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    • 6. 发明授权
    • Method for producing 4-cyano-2-aminomethylthiazole
    • 4-氰基-2-氨基甲基噻唑的制备方法
    • US06639081B1
    • 2003-10-28
    • US10031703
    • 2002-04-30
    • Monika KnoppStefan KoserBernd Schaefer
    • Monika KnoppStefan KoserBernd Schaefer
    • C07D27704
    • C07D277/56
    • The invention relates to processes for preparing 2-aminomethyl-4-cyanothiazole and its salts of the formulae Ia and Ib in which n=1 or 2 and for n=1, X is chloride, bromide, triflate and hydrogen sulfate and for n=2, X is sulfate, which comprises the process step where the aminonitrile of the formula II is stirred with a cysteine ester of the formula III, in which R1 is branched or linear C1-10-alkyl or where n=0, 1 or 2 and R2 is branched or linear C1-C10C10-alkyl or C1-C4-alkoxy or C1-C4-dialkylamino in an inert solvent in the presence of a base at from 0° C. to 80° C. until the reaction has essentially proceeded to completion, and to the compounds of the formulae Ia and Ib.
    • 本发明涉及制备2-氨基甲基-4-氰基噻唑及其盐,其中n = 1或2,n = 1,X为氯化物,溴化物,三氟甲磺酸酯和硫酸氢盐,n = 2,X为 硫酸盐,其包括其中式II的氨基腈与式III的半胱氨酸酯一起搅拌的方法步骤,其中R 1是支链或直链的C 1-10 - 烷基或其中n = 0,1或2, 2>是在0℃至80℃的碱存在下,在惰性溶剂中的支链或直链C 1 -C 10 C 10 - 烷基或C 1 -C 4 - 烷氧基或C 1 -C 4 - 二烷基氨基,直到反应基本上进行 以及式Ia和Ib的化合物。