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1. 发明申请

US20050287515A1 Removal of bacterial DNA from therapeutic fluid formulations 审中-公开
标题翻译：从治疗液制剂中去除细菌DNA
公开(公告)号：US20050287515A1
公开(公告)日：2005-12-29
申请号：US11100941
申请日：2005-04-07
申请人： Reinhold Deppisch , Werner Beck , Ralf Schindler
发明人： Reinhold Deppisch , Werner Beck , Ralf Schindler
IPC分类号： A01N1/02 , A61L2/00 , A61M1/16 , A61M1/28 , A61M5/165 , B01D69/14 , B01D71/64 , B01D71/68
CPC分类号： A61L2/0017 , A61L2/0011 , A61M1/1656 , A61M1/1672 , A61M1/1676 , A61M1/287 , A61M5/165 , A61M2202/20 , B01D69/141 , B01D71/64 , B01D71/68 , B01D2325/16 , B01J20/26 , B01J20/264
摘要： This invention discloses methods and devices useful for eliminating or reducing the adverse effects associated with the use of a variety of therapeutic fluids. It is proposed herein that the source of such side effects (e.g. fever and septic shock) is the oligonucleotides present in the fluid and that using the ultrafiltration and adsorption methods and devices disclosed in the invention one can minimize the risk of these adverse effects often associated with dialysis treatment.
摘要翻译：本发明公开了可用于消除或减少与使用各种治疗流体相关的不利影响的方法和装置。在本文中提出，这种副作用（例如发烧和败血性休克）的来源是存在于流体中的寡核苷酸，并且使用本发明公开的超滤和吸附方法和装置，可以将经常相关的这些不利影响的风险降至最低透析处理。

2. 发明申请

US20110015720A1 IMPLANTABLE ACCESS DEVICE AND METHOD FOR PREPARING THEREOF 审中-公开
标题翻译：可植入访问装置及其制备方法
公开(公告)号：US20110015720A1
公开(公告)日：2011-01-20
申请号：US11993663
申请日：2006-06-12
申请人： Andrea Schnell , Bernd Wittner , Claudia Hildwein , Ruth Dietrich , Reinhold Deppisch , Doris Deppisch , Werner Beck
发明人： Andrea Schnell , Bernd Wittner , Claudia Hildwein , Ruth Dietrich , Reinhold Deppisch , Doris Deppisch , Werner Beck
IPC分类号： A61M31/00 , A61F2/82
CPC分类号： A61L31/022 , A61L31/14 , A61L2400/16 , A61M39/0208 , A61M39/26 , A61M2039/0202 , A61M2039/0205 , A61M2039/0223 , A61M2205/0266
摘要： The present invention concerns an implantable access device and a method for preparing the device. According to the invention the device comprises a shape memory base structure with a biological substructure suitable for cell adhesion, cell engraftment and proliferation for use in transferring and transporting fluid mixtures (blood, suspensions, drug formulations, emulsions, cell suspensions) in/into/out of a human or animal body.
摘要翻译：本发明涉及可植入存取装置及其制备方法。根据本发明，该装置包括具有适于细胞粘附，细胞移植和增殖的生物亚结构的形状记忆基础结构，用于将流体混合物（血液，悬浮液，药物制剂，乳剂，细胞悬液）转移和/ 从人或动物的身体出来。

3. 发明申请

US20060275368A1 Biocompatible polymer 有权
标题翻译：生物相容性聚合物
公开(公告)号：US20060275368A1
公开(公告)日：2006-12-07
申请号：US10557996
申请日：2004-05-24
申请人： Reinhold Deppisch , Ruth Dietrich , Werner Beck , Andrea Schnell , Bernd Wittner
发明人： Reinhold Deppisch , Ruth Dietrich , Werner Beck , Andrea Schnell , Bernd Wittner
IPC分类号： A61K33/24 , A61K31/60 , A61K31/555 , A61K9/14 , A61K31/29
CPC分类号： A61K31/29 , A61K31/555 , A61K31/60 , A61K33/245 , A61K45/06 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L33/02 , A61L2300/102 , A61L2300/404 , A61L2300/624 , A61L2400/12 , Y10T428/31598 , C08L83/04 , C08L67/04 , A61K2300/00
摘要： The present disclosure relates to a biocompatible polymer composition for an article comprising a surface intended to contact blood, tissue, skin, epithelial layers, wounds, cells in culture fluids, body fluids, dialysis fluids, therapeutic fluids, or mixtures thereof for removal or infusion. The invention also relates to a method for the preparation of an article comprising the biocompatible polymer composition and a use thereof.
摘要翻译：本公开涉及用于制品的生物相容性聚合物组合物，其包含旨在接触血液，组织，皮肤，上皮层，伤口，培养液中的细胞，体液，透析液，治疗液或其混合物的表面，用于去除或输注。本发明还涉及制备包含生物相容性聚合物组合物的制品的方法及其用途。

4. 发明申请

US20090163599A1 Mif adsorbant 审中-公开
标题翻译： Mif吸附剂
公开(公告)号：US20090163599A1
公开(公告)日：2009-06-25
申请号：US11596534
申请日：2005-06-03
申请人： Markus Storr , Reinhold Deppisch , Werner Beck , Jürgen Bernhagen , Ina Merz , Georg Geiger
发明人： Markus Storr , Reinhold Deppisch , Werner Beck , Jürgen Bernhagen , Ina Merz , Georg Geiger
IPC分类号： A61K31/137 , A61P29/00
CPC分类号： B01J20/328 , A61M1/3679 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3251 , B01J20/3255 , B01J20/3274 , B01J20/3278
摘要： The present invention concerns an apheresis material or adsorbant and a method for removing, depleting or inactivating MIF (macrophage migration inhibitory factor) from blood, blood plasma, blood serum or other body fluids. The present invention is also concerned with the use of said apheresis material or adsorbant. In order to prepare a novel means and novel method, which can reduce the activity or amount of the mediator for sepsis and septic shock, MIF, in a patient's body fluid in a manner which is more pleasant and tolerable for the patient than prior art means and methods, the invention proposes that the apheresis material or adsorbant comprises a solid carrier material on the surface of which MIF-binding molecules or functional groups are immobilized. The method proposes that the apheresis material or adsorbant be brought into contact extracorporeally with the blood, blood plasma, blood serum or other body fluids.
摘要翻译：本发明涉及一种分离物质或吸附剂以及从血液，血浆，血清或其他体液中去除，消耗或失活MIF（巨噬细胞迁移抑制因子）的方法。本发明还涉及使用所述单采血浆物质或吸附剂。为了制备一种新颖的方法和新颖的方法，其可以以比现有技术手段更令人愉快和可耐受的方式，减少患者体液中败血症和败血症休克的介体的活性或量和方法，本发明提出，单采血浆材料或吸附剂在其表面上包含固定有MIF结合分子或官能团的固体载体材料。该方法提出将血浆，血浆，血清或其他体液与体外血浆物质或吸附剂接触体外。

5. 发明授权

US06841255B2 Biocompatible polymer film 有权
标题翻译：生物相容性聚合物膜
公开(公告)号：US06841255B2
公开(公告)日：2005-01-11
申请号：US10245115
申请日：2002-09-17
申请人： Reinhold Deppisch , Ulrich Bauer , Werner Beck , Ruth Dietrich , Hermann Göhl , Katja Krämer
发明人： Reinhold Deppisch , Ulrich Bauer , Werner Beck , Ruth Dietrich , Hermann Göhl , Katja Krämer
IPC分类号： A61L33/00 , A61L27/34 , A61L29/08 , A61L31/10 , A61L33/06 , B32B27/06 , C08G81/00 , C08J5/18 , B32B25/20
CPC分类号： C08J5/18 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/068 , C08G81/00 , Y10T428/31504 , Y10T428/31598 , C08L83/10
摘要： The present invention includes a co-polymer film which can be applied over a surface of an article to form a continuous surface that is more biocompatible and has a smoother surface morphology than an untreated article. In general the co-polymer film of the invention can be formed by providing a hydrophobic polymer block, such as polydimethylsiloxane (PDMS) with functional —OH end groups and reacting the —OH ends with a conventional monomer or prepolymer of a film-forming polymer capable of reacting with —OH groups. Such reactions are exemplified, using as reactive PDMS a triblock copolymer of the polylactone-polysiloxane-polylactone (PL-PDMS-PL) type, or silicone polyesters. The —OH groups of the polylactone blocks can react with any of a variety of isocyanates in a suitable solvent to form a polymer having PDMS incorporated with its structure. The film can be applied to the surface of an article by any convenient means of coating the article with the reaction mixture in solvent, and allowing the solvent to evaporate.
摘要翻译：本发明包括可以施加在制品的表面上以形成比未处理制品更具生物相容性并且具有更光滑的表面形态的连续表面的共聚物膜。通常，本发明的共聚物膜可以通过提供具有官能-OH端基的疏水性聚合物嵌段例如聚二甲基硅氧烷（PDMS）并使-OH端与常规的成膜聚合物的单体或预聚物能够与-OH基团反应。举例来说，使用聚内酯 - 聚硅氧烷 - 聚内酯（PL-PDMS-PL）型的三嵌段共聚物或硅氧烷聚酯作为反应性PDMS。聚内酯嵌段的-OH基团可以在合适的溶剂中与各种异氰酸酯中的任何一种反应，以形成具有结合其PDMS的聚合物。可以通过用反应混合物在溶剂中涂覆制品的任何便利的方法将膜施加到制品的表面，并使溶剂蒸发。

6. 发明授权

US06500549B1 Biocompatible polymer film 有权
标题翻译：生物相容性聚合物膜
公开(公告)号：US06500549B1
公开(公告)日：2002-12-31
申请号：US09415943
申请日：1999-10-08
申请人： Reinhold Deppisch , Ulrich Bauer , Werner Beck , Ruth Dietrich , Hermann Göhl , Katja Krämer
发明人： Reinhold Deppisch , Ulrich Bauer , Werner Beck , Ruth Dietrich , Hermann Göhl , Katja Krämer
IPC分类号： B32B2520
CPC分类号： C08J5/18 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/068 , C08G81/00 , Y10T428/31504 , Y10T428/31598 , C08L83/10
摘要： The present invention includes a co-polymer film which can be applied over a surface of an article to form a continuous surface that is more biocompatible and has a smoother surface morphology than an untreated article. In general the co-polymer film of the invention can be formed by providing a hydrophobic polymer block, such as polydimethylsiloxane (PDMS) with functional —OH end groups and reacting the —OH ends with a conventional monomer or prepolymer of a film-forming polymer capable of reacting with —OH groups. Such reactions are exemplified, using as reactive PDMS a triblock copolymer of the polylactone-polysiloxane-polylactone (PL-PDMS-PL) type, or silicone polyesters. The —OH groups of the polylactone blocks can react with any of a variety of isocyanates in a suitable solvent to form a polymer having PDMS incorporated with its structure. The film can be applied to the surface of an article by any convenient means of coating the article with the reaction mixture in solvent, and allowing the solvent to evaporate.
摘要翻译：本发明包括可以施加在制品的表面上以形成比未处理制品更具生物相容性并且具有更光滑的表面形态的连续表面的共聚物膜。通常，本发明的共聚物膜可以通过提供具有官能-OH端基的疏水性聚合物嵌段例如聚二甲基硅氧烷（PDMS）并使-OH端与常规的成膜聚合物的单体或预聚物能够与-OH基团反应。举例来说，使用聚内酯 - 聚硅氧烷 - 聚内酯（PL-PDMS-PL）型的三嵌段共聚物或硅氧烷聚酯作为反应性PDMS。聚内酯嵌段的-OH基团可以在合适的溶剂中与各种异氰酸酯中的任何一种反应，以形成具有结合其PDMS的聚合物。可以通过用反应混合物在溶剂中涂覆制品的任何便利的方法将膜施加到制品的表面，并使溶剂蒸发。

7. 发明授权

US08821906B2 Biocompatible polymer 有权
标题翻译：生物相容性聚合物
公开(公告)号：US08821906B2
公开(公告)日：2014-09-02
申请号：US10557996
申请日：2004-05-24
申请人： Reinhold Deppisch , Ruth Dietrich , Werner Beck , Andrea Schnell , Bernd Wittner
发明人： Reinhold Deppisch , Ruth Dietrich , Werner Beck , Andrea Schnell , Bernd Wittner
IPC分类号： A01N25/00 , A61F2/00 , A61K9/14 , A01N59/16 , B32B27/00 , B32B27/40 , A01N55/02 , A61K31/29 , C08F283/04 , A61K33/24 , A61L27/54 , A61L29/08 , A61K31/555 , A61L27/34 , A61L31/10 , A61K31/60 , A61L31/16 , A61L29/16 , A61L31/08 , A61K45/06 , A61L33/02
CPC分类号： A61K31/29 , A61K31/555 , A61K31/60 , A61K33/245 , A61K45/06 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L33/02 , A61L2300/102 , A61L2300/404 , A61L2300/624 , A61L2400/12 , Y10T428/31598 , C08L83/04 , C08L67/04 , A61K2300/00
摘要： The present disclosure relates to a biocompatible polymer composition for an article comprising a surface intended to contact blood, tissue, skin, epithelial layers, wounds, cells in culture fluids, body fluids, dialysis fluids, therapeutic fluids, or mixtures thereof for removal or infusion. The invention also relates to a method for the preparation of an article comprising the biocompatible polymer composition and a use thereof.
摘要翻译：本公开涉及用于制品的生物相容性聚合物组合物，其包含旨在接触血液，组织，皮肤，上皮层，伤口，培养液中的细胞，体液，透析液，治疗液或其混合物的表面，用于去除或输注。本发明还涉及制备包含生物相容性聚合物组合物的制品的方法及其用途。

8. 发明申请

US20110160664A1 Applicator and method for applying lock solution in a catheter 有权
标题翻译：将溶液施加在导管中的施用器和方法
公开(公告)号：US20110160664A1
公开(公告)日：2011-06-30
申请号：US11629783
申请日：2005-06-15
申请人： Reinhold Deppisch , Werner Beck , Ruth Dietrich , Björn Frederik Seidler , Andrea Schnell , Claudia Hildwein
发明人： Reinhold Deppisch , Werner Beck , Ruth Dietrich , Björn Frederik Seidler , Andrea Schnell , Claudia Hildwein
IPC分类号： A61M5/31 , A61M5/315 , A61M5/36
CPC分类号： A61M25/0097 , A61M25/00 , A61M2005/3103
摘要： A device for applying a lock solution in a catheter or other access system comprises a syringe (302) having an expulsion arrangement (305, 311) for expelling the lock solution from the device, said expulsion arrangement including a plunger (305) arranged in a housing (304), further comprising a sterile connector (303) for connecting the syringe (302) to the catheter. The connector (303) is arranged to engage a tip (307) of the expulsion arrangement (305, 311) tightly when the syringe (302) is inserted in the connector (303). The connector (303) is arranged to prevent the tip (307) of the expulsion arrangement (305, 311) from entering the catheter. The tip (307) is frangible. A method of applying a lock solution in a catheter or other access system is also disclosed.
摘要翻译：一种用于在导管或其他进入系统中施加锁定溶液的装置包括具有用于将锁定溶液从装置排出的排出装置（305,311）的注射器（302），所述排出装置包括柱塞（305）壳体（304），还包括用于将注射器（302）连接到导管的无菌连接器（303）。连接器（303）被布置成当注射器（302）插入连接器（303）中时紧密地接合排出装置（305,311）的尖端（307）。连接器（303）布置成防止排出装置（305,311）的尖端（307）进入导管。尖端（307）是易碎的。还公开了将锁溶液应用于导管或其他接入系统的方法。

9. 发明申请

US20100204328A1 Solution and Method to Reduce, Treat and/or Prevent Oxidative Stress and Cell Activation 审中-公开
标题翻译：减少，治疗和/或预防氧化应激和细胞活化的方法和方法
公开(公告)号：US20100204328A1
公开(公告)日：2010-08-12
申请号：US12305481
申请日：2007-06-21
申请人： Reinhold Deppisch , Doris Deppisch , Werner Beck , Andrea Schnell , Hans-Rainer Drieschmanns
发明人： Reinhold Deppisch , Doris Deppisch , Werner Beck , Andrea Schnell , Hans-Rainer Drieschmanns
IPC分类号： A61K31/198 , A61P39/00
CPC分类号： A61K31/191 , A61K9/0019 , A61K31/198 , A61K31/375 , A61K38/063 , A61K38/38 , A61K45/06 , A61K2300/00
摘要： The present invention concerns a solution and methods to reduce, treat and/or prevent oxidative stress and cell activation. According to the invention the solution gives rise to the following concentrations of constituents within a blood flow of 0.1-18 mM N-acetyl-cysteine, optionally of 0.01-0.21 mM vitamin C, optionally of 2-26 mM gluconic acid and optionally of 0.01-5 mM glutathione. According to the invention the methods comprises adding a solution according to the invention in an extracorporeal setting through the membrane by adding the solution to the dialysis fluid, or by infusion of a solution according to the invention, either by bolus injection, continuous injection or a combination thereof.
摘要翻译：本发明涉及减少，治疗和/或预防氧化应激和细胞活化的方法和方法。根据本发明，该溶液在0.1-18mM N-乙酰半胱氨酸，任选地0.011-0.21mM维生素C，任选的2-26mM葡萄糖酸和任选0.01重量％的血液流中产生以下浓度的组分 -5 mM谷胱甘肽。根据本发明，所述方法包括通过将溶液加入到透析液中或通过输注本发明的溶液，通过推注，连续注射或者的组合。

10. 发明申请

US20090047654A1 Polymer affinity matrix, a method for the production and use thereof 审中-公开
标题翻译：聚合物亲和基质，其生产和使用方法
公开(公告)号：US20090047654A1
公开(公告)日：2009-02-19
申请号：US12219356
申请日：2008-07-21
申请人： Wolfgang Rapp , Reinhold Deppisch , Hermann Gohl , Bernd Wittner , Werner Beck
发明人： Wolfgang Rapp , Reinhold Deppisch , Hermann Gohl , Bernd Wittner , Werner Beck
IPC分类号： B01D15/38 , B01D67/00 , A01N1/00 , C07C229/26 , C07K5/09 , C07K7/06 , C07K7/08 , C07K5/11 , C07K14/00 , C07K7/54 , C08G63/91 , C08F8/32
CPC分类号： B01J20/28016 , A61K31/195 , B01J20/26 , B01J20/28033 , B01J20/3219 , B01J20/3242 , B01J20/3248 , G01N33/54353
摘要： A polymer affinity matrix for the binding of one or more substances in a fluid or removing said substance(s) from the fluid and/or decreasing the amount or concentration thereof in said fluid with a view to preventing, eliminating or reducing undesired activation of components in said fluid is described, as well as a method for removing said substance(s) from the fluid and/or decreasing the amount or concentration thereof in said fluid, a method for the production of said matrix, use of said matrix and a kit comprising said matrix. The polymer affinity matrix comprises a solid support, a spacer and a ligand, containing arginine as a binding unit.
摘要翻译：用于结合流体中的一种或多种物质或从流体中除去所述物质和/或减少所述流体的量或浓度的聚合物亲和基质，以防止，消除或减少组分的不期望的活化在所述流体中描述，以及用于从流体中除去所述物质和/或减少所述流体的量或浓度的方法，用于生产所述基质的方法，所述基质的使用和试剂盒包括所述矩阵。聚合物亲和基质包含固体支持物，间隔基和配体，其含有精氨酸作为结合单元。

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