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1. 发明申请

US20060105030A1 Transdermal therapeutic system 审中-公开
公开(公告)号：US20060105030A1
公开(公告)日：2006-05-18
申请号：US11087754
申请日：2005-03-24
申请人： Fred Windt-Hanke , Clemens Gunther , Reinhard Horowski , Johannes Tack , Adalbert Engfer , Katalin Bostedt , Dirk Schenk
发明人： Fred Windt-Hanke , Clemens Gunther , Reinhard Horowski , Johannes Tack , Adalbert Engfer , Katalin Bostedt , Dirk Schenk
IPC分类号： A61K9/70
CPC分类号： A61K9/7061 , A61K9/7053 , A61K31/48
摘要： The invention concerns a transdermal therapeutic system containing ergoline derivatives, preferably lisuride, with a stabilized ergoline compound. Stabilization of the oxidation sensitive ergoline combination is done through a combination of at least one fat-soluble, radical-trapping antioxidant, preferably Di-tert.-butylmethylphenols, Di-tert.-butylmetoxyphenols, tocopherols or ubichinones and a basic polymer. Use of a transdermal therapeutic system (TTS) comprising a pharmaceutical layer containing at least one matrix having an active ingredient and/or an active ingredient reservoir; a diffusion barrier that is permeable to said active ingredient and arranged on the skin side of the active ingredient reservoir; and an ergoline derivative or salt thereof as an active ingredient for producing an agent for obtaining and maintaining the circadian rhythm under dopamine therapy. The invention relates to the use of a transdermal therapeutic system (TTS) comprising a medicinal layer, which contains at least one matrix comprising an active ingredient and/or an active ingredient reservoir and a diffusion barrier situated on the skin side of the active ingredient reservoir and permeable to active ingredients, in addition to, an ergoline-derivative or physiologically compatible salt with an acid thereof, as an active ingredient, for producing a means for treating the Restless Leg Syndrome and Periodic Limb Movement Disorder. The invention relates to the use of a dopamine agonist in the form of an agent consisting of at least two spatially discrete compositions, of which one is a transdermal therapeutic system (TTS) containing the dopaminergic agent and another one or more are preparations for oral and/or parenteral application containing that same dopaminergic agent for the treatment of dopaminergically treatable diseases with the following elements: a) the TTS is continuously applied, b) within the duration of application in a) the composition for oral or parenteral dosage is administered.

2. 发明申请

US20070243240A9 Transdermal therapeutic system 审中-公开
公开(公告)号：US20070243240A9
公开(公告)日：2007-10-18
申请号：US11087754
申请日：2005-03-24
申请人： Fred Windt-Hanke , Clemens Gunther , Reinhard Horowski , Johannes Tack , Adalbert Engfer , Katalin Bostedt , Dirk Schenk
发明人： Fred Windt-Hanke , Clemens Gunther , Reinhard Horowski , Johannes Tack , Adalbert Engfer , Katalin Bostedt , Dirk Schenk
IPC分类号： A61K9/70
CPC分类号： A61K9/7061 , A61K9/7053 , A61K31/48
摘要： The invention concerns a transdermal therapeutic system containing ergoline derivatives, preferably lisuride, with a stabilized ergoline compound. Stabilization of the oxidation sensitive ergoline combination is done through a combination of at least one fat-soluble, radical-trapping antioxidant, preferably Di-tert.-butylmethylphenols, Di-tert.-butylmetoxyphenols, tocopherols or ubichinones and a basic polymer. Use of a transdermal therapeutic system (TTS) comprising a pharmaceutical layer containing at least one matrix having an active ingredient and/or an active ingredient reservoir; a diffusion barrier that is permeable to said active ingredient and arranged on the skin side of the active ingredient reservoir; and an ergoline derivative or salt thereof as an active ingredient for producing an agent for obtaining and maintaining the circadian rhythm under dopamine therapy. The invention relates to the use of a transdermal therapeutic system (TTS) comprising a medicinal layer, which contains at least one matrix comprising an active ingredient and/or an active ingredient reservoir and a diffusion barrier situated on the skin side of the active ingredient reservoir and permeable to active ingredients, in addition to, an ergoline-derivative or physiologically compatible salt with an acid thereof, as an active ingredient, for producing a means for treating the Restless Leg Syndrome and Periodic Limb Movement Disorder. The invention relates to the use of a dopamine agonist in the form of an agent consisting of at least two spatially discrete compositions, of which one is a transdermal therapeutic system (TTS) containing the dopaminergic agent and another one or more are preparations for oral and/or parenteral application containing that same dopaminergic agent for the treatment of dopaminergically treatable diseases with the following elements: a) the TTS is continuously applied, b) within the duration of application in a) the composition for oral or parenteral dosage is administered.

3. 发明申请

US20050220855A1 Transdermal therapeutic system 审中-公开
公开(公告)号：US20050220855A1
公开(公告)日：2005-10-06
申请号：US11116279
申请日：2005-04-28
申请人： Reinhard Horowski , Johannes Tack , Fred Windt-Hanke , Clemens Gunther , Adalbert Engfer , Katalin Bostedt , Dirk Schenk
发明人： Reinhard Horowski , Johannes Tack , Fred Windt-Hanke , Clemens Gunther , Adalbert Engfer , Katalin Bostedt , Dirk Schenk
IPC分类号： C07D457/00 , A61K9/70 , A61K31/437 , A61K31/48 , A61K47/02 , A61K47/04 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/20 , A61K47/28 , A61K47/30 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61L15/58 , A61P5/08 , A61P5/24 , A61P13/02 , A61P13/10 , A61P15/00 , A61P15/08 , A61P15/14 , A61P25/02 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P43/00
CPC分类号： A61K9/7061 , A61K31/48
摘要： Use of a transdermal therapeutic system (TTS) comprising a pharmaceutical layer containing at least one matrix having an active ingredient and/or an active ingredient reservoir; a diffusion barrier that is permeable to said active ingredient and arranged on the skin side of the active ingredient reservoir; and an ergoline derivative or salt thereof as an active ingredient for producing an agent for obtaining and maintaining the circadian rhythm under dopamine therapy. The invention relates to the use of a transdermal therapeutic system (TTS) comprising a medicinal layer, which contains at least one matrix comprising an active ingredient and/or an active ingredient reservoir and a diffusion barrier situated on the skin side of the active ingredient reservoir and permeable to active ingredients, in addition to, an ergoline-derivative or physiologically compatible salt with an acid thereof, as an active ingredient, for producing a means for treating the restless-legs-syndrome. The invention relates to the use of a dopamine agonist in the form of an agent consisting of at least two spatially discrete compositions, of which one is a transdermal therapeutic system (TTS) containing the dopaminergic agent and another one or more are preparations for oral and/or parenteral application containing that same dopaminergic agent for the treatment of dopaminergically treatable diseases with the following elements: a) the TTS is continuously applied, b) within the duration of application in a) the composition for oral or parenteral dosage is administered. The invention concerns a transdermal therapeutic system containing ergoline derivatives, preferably lisuride, with a stabilized ergoline compound. Stabilization of the oxidation sensitive ergoline combination is done through a combination of at least one fat-soluble, radical-trapping antioxidant, preferably Di-tert.-butylmethylphenols, Di-tert.-butylmetoxyphenols, tocopherols or ubichinones and a basic polymer.

4. 发明申请

US20050214353A1 Transdermal therapeutic system 审中-公开
标题翻译：透皮治疗系统
公开(公告)号：US20050214353A1
公开(公告)日：2005-09-29
申请号：US11116278
申请日：2005-04-28
申请人： Reinhard Horowski , Johannes Tack , Fred Windt-Hanke , Clemens Gunther , Adalbert Engfer
发明人： Reinhard Horowski , Johannes Tack , Fred Windt-Hanke , Clemens Gunther , Adalbert Engfer
IPC分类号： C07D457/12 , A61K9/08 , A61K9/10 , A61K9/20 , A61K9/70 , A61K31/48 , A61K45/00 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/32 , A61K47/34 , A61K47/38 , A61P25/14 , A61P25/16
CPC分类号： A61K9/7061 , A61K31/48
摘要： Use of a transdermal therapeutic system (TTS) comprising a pharmaceutical layer containing at least one matrix having an active ingredient and/or an active ingredient reservoir; a diffusion barrier that is permeable to said active ingredient and arranged on the skin side of the active ingredient reservoir; and an ergoline derivative or salt thereof as an active ingredient for producing an agent for obtaining and maintaining the circadian rhythm under dopamine therapy. The invention relates to the use of a transdermal therapeutic system (TTS) comprising a medicinal layer, which contains at least one matrix comprising an active ingredient and/or an active ingredient reservoir and a diffusion barrier situated on the skin side of the active ingredient reservoir and permeable to active ingredients, in addition to, an ergoline-derivative or physiologically compatible salt with an acid thereof, as an active ingredient, for producing a means for treating the restless-legs-syndrome. The invention relates to the use of a dopamine agonist in the form of an agent consisting of at least two spatially discrete compositions, of which one is a transdermal therapeutic system (TTS) containing the dopaminergic agent and another one or more are preparations for oral and/or parenteral application containing that same dopaminergic agent for the treatment of dopaminergically treatable diseases with the following elements: a) the TTS is continuously applied, b) within the duration of application in a) the composition for oral or parenteral dosage is administered.
摘要翻译： 1.一种透皮治疗系统（TTS），其包含含有至少一种具有活性成分和/或活性成分储存器的基质的药物层; 扩散阻挡层，其对所述活性成分是可渗透的并且设置在活性成分贮存器的皮肤侧上; 麦角灵衍生物或其盐作为制备用于在多巴胺治疗下获得和维持昼夜节律的药剂的活性成分。本发明涉及包含药用层的透皮治疗系统（TTS）的用途，所述药物层包含至少一种包含活性成分和/或活性成分储存器的基质和位于活性成分储存器的皮肤侧的扩散阻挡层对于产生用于治疗不宁腿综合症的方法，除了作为活性成分的麦角灵衍生物或与其酸的生理上相容的盐之外，活性成分可以渗透。本发明涉及由至少两个空间上分散的组合物组成的药剂形式的多巴胺激动剂的用途，其中一种是含有多巴胺能药物的透皮治疗系统（TTS），另一种是另外一种或多种用于口服和 /或肠胃外应用，其含有用于治疗多巴胺可治疗疾病的相同多巴胺能药物，其具有以下元件：a）连续施用TTS，b）在施用期间内，a）施用用于口服或非肠道给药的组合物。

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