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1. 发明申请

US20060163162A1 Device for solid phase extraction and method for purifying samples prior to analysis 有权
标题翻译：固相萃取装置和分析前样品的纯化方法
公开(公告)号：US20060163162A1
公开(公告)日：2006-07-27
申请号：US11393076
申请日：2006-03-30
申请人： Raymond Fisk , Pamela Iraneta , Yuri Tuvim , Edouard Bouvier , Jonathan Belanger , Martin Gilar
发明人： Raymond Fisk , Pamela Iraneta , Yuri Tuvim , Edouard Bouvier , Jonathan Belanger , Martin Gilar
IPC分类号： B01D15/08
CPC分类号： B01L3/5085 , B01D15/203 , B01D15/22 , B01D15/424 , B01J2220/64 , B01L3/50255 , B01L2200/0631 , B01L2300/0681 , B01L2300/0829 , B01L2300/12 , G01N1/405 , G01N30/6004 , G01N30/6065 , G01N35/028 , G01N2030/009 , G01N2030/062 , G01N2035/1053 , Y10T436/25375 , Y10T436/255 , G01N30/603
摘要： A solid phase extraction (SPE) device having a reservoir with an opening; a well comprising an internally tapered wall, the well having a wider interior diameter at an end closest to the opening than at an exit spout; a first filter within the well; a bed of sorbent particles within the well below the first filter; and a second filter having a diameter smaller than the first filter within the well below the bed of sorbent particles and above the exit spout is provided. A method of performing SPE using the device is also provided.
摘要翻译：固相萃取（SPE）装置，其具有带有开口的储存器; 一个包括内部锥形壁的井，该井在最靠近开口的一端具有比在出口处出口处更宽的内径; 井内的第一个过滤器; 在第一过滤器下面的井内的吸附剂颗粒床; 并且提供具有小于第一过滤器的第二过滤器，该第二过滤器位于吸附剂颗粒床之下的井内以及排出口上方。还提供了使用该装置执行SPE的方法。

2. 发明授权

US07192525B2 Device for solid phase extraction and method for purifying samples prior to analysis 有权
标题翻译：固相萃取装置和分析前样品的纯化方法
公开(公告)号：US07192525B2
公开(公告)日：2007-03-20
申请号：US11393076
申请日：2006-03-30
申请人： Raymond P. Fisk , Pamela Carmen Iraneta , Yuri Tuvim , Edouard S. P. Bouvier , Jonathan Belanger , Martin Gilar
发明人： Raymond P. Fisk , Pamela Carmen Iraneta , Yuri Tuvim , Edouard S. P. Bouvier , Jonathan Belanger , Martin Gilar
IPC分类号： B01D15/08
CPC分类号： B01L3/5085 , B01D15/203 , B01D15/22 , B01D15/424 , B01J2220/64 , B01L3/50255 , B01L2200/0631 , B01L2300/0681 , B01L2300/0829 , B01L2300/12 , G01N1/405 , G01N30/6004 , G01N30/6065 , G01N35/028 , G01N2030/009 , G01N2030/062 , G01N2035/1053 , Y10T436/25375 , Y10T436/255 , G01N30/603
摘要： A solid phase extraction (SPE) device having a reservoir with an opening; a well comprising an internally tapered wall, the well having a wider interior diameter at an end closest to the opening than at an exit spout; a first filter within the well; a bed of sorbent particles within the well below the first filter; and a second filter having a diameter smaller than the first filter within the well below the bed of sorbent particles and above the exit spout is provided. A method of performing SPE using the device is also provided.
摘要翻译：固相萃取（SPE）装置，其具有带有开口的储存器; 一个包括内部锥形壁的井，该井在最靠近开口的一端具有比在出口处出口处更宽的内径; 井内的第一个过滤器; 在第一过滤器下面的井内的吸附剂颗粒床; 并且提供具有小于第一过滤器的第二过滤器，该第二过滤器位于吸附剂颗粒床之下的井内以及排出口上方。还提供了使用该装置执行SPE的方法。

3. 发明授权

US07052611B2 Device for solid phase extraction and method for purifying samples prior to analysis 有权
公开(公告)号：US07052611B2
公开(公告)日：2006-05-30
申请号：US10785754
申请日：2004-02-24
申请人： Raymond P. Fisk , Pamela Carmen Iraneta , Yuri Tuvim , Edouard S. P. Bouvier , Jonathan Belanger , Martin Gilar
发明人： Raymond P. Fisk , Pamela Carmen Iraneta , Yuri Tuvim , Edouard S. P. Bouvier , Jonathan Belanger , Martin Gilar
IPC分类号： B01D15/08
CPC分类号： B01L3/5085 , B01D15/203 , B01D15/22 , B01D15/424 , B01J2220/64 , B01L3/50255 , B01L2200/0631 , B01L2300/0681 , B01L2300/0829 , B01L2300/12 , G01N1/405 , G01N30/6004 , G01N30/6065 , G01N35/028 , G01N2030/009 , G01N2030/062 , G01N2035/1053 , Y10T436/25375 , Y10T436/255 , G01N30/603
摘要： A solid phase extraction (SPE) device having a reservoir with an opening; a well comprising an internally tapered wall, the well having a wider interior diameter at an end closest to the opening than at an exit spout; a first filter within the well; a bed of sorbent particles within the well below the first filter; and a second filter having a diameter smaller than the first filter within the well below the bed of sorbent particles and above the exit spout is provided. A method of performing SPE using the device is also provided.

4. 发明授权

US06723236B2 Device for solid phase extraction and method for purifying samples prior to analysis 有权
标题翻译：固相萃取装置和分析前样品的纯化方法
公开(公告)号：US06723236B2
公开(公告)日：2004-04-20
申请号：US10100762
申请日：2002-03-19
申请人： Raymond P. Fisk , Pamela Carmen Iraneta , Yuri Tuvim , Edouard S. P. Bouvier , Jonathan Belanger , Martin Gilar
发明人： Raymond P. Fisk , Pamela Carmen Iraneta , Yuri Tuvim , Edouard S. P. Bouvier , Jonathan Belanger , Martin Gilar
IPC分类号： B01D1508
CPC分类号： B01L3/5085 , B01D15/203 , B01D15/22 , B01D15/424 , B01J2220/64 , B01L3/50255 , B01L2200/0631 , B01L2300/0681 , B01L2300/0829 , B01L2300/12 , G01N1/405 , G01N30/6004 , G01N30/6065 , G01N35/028 , G01N2030/009 , G01N2030/062 , G01N2035/1053 , Y10T436/25375 , Y10T436/255 , G01N30/603
摘要： A solid phase extraction (SPE) device having a reservoir with an opening; a well comprising an internally tapered wall, the well having a wider interior diameter at an end closest to the opening than at an exit spout; a first filter within the well; a bed of sorbent particles within the well below the first filter, and a second filter having a diameter smaller than the first filter within the well below the bed of sorbent particles and above the exit spout is provided. A method of performing SPE using the device is also provided.
摘要翻译：固相萃取（SPE）装置，其具有带有开口的储存器; 一个包括内部锥形壁的井，该井在最靠近开口的一端具有比在出口处出口处更宽的内径; 井内的第一个过滤器; 提供了在第一过滤器下面的井内的吸附剂颗粒床，以及具有比吸附剂颗粒床下方的井内的第一过滤器的直径小的第二过滤器，并且在出口喷口之上。还提供了使用该装置执行SPE的方法。

5. 发明申请

US20060057659A1 Destructible surfactants and uses thereof 有权
公开(公告)号：US20060057659A1
公开(公告)日：2006-03-16
申请号：US10516418
申请日：2003-05-30
申请人： Edouard Bouvier , Bruce Compton , John Gebler , Martin Gilar , Ying-Qing Yu , Peter Lee , Elizabeth Brown
发明人： Edouard Bouvier , Bruce Compton , John Gebler , Martin Gilar , Ying-Qing Yu , Peter Lee , Elizabeth Brown
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , C12P21/06 , G01N27/44726 , G01N27/44747 , G01N33/5306
摘要： The present invention provides methods for enhancing chemical reactions of molecules, e.g., biomolecules, with destructible surfactants. The chemical reactions may involve and/or be associate with analysis, e.g., solubilizing, separating, purifying and/or characterizing the molecules. In one aspect, the anionic surfactants of the present invention may be selectively broken up at relatively low pH. The resulting breakdown products of the surfactants may be removed from the molecule/sample with relative ease. The invention has applicability in a variety of analytical techniques.

6. 发明授权

US08580533B2 Destructible surfactants and uses thereof 有权
标题翻译：可破坏的表面活性剂及其用途
公开(公告)号：US08580533B2
公开(公告)日：2013-11-12
申请号：US10516418
申请日：2003-05-30
申请人： Edouard S. P. Bouvier , Bruce J. Compton , John C. Gebler , Martin Gilar , Ying-Qing Yu , Peter Jeng-Jong Lee , Elizabeth K. Brown
发明人： Edouard S. P. Bouvier , Bruce J. Compton , John C. Gebler , Martin Gilar , Ying-Qing Yu , Peter Jeng-Jong Lee , Elizabeth K. Brown
IPC分类号： C12Q1/37 , A61K31/095
CPC分类号： C12Q1/37 , C12P21/06 , G01N27/44726 , G01N27/44747 , G01N33/5306
摘要： The present invention provides methods for enhancing chemical reactions of molecules, e.g., biomolecules, with destructible surfactants. The chemical reactions may involve and/or be associate with analysis, e.g., solubilizing, separating, purifying and/or characterizing the molecules. In one aspect, the anionic surfactants of the present invention may be selectively broken up at relatively low pH. The resulting breakdown products of the surfactants may be removed from the molecule/sample with relative ease. The invention has applicability in a variety of analytical techniques.
摘要翻译：本发明提供了增强具有可破坏表面活性剂的分子（例如生物分子）的化学反应的方法。化学反应可能涉及和/或与分析有关，例如增溶，分离，纯化和/或表征分子。在一个方面，本发明的阴离子表面活性剂可以在相对低的pH下选择性地分解。可以相对容易地从分子/样品中除去所得表面活性剂的分解产物。本发明适用于各种分析技术。

7. 发明申请

US20130011925A1 Separation Devices and Method For Separating Phosphorylated Peptides and Proteins 有权
标题翻译：分离装置和分离磷酸化肽和蛋白质的方法
公开(公告)号：US20130011925A1
公开(公告)日：2013-01-10
申请号：US13545762
申请日：2012-07-10
申请人： Martin Gilar , Ying-Qing Yu , Jennifer Fournier , John E. O'Gara
发明人： Martin Gilar , Ying-Qing Yu , Jennifer Fournier , John E. O'Gara
IPC分类号： G01N30/96 , G01N27/62
CPC分类号： C07K1/36 , C12Q1/37 , G01N1/405 , G01N1/4055 , G01N30/34 , G01N30/6069 , G01N35/1097
摘要： Embodiments of the present invention are directed to articles of manufacture, devices, methods and apparatus for performing liquid chromatography featuring a chromatographic sorbent having one or more pentafluorophenyl groups, wherein said one or more pentafluorophenyl groups are a bonded phase on a sorbent selected from the group comprising silica, organic polymers or hybrid organic diene material and said pentafluorophenyl groups are in a mono-, bi-, and tridentate forms.
摘要翻译：本发明的实施方案涉及用于进行液相色谱的制品，装置，方法和装置，其特征在于具有一个或多个五氟苯基的色谱吸附剂，其中所述一个或多个五氟苯基是选自组中的吸附剂上的键合相包括二氧化硅，有机聚合物或杂化有机二烯材料，所述五氟苯基是单，双和三齿形式。

8. 发明授权

US08409443B2 Vessel, dispensing devices, kits and methods for containing fluids 有权
标题翻译：容器，分配装置，用于容纳流体的试剂盒和方法
公开(公告)号：US08409443B2
公开(公告)日：2013-04-02
申请号：US12595344
申请日：2008-04-10
申请人： Martin Gilar , Christopher C. Benevides , Jennifer Fournier
发明人： Martin Gilar , Christopher C. Benevides , Jennifer Fournier
IPC分类号： B01D15/08 , B01D21/26 , B04B15/00 , B65D51/18
CPC分类号： B01L3/50825 , B01L3/5021 , B01L2200/026 , B01L2200/142 , B01L2300/0858 , Y10T137/0318 , Y10T137/7869 , Y10T137/86187 , Y10T436/25375 , Y10T436/255
摘要： A device for limiting sample evaporation. The device has a vessel body having a body exterior surface and at least one body interior surface. The at least one body interior surface has one or more walls defining a first chamber, a second chamber and a conduit means. The first chamber has a first chamber opening for receiving at least one of the groups selected from a sample and a sample dispensing device. The first chamber opening defines the border of the body exterior surface and the body interior surface. The conduit means is in communication with the first chamber and the second chamber for receiving at least one of the group consisting of sample from said first chamber, a sample from a sample dispensing device and a sample dispensing device passing through or into the conduit means for placing the sample in the conduit means or into the second chamber. The second chamber is in communication with the conduit means for receiving and containing the sample from at least one of the group selected from the sample dispensing device and conduit means. The conduit means is arranged such that the sample in the second chamber is substantially isolated from the atmosphere to limit sample evaporation in the second chamber as the sample is contained therein.
摘要翻译：用于限制样品蒸发的装置。该装置具有容器主体，其具有主体外表面和至少一个主体内表面。所述至少一个主体内表面具有限定第一室，第二室和导管装置的一个或多个壁。第一室具有用于接收从样品和样品分配装置中选择的至少一个组的第一室开口。第一腔室开口限定身体外表面和身体内表面的边界。导管装置与第一腔室和第二腔室连通，用于接收来自所述第一腔室的样品，来自样品分配装置的样品和通过或进入导管装置的样品分配装置中的至少一个，将样品放置在导管装置中或进入第二室。第二室与用于从选自样品分配装置和导管装置中的组中的至少一个接收和容纳样品的导管装置连通。管道装置被布置成使得第二室中的样品基本上与大气隔离，以在样品被包含在第二室中时限制第二室中的样品蒸发。

9. 发明授权

US08153009B2 Apparatus and methods for mass-spectrometric directed purification of biopolymers 有权
标题翻译：用于生物聚合物质谱定向纯化的装置和方法
公开(公告)号：US08153009B2
公开(公告)日：2012-04-10
申请号：US11912047
申请日：2006-04-21
申请人： Martin Gilar , John C. Gebler , Fang Xia
发明人： Martin Gilar , John C. Gebler , Fang Xia
IPC分类号： B01D15/08
CPC分类号： G01N30/34
摘要： A method for extracting at least one target compound from a sample includes injecting an overloaded amount of the sample into a chromatographic conduit (110), and flowing a solvent having a time-varying composition through the conduit (110). An apparatus for extracting at least one target compound from a sample includes a chromatography module, a mass-spectrometry module in fluid communication with the chromatography module to receive a portion of an eluent from the chromatography module, and a control unit in communication with the chromatography module and the mass-spectrometry module.
摘要翻译：从样品中提取至少一种目标化合物的方法包括将过量的样品注入色谱管道（110）中，并使具有时变组成的溶剂流经导管（110）。用于从样品中提取至少一种目标化合物的装置包括色谱模块，与色谱模块流体连通以从色谱模块接收一部分洗脱液的质谱模块，以及与色谱法连通的控制单元模块和质谱模块。

10. 发明申请

US20100285596A1 METHODS FOR ISOLATING FUNCTIONALIZED MACROMOLECULES 审中-公开
标题翻译：分离功能化大分子的方法
公开(公告)号：US20100285596A1
公开(公告)日：2010-11-11
申请号：US12676009
申请日：2008-09-05
申请人： Ying Qing Yu , Martin Gilar
发明人： Ying Qing Yu , Martin Gilar
IPC分类号： G01N33/92 , G01N33/00 , C07K1/16 , C07H21/02 , C07H21/04 , C07H21/00 , C08F6/28 , B01D15/00
CPC分类号： B01J20/284 , B01D15/08 , B01D15/424 , B01J2220/54 , G01N1/405 , G01N1/4055 , Y10T436/143333
摘要： The invention provides methods of isolating, purifying, analyzing and/or detecting, functionalized macromolecules, e.g., peptides, phosphopeptides, polypeptides, proteins, oligonucleotides, or phospholipids in a sample, e.g., a biological mixture, using solid phase extraction with an alumina sorbent packed in a micro-elution plate.
摘要翻译：本发明提供了使用固相萃取与氧化铝吸附剂分离，纯化，分析和/或检测样品（例如生物混合物）中的官能化大分子，例如肽，磷酸肽，多肽，蛋白质，寡核苷酸或磷脂的方法包装在微量洗脱板中。

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