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1. 发明授权

US06486168B1 Formulations and methods for treatment of mucosal associated conditions with an immune response modifier 失效
标题翻译：用免疫反应调节剂治疗粘膜相关病症的制剂和方法
公开(公告)号：US06486168B1
公开(公告)日：2002-11-26
申请号：US09676339
申请日：2000-09-29
申请人： Raymond D. Skwierczynski , Kenneth R. Phares , Richard L. Miller , Zheng Jane Li , Michael J. Jozwiakowski , Terri F. Busch
发明人： Raymond D. Skwierczynski , Kenneth R. Phares , Richard L. Miller , Zheng Jane Li , Michael J. Jozwiakowski , Terri F. Busch
IPC分类号： A61K3144
CPC分类号： C07D203/08 , A61K9/0034 , A61K31/437 , A61K31/4745 , A61K31/4748 , C07D213/30 , C07D213/38 , C07D303/08 , C07D471/04
摘要： Immune response modifier (IRM) compounds—imidazoquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, 1,2-bridged imidazoquinoline amines, thiazolo- and oxazolo-quinolinamines and pyridinamines, imidazonaphthyridine and tetrahydroimidazonaphthyridine amines—are useful for the treatment of conditions at and below the mucosal surfaces by administering a therapeutically effective amount of such compounds to the mucosal surface. Novel pharmaceutical formulations are provided. In one embodiment, the pharmaceutical formulations are advantageous for treatment of cervical conditions such as cervical dysplasias including cervical intraepithelial neoplasias.
摘要翻译：免疫应答调节剂（IRM）化合物 - 咪唑并喹啉胺，咪唑并吡啶胺，6,7-稠合环烷基咪唑并吡啶胺，1,2-桥连咪唑并喹啉胺，噻唑并恶唑并喹啉胺和吡啶胺，咪唑并吡啶和四氢咪唑并吡啶胺 - 可用于治疗通过向粘膜表面施用治疗有效量的这种化合物，在粘膜表面和下方的条件。提供了新的药物制剂。在一个实施方案中，药物制剂对于治疗子宫颈病症例如宫颈发育不良（包括宫颈上皮内瘤变）是有利的。

2. 发明授权

US06245776B1 Formulations and methods for treatment of mucosal associated conditions with an immune response modifier 有权
标题翻译：用免疫反应调节剂治疗粘膜相关病症的制剂和方法
公开(公告)号：US06245776B1
公开(公告)日：2001-06-12
申请号：US09479578
申请日：2000-01-07
申请人： Raymond D. Skwierczynski , Kenneth R. Phares , Richard L. Miller , Zheng Jane Li , Michael J. Jozwiakowski , Terri F. Busch
发明人： Raymond D. Skwierczynski , Kenneth R. Phares , Richard L. Miller , Zheng Jane Li , Michael J. Jozwiakowski , Terri F. Busch
IPC分类号： A61K3144
CPC分类号： A61K9/0034 , A61K9/0014 , A61K31/437 , A61K31/44 , A61K31/4745 , A61K47/10 , A61K47/12 , C07D471/04
摘要： Immune response modifier (IRM) compounds—imidazoquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, 1,2-bridged imidazoquinoline amines, thiazolo- and oxazolo-quinolinamines and pyridinamines, imidazonaphthyridine and tetrahydroimidazonaphthyridine amines—are useful for the treatment of conditions at and below the mucosal surfaces by administering a therapeutically effective amount of such compounds to the mucosal surface. Novel pharmaceutical formulations are provided. In one embodiment, the pharmaceutical formulations are advantageous for treatment of cervical conditions such as cervical dysplasias including cervical intraepithelial neoplasias.
摘要翻译：免疫应答调节剂（IRM）化合物 - 咪唑并喹啉胺，咪唑并吡啶胺，6,7-稠合环烷基咪唑并吡啶胺，1,2-桥连咪唑并喹啉胺，噻唑并恶唑并喹啉胺和吡啶胺，咪唑并吡啶和四氢咪唑并吡啶胺 - 可用于治疗通过向粘膜表面施用治疗有效量的这种化合物，在粘膜表面和下方的条件。提供了新的药物制剂。在一个实施方案中，药物制剂对于治疗子宫颈病症例如宫颈发育不良（包括宫颈上皮内瘤变）是有利的。

3. 发明授权

US09854962B2 Visualization instrument 有权
公开(公告)号：US09854962B2
公开(公告)日：2018-01-02
申请号：US12874058
申请日：2010-09-01
申请人： Thomas W. McGrail , Michael S. Pargett , David J. Miller , Yun Siung Tony Yeh , Randal B. Chinnock , George Grubner , Elizabeth Powell Goodrich , Paul Crosby Gregory , Gary Vincent Palladino , Brian Hack , Kristin Jugenheimer Size , Richard L. Miller
发明人： Thomas W. McGrail , Michael S. Pargett , David J. Miller , Yun Siung Tony Yeh , Randal B. Chinnock , George Grubner , Elizabeth Powell Goodrich , Paul Crosby Gregory , Gary Vincent Palladino , Brian Hack , Kristin Jugenheimer Size , Richard L. Miller
IPC分类号： A61B1/00 , A61B1/267 , A61B1/05 , G02B23/24 , A61B1/018
CPC分类号： A61B1/267 , A61B1/00016 , A61B1/00052 , A61B1/00103 , A61B1/00105 , A61B1/018 , A61B1/05 , G02B23/2423 , G02B23/2446
摘要： A visualization instrument comprising a display support component removably coupled to a component insertable into a target space. The insertable component includes a camera providing images of the target space. The images are presented in a display device supported by the display support component. The insertable component may be discarded after a permitted number of uses.

4. 发明授权

US08550074B2 Delivery device and related methods 有权
公开(公告)号：US08550074B2
公开(公告)日：2013-10-08
申请号：US12688852
申请日：2010-01-15
申请人： Andrew Jones , Richard L. Miller
发明人： Andrew Jones , Richard L. Miller
IPC分类号： A61M16/00
CPC分类号： A61M15/0028 , A61M15/0041 , A61M15/0043 , A61M15/0045 , A61M15/0061 , A61M15/0075 , A61M2206/16
摘要： A delivery device that includes a cutter for opening a barrier layer to provide fluid access to a dose chamber, and a diverting structure for direct air flow toward the dose chamber.

5. 发明授权

US08366810B1 Pneumatic particulates and/or rock processing 有权
标题翻译：气动颗粒和/或岩石加工
公开(公告)号：US08366810B1
公开(公告)日：2013-02-05
申请号：US12803990
申请日：2010-07-12
申请人： Richard L. Miller
发明人： Richard L. Miller
IPC分类号： B01D46/00
CPC分类号： B07B7/01 , B07B11/06 , E01B27/06
摘要： A method for separating mixed granular material based upon dissimilar specific gravities, (such as in firearm range cleaning) thereby separating lead from backstop material. Lead falling from an airstream is airwashed by an upwardly directed second airstream. The preferred method is performed under negative pressure to control lead dust. Application to pick up and clean or recover fouled ballast rock (such as used in the rail industry). Processes and apparatus are disclosed that pick up and clean or enrich precious metal bearing ore.
摘要翻译：基于不同的比重（例如在火器范围清洁中）分离混合颗粒材料的方法，从而将铅与止挡材料分离。从气流中掉落的铅被向上引导的第二气流吹扫。优选的方法是在负压下进行以控制铅尘。应用于拾取和清洁或回收污染的压载岩（如用于铁路行业）。公开了拾取和清洁或富集含贵金属的矿石的方法和装置。

6. 发明申请

US20110132814A1 Pneumatic classification of mixtures of particulates 有权
标题翻译：颗粒混合物的气动分类
公开(公告)号：US20110132814A1
公开(公告)日：2011-06-09
申请号：US12931825
申请日：2011-02-10
申请人： Richard L. Miller
发明人： Richard L. Miller
IPC分类号： B07B4/02
CPC分类号： B07B4/04 , B07B7/01 , B07B11/06
摘要： Process for pneumatic classification of mixture of granular particulates by providing an apparatus, entraining mixture, reducing velocity of entraining airstream, and airwashing falling particulates of low aerodynamic support. Specific applications include a method separating mixed granular material based upon dissimilar specific gravities, useful in cleaning firearm ranges by separating lead from backstop material. Falling granular lead particulates can also be airwashed and negative pressure facilitates control of lead dust. Also disclosed are applications that pick up and clean or enrich precious metal bearing ore, and a broad range of applications from heavy mixtures, such as landscape rock, to light mixtures such as grain.
摘要翻译：通过提供装置，夹带混合物，减少夹带气流的速度和低空气动力学支持的空气洗涤落下的颗粒来气动分级粒状颗粒的混合物的方法。具体应用包括基于不同的比重分离混合颗粒材料的方法，其用于通过将反萃材料分离出来来清洁火器范围。落下的颗粒状铅颗粒也可以是空气清洗的，负压有助于控制铅尘。还公开了拾取和清洁或富集贵金属轴承矿石的应用，以及从重质混合物（例如风景岩）到轻质混合物如谷物的广泛应用。

7. 发明申请

US20100329782A1 Utilities Access Closure 有权
标题翻译：实用程序访问关闭
公开(公告)号：US20100329782A1
公开(公告)日：2010-12-30
申请号：US12494105
申请日：2009-06-29
申请人： Richard L. Miller , Stephen L. Miller
发明人： Richard L. Miller , Stephen L. Miller
IPC分类号： E02D29/14
CPC分类号： E02D29/14 , E02D29/1454 , Y10T29/49826
摘要： A concrete lid for an in-ground utilities box includes a reinforcement structure filled with concrete. The reinforcement structure includes a plastic frame and one or more reinforcing trusses that extend between opposing sidewalls of the plastic frame. The reinforcing trusses also extend substantially between the upper and lower edges of the opposing sidewalls. For example, a reinforcing truss may include a flat truss member that is substantially coplanar with the lower edges of the sidewalls, and an arched truss member that extends towards (but does not reach) a plane defined by the upper edges of the sidewalls. The reinforcing trusses include openings that allow wet concrete to pass through. The sidewalls of the plastic frame protect the edges of the lid from damage. The reinforcing trusses reinforce the concrete lid, eliminating the need for separate reinforcement material.
摘要翻译：用于地下电力箱的混凝土盖包括一个充满混凝土的钢筋结构。加强结构包括塑料框架和在塑料框架的相对侧壁之间延伸的一个或多个加强桁架。加强桁架基本上在相对侧壁的上边缘和下边缘之间延伸。例如，加强桁架可以包括与侧壁的下边缘基本上共面的平坦桁架构件和朝向（但不到达）由侧壁的上边缘限定的平面延伸的拱形桁架构件。加强桁架包括允许湿混凝土穿过的开口。塑料框架的侧壁保护盖子的边缘免受损坏。加强桁架加固混凝土盖，不需要单独的加固材料。

8. 发明申请

US20090202443A1 METHODS OF IMPROVING SKIN QUALITY 审中-公开
标题翻译：改善皮肤质量的方法
公开(公告)号：US20090202443A1
公开(公告)日：2009-08-13
申请号：US12425961
申请日：2009-04-17
申请人： Richard L. Miller , James H. Lee , Mary L. Owens
发明人： Richard L. Miller , James H. Lee , Mary L. Owens
IPC分类号： A61K49/00 , A61K31/437 , A61P17/02 , A61P35/00
CPC分类号： A61K8/4946 , A61K31/397 , A61K31/4745 , A61K2800/70 , A61Q19/08 , Y10S514/844 , Y10S514/878
摘要： Methods of improving skin quality are disclosed. Generally, the methods include topically administering an IRM compound to a treatment area of skin for a period of time and in an amount effective for improving the quality of the skin. Suitable IRM compound compounds include agonists of one or more TLRs.
摘要翻译：公开了改善皮肤质量的方法。通常，所述方法包括将IRM化合物局部给予皮肤治疗区域一段时间，并且以有效改善皮肤质量的量。合适的IRM化合物包括一种或多种TLR的激动剂。

9. 外观设计

USD594737S1 Rebar chair 有权
标题翻译：钢筋椅
公开(公告)号：USD594737S1
公开(公告)日：2009-06-23
申请号：US29312524
申请日：2008-10-28
申请人： David L. Kelly , Stephen L. Miller , Richard L. Miller
设计人： David L. Kelly , Stephen L. Miller , Richard L. Miller

10. 发明授权

US06603556B2 Photometric detection system having multiple path length flow cell 有权
公开(公告)号：US06603556B2
公开(公告)日：2003-08-05
申请号：US09975164
申请日：2001-10-11
申请人： Mathias Belz , Su Yi Liu , Richard L. Miller
发明人： Mathias Belz , Su Yi Liu , Richard L. Miller
IPC分类号： G01N2100
CPC分类号： G01N21/05 , G01N2021/0346
摘要： A photometric detection system including a light source, a photometric detector, and a flow cell assembly. The flow cell assembly includes a tubular liquid core waveguide having inlet and discharge ends for receiving and discharging a flow of the sample fluid. A first coupling device optically couples the light source to the waveguide at a first position along the length of the waveguide. A second coupling device optically couples the detector to the waveguide at a second position along the length of the waveguide. The first and second positions define an optical path length within the waveguide. The second position is variable relative to the first position such that the optical path length is selectively varied.

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