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    • 3. 发明授权
    • Releasable coupling
    • 可释放耦合
    • US4708548A
    • 1987-11-24
    • US808387
    • 1985-12-16
    • Peter TaylorRoger B. Griffin
    • Peter TaylorRoger B. Griffin
    • B23B31/107F16D1/10B23B31/06B23B31/10
    • F16D1/10B23B31/1071Y10S279/905Y10T279/17803Y10T279/32Y10T279/3481Y10T409/30952
    • A releasable coupling especially for quick inter-changeable tool mounting purposes comprises a socket member, e.g. for mounting in a machine tool drive spindle and a spigot shown of taper form and received by a corresponding socket in the socket member. The socket member has a driving engagement with the spigot and a shank of the latter may consist of or carry any one of a variety of tooling. A collar movable between locking and release positions about the socket member has internal cam formation acting on retaining elements such as balls in bores through the socket member which balls engage an annular groove about the spigot to retain it in the socket. Release movement of the collar enables the balls to radially retract for withdrawal of the spigot. The collar is spring loaded towards the locking position and a spring loaded ball carried by the collar is arranged to engage a flange of the socket member to hold the collar in the release position which ball is disengaged by a flange of the spigot on full insertion of the latter into the socket in order to obtain automatic spring loaded turning of the collar to the locking position. The collar is retained in the locking position by spring loaded pawl and ratchet mechanism releasably by an externally operable plunger, i.e. when it is required to turn the collar to the release position.
    • 特别是用于快速互换工具安装目的的可释放联接件包括插座构件, 用于安装在机床驱动主轴和锥形形式的插口中,并由插座构件中的相应插座接收。 插座构件具有与插口的驱动接合,并且插座构件的柄可以由各种工具组成或承载任何一种工具。 在围绕插座构件的锁定和释放位置之间可移动的套环具有通过插座构件作用在诸如孔中的球的保持元件上的内部凸轮形成,所述球接合围绕插口的环形槽以将其保持在插座中。 套环的释放运动使得球可以径向缩回,以便抽出套管。 轴环朝向锁定位置弹簧加载,并且由轴环承载的弹簧加载的球被布置成接合插座构件的凸缘以将套环保持在释放位置,该球在完全插入时由插口的凸缘脱离 后者进入插座,以获得套环自动弹簧加载到锁定位置。 套环通过弹簧加载的棘爪和棘轮机构由外部可操作的柱塞可释放地保持在锁定位置,即当需要将套环转动到释放位置时。
    • 8. 发明申请
    • Safe locking mechanism
    • 安全锁定机构
    • US20090056599A1
    • 2009-03-05
    • US12229266
    • 2008-08-20
    • Robert TurnerPeter Taylor
    • Robert TurnerPeter Taylor
    • E05G1/06
    • E05G1/04E05B63/143E05B65/0075
    • A secure safe for dealing with large volumes of cash at point of sale and storing in a safe box, the safe including: a slidably mounted front access door; a note validator mounted in the door; a dual-level access means for securing the door at two different positions, wherein the dual-level access means includes a first locking stage that enables a retail operator to move the door to a first position where access to a note-receiving means in communication with the note validator is exposed; a second locking stage enabling a cash removal operator to move the door to a second position to expose the contents of the safe box; and the note validator being in communication with the safe box for storing validated notes in the safe box.
    • 一个安全的保险箱,用于在销售点处理大量现金并存放在保险柜内,该保险箱包括:可滑动安装的前门; 安装在门上的笔记验证器; 用于将门固定在两个不同位置的双级存取装置,其中所述双级存取装置包括第一锁定级,其使得零售操作者能够将所述门移动到第一位置,在所述第一位置,访问通信中的纸币接收装置 笔记验证器被暴露; 第二锁定台,使得现金清除操作者将门移动到第二位置以露出保险箱的内容物; 并且钞票验证器正在与保险柜中保存有效的笔记的保险箱通信。
    • 9. 发明申请
    • Compounds for use in the treatment of infection
    • 用于治疗感染的化合物
    • US20070021384A1
    • 2007-01-25
    • US11455889
    • 2006-06-20
    • James AndersonCatherine HeadleyPaul StapletonPeter Taylor
    • James AndersonCatherine HeadleyPaul StapletonPeter Taylor
    • A61K31/695A61K31/353C07F7/02
    • C07D311/62C07D311/60
    • There is provided a novel compound of the general formula I in which each of R8 to R10 is hydrogen, aryl, C1-6 alkyl, trialkylsilyl or acyl; R1 to R5 are individually selected from hydrogen, hydroxy, C1-6 alkoxy and acyloxy; R6 and R7 are H, C1-4 alkyl, trialkylsilyl or acyl; X is O or NR, and R is H or Me; in which any of the alkyl groups including alkyl groups in alkoxy, acyl and acyloxy groups may be substituted by aryl, C1-4 alkyl, C1-4 alkoxy, hydroxyl, trialkylsiloxy or acyloxy groups; with the proviso that R2 and R3 are not both OH when R4 is H or OH, R1 and R5 are both H, and X is O. The amide compounds (X is NR) are analogues of epigallocatechin gallate or epicatechin galate, with an amide bond in place of the natural ester bond, with resistance to hydrolysis by esterase enzymes. The ester compounds (X is O) have a different hydroxylation pattern on the B ring as compared to the natural products. The compounds may be used to modulate the resistance to β-lactam antibiotics of various infections, especially methicillin resistant Staphylococcus aureus (MRSA). Pharmaceutical compositions containing the novel compounds and combinations of the novel compounds and β-lactam antibiotics are described.
    • 提供了通式I的新化合物,其中R 8和R 10各自为氢,芳基,C 1-6烷基, 烷基,三烷基甲硅烷基或酰基; R 1至R 5各自独立地选自氢,羟基,C 1-6烷氧基和酰氧基; R 6和R 7是H,C 1-4烷基,三烷基甲硅烷基或酰基; X是O或NR,R是H或Me; 其中包括烷氧基,酰基和酰氧基中的烷基的任何烷基可以被芳基,C 1-4烷基,C 1-4烷氧基,羟基 三烷基甲硅烷氧基或酰氧基; 条件是当R 4为H或OH时,R 2和R 3不同时为OH,R 1为H >和R 5都是H,X是O.酰胺化合物(X是NR)是表没食子儿茶素没食子酸酯或表儿茶素加成酸酯的类似物,酰胺键代替天然酯键,与 耐酯酶水解。 与天然产物相比,酯化合物(X为O)在B环上具有不同的羟基化模式。 该化合物可用于调节对各种感染的β-内酰胺抗生素的抗性,特别是耐甲氧西林金黄色葡萄球菌(MRSA)。 描述了含有新化合物和新化合物和β-内酰胺抗生素的组合的药物组合物。