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1. 发明授权

US08008502B2 Thiazoline acid derivatives 有权
标题翻译：噻唑啉酸衍生物
公开(公告)号：US08008502B2
公开(公告)日：2011-08-30
申请号：US12383854
申请日：2009-03-27
申请人： Raymond J. Bergeron
发明人： Raymond J. Bergeron
IPC分类号： C07D277/08
CPC分类号： A61K31/426 , C07D277/12
摘要： The present invention relates to novel thiazoline acids and derivatives thereof useful as chelators of trivalent metals in therapeutic applications. For example, the thiazoline acid derivatives are useful in diagnosing and treating pathological conditions associated with an excess of trivalent metals in humans and animals.
摘要翻译：本发明涉及在治疗应用中用作三价金属螯合剂的新型噻唑啉酸及其衍生物。例如，噻唑啉酸衍生物可用于诊断和治疗与人和动物中过量的三价金属相关的病理状况。

2. 发明授权

US07531563B2 Thiazoline acid derivatives 有权
标题翻译：噻唑啉酸衍生物
公开(公告)号：US07531563B2
公开(公告)日：2009-05-12
申请号：US11522299
申请日：2006-09-15
申请人： Raymond J. Bergeron
发明人： Raymond J. Bergeron
IPC分类号： A61K31/426 , C07D277/08
CPC分类号： A61K31/426 , C07D277/12
摘要： The present invention relates to novel thiazoline acids and derivatives thereof useful as chelators of trivalent metals in therapeutic applications. For example, the thiazoline acid derivatives are useful in diagnosing and treating pathological conditions associated with an excess of trivalent metals in humans and animals.
摘要翻译：本发明涉及在治疗应用中用作三价金属螯合剂的新型噻唑啉酸及其衍生物。例如，噻唑啉酸衍生物可用于诊断和治疗与人和动物中过量的三价金属相关的病理状况。

3. 发明授权

US5827894A Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives 失效
标题翻译：抗肿瘤，抗病毒或抗逆转录病毒精胺衍生物
公开(公告)号：US5827894A
公开(公告)日：1998-10-27
申请号：US714296
申请日：1996-09-18
申请人： Raymond J. Bergeron
发明人： Raymond J. Bergeron
IPC分类号： A01N33/04 , A01N43/54 , A61K31/13 , A61K31/131 , A61K31/135 , A61K31/505 , A61K31/506 , A61K31/785 , C07C209/08 , C07C209/62 , C07C211/14 , C07D239/04
CPC分类号： C07D239/04 , A01N33/04 , A01N43/54 , A61K31/13 , A61K31/131 , A61K31/135 , A61K31/505 , A61K31/506 , A61K31/785 , C07C209/08 , C07C209/62 , C07C211/14
摘要： An anti-viral, anti-psoriasis or anti-retroviral therapy based on the administration of a compound having one of the formulae: ##STR1## wherein: R.sub.1 and R.sub.6 may be the same or different and are alkyl having from 1 to 12 carbon atoms or hydrocarbyl aralkyl having up to 12 carbon atoms; R.sub.2 -R.sub.5 may be the same or different and are H, R.sub.1 or R.sub.6 ; m is an integer from 3 to 6, inclusive; n is an integer from 3 to 6, inclusive; or (III) a salt thereof with a pharmaceutically acceptable acid.
摘要翻译：（I）R1N1H（CH2）3N2H（CH2）3N3H（Ⅱ）+ TR（CH2）4N4H（Ⅱ）的化合物的抗病毒，抗牛皮癣或抗逆转录病毒疗法（CH 2）3 N 5 H（CH 2）3 N 6 HR 6其中：R 1和R 6可以相同或不同，为具有1至12个碳原子的烷基或具有至多12个碳原子的烃基芳烷基; R2-R5可以相同或不同，为H，R1或R6; m为3〜6的整数，包括3〜6; n为3〜6的整数，包括3〜6的整数。或（III）其与药学上可接受的酸的盐。

4. 发明授权

US5519041A Anti-neoplastic, anti-viral and ribonucleotide reductase activity affecting pharmaceutical compositions and methods of treatment 失效
公开(公告)号：US5519041A
公开(公告)日：1996-05-21
申请号：US477551
申请日：1995-06-07
申请人： Raymond J. Bergeron
发明人： Raymond J. Bergeron
IPC分类号： A61K31/165 , A61K31/42 , A61K31/40 , A01N43/36 , A01N43/38 , A01N43/76
CPC分类号： A61K31/42 , A61K31/165
摘要： A method for treating a human or non-human animal afflicted with malignant cells sensitive to parabactin or a pharmaceutically acceptable salt or complex thereof comprising administering to the animal an amount of parabactin effective to inhibit the proliferation of the malignant cells.

5. 发明授权

US06362232B1 Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives 失效
公开(公告)号：US06362232B1
公开(公告)日：2002-03-26
申请号：US09645510
申请日：2000-08-25
申请人： Raymond J. Bergeron
发明人： Raymond J. Bergeron
IPC分类号： A61K3113
CPC分类号： C07D239/04 , A01N33/04 , A01N43/54 , A61K31/13 , A61K31/131 , A61K31/135 , A61K31/505 , A61K31/506 , A61K31/785 , C07C209/08 , C07C209/62 , C07C211/14
摘要： The present invention relates to anti-neoplastic and anti-psoriasis pharmaceutical compositions and methods of treatment and to insecticidal compositions and methods of controlling the growth of insects.

6. 发明授权

US06147262A Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives 失效
标题翻译：抗肿瘤，抗病毒或抗逆转录病毒精胺衍生物
公开(公告)号：US06147262A
公开(公告)日：2000-11-14
申请号：US986576
申请日：1992-12-07
申请人： Raymond J. Bergeron
发明人： Raymond J. Bergeron
IPC分类号： A01N33/04 , A01N43/54 , A61K31/13 , A61K31/131 , A61K31/135 , A61K31/505 , A61K31/506 , A61K31/785 , C07C209/08 , C07C209/62 , C07C211/14 , C07D239/04 , C07C211/13 , C07C211/43
CPC分类号： C07D239/04 , A01N33/04 , A01N43/54 , A61K31/13 , A61K31/131 , A61K31/135 , A61K31/505 , A61K31/506 , A61K31/785 , C07C209/08 , C07C209/62 , C07C211/14
摘要： A compound having the formula: ##STR1## wherein: R.sub.1 -R.sub.6 may be the same or different and are H, alkyl or aralkyl having from1 to 12 carbon atoms;m is an integer from 3 to 6, inclusive;n is an integer from 3 to 6, inclusive;excluding those compounds of formula (I) wherein all of R.sub.1 -R.sub.6 are H and further excluding those compounds of formula (I) wherein:1) m is 3, n is 4, R.sub.1, R.sub.2, R.sub.5 and R.sub.6 are all H, and R.sub.3 and R.sub.4 are methyl;2) m is 3, n is 4, R.sub.1 and R.sub.6 are methyl or ethyl, and R.sub.2 -R.sub.5 are all H;3) m is 3, n is 4, and R.sub.1 -R.sub.6 are all methyl, ethyl or propyl;4) m and n are 3, R.sub.1, R.sub.2, R.sub.5 and R.sub.6 are all H, and R.sub.3 and R.sub.4 are methyl;5) m and n are 3 and R.sub.1 -R.sub.6 are all methyl;6) m and n are 3, R.sub.1 and R.sub.6 are H, and R.sub.2 -R.sub.5 are all methyl;7) m and n are 3, R.sub.1 and R.sub.6 are methyl, and R.sub.2 -R.sub.5 are all H;8) m and n are 3, R.sub.1 and are R.sub.6 are hydrogen, R.sub.2 and R.sub.5 are each ethyl and R.sub.3 and R.sub.4 are methyl; and9) m and n are 4, and R.sub.1 -R.sub.6 are all methyl;or (II) a salt thereof with a pharmaceutically acceptable acid.
摘要翻译：具有下式的化合物：其中：R 1 -R 6可以相同或不同，为H，具有1至12个碳原子的烷基或芳烷基; m为3〜6的整数，包括3〜6; n为3〜6的整数，包括3〜6的整数。不包括那些其中所有的R 1 -R 6是H并且进一步排除那些其中：1）m为3，n为4，R1，R2，R5和R6全部为H的式（Ⅰ）化合物的式（Ⅰ）化合物，和 R3和R4是甲基; 2）m为3，n为4，R 1和R 6为甲基或乙基，R 2 -R 5均为H; 3）m为3，n为4，R1-R6全部为甲基，乙基或丙基; 4）m和n是3，R1，R2，R5和R6都是H，R3和R4是甲基; 5）m和n是3，R1-R6全部是甲基; 6）m和n是3，R1和R6是H，R2-R5全部是甲基; 7）m和n是3，R1和R6是甲基，R2-R5全部是H; 8）m和n是3，R1和R6是氢，R2和R5各自是乙基，R3和R4是甲基; 和9）m和n是4，并且R 1 -R 6都是甲基; 或（II）其盐与药学上可接受的酸。

7. 发明授权

US5679682A Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives 失效
标题翻译：抗肿瘤，抗病毒或抗逆转录病毒精胺衍生物
公开(公告)号：US5679682A
公开(公告)日：1997-10-21
申请号：US714284
申请日：1996-09-18
申请人： Raymond J. Bergeron
发明人： Raymond J. Bergeron
IPC分类号： A01N33/04 , A01N43/54 , A61K31/13 , A61K31/131 , A61K31/135 , A61K31/505 , A61K31/506 , A61K31/785 , C07C209/08 , C07C209/62 , C07C211/14 , C07D239/04
CPC分类号： C07D239/04 , A01N33/04 , A01N43/54 , A61K31/13 , A61K31/131 , A61K31/135 , A61K31/505 , A61K31/506 , A61K31/785 , C07C209/08 , C07C209/62 , C07C211/14
摘要： A method of controlling the growth of mosquitos comprising administering to the mosquitos a mosquito insecticidal effective amount of a compound having one of the formulae: ##STR1## R.sub.1 --N.sup.1 H--(CH.sub.2).sub.3 --N.sup.2 H--(CH.sub.2).sub.3 --N.sup.3 H--(CH.sub.2).sub.4 --N.sup.4 H--(CH.sub.2).sub.3 --N.sup.5 H--(CH.sub.2).sub.3 --N.sup.6 H--R.sub.6 (II); or ##STR2## wherein: R.sub.1 and R.sub.6 may be the same or different and are alkyl having from 1 to 12 carbon atoms or hydrocarbyl aralkyl having up to 12 carbon atoms; R.sub.2 -R.sub.5 may be the same or different and are H, R.sub.1 or R.sub.6 ; R.sub.7 is H, alkyl having from 1 to 12 carbon atoms, hydrocarbyl aryl or hydrocarbyl aralkyl, each having up to 12 carbon atoms; m is an integer from 3 to 6, inclusive; n is an integer from 3 to 6, inclusive; or (IV) a salt thereof with an acid and a carrier therefor.
摘要翻译：一种控制蚊子生长的方法，包括向蚊子施用杀虫杀虫有效量的具有以下结构式之一的化合物：其中R 1 -R 1 -NH-（CH 2）3 -NH-（CH 2）3 -N 3 H - （CH 2）4 -N 4 -H（CH 2）3 -N 5 - （CH 2）3 -N 6 H-R 6（II）; 或其中：R 1和R 6可以相同或不同，为具有1至12个碳原子的烷基或具有至多12个碳原子的烃基芳烷基; R2-R5可以相同或不同，为H，R1或R6; R 7为H，具有1至12个碳原子的烷基，烃基芳基或烃基芳烷基，各自具有至多12个碳原子; m为3〜6的整数，包括3〜6; n为3〜6的整数，包括3〜6的整数。或（Ⅳ）其酸与酸及其载体。

8. 发明授权

US5550144A Anti-neoplastic, anti-viral and ribonucleotide reductase activity affecting pharmaceutical compositions and methods of treatment 失效
公开(公告)号：US5550144A
公开(公告)日：1996-08-27
申请号：US477550
申请日：1995-06-07
申请人： Raymond J. Bergeron
发明人： Raymond J. Bergeron
IPC分类号： A61K31/165 , A61K31/42 , A01N43/36 , A01N43/38 , A01N43/76 , A61K31/40
CPC分类号： A61K31/42 , A61K31/165
摘要： A method for treating a human or non-human animal afflicted with malignant cells sensitive to vibriobactin or a pharmaceutically acceptable salt or complex thereof comprising administering to the animal an amount of vibriobactin effective to inhibit the proliferation of the malignant cells.

9. 发明授权

US5498622A Anti-neoplastic, anti-viral and ribonucleotide reductase activity affecting pharmaceutical compositions and methods of treatment 失效
公开(公告)号：US5498622A
公开(公告)日：1996-03-12
申请号：US474919
申请日：1995-06-07
申请人： Raymond J. Bergeron
发明人： Raymond J. Bergeron
IPC分类号： A61K31/165 , A61K31/42 , A61K31/40 , A01N43/36 , A01N43/38 , A01N43/76
CPC分类号： A61K31/42 , A61K31/165
摘要： A method for treating a human or non-human animal afflicted with malignant cells sensitive to vibriobactin or a pharmaceutically acceptable salt or complex thereof comprising administering to the animal an amount of vibriobactin effective to inhibit the proliferation of the malignant cells.

10. 发明授权

US5496841A Anti-neoplastic, anti-viral and ribonucleotide reductase activity affecting pharmaceutical compositions and method of treatment 失效
公开(公告)号：US5496841A
公开(公告)日：1996-03-05
申请号：US485836
申请日：1995-06-07
申请人： Raymond J. Bergeron
发明人： Raymond J. Bergeron
IPC分类号： A61K31/165 , A61K31/42 , A01N43/36 , A01N43/38 , A01N43/76 , A61K31/40
CPC分类号： A61K31/42 , A61K31/165
摘要： A method for treating a human or non-human animal afflicted with malignant cells sensitive to vibriobactin or a pharmaceutically acceptable salt or complex thereof comprising administering to the animal an amount of vibriobactin effective to inhibit the proliferation of the malignant cells.

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