专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070021384A1 Compounds for use in the treatment of infection 失效
标题翻译：用于治疗感染的化合物
公开(公告)号：US20070021384A1
公开(公告)日：2007-01-25
申请号：US11455889
申请日：2006-06-20
申请人： James Anderson , Catherine Headley , Paul Stapleton , Peter Taylor
发明人： James Anderson , Catherine Headley , Paul Stapleton , Peter Taylor
IPC分类号： A61K31/695 , A61K31/353 , C07F7/02
CPC分类号： C07D311/62 , C07D311/60
摘要： There is provided a novel compound of the general formula I in which each of R8 to R10 is hydrogen, aryl, C1-6 alkyl, trialkylsilyl or acyl; R1 to R5 are individually selected from hydrogen, hydroxy, C1-6 alkoxy and acyloxy; R6 and R7 are H, C1-4 alkyl, trialkylsilyl or acyl; X is O or NR, and R is H or Me; in which any of the alkyl groups including alkyl groups in alkoxy, acyl and acyloxy groups may be substituted by aryl, C1-4 alkyl, C1-4 alkoxy, hydroxyl, trialkylsiloxy or acyloxy groups; with the proviso that R2 and R3 are not both OH when R4 is H or OH, R1 and R5 are both H, and X is O. The amide compounds (X is NR) are analogues of epigallocatechin gallate or epicatechin galate, with an amide bond in place of the natural ester bond, with resistance to hydrolysis by esterase enzymes. The ester compounds (X is O) have a different hydroxylation pattern on the B ring as compared to the natural products. The compounds may be used to modulate the resistance to β-lactam antibiotics of various infections, especially methicillin resistant Staphylococcus aureus (MRSA). Pharmaceutical compositions containing the novel compounds and combinations of the novel compounds and β-lactam antibiotics are described.
摘要翻译：提供了通式I的新化合物，其中R 8和R 10各自为氢，芳基，C 1-6烷基，烷基，三烷基甲硅烷基或酰基; R 1至R 5各自独立地选自氢，羟基，C 1-6烷氧基和酰氧基; R 6和R 7是H，C 1-4烷基，三烷基甲硅烷基或酰基; X是O或NR，R是H或Me; 其中包括烷氧基，酰基和酰氧基中的烷基的任何烷基可以被芳基，C 1-4烷基，C 1-4烷氧基，羟基三烷基甲硅烷氧基或酰氧基; 条件是当R 4为H或OH时，R 2和R 3不同时为OH，R 1为H >和R 5都是H，X是O.酰胺化合物（X是NR）是表没食子儿茶素没食子酸酯或表儿茶素加成酸酯的类似物，酰胺键代替天然酯键，与耐酯酶水解。与天然产物相比，酯化合物（X为O）在B环上具有不同的羟基化模式。该化合物可用于调节对各种感染的β-内酰胺抗生素的抗性，特别是耐甲氧西林金黄色葡萄球菌（MRSA）。描述了含有新化合物和新化合物和β-内酰胺抗生素的组合的药物组合物。

2. 发明授权

US08338476B2 Compositions and methods of sensitizing methicillin resistant Staphylococcus aureus to beta-lactam antibiotics 有权
标题翻译：使耐甲氧西林金黄色葡萄球菌对β-内酰胺抗生素敏感的组合物和方法
公开(公告)号：US08338476B2
公开(公告)日：2012-12-25
申请号：US12095960
申请日：2005-12-29
申请人： Paul Stapleton , Yukihiko Hara , Peter Taylor
发明人： Paul Stapleton , Yukihiko Hara , Peter Taylor
IPC分类号： A61K31/352 , A61K31/397 , A01N43/16 , A01N43/44 , A01N43/90
CPC分类号： A61K31/353 , A61K31/05 , A61K45/06 , A61K2300/00
摘要： Contemplated methods and compositions further increase susceptibility of sensitized MRSA against various antibiotic drugs. Most preferably, the MRSA is already sensitized with a galloylated catechin (e.g., ECG), and further sensitization is achieved by exposure to a non-galloylated catechin (e.g., EC), and most preferably the corresponding non-galloylated catechin.
摘要翻译：考虑的方法和组合物进一步增加致敏MRSA对各种抗生素药物的敏感性。最优选地，MRSA已经被乳糖化儿茶素（例如ECG）敏化，并且通过暴露于非半乳糖化儿茶素（例如EC），最优选相应的非乙酰化儿茶素来实现进一步的敏化。

3. 发明申请

US20100035979A1 Compositions and Methods of Sensitizing Methicillin Resistant Staphylococcus Aureus to Oxacillin 有权
标题翻译：将耐甲氧西林金黄色葡萄球菌对奥西西林敏化的组合物和方法
公开(公告)号：US20100035979A1
公开(公告)日：2010-02-11
申请号：US12095960
申请日：2005-12-29
申请人： Paul Stapleton , Yukihiko Hara , Peter Taylor
发明人： Paul Stapleton , Yukihiko Hara , Peter Taylor
IPC分类号： A61K31/352 , C12N1/20
CPC分类号： A61K31/353 , A61K31/05 , A61K45/06 , A61K2300/00
摘要： Contemplated methods and compositions further increase susceptibility of sensitized MRSA against various antibiotic drugs. Most preferably, the MRSA is already sensitized with a galloylated catechin (e.g., ECG), and further sensitization is achieved by exposure to a non-galloylated catechin (e.g., EC), and most preferably the corresponding non-galloylated catechin.
摘要翻译：考虑的方法和组合物进一步增加致敏MRSA对各种抗生素药物的敏感性。最优选地，MRSA已经被乳糖化儿茶素（例如ECG）敏化，并且通过暴露于非半乳糖化儿茶素（例如EC），最优选相应的非乙酰化儿茶素来实现进一步的敏化。

4. 发明申请

US20070082944A1 Antimicrobial compositions and methods of use 审中-公开
标题翻译：抗微生物组合物和使用方法
公开(公告)号：US20070082944A1
公开(公告)日：2007-04-12
申请号：US10569526
申请日：2003-09-12
申请人： Paul Stapleton , Shinich Uesato , Peter Taylor , Yukihiko Hara
发明人： Paul Stapleton , Shinich Uesato , Peter Taylor , Yukihiko Hara
IPC分类号： A61K31/353 , G06Q50/00
CPC分类号： A61K31/353 , G06Q50/22
摘要： A catechin is modified in at least one position (most preferably in the 3-position of the C-ring) to increase its lipophilicity. Contemplated catechins are demonstrated to have significantly improved antibacterial properties, likely due to catastrophic membrane damage.
摘要翻译：儿茶素在至少一个位置（最优选在C环的3-位）被修饰以增加其亲油性。被证明的儿茶素具有显着改善的抗菌性能，可能是由于灾难性的膜损伤。

5. 发明申请

US20070185073A1 Pyrrolobenzodiazepines 有权
标题翻译：吡咯并苯并二氮杂卓
公开(公告)号：US20070185073A1
公开(公告)日：2007-08-09
申请号：US10598691
申请日：2005-03-09
申请人： Philip Howard , Stephen Gregson , Peter Taylor , David Thurston , Tsveta Hadjivassileva
发明人： Philip Howard , Stephen Gregson , Peter Taylor , David Thurston , Tsveta Hadjivassileva
IPC分类号： A61K31/395
CPC分类号： C07D519/00 , Y02P20/55
摘要： A compound of formula (I) and salts and solvates thereof, wherein: R10 is a nitrogen protecting group and R11 is either OH or O—R12, wherein R12 is an oxygen protecting group, or R10 and R11 together form a double bond between N10 and C11; and R10′ and R11′ are selected from the same options as R10 and R11 respectively.
摘要翻译：式（I）化合物及其盐和溶剂合物，其中：R 10是氮保护基，R 11是OH或OR 12， SUP>，其中R 12为氧保护基，或R 10和R 11一起形成N 10和C 11之间的双键; 和R 10'和R 11'分别选自与R 10和R 11相同的选项。

6. 发明授权

US4708548A Releasable coupling 失效
标题翻译：可释放耦合
公开(公告)号：US4708548A
公开(公告)日：1987-11-24
申请号：US808387
申请日：1985-12-16
申请人： Peter Taylor , Roger B. Griffin
发明人： Peter Taylor , Roger B. Griffin
IPC分类号： B23B31/107 , F16D1/10 , B23B31/06 , B23B31/10
CPC分类号： F16D1/10 , B23B31/1071 , Y10S279/905 , Y10T279/17803 , Y10T279/32 , Y10T279/3481 , Y10T409/30952
摘要： A releasable coupling especially for quick inter-changeable tool mounting purposes comprises a socket member, e.g. for mounting in a machine tool drive spindle and a spigot shown of taper form and received by a corresponding socket in the socket member. The socket member has a driving engagement with the spigot and a shank of the latter may consist of or carry any one of a variety of tooling. A collar movable between locking and release positions about the socket member has internal cam formation acting on retaining elements such as balls in bores through the socket member which balls engage an annular groove about the spigot to retain it in the socket. Release movement of the collar enables the balls to radially retract for withdrawal of the spigot. The collar is spring loaded towards the locking position and a spring loaded ball carried by the collar is arranged to engage a flange of the socket member to hold the collar in the release position which ball is disengaged by a flange of the spigot on full insertion of the latter into the socket in order to obtain automatic spring loaded turning of the collar to the locking position. The collar is retained in the locking position by spring loaded pawl and ratchet mechanism releasably by an externally operable plunger, i.e. when it is required to turn the collar to the release position.
摘要翻译：特别是用于快速互换工具安装目的的可释放联接件包括插座构件，用于安装在机床驱动主轴和锥形形式的插口中，并由插座构件中的相应插座接收。插座构件具有与插口的驱动接合，并且插座构件的柄可以由各种工具组成或承载任何一种工具。在围绕插座构件的锁定和释放位置之间可移动的套环具有通过插座构件作用在诸如孔中的球的保持元件上的内部凸轮形成，所述球接合围绕插口的环形槽以将其保持在插座中。套环的释放运动使得球可以径向缩回，以便抽出套管。轴环朝向锁定位置弹簧加载，并且由轴环承载的弹簧加载的球被布置成接合插座构件的凸缘以将套环保持在释放位置，该球在完全插入时由插口的凸缘脱离后者进入插座，以获得套环自动弹簧加载到锁定位置。套环通过弹簧加载的棘爪和棘轮机构由外部可操作的柱塞可释放地保持在锁定位置，即当需要将套环转动到释放位置时。

7. 发明授权

US4505924A Pharmaceutical preparation for the topical treatment of acne 失效
标题翻译：用于局部治疗痤疮的药物制剂
公开(公告)号：US4505924A
公开(公告)日：1985-03-19
申请号：US482420
申请日：1983-04-06
申请人： Peter Taylor , Alan A. Levy
发明人： Peter Taylor , Alan A. Levy
IPC分类号： A61K8/40 , A61K8/49 , A61K9/06 , A61K31/255 , A61K31/415 , A61P17/00 , A61Q19/00
CPC分类号： A61K8/4946 , A61K31/415 , A61K8/40 , A61Q19/00 , Y10S514/859
摘要： A pharmaceutical preparation for the topical treatment of acne is disclosed comprising a combination of Imazilil and Hexamidine as essential active substances. This combination shows antimicrobial activity higher than that of the individual substances.
摘要翻译：公开了用于局部治疗痤疮的药物制剂，其包含Imazilil和Hexamidine作为必需活性物质的组合。该组合显示出比单独物质高的抗微生物活性。

8. 发明授权

US09919844B2 Sealable bag 有权
公开(公告)号：US09919844B2
公开(公告)日：2018-03-20
申请号：US15300840
申请日：2015-04-02
申请人： Peter Taylor
发明人： Peter Taylor
IPC分类号： B65D33/16 , B65D33/18 , B65D33/14
CPC分类号： B65D33/18 , B65D33/14
摘要： A bag has a tubular edge portion defining an open end, the edge portion being defined by two elongate parts. Adhesive is disposed upon one of the parts and is adapted to grip the other of the parts. A strip extends from the open end to a terminus disposed interiorly of the bag, is adhesively secured to the one part in overlying relation to the adhesive and has apertures thereby defining areas of exposed adhesive. A lip has a release portion that extends from the terminus and is frangibly connected thereto, the release portion being disposed in overlying relation to the strip, to isolate the other of the parts from the areas of exposed adhesive and has an adhesive resistant surface to permit the lip to be detached via the frangible connection, thereby to permit closure by adhesion of said other of the parts to the areas of exposed adhesive.

9. 发明申请

US20090056599A1 Safe locking mechanism 审中-公开
标题翻译：安全锁定机构
公开(公告)号：US20090056599A1
公开(公告)日：2009-03-05
申请号：US12229266
申请日：2008-08-20
申请人： Robert Turner , Peter Taylor
发明人： Robert Turner , Peter Taylor
IPC分类号： E05G1/06
CPC分类号： E05G1/04 , E05B63/143 , E05B65/0075
摘要： A secure safe for dealing with large volumes of cash at point of sale and storing in a safe box, the safe including: a slidably mounted front access door; a note validator mounted in the door; a dual-level access means for securing the door at two different positions, wherein the dual-level access means includes a first locking stage that enables a retail operator to move the door to a first position where access to a note-receiving means in communication with the note validator is exposed; a second locking stage enabling a cash removal operator to move the door to a second position to expose the contents of the safe box; and the note validator being in communication with the safe box for storing validated notes in the safe box.
摘要翻译：一个安全的保险箱，用于在销售点处理大量现金并存放在保险柜内，该保险箱包括：可滑动安装的前门; 安装在门上的笔记验证器; 用于将门固定在两个不同位置的双级存取装置，其中所述双级存取装置包括第一锁定级，其使得零售操作者能够将所述门移动到第一位置，在所述第一位置，访问通信中的纸币接收装置笔记验证器被暴露; 第二锁定台，使得现金清除操作者将门移动到第二位置以露出保险箱的内容物; 并且钞票验证器正在与保险柜中保存有效的笔记的保险箱通信。

10. 发明授权

US06730340B1 Edible casing film formulation 有权
标题翻译：食用套管膜配方
公开(公告)号：US06730340B1
公开(公告)日：2004-05-04
申请号：US09926461
申请日：2001-11-07
申请人： Reg Macquarrie , Kurt Schupp , Peter Taylor
发明人： Reg Macquarrie , Kurt Schupp , Peter Taylor
IPC分类号： C08L500
CPC分类号： A22C13/0013
摘要： Edible films incorporating carrageenan in conjunction with Konjac and/or Gellan gums have been prepared as substitutes for edible collagen film currently used in meat processing. Compositions according to the present invention overcome the inherent thermoreversibility of carrageenan gel and do not disintegrate from exposure to hot or boiling water. The film can readily be processed to form casing, bags or other packaging useful in the food industry.
摘要翻译：已经制备了将角叉菜胶与魔芋和/或结冷胶相结合的食用薄膜作为肉类加工中目前使用的可食用胶原薄膜的替代品。根据本发明的组合物克服了角叉菜胶凝胶的固有热可逆性，并且不会从暴露于热或沸水中分解。该膜可以容易地被加工以形成用于食品工业的套管，袋或其他包装。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式