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1. 发明申请

US20080312466A1 Synthesis and intermediates 有权
标题翻译：合成和中间体
公开(公告)号：US20080312466A1
公开(公告)日：2008-12-18
申请号：US12220390
申请日：2008-07-24
申请人： Reinhold Ohrlein , Gabriele Baisch , Nicole End , Stephan Burkhardt , Martin Studer
发明人： Reinhold Ohrlein , Gabriele Baisch , Nicole End , Stephan Burkhardt , Martin Studer
IPC分类号： C07C69/73 , C07C67/30 , C07C229/34
CPC分类号： C07C235/74 , C07C69/67 , C07C69/716 , C07C69/732 , C07C69/738 , C07C227/32 , C07C229/22 , C07C235/06 , C12P7/62 , Y02P20/55
摘要： The invention relates to novel synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or —N(CH3)OCH3, Ra is a hydroxy-protecting group and Rb is a carboxy-protecting group, and, as well as to the compound of formula I, to further new intermediates and methods for their preparation by Friedel-Crafts acylation.
摘要翻译：本发明涉及用于制备他汀类衍生物的新型合成方法，该方法通过式I的关键中间体进行，其中X是卤素，酰氧基，活化的烃氧基，活化的烃基硫基或-N（CH 3）OCH 3，R a是羟基保护基团，Rb是羧基保护基团，以及式I化合物，用于通过Friedel-Crafts酰化进一步制备新的中间体及其制备方法。

2. 发明授权

US07855302B2 Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino-3.5-dihydroxyhepanoic acid derivatives and intermediates thereof 有权
标题翻译：制备可用于合成他汀类衍生物，特别是7-氨基-3,5-二羟基庚酸衍生物的中间体的方法及其中间体
公开(公告)号：US07855302B2
公开(公告)日：2010-12-21
申请号：US12220390
申请日：2008-07-24
申请人： Reinhold Öhrlein , Gabriele Baisch , Nicole End , Stephan Burkhardt , Martin Studer
发明人： Reinhold Öhrlein , Gabriele Baisch , Nicole End , Stephan Burkhardt , Martin Studer
IPC分类号： C07C69/66 , C07C259/06 , C07C69/22
CPC分类号： C07C235/74 , C07C69/67 , C07C69/716 , C07C69/732 , C07C69/738 , C07C227/32 , C07C229/22 , C07C235/06 , C12P7/62 , Y02P20/55
摘要： The invention relates to novel synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or —N(CH3)OCH3, Ra is a hydroxy-protecting group and Rb is a carboxy-protecting group, and, as well as to the compound of formula I, to further new intermediates and methods for their preparation by Friedel-Crafts acylation.
摘要翻译：本发明涉及用于制备他汀类衍生物的新型合成方法，该方法通过式I的关键中间体进行，其中X是卤素，酰氧基，活化的烃氧基，活化的烃基硫基或-N（CH 3）OCH 3，R a是羟基保护基团，Rb是羧基保护基团，以及式I化合物，用于通过Friedel-Crafts酰化进一步制备新的中间体及其制备方法。

3. 发明授权

US07420078B2 Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof 有权
标题翻译：制备可用于合成他汀类衍生物，特别是7-氨基3,5-二羟基庚酸衍生物的中间体的方法及其中间体
公开(公告)号：US07420078B2
公开(公告)日：2008-09-02
申请号：US10482463
申请日：2002-07-02
申请人： Reinhold Öhrlein , Gabriele Baisch , Nicole End , Stephan Burkhardt , Martin Studer
发明人： Reinhold Öhrlein , Gabriele Baisch , Nicole End , Stephan Burkhardt , Martin Studer
IPC分类号： C07C69/66 , C07C259/06 , C07C69/22
CPC分类号： C07C235/74 , C07C69/67 , C07C69/716 , C07C69/732 , C07C69/738 , C07C227/32 , C07C229/22 , C07C235/06 , C12P7/62 , Y02P20/55
摘要： The invention relates to synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or N(CH3)OCH3, Ra is a hydroxy-protecting group, and Rb is a carboxy-protecting group, and, as well as to the compound of formula I, to further intermediates and methods for their preparation by Friedel-Crafts acylation.
摘要翻译：本发明涉及用于制备他汀类衍生物的合成方法，该方法通过式I的关键中间体进行，其中X是卤素，酰氧基，活化的烃氧基，活化的烃基硫基或N（CH 3） OCH 3，R a是羟基保护基，R b是羧基保护基，以及对于式I化合物，其进一步的中间体及其通过Friedel-Crafts酰化制备的方法。

4. 发明授权

US08026383B2 Process for the preparation of intermediates useful in the synthesis of statin derivatives 有权
标题翻译：制备可用于合成他汀类衍生物的中间体的方法
公开(公告)号：US08026383B2
公开(公告)日：2011-09-27
申请号：US12939401
申请日：2010-11-04
申请人： Reinhold Öhrlein , Gabriele Baisch , Nicole End , Stephan Burkhardt , Martin Studer
发明人： Reinhold Öhrlein , Gabriele Baisch , Nicole End , Stephan Burkhardt , Martin Studer
IPC分类号： C07C69/66 , C07C259/06 , C07C69/22
CPC分类号： C07C235/74 , C07C69/67 , C07C69/716 , C07C69/732 , C07C69/738 , C07C227/32 , C07C229/22 , C07C235/06 , C12P7/62 , Y02P20/55
摘要： The invention relates to novel synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or —N(CH3)OCH3, Ra is a hydroxy-protecting group and Rb is a carboxy-protecting group, and, as well as to the compound of formula I, to further new intermediates and methods for their preparation by Friedel-Crafts acylation.
摘要翻译：本发明涉及用于制备他汀类衍生物的新型合成方法，该方法通过式I的关键中间体进行，其中X是卤素，酰氧基，活化的烃氧基，活化的烃基硫基或-N（CH 3）OCH 3，R a是羟基保护基团，Rb是羧基保护基团，以及式I化合物，用于通过Friedel-Crafts酰化进一步制备新的中间体及其制备方法。

5. 发明申请

US20110046411A1 PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL IN THE SYNTHESIS OF STATIN DERIVATIVES 有权
标题翻译：制备苯丙氨酸衍生物合成中的有用途的方法
公开(公告)号：US20110046411A1
公开(公告)日：2011-02-24
申请号：US12939401
申请日：2010-11-04
申请人： REINHOLD ÖHRLEIN , Gabriele Baisch , Nicole End , Stephan Burkhardt , Martin Studer
发明人： REINHOLD ÖHRLEIN , Gabriele Baisch , Nicole End , Stephan Burkhardt , Martin Studer
IPC分类号： C07C227/00 , C07C69/67
CPC分类号： C07C235/74 , C07C69/67 , C07C69/716 , C07C69/732 , C07C69/738 , C07C227/32 , C07C229/22 , C07C235/06 , C12P7/62 , Y02P20/55
摘要： The invention relates to novel synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or —N(CH3)OCH3, Ra is a hydroxy-protecting group and Rb is a carboxy-protecting group, and, as well as to the compound of formula I, to further new intermediates and methods for their preparation by Friedel-Crafts acylation.
摘要翻译：本发明涉及用于制备他汀类衍生物的新型合成方法，该方法通过式I的关键中间体进行，其中X是卤素，酰氧基，活化的烃氧基，活化的烃基硫基或-N（CH 3）OCH 3，R a是羟基保护基团，Rb是羧基保护基团，以及式I化合物，用于通过Friedel-Crafts酰化进一步制备新的中间体及其制备方法。

6. 发明申请

US20060105441A1 Process for the preparation of indole derivatives by enzymatic acylation 审中-公开
标题翻译：通过酶酰化制备吲哚衍生物的方法
公开(公告)号：US20060105441A1
公开(公告)日：2006-05-18
申请号：US10548356
申请日：2004-03-03
申请人： Reinhold Ohrlein , Nicole End , Gabriele Baisch
发明人： Reinhold Ohrlein , Nicole End , Gabriele Baisch
IPC分类号： C12P7/40 , C07D209/18
CPC分类号： C07D209/24
摘要： A process for the preparation of compounds of formula (1), by enzymatic acylation to form compounds of formulae (3a) and (3a) and then reacting the compound of formula (3a) with a compound introducing the radical of formula —CH2—COOR8, R8 being an organic radical, and then reducing, and optionally hydrolysing, the resulting compound of formula (4).
摘要翻译：通过酶促酰化制备式（1）化合物以形成式（3a）和（3a）化合物的方法，然后使式（3a）化合物与引入式-CH

7. 发明授权

US08575394B2 Preparation of alpha-hydroxyketones 有权
标题翻译： α-羟基酮的制备
公开(公告)号：US08575394B2
公开(公告)日：2013-11-05
申请号：US13557281
申请日：2012-07-25
申请人： Nicole End , Reinhard H. Sommerlade , Yvonne Richter
发明人： Nicole End , Reinhard H. Sommerlade , Yvonne Richter
IPC分类号： C07C225/00 , C07C223/00
CPC分类号： C07F7/1892 , C07C45/30 , C07C45/58 , C07C49/82 , C07C49/83 , C07C49/747 , C07C49/84
摘要： A process for the preparation of an 1,1-disubstituted oxirane is disclosed, wherein an organic sulphide is reacted in a polar solvent with an educt containing a leaving group attached to a primary or secondary carbon atom, and/or the sulfonium salt formed in this way is reacted with a ketone in presence of a base and a polar solvent. Oxiranes of the type obtained may be further converted into the corresponding α-hydroxyketone or α-aminoketone, either in one step by subjecting to aerobic oxidation in the presence of a transition metal catalyst, or in two steps by hydrolyzation in the presence of an aqueous acid to the corresponding dialcohol and subsequent selective oxidation. Further described are some novel epoxide intermediates. The α-hydroxyketones and α-aminoketones thus obtainable are useful inter alia as photoinitiators.
摘要翻译：公开了一种制备1,1-二取代的环氧乙烷的方法，其中有机硫化物在极性溶剂中与含有连接到伯或仲碳原子的离去基团的离子和/或在在碱和极性溶剂的存在下，与酮反应。所得类型的环氧乙烷可以通过在过渡金属催化剂存在下进行有氧氧化，或者在两步骤中在水溶液存在下进行水解，可以在一个步骤中进一步转化为相应的α-羟基酮或α-氨基酮酸至相应的二醇并随后进行选择性氧化。进一步描述了一些新型的环氧化物中间体。因此可获得的α-羟基酮和α-氨基酮特别可用作光引发剂。

8. 发明授权

US07928049B2 Use of metal complex compounds as oxidation catalysts 有权
标题翻译：使用金属络合物作为氧化催化剂
公开(公告)号：US07928049B2
公开(公告)日：2011-04-19
申请号：US12669797
申请日：2008-07-14
申请人： Barbara Wagner , Hauke Rohwer , Marie-Josée Dubs , Nicole End , Menno Hazenkamp , Sophie Marquais-Bienewald
发明人： Barbara Wagner , Hauke Rohwer , Marie-Josée Dubs , Nicole End , Menno Hazenkamp , Sophie Marquais-Bienewald
IPC分类号： C11D1/02 , C11D1/66 , C11D3/28 , C11D3/39 , C11D3/395
CPC分类号： B01J31/1815 , B01J31/1825 , B01J31/2217 , B01J2231/70 , B01J2531/0238 , B01J2531/0258 , B01J2531/16 , B01J2531/46 , B01J2531/72 , B01J2531/842 , B01J2531/845 , B01J2531/847 , C07D213/81 , C07D213/88 , C07D215/38 , C07D401/12 , C11D3/0021 , C11D3/168 , C11D3/3932 , C11D3/3935 , C11D3/48
摘要： The present invention relates to the use of metal complex compounds having hydrazide ligands as oxidation catalysts. Further aspects of the invention are formulations comprising such metal complex compounds, novel metal complex compounds and novel ligands. The metal complex compounds are used especially for enhancing the action of peroxides, for example in the treatment of textile material, without at the same time causing any appreciable damage to fibers and dyeings. There is also no appreciable damage to fibers and dyeings if these metal complexes are used in combination with an enzyme or a mixture of enzymes.
摘要翻译：本发明涉及具有酰肼配位体的金属络合物作为氧化催化剂的用途。本发明的其它方面是包含这种金属络合物，新型金属络合物和新型配体的制剂。金属络合物特别用于增强过氧化物的作用，例如在纺织材料的处理中，而不会同时对纤维和染色造成明显的损害。如果这些金属配合物与酶或酶的混合物组合使用，纤维和染色也不会有明显的损害。

9. 发明申请

US20110021407A1 USE OF METAL COMPLEX COMPOUNDS AS OXIDATION CATALYSTS 有权
标题翻译：使用金属复合化合物作为氧化催化剂
公开(公告)号：US20110021407A1
公开(公告)日：2011-01-27
申请号：US12669797
申请日：2008-07-14
申请人： Barbara Wagner , Hauke Rohwer , Marie-Josee Dubs , Nicole End , Menno Hazenkamp , Sophie Marquais-Bienewald
发明人： Barbara Wagner , Hauke Rohwer , Marie-Josee Dubs , Nicole End , Menno Hazenkamp , Sophie Marquais-Bienewald
IPC分类号： C11D3/60 , C07D401/12 , C07F15/02 , C07F7/28 , C07F13/00 , C07F15/06 , C07F15/04 , C07F1/08 , C09K3/00
CPC分类号： B01J31/1815 , B01J31/1825 , B01J31/2217 , B01J2231/70 , B01J2531/0238 , B01J2531/0258 , B01J2531/16 , B01J2531/46 , B01J2531/72 , B01J2531/842 , B01J2531/845 , B01J2531/847 , C07D213/81 , C07D213/88 , C07D215/38 , C07D401/12 , C11D3/0021 , C11D3/168 , C11D3/3932 , C11D3/3935 , C11D3/48
摘要： The present invention relates to the use of metal complex compounds having hydrazide ligands as oxidation catalysts. Further aspects of the invention are formulations comprising such metal complex compounds, novel metal complex compounds and novel ligands. The metal complex compounds are used especially for enhancing the action of peroxides, for example in the treatment of textile material, without at the same time causing any appreciable damage to fibres and dyeings. There is also no appreciable damage to fibres and dyeings if these metal complexes are used in combination with an enzyme or a mixture of enzymes.
摘要翻译：本发明涉及具有酰肼配位体的金属络合物作为氧化催化剂的用途。本发明的其它方面是包含这种金属络合物，新型金属络合物和新型配体的制剂。金属络合物特别用于增强过氧化物的作用，例如在纺织材料的处理中，而不会同时对纤维和染色造成明显的损害。如果这些金属配合物与酶或酶的混合物组合使用，纤维和染色也不会有明显的损害。

10. 发明申请

US20090106915A1 Coloring keratin fibers with metal complexes 失效
标题翻译：用金属络合物着色角蛋白纤维
公开(公告)号：US20090106915A1
公开(公告)日：2009-04-30
申请号：US11919606
申请日：2006-05-03
申请人： Nicole End , Kai-Uwe Schoning , Beate Frohling
发明人： Nicole End , Kai-Uwe Schoning , Beate Frohling
IPC分类号： A61K8/49 , C07D249/08 , C07D285/08 , C07D271/06 , A61Q5/10
CPC分类号： C07D271/06 , A61K8/19 , A61K8/40 , A61K8/49 , A61K8/4926 , A61K8/496 , A61K8/4966 , A61K2800/58 , A61Q5/065 , C07D213/74 , C07D249/08 , C07D285/08 , C07D471/04 , C09B55/006 , C09B57/00 , C09B57/10
摘要： The present invention concerns coloring keratin fibers, especially human hair, with colored metal complexes.
摘要翻译：本发明涉及用着色金属络合物着色角蛋白纤维，特别是人类头发。

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