专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4396621A Certain 2-oxo-2,3-dihydro-3-benzothiophene-carboxamides and their pharmaceutical compositions 失效
标题翻译：某些2-氧代-2,3-二氢-3-苯并噻吩 - 甲酰胺及其药物组合物
公开(公告)号：US4396621A
公开(公告)日：1983-08-02
申请号：US204747
申请日：1980-11-07
申请人： Raymond Bernasconi , Pier G. Ferrini , Richard Goschke , Jacques Gosteli
发明人： Raymond Bernasconi , Pier G. Ferrini , Richard Goschke , Jacques Gosteli
IPC分类号： C07D333/36 , C07D333/64 , C07D333/68 , C07D333/70 , A61K31/425 , C07D409/12
CPC分类号： C07D333/36 , C07D333/64 , C07D333/68 , C07D333/70
摘要： Oxothia compounds, especially 2-oxo-2,3-dihydro-benzo[b]-thiophene compounds of the formula ##STR1## in which Ph represents an optionally substituted 1,2-phenylene radical, X represents oxygen or sulphur, R.sub.1 represents an organic radical bonded via a carbon atom and R.sub.2 denotes hydrogen or an optionally substituted hydrocarbon radical of aliphatic character, and their salts are useful as peripheral analgetics and/or as antiphlogistic uricosuric and/or thrombolytic agents.
摘要翻译：式（Ⅰ）的氧化噻吩化合物，特别是2-氧代-2,3-二氢 - 苯并[b] - 噻吩化合物，其中Ph代表任意取代的1,2-亚苯基，X代表氧或硫， R1表示通过碳原子键合的有机基团，R 2表示氢或任选取代的具有脂族特征的烃基，其盐可用作外周止痛剂和/或作为消炎性尿酸和/或溶栓剂。

2. 发明授权

US4260779A Oxothia compounds 失效
标题翻译： Oxothia化合物
公开(公告)号：US4260779A
公开(公告)日：1981-04-07
申请号：US92821
申请日：1979-11-09
申请人： Raymond Bernasconi , Pier G. Ferrini , Richard Goschke , Jacques Gosteli
发明人： Raymond Bernasconi , Pier G. Ferrini , Richard Goschke , Jacques Gosteli
IPC分类号： C07D333/64 , C07D333/68 , C07D333/70
CPC分类号： C07D333/68 , C07D333/64 , C07D333/70 , Y10S514/822
摘要： Oxothia compounds, especially 2-oxo-2,3-dihydro-benzo[b]thiophene compounds of the formula ##STR1## in which Ph represents an optionally substituted 1,2-phenylene radical, X represents oxygen or sulphur, R.sub.1 represents an organic radical bonded via a carbon atom and R.sub.2 denotes hydrogen or an optionally substituted hydrocarbon radical of aliphatic character, and their salts are useful as peripheral analgetics and/or as antiphlogistic uricosuric and/or thrombolytic agents.
摘要翻译：其中Ph代表任选取代的1,2-亚苯基，X表示氧或硫，R 1，R 2，R 3，R 4，R 4，R 4，表示通过碳原子键合的有机基团，R 2表示氢或任选取代的脂肪族特征的烃基，其盐可用作外周止痛剂和/或作为消炎性尿酸和/或溶栓剂。

3. 发明授权

US4320138A Oxothia compounds 失效
标题翻译： Oxothia化合物
公开(公告)号：US4320138A
公开(公告)日：1982-03-16
申请号：US214168
申请日：1980-12-08
申请人： Raymond Bernasconi , Pier G. Ferrini , Richard Goschke , Jacques Gosteli
发明人： Raymond Bernasconi , Pier G. Ferrini , Richard Goschke , Jacques Gosteli
IPC分类号： A61K31/38 , A61K31/381 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/4433 , A61P7/02 , A61P7/10 , A61P19/06 , A61P25/04 , A61P29/00 , A61P43/00 , C07D333/64 , C07D333/68 , C07D333/70 , C07D409/12 , C07D413/12 , C07D417/12
CPC分类号： C07D333/64 , C07D333/68 , C07D333/70 , Y10S514/825
摘要： Oxothia compounds, especially 2-oxo-2,3-dihydro-benzo[b]-thiophene compounds of the formula ##STR1## in which Ph represents an optionally substituted 1,2-phenylene radical, X represents oxygen or sulphur, R.sub.1 represents an organic radical bonded via a carbon atom and R.sub.2 denotes hydrogen or an optionally substituted hydrocarbon radical of aliphatic character, and their salts are useful as peripheral analgetics and/or as antiphlogistic uricosuric and/or thrombolytic agents.
摘要翻译：式（Ⅰ）的氧化噻吩化合物，特别是2-氧代-2,3-二氢 - 苯并[b] - 噻吩化合物，其中Ph代表任意取代的1,2-亚苯基，X代表氧或硫， R1表示通过碳原子键合的有机基团，R 2表示氢或任选取代的具有脂族特征的烃基，其盐可用作外周止痛剂和/或作为消炎性尿酸和/或溶栓剂。

4. 发明授权

US4584310A Novel mercaptoimidazole derivatives 失效
标题翻译：新型巯基咪唑衍生物
公开(公告)号：US4584310A
公开(公告)日：1986-04-22
申请号：US588024
申请日：1984-03-09
申请人： Pier G. Ferrini , Richard Goschke
发明人： Pier G. Ferrini , Richard Goschke
IPC分类号： C07D409/12 , A61K31/415 , A61K31/4164 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61P7/02 , A61P29/00 , A61P29/02 , C07D213/50 , C07D213/53 , C07D233/84 , C07D401/04 , C07D405/04 , C07D409/04 , C07D409/14
CPC分类号： C07D213/53 , C07D213/50
摘要： Novel substituted 2-mercaptoimidazoles of the formula ##STR1## in which at least one of the radicals R.sub.1 and R.sub.2 is a substituted or unsubstituted heteroaryl group and the other is a substituted or unsubstituted aryl group, R.sub.3 is hydrogen or lower alkyl, n is 0, 1 or 2 and R.sub.4 is a substituted or unsubstituted aliphatic hydrocarbon radical and their pharmaceutically usable salts exhibit anti-inflammatory, anti-nociceptive and/or antithrombotic activity.
摘要翻译：式（I）的新型取代的2-巯基咪唑，其中基团R 1和R 2中的至少一个是取代或未取代的杂芳基，另一个是取代或未取代的芳基，R 3是氢或低级烷基， n为0,1或2，R4为取代或未取代的脂族烃基，其药学上可用的盐显示抗炎，抗伤害感受和/或抗血栓形成活性。

5. 发明授权

US4263455A Novel 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophenones 失效
标题翻译：新的2-磺酰基 - （或 - 亚磺酰基）-2'-氨基苯乙酮
公开(公告)号：US4263455A
公开(公告)日：1981-04-21
申请号：US79605
申请日：1979-09-27
申请人： Pier G. Ferrini , Richard Goschke , Alfred Sallmann , Alberto Rossi
发明人： Pier G. Ferrini , Richard Goschke , Alfred Sallmann , Alberto Rossi
IPC分类号： A61K31/135 , A61K31/18 , A61K31/255 , A61K31/44 , A61P7/02 , A61P29/00 , C07C67/00 , C07C313/00 , C07C315/04 , C07C317/28 , C07D213/70 , C07D213/71 , C07C87/60 , C07C97/10
CPC分类号： A61K31/255
摘要： The invention relates to novel ortho-aminoacetophenones of the formula I ##STR1## and their tautomers, in which Z is hydrogen, halogen, lower alkyl, cycloalkyl, lower alkoxy, trifluoromethyl, nitro or substituted or unsubstituted sulphamoyl, m is 1 or 2, R is hydrogen, aryl or lower alkyl, R.sub.1 is hydrogen or lower alkyl, R.sub.2 is lower alkyl, cycloalkyl, aryl, cycloalkyl-lower alkyl, aryl-lower alkyl or substituted or unsubstituted pyridyl, R.sub.3 is hydrogen or lower alkyl and n is 1 or 2, with the exception of 2'-[N-(p-methoxyphenyl)-amino]-2-(methyl-sulphinyl)-acetophenone, 2'-amino-2-(methylsulphinyl)-acetophenone, 2'-amino-5'-chloro-2-(methylsulphinyl)-acetophenone, 2'-methylamino-2-(methylsulphinyl)-acetophenone, 2'-amino-5'-methyl-2-(methylsulphinyl)-acetophenone, 2'-amino-4'-chloro-2-(methylsulphinyl)-acetophenone, 2'-amino-6'-chloro-2-(methylsulphinyl)-acetophenone, 2'-amino-5',6'-dimethoxy-2-(methylsulphinyl)-acetophenone and 2'-amino-4',5'-dimethoxy-2-(methylsulphinyl)-acetophenone, and also to their salts.These compounds have a fibrinolytic and an antiinflammatory action.
摘要翻译：本发明涉及式I（I）的新型邻氨基苯乙酮及其互变异构体，其中Z为氢，卤素，低级烷基，环烷基，低级烷氧基，三氟甲基，硝基或取代或未取代的氨磺酰基，m为1 或2，R是氢，芳基或低级烷基，R1是氢或低级烷基，R2是低级烷基，环烷基，芳基，环烷基 - 低级烷基，芳基 - 低级烷基或取代或未取代的吡啶基，R3是氢或低级烷基， n为1或2，2' - [N-（对甲氧基苯基） - 氨基] -2-（甲基 - 亚磺酰基） - 苯乙酮，2'-氨基-2-（甲基亚磺酰基） - 苯乙酮，2' - 氨基-5'-氯-2-（甲基亚磺酰基） - 苯乙酮，2'-甲基氨基-2-（甲基亚磺酰基） - 苯乙酮，2'-氨基-5'-甲基-2-（甲基亚磺酰基） - 苯乙酮，氨基-4'-氯-2-（甲基亚磺酰基） - 苯乙酮，2'-氨基-6'-氯-2-（甲基亚磺酰基） - 苯乙酮，2'-氨基-5'，6'-二甲氧基-2-（甲基亚磺酰基） - 苯乙酮和2'-氨基-4'，5'-二甲氧基-2-（甲基亚磺酰基） - 苯乙酮 ne，以及它们的盐。这些化合物具有纤维蛋白溶解和抗炎作用。

6. 发明授权

US4187234A Alkanecarboxylic acid compounds which have benzofuranyl or benzothienyl substituents 失效
标题翻译：具有苯并呋喃基或苯并噻吩基取代基的烷烃羧酸化合物
公开(公告)号：US4187234A
公开(公告)日：1980-02-05
申请号：US931055
申请日：1978-08-04
申请人： Raymond Bernasconi , Pier G. Ferrini
发明人： Raymond Bernasconi , Pier G. Ferrini
IPC分类号： C07D307/80 , C07D333/56
CPC分类号： C07C323/00 , C07C45/71 , C07D307/80 , C07D333/56
摘要： Compounds of the formula ##STR1## in which Ar represents optionally substituted 1,2-phenylene, X.sub.1 represents oxygen or sulphur, R.sub.1 represents the radical of the formula ##STR2## in which Ph represents optionally substituted phenylene, X.sub.2 represents oxygen or sulphur, R.sub.3 and R.sub.4 independently of one another denote hydrogen or alkyl and R.sub.5 represents optionally etherified hydroxyl or optionally substituted amino and in which R.sub.2 denotes hydrogen, lower alkyl or the radical of the formula Ia and one of the groups R.sub.1 and R.sub.2 takes up the 2-position and the other takes up the 3-position, and salts of such compounds having salt-forming groups, e.g. ethyl 2-[4-(2-benzofuranyl)-phenoxy]-heptanoate. These compounds may be used as fibrinolytic and thrombolytic agents.
摘要翻译：式（Ⅰ）化合物其中Ar表示任意取代的1,2-亚苯基，X1表示氧或硫，R1表示式（Ia）中的基团，其中Ph表示任意取代的亚苯基，X2 R 3和R 4彼此独立地表示氢或烷基，R 5表示任选醚化的羟基或任选取代的氨基，其中R 2表示氢，低级烷基或式Ia基团和基团R 1和R 2之一占据2-位，另一个占据3位，并且这些具有成盐基团的化合物的盐例如 2- [4-（2-苯并呋喃基） - 苯氧基] - 庚酸乙酯。这些化合物可以用作纤维蛋白溶解和溶栓剂。

7. 发明授权

US4308277A 2,4,5-Trisubstituted imidazolines and pharmaceutical compositions containing same 失效
标题翻译： 2,4,5-三取代咪唑啉和含有它们的药物组合物
公开(公告)号：US4308277A
公开(公告)日：1981-12-29
申请号：US061792
申请日：1979-07-30
申请人： Pier G. Ferrini , Richard Goschke
发明人： Pier G. Ferrini , Richard Goschke
IPC分类号： A61K31/415 , A61K31/4166 , A61P29/00 , C07D213/50 , C07D213/53 , C07D233/22 , C07D233/42 , C07D233/30 , C07D401/04
CPC分类号： C07D213/53 , A61K31/415 , C07D213/50 , C07D233/22 , C07D233/42
摘要： Compounds of the formula ##STR1## in which R.sub.1 and R.sub.2 independently of one another are substituted or unsubstituted aryl or hetero-aryl groups, R.sub.3 is hydrogen or lower alkyl and R.sub.4 is a substituted or unsubstituted aliphatic hydrocarbon radical, and their pharmaceutically usable salts. These compounds possess immunoregulatory, antithrombotic and antiinflammatory properties and can be used as active ingredients in medicaments. They are prepared, for example, by reacting compounds of the formulae ##STR2## in which one of the radicals X and Y is mercapto, which can be in the form of a salt, and the other is a radical replaceable by etherified mercapto, with one another.
摘要翻译：其中R 1和R 2彼此独立地是取代或未取代的芳基或杂芳基的式（I）化合物，R 3是氢或低级烷基，R 4是取代或未取代的脂族烃基，可用盐。这些化合物具有免疫调节，抗血栓和抗炎特性，可用作药物中的有效成分。它们例如通过使基团X和Y中的一个为巯基的式（IMAGE）化合物，其可以是盐的形式，另一种是可以被醚化的巯基取代的基团，与另一个。

8. 发明授权

US4608382A 2-(Sulphinyl and sulfonyl)-4(5)-phenyl-5(4)-(3'-pyridyl)-imidazols 失效
标题翻译： 2-（亚磺酰基和磺酰基）-4（5） - 苯基-5（4） - （3'-吡啶基） - 咪唑
公开(公告)号：US4608382A
公开(公告)日：1986-08-26
申请号：US588025
申请日：1984-03-09
申请人： Pier G. Ferrini , Richard Goschke
发明人： Pier G. Ferrini , Richard Goschke
IPC分类号： C07D409/12 , A61K31/415 , A61K31/4164 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61P7/02 , A61P29/00 , A61P29/02 , C07D213/50 , C07D213/53 , C07D233/84 , C07D401/04 , C07D405/04 , C07D409/04 , C07D409/14
CPC分类号： C07D213/53 , C07D213/50
摘要： Novel substituted 2-mercaptoimidazoles of the formula ##STR1## in which at least one of the radicals R.sub.1 and R.sub.2 is a substituted or unsubstituted heteroaryl group and the other is a substituted or unsubstituted aryl group, R.sub.3 is hydrogen or lower alkyl, n is 0, 1 or 2 and R.sub.4 is a substituted or unsubstituted aliphatic hydrocarbon radical and their pharmaceutically usable salts exhibit anti-inflammatory, anti-nociceptive and/or antithrombotic activity.
摘要翻译：式（I）的新型取代的2-巯基咪唑，其中基团R 1和R 2中的至少一个是取代或未取代的杂芳基，另一个是取代或未取代的芳基，R 3是氢或低级烷基， n为0,1或2，R4为取代或未取代的脂族烃基，其药学上可用的盐显示抗炎，抗伤害感受和/或抗血栓形成活性。

9. 发明授权

US4451471A Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same 失效
公开(公告)号：US4451471A
公开(公告)日：1984-05-29
申请号：US355989
申请日：1982-03-08
申请人： Pier G. Ferrini , Richard Goschke
发明人： Pier G. Ferrini , Richard Goschke
IPC分类号： C07D277/20 , A61K31/425 , A61K31/426 , A61K31/44 , A61P29/00 , C07D213/50 , C07D277/24 , C07D277/30 , C07D277/32 , C07D277/36 , C07D417/04 , C07D417/12 , C07D513/04
CPC分类号： C07D277/32 , C07D213/50 , C07D277/24 , C07D277/30 , C07D277/36 , C07D513/04
摘要： 2,4,5-Trisubstituted thiazoles of the formula ##STR1## in which each of R.sub.1 and R.sub.2, independently of the other, represents an aryl or optionally N-oxidized heteroaryl radical each of which is unsubstituted or substituted by aliphatic hydrocarbon radicals, free, etherified or esterified hydroxy, etherified optionally S-oxidized mercapto, aliphatically substituted amino and/or trifluoromethyl,X represents thio,n represents 0, 1, or 2, andR.sub.3 represents an aliphatic hydrocarbon radical that is unsubstituted or substituted by etherified or esterified hydroxy, etherified optionally S-oxidized mercapto and/or, in a position higher than the .alpha.-position, by oxo and/or hydroxy and optionally contains, in addition to terminally bonded hydroxy, sulpho that is present in salt form, or represents an araliphatic hydrocarbon radical that is unsubstituted or substituted in the aryl moiety as indicated for R.sub.1 and R.sub.2, or represents a cycloaliphatic or cycloaliphatic-aliphatic hydrocarbon radical that is unsubstituted or substituted in a position higher than the .alpha.-position by free, etherified or esterified hydroxy, or represents a group of the formula ##STR2## in which m represents, 0, 1 or 2, R.sub.4 represents an aliphatic hydrocarbon radical that is unsubstituted or substituted by etherified or esterified hydroxy, optionally S-oxidized etherified mercapto or, in a position higher than the .alpha.-position and lower than the .omega.-position, by oxo and/or hydroxy and that is optionally interrupted by oxa or thia, which may also be S-oxidized, or, if n and m represent O, represents a direct bond, and R.sub.1 ' and R.sub.2 ' have one of the meanings given for R.sub.1 and R.sub.2,and pharmaceutically acceptable salts thereof are suitable for combating rheumatic disorders, preferably as active ingredients in anti-rheumatic medicaments. The invention relates to medicaments of this type and to non-chemical processes for their manufacture, and also to novel compounds of the formula I and to processes for their manufacture.

10. 发明授权

US4192873A Anti-inflammatory 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophenones 失效
标题翻译：抗炎2-磺酰基 - （或 - 亚磺酰基）-2'-氨基苯乙酮
公开(公告)号：US4192873A
公开(公告)日：1980-03-11
申请号：US846305
申请日：1977-10-28
申请人： Pier G. Ferrini , Richard Goschke , Alfred Sallmann , Alberto Rossi
发明人： Pier G. Ferrini , Richard Goschke , Alfred Sallmann , Alberto Rossi
IPC分类号： A61K31/135 , A61K31/18 , A61K31/255 , A61K31/44 , A61P7/02 , A61P29/00 , C07C67/00 , C07C313/00 , C07C315/04 , C07C317/28 , C07D213/70 , C07D213/71 , C07C87/50 , C07C87/60
CPC分类号： A61K31/255
摘要： The invention relates to novel ortho-aminoacetophenones of the formula I ##STR1## and their tautomers, in which Z is hydrogen, halogen, lower alkyl, cycloalkyl, lower alkoxy, trifluoromethyl, nitro or substituted or unsubstituted sulphamoyl, m is 1 or 2, R is hydrogen, aryl or lower alkyl, R.sub.1 is hydrogen or lower alkyl, R.sub.2 is lower alkyl, cycloalkyl, aryl, cycloalkyl-lower alkyl, aryl-lower alkyl or substituted or unsubstituted pyridyl, R.sub.3 is hydrogen or lower alkyl and n is 1 or 2, with the exception of 2'-[N-(p-methoxyphenyl)-amino]-2-(methyl-sulphinyl)-acetophenone, 2'-amino-2-(methylsulphinyl)-acetophenone, 2'-amino-5'-chloro-2-(methylsulphinyl)-acetophenone, 2'-methylamino-2-(methylsulphinyl)-acetophenone, 2'-amino-5'-methyl-2-(methylsulphinyl)-acetophenone, 2'-amino-4'-chloro-2-(methylsulphinyl)-acetophenone, 2'-amino-6'-chloro-2-(methylsulphinyl)-acetophenone, 2'-amino-5',6'-dimethoxy-2-(methylsulphinyl)-acetophenone and 2'-amino-4',5'-dimethoxy-2-(methylsulphinyl)-acetophenone, and also to their salts.These compounds have a fibrinolytic and an antiinflammatory action.
摘要翻译：本发明涉及式I（I）的新型邻氨基苯乙酮及其互变异构体，其中Z为氢，卤素，低级烷基，环烷基，低级烷氧基，三氟甲基，硝基或取代或未取代的氨磺酰基，m为1 或2，R是氢，芳基或低级烷基，R1是氢或低级烷基，R2是低级烷基，环烷基，芳基，环烷基 - 低级烷基，芳基 - 低级烷基或取代或未取代的吡啶基，R3是氢或低级烷基， n为1或2，2' - [N-（对甲氧基苯基） - 氨基] -2-（甲基 - 亚磺酰基） - 苯乙酮，2'-氨基-2-（甲基亚磺酰基） - 苯乙酮，2' - 氨基-5'-氯-2-（甲基亚磺酰基） - 苯乙酮，2'-甲基氨基-2-（甲基亚磺酰基） - 苯乙酮，2'-氨基-5'-甲基-2-（甲基亚磺酰基） - 苯乙酮，氨基-4'-氯-2-（甲基亚磺酰基） - 苯乙酮，2'-氨基-6'-氯-2-（甲基亚磺酰基） - 苯乙酮，2'-氨基-5'，6'-二甲氧基-2-（甲基亚磺酰基） - 苯乙酮和2'-氨基-4'，5'-二甲氧基-2-（甲基亚磺酰基） - 苯乙酮 ne，以及它们的盐。这些化合物具有纤维蛋白溶解和抗炎作用。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式