专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08435491B2 Quantification method for remaining liver function and novel liver receptor imaging agent 有权
标题翻译：剩余肝功能定量方法及新型肝脏受体显像剂
公开(公告)号：US08435491B2
公开(公告)日：2013-05-07
申请号：US12779374
申请日：2010-05-13
申请人： Mei-Hui Wang , Wuu-Jyh Lin , Chuan-Yi Chien , Hung-Man Yu , Reiko Takasaka Lee , Yuan-Chuan Lee
发明人： Mei-Hui Wang , Wuu-Jyh Lin , Chuan-Yi Chien , Hung-Man Yu , Reiko Takasaka Lee , Yuan-Chuan Lee
IPC分类号： A61K51/00 , A61K38/14 , A61M36/14 , C07K9/00
CPC分类号： C07H15/04 , A61K51/0491 , A61K51/0497
摘要： A test indicator for quantifying remaining liver function is provided. A novel liver receptor imaging agent with liver targeting property is utilized to develop a method for quantifying remaining liver function to serve as test indicator for judging the liver failure outcome in clinic, particularly for judging the necessity of liver transplantation for patients with liver failure or liver disease. The radioactivity uptake of the test indicator was negatively correlated with the extent of liver reserve. The cutoff value of liver reserve for liver transplantation is also disclosed.
摘要翻译：提供了用于量化剩余肝功能的测试指标。利用具有肝靶向特性的新型肝脏受体显像剂，开发了一种量化剩余肝功能的方法，作为判断临床肝功能衰竭结果的检测指标，特别是用于判断肝衰竭或肝脏肝移植的必要性疾病。测试指标的放射性摄取与肝脏储备的程度呈负相关。肝移植肝储备的临界值也被披露。

2. 发明授权

US08552163B2 Liver-targeting agents and their synthesis 有权
标题翻译：肝靶向剂及其合成
公开(公告)号：US08552163B2
公开(公告)日：2013-10-08
申请号：US12891004
申请日：2010-09-27
申请人： Reiko Takasaka Lee , Yuan-Chuan Lee , Mei-Hui Wang , Wuu-Jyh Lin
发明人： Reiko Takasaka Lee , Yuan-Chuan Lee , Mei-Hui Wang , Wuu-Jyh Lin
IPC分类号： C07H17/02 , C07C229/00
CPC分类号： C07H15/04
摘要： This invention provides novel liver targeting agents and their synthetic methods. A liver targeting agent, with a lysine based nitrilotriacetic acid structure as backbone which acquires multivalency with saccharide groups, to bind with a galactosamine chain or lactose chain is disclosed. In particular, only one amino acid L-lysine is involved to provide trivalency. All carboxyl groups in Nε-benzyloxycarbonyl-Nα-dicarboxymethyl-L-lysine can be conjugated with three glycosides of ahGalNAc or ahLac in one step. This invention also provides a hexa-lactoside. In particular, the TFA-AHA-Asp was used to conjugate 2 molecules of NTA(ahLac)3. This invention also provides a method for adding a spacer between NTA and DTPA. The extended hepatocyte-specific glyco-ligand has higher 111In-radiolabelling yield than those non-extended.
摘要翻译：本发明提供新型肝靶向剂及其合成方法。公开了以赖氨酸的次氮基三乙酸结构作为骨架的肝靶向剂，其以糖基取代多价，与半乳糖胺链或乳糖链结合。特别地，仅涉及一个氨基酸L-赖氨酸以提供三价值。 Nepsilon-苄氧基羰基-Nalpha-二羧甲基-L-赖氨酸中的所有羧基可以在一个步骤中与ahGalNAc或ahLac的三种糖苷缀合。本发明还提供了六乳糖苷。特别地，TFA-AHA-Asp用于结合2分子的NTA（ahLac）3。本发明还提供了一种在NTA和DTPA之间添加间隔物的方法。延长的肝细胞特异性糖配体比未延长的肝细胞特异性糖配体具有更高的111In-放射性标记产率。

3. 发明申请

US20110097265A1 QUANTIFICATION METHOD FOR REMAINING LIVER FUNCTION AND NOVEL LIVER RECEPTOR IMAGING AGENT 有权
标题翻译：肝功能和肝脏受体成像剂的定量方法
公开(公告)号：US20110097265A1
公开(公告)日：2011-04-28
申请号：US12779374
申请日：2010-05-13
申请人： Mei-Hui Wang , Wuu-Jyh Lin , Chuan-Yi Chien , Hung-Man Yu , Reiko Takasaka Lee , Yuan-Chuan Lee
发明人： Mei-Hui Wang , Wuu-Jyh Lin , Chuan-Yi Chien , Hung-Man Yu , Reiko Takasaka Lee , Yuan-Chuan Lee
IPC分类号： A61K49/14 , A61K49/10 , C07F5/00 , C07K9/00 , C07F13/00
CPC分类号： C07H15/04 , A61K51/0491 , A61K51/0497
摘要： A test indicator for quantifying remaining liver function is provided. A novel liver receptor imaging agent with liver targeting property is utilized to develop a method for quantifying remaining liver function to serve as test indicator for judging the liver failure outcome in clinic, particularly for judging the necessity of liver transplantation for patients with liver failure or liver disease. The radioactivity uptake of the test indicator was negatively correlated with the extent of liver reserve. The cutoff value of liver reserve for liver transplantation is also disclosed.
摘要翻译：提供了用于量化剩余肝功能的测试指标。利用具有肝靶向特性的新型肝脏受体显像剂，开发了一种量化剩余肝功能的方法，作为判断临床肝功能衰竭结果的检测指标，特别是用于判断肝衰竭或肝脏肝移植的必要性疾病。测试指标的放射性摄取与肝脏储备的程度呈负相关。肝移植肝储备的临界值也被公开。

4. 发明申请

US20110097264A1 RADIOLABELING METHOD USING MULTIVALENT GLYCOLIGANDS AS HEPATIC RECEPTOR IMAGING AGENT 审中-公开
标题翻译：使用多种甘氨酸作为胃肠吸收成像剂的放射性标记方法
公开(公告)号：US20110097264A1
公开(公告)日：2011-04-28
申请号：US12779328
申请日：2010-05-13
申请人： Mei-Hui Wang , Wuu-Jyh Lin , Chuan-Yi Chien , Hung-Man Yu , Reiko Takasaka Lee , Yuan-Chuan Lee
发明人： Mei-Hui Wang , Wuu-Jyh Lin , Chuan-Yi Chien , Hung-Man Yu , Reiko Takasaka Lee , Yuan-Chuan Lee
IPC分类号： A61K51/08 , C07K5/083 , C07F5/00 , A61K51/04
CPC分类号： A61K51/0491 , A61K51/0497 , C07F13/005 , C07K1/13
摘要： A radiolabeling method using a multivalent glycoligand as hepatic receptor imaging agent is provided. The multivalent glycoligand-DTPA derivatives (In-111-DTPA-hexa lactoside and In-111-DTPA-tri-galactosamine glycoside) labeled with In-111 are used as hepatic receptor imaging agent. The effects of imaging of a hepatic receptor in different species are evaluated, the lowest specific radioactivity values of hepatic receptor imaging required in different species are discovered. Since the specificity of the human ASGPR closely resembles that of the mouse. This kind of radiolabelling method, agent and related study about specific radioactivity could be used in clinical trial in the future.
摘要翻译：提供了一种使用多价糖配位体作为肝脏受体成像剂的放射性标记方法。用In-111标记的多价甘油配体-DTPA衍生物（In-111-DTPA-hexa lactoside和In-111-DTPA-tri-galactosamine glycoside）用作肝脏受体显像剂。对不同物种肝受体成像的影响进行了评估，发现了不同物种所需肝脏受体成像的最低比放射性值。由于人类ASGPR的特异性与小鼠的特异性非常相似。这种放射性标记方法，药剂和相关研究有关的放射性可以在今后的临床试验中使用。

5. 发明授权

US08142759B2 Glyco-molecular imaging method for grade classification of liver fibrosis and its glyco-molecular imaging agent thereof 有权
标题翻译：用于肝纤维化分级的糖分子成像方法及其糖分子成像剂
公开(公告)号：US08142759B2
公开(公告)日：2012-03-27
申请号：US11954221
申请日：2007-12-12
申请人： Mei-Hui Wang , Wuu-Jyh Lin , Shui-Cheng Lee , Lie-Hang Shen , Haw-Jan Chen
发明人： Mei-Hui Wang , Wuu-Jyh Lin , Shui-Cheng Lee , Lie-Hang Shen , Haw-Jan Chen
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K51/088 , A61K49/085 , A61K49/14
摘要： The invention discloses one glyco-molecular imaging method for grade classification of liver fibrosis and its glyco-molecular imaging agent. The agent combining with glyco-molecular imaging method for liver targeting could be used to differentiate the grade of liver fibrosis and follow-up evaluation of the therapeutic effect.
摘要翻译：本发明公开了一种用于肝纤维化等级分类的糖分子成像方法及其糖分子成像剂。结合糖分子成像方法进行肝脏靶向的药物可用于区分肝纤维化分级和治疗效果的随访评估。

6. 发明授权

US09040017B2 Liver-receptor imaging injection, dispensing method and pharmaceutical composition thereof 有权
标题翻译：肝 - 受体成像注射，分配方法及其药物组合物
公开(公告)号：US09040017B2
公开(公告)日：2015-05-26
申请号：US13243225
申请日：2011-09-23
申请人： Mei-Hui Wang , Wuu-Jyh Lin , Hung-Man Yu , Chuan-Yi Chien , Ping-Yen Wang
发明人： Mei-Hui Wang , Wuu-Jyh Lin , Hung-Man Yu , Chuan-Yi Chien , Ping-Yen Wang
IPC分类号： A61K51/04 , A61K51/06
CPC分类号： A61K51/0491 , A61K51/0406 , A61K51/0497 , A61K51/065
摘要： The present invention is related to a pharmaceutical composition for a liver-receptor imaging injection, the pharmaceutical composition including a bi-functional compound which has a ASGPR specificity, wherein the bi-functional compound includes a backbone of alpha-amino acid (or the derivatives thereof) and a poly-galactosamine chain (or a poly-lactose chain) connected to the alpha-amino acid. Thereby, the pharmaceutical composition can quantify potential of liver storage ability and evaluate severity of the course of liver disease. A liver-receptor imaging injection using the same and the one-step dispensing method thereof are also provided to improve defects of iodine-labeled and overcome disadvantages of the reduced labeling-yield and the instability after autoclave sterilization.
摘要翻译：本发明涉及一种肝 - 受体成像注射用药物组合物，该药物组合物包含具有ASGPR特异性的双功能化合物，其中双官能化合物包括α-氨基酸（或其衍生物）和与α-氨基酸连接的聚半乳糖胺链（或聚乳糖链）。因此，药物组合物可以量化肝脏储存能力的潜力并评估肝脏疾病过程的严重程度。还提供使用其的肝受体成像注射器及其一步式分配方法，以改善碘标记的缺陷，克服降压标记产率和高压灭菌后的不稳定性的缺点。

7. 发明授权

US09045513B2 Method for preparing precursor used for labeling hepatocyte receptor and containing trisaccharide and DTPA ligand 有权
标题翻译：制备用于标记肝细胞受体并含有三糖和DTPA配体的前体的方法
公开(公告)号：US09045513B2
公开(公告)日：2015-06-02
申请号：US13571731
申请日：2012-08-10
申请人： Chih-Yuan Lin , Yu Chang , Jen-Tsung Wang , Cheng-Fang Hsu , Wei-Ti Kuo , Hung-Wen Yu , Wuu-Jyh Lin , Mei-Hui Wang
发明人： Chih-Yuan Lin , Yu Chang , Jen-Tsung Wang , Cheng-Fang Hsu , Wei-Ti Kuo , Hung-Wen Yu , Wuu-Jyh Lin , Mei-Hui Wang
IPC分类号： C07H15/04 , C07H1/06 , C07K1/13
CPC分类号： C07H1/06 , C07H15/04 , C07K1/13
摘要： A method for preparing a precursor used to label hepatocyte receptors is revealed. The precursor contains a bifunctional structure including trisaccharide and DTPA ligand. During synthesis processes of the precursor, silica gel columns and Reverse phase-18 (RP-18) columns are used for purification. Thus both the purification times and cost of each purification are reduced. Moreover, use diethyl ether to facilitate precipitation of products and remove a part of coupling reagent. Removing the coupling reagent helps purification of products. Furthermore, Nα,Nα-bis(carboxymethyl)-L-lysine hydrate and benzyl chloroformate are coupled to form a trisaccharide skeleton so as to ensure the yield rate of trisaccharide structure.
摘要翻译：揭示了制备用于标记肝细胞受体的前体的方法。该前体含有包括三糖和DTPA配体的双功能结构。在前体的合成过程中，使用硅胶柱和反相18（RP-18）柱进行纯化。因此，每次纯化的纯化时间和成本均降低。此外，使用乙醚促进产物沉淀并除去一部分偶联剂。去除偶联剂有助于净化产品。此外，Nα，Nα-双（羧甲基）-L-赖氨酸水合物和氯甲酸苄酯偶联形成三糖骨架，以确保三糖结构的产率。

8. 发明授权

US07682163B2 Connector 有权
标题翻译：连接器
公开(公告)号：US07682163B2
公开(公告)日：2010-03-23
申请号：US12394936
申请日：2009-02-27
申请人： Pin-Yuan Hou , Mei-Hui Wang
发明人： Pin-Yuan Hou , Mei-Hui Wang
IPC分类号： H01R12/00
CPC分类号： H01R12/712 , H01R13/658
摘要： A connector has an insulative housing, a plurality of terminals and a metal shell. Each terminal has a soldering section. The soldering sections of a power terminal and a grounding terminal are the outermost terminals and are located outside remaining terminals instead of being located respectively between the soldering sections of signal transmitting or receiving terminals. The outermost soldering sections of the power and grounding terminals prevent the interference with the signal transmitting and receiving terminals during signal transmission.
摘要翻译：连接器具有绝缘壳体，多个端子和金属壳体。每个端子都有一个焊接部分。电源端子和接地端子的焊接部分是最外端子，位于剩余端子之外，而不是位于信号发送或接收端子的焊接部分之间。电源和接地端子的最外侧焊接部分在信号传输期间可防止信号发送和接收端子的干扰。

9. 发明申请

US20070174703A1 Method for enhancing debugger performance of hardware assisted breakpoints 失效
标题翻译：增强硬件辅助断点调试器性能的方法
公开(公告)号：US20070174703A1
公开(公告)日：2007-07-26
申请号：US11330452
申请日：2006-01-12
申请人： Daniel Gritter , Gerald Strait , Mei-Hui Wang , Joshua Wisniewski
发明人： Daniel Gritter , Gerald Strait , Mei-Hui Wang , Joshua Wisniewski
IPC分类号： G06F11/00
CPC分类号： G06F11/362
摘要： A method for enhancing debugger performance of hardware assisted breakpoints across multiple units includes deferring all active location breakpoints within the multiple modules, and subsequently activating each valid location breakpoint in a present one of the multiple modules being entered.
摘要翻译：用于增强跨多个单元的硬件辅助断点的调试器性能的方法包括延迟多个模块内的所有活动位置断点，并随后激活正在输入的多个模块中的当前一个中的每个有效位置断点。

10. 发明申请

US20090305532A1 CONNECTOR 有权
标题翻译：连接器
公开(公告)号：US20090305532A1
公开(公告)日：2009-12-10
申请号：US12394936
申请日：2009-02-27
申请人： Pin-Yuan HOU , Mei-Hui Wang
发明人： Pin-Yuan HOU , Mei-Hui Wang
IPC分类号： H01R12/14
CPC分类号： H01R12/712 , H01R13/658
摘要： A connector has an insulative housing, a plurality of terminals and a metal shell. Each terminal has a soldering section. The soldering sections of a power terminal and a grounding terminal are the outermost terminals and are located outside remaining terminals instead of being located respectively between the soldering sections of signal transmitting or receiving terminals. The outermost soldering sections of the power and grounding terminals prevent the interference with the signal transmitting and receiving terminals during signal transmission.
摘要翻译：连接器具有绝缘壳体，多个端子和金属壳体。每个端子都有一个焊接部分。电源端子和接地端子的焊接部分是最外端子，位于剩余端子之外，而不是位于信号发送或接收端子的焊接部分之间。电源和接地端子的最外侧焊接部分在信号传输期间可防止信号发送和接收端子的干扰。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式