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1. 发明申请

US20220205925A1 Flow Cell System for Optical Fluid Analysis and Bioreactor System 有权
公开(公告)号：US20220205925A1
公开(公告)日：2022-06-30
申请号：US17262363
申请日：2020-09-04
申请人： Mathias Belz , Philipp Raithel , Dörte Solle , Tobias Steinwedel
发明人： Mathias Belz , Philipp Raithel , Dörte Solle , Tobias Steinwedel
IPC分类号： G01N21/85 , C12M1/00 , G01N21/03 , C12M1/34 , G01N21/05 , G01N21/31 , G01N21/64
摘要： A flow cell system for an optical fluid analysis comprises a disposable flow cell having at least one flow chamber comprising a fluid pathway, and at least one pair of opposed light transmitting windows along the fluid pathway, an external flow cell holder for holding the flow cell, at least one light source, and an external detection device couplable with at least one of the flow cell holder and the flow cell for bringing the external detection device in optical communication with the flow cell, the device having at least one optical detection unit. The external detection device is configured to conduct optical measurements of the fluid that flows in the flow cell through at least one pair of windows from externally under illumination by the at least one light source.

2. 发明申请

US20110188042A1 SELF REFERENCING LED DETECTION SYSTEM FOR SPECTROSCOPY APPLICATIONS 有权
标题翻译：自动参考LED检测系统用于光谱应用
公开(公告)号：US20110188042A1
公开(公告)日：2011-08-04
申请号：US13082087
申请日：2011-04-07
申请人： Mathias Belz
发明人： Mathias Belz
IPC分类号： G01N21/25
CPC分类号： C07D209/52 , C07D209/42 , C07D209/94 , C07D487/04 , C07D491/04 , C07D495/04 , G01N21/253 , G01N21/255 , G01N21/3151
摘要： A light emitting diode (LED) based detection system is employed for spectroscopy based applications. LEDs are used as monochromatic light sources for applications at specific and pre-defined wavelengths. Spectrographic information is generated using LEDs of different wavelengths ranging from 260 nm to 1400 nm. Multiple wavelength information is generated by coupling light from each LED into an intensity and mode mixing fiber bundle. A dual beam approach of using a reference and a sample photodiode ensures automatic drift correction. Interference filters at the LED input fiber reduce the spectral bandwidth of the monochromatic light emission to a useful 10 nm bandwidth by cutting off the LEDs trailing emission distribution allowing for absorbance measurements similar to typical spectrometers.
摘要翻译：基于发光二极管（LED）的检测系统被用于基于光谱的应用。 LED用作单色光源，用于特定和预定义波长的应用。使用260nm至1400nm范围内的不同波长的LED产生光谱信息。通过将来自每个LED的光耦合到强度和模式混合纤维束中来产生多个波长信息。使用参考和采样光电二极管的双光束方法可确保自动漂移校正。 LED输入光纤上的干涉滤光片通过切断LED尾部发射分布，将单色光发射的光谱带宽降低到有用的10 nm带宽，从而实现与典型光谱仪类似的吸光度测量。

3. 发明申请

US20080175989A1 High temperature coating techniques for amorphous fluoropolymers 有权
标题翻译：无定形含氟聚合物的高温涂层技术
公开(公告)号：US20080175989A1
公开(公告)日：2008-07-24
申请号：US12002980
申请日：2007-12-19
申请人： Mathias Belz , Guoming Guan
发明人： Mathias Belz , Guoming Guan
IPC分类号： G02B1/04
CPC分类号： G02B6/032
摘要： A coating technique for amorphous fluoropolymer involves adding amorphous fluoropolymer resin to a solvent. The resin solvent mixture is heated to a predetermined temperature above room temperature. The amorphous fluoropolymer resin is dissolved in a heated solvent, and the liquid coating solution is applied to a substrate. The solvent is then removed from the applied liquid coating solution. The coating technique may be employed in connection with liquid core waveguides.
摘要翻译：无定形含氟聚合物的涂覆技术包括向溶剂中加入无定形含氟聚合物树脂。将树脂溶剂混合物加热至高于室温的预定温度。将无定形含氟聚合物树脂溶解在加热溶剂中，并将液体涂布溶液施加到基材上。然后从所施加的液体涂布溶液中除去溶剂。涂层技术可以与液芯波导结合使用。

4. 发明授权

US08189196B2 Self referencing LED detection system for spectroscopy applications 有权
标题翻译：自动参考用于光谱应用的LED检测系统
公开(公告)号：US08189196B2
公开(公告)日：2012-05-29
申请号：US13082087
申请日：2011-04-07
申请人： Mathias Belz
发明人： Mathias Belz
IPC分类号： G01N21/25
CPC分类号： C07D209/52 , C07D209/42 , C07D209/94 , C07D487/04 , C07D491/04 , C07D495/04 , G01N21/253 , G01N21/255 , G01N21/3151
摘要： A light emitting diode (LED) based detection system is employed for spectroscopy based applications. LEDs are used as monochromatic light sources for applications at specific and pre-defined wavelengths. Spectrographic information is generated using LEDs of different wavelengths ranging from 260 nm to 1400 nm. Multiple wavelength information is generated by coupling light from each LED into an intensity and mode mixing fiber bundle. A dual beam approach of using a reference and a sample photodiode ensures automatic drift correction. Interference filters at the LED input fiber reduce the spectral bandwidth of the monochromatic light emission to a useful 10 nm bandwidth by cutting off the LEDs trailing emission distribution allowing for absorbance measurements similar to typical spectrometers.
摘要翻译：基于发光二极管（LED）的检测系统被用于基于光谱的应用。 LED用作单色光源，用于特定和预定义波长的应用。使用260nm至1400nm范围内的不同波长的LED产生光谱信息。通过将来自每个LED的光耦合到强度和模式混合纤维束中来产生多个波长信息。使用参考和采样光电二极管的双光束方法可确保自动漂移校正。 LED输入光纤上的干涉滤光片通过切断LED尾部发射分布，将单色光发射的光谱带宽降低到有用的10 nm带宽，从而实现与典型光谱仪类似的吸光度测量。

5. 发明申请

US20080174768A1 Self referencing LED detection system for spectroscopy applications 审中-公开
标题翻译：自动参考用于光谱应用的LED检测系统
公开(公告)号：US20080174768A1
公开(公告)日：2008-07-24
申请号：US12009492
申请日：2008-01-18
申请人： Mathias Belz
发明人： Mathias Belz
IPC分类号： G01N21/00
CPC分类号： C07D209/52 , C07D209/42 , C07D209/94 , C07D487/04 , C07D491/04 , C07D495/04 , G01N21/253 , G01N21/255 , G01N21/3151
摘要： A light emitting diode (LED) based detection system is employed for spectroscopy based applications. LEDs are used as monochromatic light sources for applications at specific and pre-defined wavelengths. Spectrographic information is generated using LEDs of different wavelengths ranging from 260 nm to 1400 nm. Multiple wavelength information is generated by coupling light from each LED into an intensity and mode mixing fiber bundle. A dual beam approach of using a reference and a sample photodiode ensures automatic drift correction. Interference filters at the LED input fiber reduce the spectral bandwidth of the monochromatic light emission to a useful 10 nm bandwidth by cutting off the LEDs trailing emission distribution allowing for absorbance measurements similar to typical spectrometers.
摘要翻译：基于发光二极管（LED）的检测系统被用于基于光谱的应用。 LED用作单色光源，用于特定和预定义波长的应用。使用260nm至1400nm范围内的不同波长的LED产生光谱信息。通过将来自每个LED的光耦合到强度和模式混合纤维束中来产生多个波长信息。使用参考和采样光电二极管的双光束方法可确保自动漂移校正。 LED输入光纤上的干涉滤光片通过切断LED尾部发射分布，将单色光发射的光谱带宽降低到有用的10 nm带宽，从而实现与典型光谱仪类似的吸光度测量。

6. 发明授权

US06385380B1 Hollow optical waveguide for trace analysis in aqueous solutions 有权
标题翻译：空心光波导，用于在水溶液中进行痕量分析
公开(公告)号：US06385380B1
公开(公告)日：2002-05-07
申请号：US09294686
申请日：1999-04-19
申请人： Karl Friedrich , Peter Dress , Mathias Belz
发明人： Karl Friedrich , Peter Dress , Mathias Belz
IPC分类号： G02B602
CPC分类号： G02B6/032 , G01N21/6428 , G01N21/645 , G01N2021/6482
摘要： Low concentrations of substances dissolved in liquids are detected by coupling analysis/excitation light into the liquid core of an optical waveguide in the form of a capillary. When the substance of interest is to be excited to cause the emission of fluorescent light, the excitation light is transversely coupled into the hollow core of the waveguide and the generated fluorescent light is kept in the optical path of the waveguide for as long as possible. The invention also contemplates the use, in either an absorption or fluorescence mode, of specially treated fused silica fibers to deliver analysis/excitation light with very short wavelengths into the liquid core of an optical waveguide.
摘要翻译：通过将分析/激发光耦合到毛细管形式的光波导的液芯中来检测溶解在液体中的低浓度物质。当感兴趣的物质被激发以引起荧光的发射时，激发光横向耦合到波导的中空芯中，并且所产生的荧光保持在波导的光路中尽可能长。本发明还考虑在吸收或荧光模式中使用特殊处理的熔融石英纤维将具有非常短的波长的分析/激发光输送到光波导的液芯中。

7. 发明授权

US07914852B2 High temperature coating techniques for amorphous fluoropolymers 有权
标题翻译：无定形含氟聚合物的高温涂层技术
公开(公告)号：US07914852B2
公开(公告)日：2011-03-29
申请号：US12002980
申请日：2007-12-19
申请人： Mathias Belz , Guoming Guan
发明人： Mathias Belz , Guoming Guan
IPC分类号： B05D3/02
CPC分类号： G02B6/032
摘要： A coating technique for amorphous fluoropolymer involves adding amorphous fluoropolymer resin to a solvent. The resin solvent mixture is heated to a predetermined temperature above room temperature. The amorphous fluoropolymer resin is dissolved in a heated solvent, and the liquid coating solution is applied to a substrate. The solvent is then removed from the applied liquid coating solution. The coating technique may be employed in connection with liquid core waveguides.
摘要翻译：无定形含氟聚合物的涂覆技术包括向溶剂中加入无定形含氟聚合物树脂。将树脂溶剂混合物加热至高于室温的预定温度。将无定形含氟聚合物树脂溶解在加热溶剂中，并将液体涂布溶液施加到基材上。然后从所施加的液体涂布溶液中除去溶剂。涂层技术可以与液芯波导结合使用。

8. 发明授权

US06603556B2 Photometric detection system having multiple path length flow cell 有权
公开(公告)号：US06603556B2
公开(公告)日：2003-08-05
申请号：US09975164
申请日：2001-10-11
申请人： Mathias Belz , Su Yi Liu , Richard L. Miller
发明人： Mathias Belz , Su Yi Liu , Richard L. Miller
IPC分类号： G01N2100
CPC分类号： G01N21/05 , G01N2021/0346
摘要： A photometric detection system including a light source, a photometric detector, and a flow cell assembly. The flow cell assembly includes a tubular liquid core waveguide having inlet and discharge ends for receiving and discharging a flow of the sample fluid. A first coupling device optically couples the light source to the waveguide at a first position along the length of the waveguide. A second coupling device optically couples the detector to the waveguide at a second position along the length of the waveguide. The first and second positions define an optical path length within the waveguide. The second position is variable relative to the first position such that the optical path length is selectively varied.

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