A61P43/00 , C07H21/04 , C07K14/705 , C07K14/72 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , C12N15/00
CPC分类号： C07K14/70571 , A61K38/00
摘要： The present invention concerns novel polypeptides designated 5HT5a having serotonin receptor activity, genetic material permitting their expression, any recombinant cell expressing said polypeptides and uses thereof.
摘要翻译： PCT No.PCT / FR93 / 00650 Sec。 371日期1995年3月29日 102（e）1995年3月29日PCT PCT 1993年6月29日PCT公布。出版物WO94 / 01555 日期1994年1月20日本发明涉及具有5-羟色胺受体活性的5HT5a的新多肽，允许其表达的遗传物质，表达所述多肽的任何重组细胞及其用途。

5. 发明申请

US20130061343A1 IN VIVO GENE REGULATION BY THE COMBINATION OF KNOCK-IN-TETO SEQUENCE INTO THE GENOME AND TETRACYCLINE-CONTROLLED TRANS-SUPPRESSOR (TTS) PROTEIN 有权
标题翻译：通过将基因组序列与基因组和四核苷酸控制的转导抑制剂（TTS）蛋白的组合进行体内基因调控
公开(公告)号：US20130061343A1
公开(公告)日：2013-03-07
申请号：US13577281
申请日：2011-02-08
申请人： Rene Hen , Kenji Tanaka
发明人： Rene Hen , Kenji Tanaka
IPC分类号： C12N15/85 , C12P19/34 , C12N5/10
CPC分类号： C07H21/00 , A01K67/0275 , A01K2217/072 , A01K2217/075 , A01K2217/203 , A01K2217/206 , A01K2227/105 , C12N15/85 , C12N15/8509 , C12N2800/107 , C12N2800/30 , C12N2830/003
摘要： Disclosed is a FAST (Flexible Accelerated STOP TetO-knockin) system, an efficient method for manipulating gene expression in vivo to rapidly screen animal models of disease. This invention further discloses a single gene targeting event yielding 2 distinct knockin mice—STOP-tetO and tetO knockin—which permit generation of multiple strains with variable expression patterns: 1) knockout, 2) Cre-mediated rescue; 3) tTA-mediated misexpression; 4) tTA-mediated overexpression; and 5) tTS-mediated conditional knockout/knockdown. Using the FAST system, multiple gain- and loss-of-function strains can therefore be generated on a timescale not previously achievable. These strains can then be screened for clinically-relevant abnormalities. The flexibility and broad applicability of the FAST system is demonstrated by targeting several genes encoding proteins implicated in neuropsychiatric disorders: Mlc1, Neuroligin 3, the serotonin 1A receptor, and the serotonin 1B receptor.
摘要翻译：公开了一种FAST（Flexible Accelerated STOP TetO-knockin）系统，其是在体内操纵基因表达以快速筛选动物疾病模型的有效方法。本发明进一步公开了产生2个不同敲入小鼠-STAT-tetO和tetO敲入物的单一基因靶向事件，其允许产生具有可变表达模式的多个菌株：1）敲除，2）Cre介导的营救; 3）tTA介导的错误表达; 4）tTA介导的过度表达; 和5）tTS介导的条件敲除/击倒。因此，使用FAST系统，可以在以前不能实现的时间范围内生成多个功能损失增益和损失。然后可以筛选这些菌株用于临床相关的异常。 FAST系统的灵活性和广泛适用性通过靶向编码与神经精神障碍相关的蛋白质的几种基因来证明：Mlc1，神经丝氨酸3，5-羟色胺1A受体和血清素1B受体。

6. 发明申请

US20110296540A1 ASSAY FOR SCREENING ANTIDEPRESSANTS 审中-公开
标题翻译：用于筛选抗生素的测定
公开(公告)号：US20110296540A1
公开(公告)日：2011-12-01
申请号：US13131558
申请日：2009-12-01
申请人： Rene Hen , Jingwen Wang , Eduardo David Leonardo , Jesse Richardson-Jones
发明人： Rene Hen , Jingwen Wang , Eduardo David Leonardo , Jesse Richardson-Jones
IPC分类号： G01N33/48 , A01K67/00 , G01N33/82 , A61K49/00 , C12Q1/68
CPC分类号： G01N33/5058 , A01K67/0275 , A01K2217/054 , A01K2217/203 , A01K2217/206 , A01K2227/105 , A01K2267/0356 , C12N15/8509 , G01N33/5088
摘要： This invention provides a method for identifying a small molecule as an antidepressant, a method for identifying a small molecule as an anxiolytic, and a method for identifying a small molecule as able to increase dendritic arborization, decrease expression of an immaturity marker, increase expression of a maturity marker, or enhance artificial cerebrospinal fluid-type long-term potentiation in central nervous system. This invention also provides a transgenic mouse model for SSRI-non-responders.
摘要翻译：本发明提供了用于鉴定作为抗抑郁药的小分子的方法，用于鉴定作为抗焦虑药的小分子的方法，以及用于鉴定能够增加树突状结构的小分子，降低未成熟标记物的表达，增加表达的方法成熟标志物，或增强人脑中枢神经系统长期增强的脑脊液。本发明还提供了用于SSRI-无应答者的转基因小鼠模型。

7. 发明申请

US20050186137A1 Novelty-induced hypophagia-based assays for identifying agents to treat anxiety and depression 审中-公开
标题翻译：新奇诱导的基于嗜酸细胞的检测方法，用于鉴定治疗焦虑和抑郁症的药物
公开(公告)号：US20050186137A1
公开(公告)日：2005-08-25
申请号：US10977911
申请日：2004-10-29
申请人： Rene Hen , Stephanie Dulawa
发明人： Rene Hen , Stephanie Dulawa
IPC分类号： A61K49/00
CPC分类号： A61K49/0004
摘要： This invention provides a method for determining whether an agent reduces anxiety and/or depression in a depressed, non-human subject. This invention also provides methods for treating anxiety and depression in subjects afflicted with those disorders comprising administering a therapeutically effective amount of an anxiety-reducing or depression-reducing agent identified by the instant method.
摘要翻译：本发明提供了一种用于确定药物是否减少抑郁，非人类受试者的焦虑和/或抑郁症的方法。本发明还提供了治疗患有这些疾病的受试者的焦虑和抑郁症的方法，包括施用治疗有效量的本发明方法鉴定的减少焦虑的抑制剂。

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