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1. 发明授权

US4263455A Novel 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophenones 失效
标题翻译：新的2-磺酰基 - （或 - 亚磺酰基）-2'-氨基苯乙酮
公开(公告)号：US4263455A
公开(公告)日：1981-04-21
申请号：US79605
申请日：1979-09-27
申请人： Pier G. Ferrini , Richard Goschke , Alfred Sallmann , Alberto Rossi
发明人： Pier G. Ferrini , Richard Goschke , Alfred Sallmann , Alberto Rossi
IPC分类号： A61K31/135 , A61K31/18 , A61K31/255 , A61K31/44 , A61P7/02 , A61P29/00 , C07C67/00 , C07C313/00 , C07C315/04 , C07C317/28 , C07D213/70 , C07D213/71 , C07C87/60 , C07C97/10
CPC分类号： A61K31/255
摘要： The invention relates to novel ortho-aminoacetophenones of the formula I ##STR1## and their tautomers, in which Z is hydrogen, halogen, lower alkyl, cycloalkyl, lower alkoxy, trifluoromethyl, nitro or substituted or unsubstituted sulphamoyl, m is 1 or 2, R is hydrogen, aryl or lower alkyl, R.sub.1 is hydrogen or lower alkyl, R.sub.2 is lower alkyl, cycloalkyl, aryl, cycloalkyl-lower alkyl, aryl-lower alkyl or substituted or unsubstituted pyridyl, R.sub.3 is hydrogen or lower alkyl and n is 1 or 2, with the exception of 2'-[N-(p-methoxyphenyl)-amino]-2-(methyl-sulphinyl)-acetophenone, 2'-amino-2-(methylsulphinyl)-acetophenone, 2'-amino-5'-chloro-2-(methylsulphinyl)-acetophenone, 2'-methylamino-2-(methylsulphinyl)-acetophenone, 2'-amino-5'-methyl-2-(methylsulphinyl)-acetophenone, 2'-amino-4'-chloro-2-(methylsulphinyl)-acetophenone, 2'-amino-6'-chloro-2-(methylsulphinyl)-acetophenone, 2'-amino-5',6'-dimethoxy-2-(methylsulphinyl)-acetophenone and 2'-amino-4',5'-dimethoxy-2-(methylsulphinyl)-acetophenone, and also to their salts.These compounds have a fibrinolytic and an antiinflammatory action.
摘要翻译：本发明涉及式I（I）的新型邻氨基苯乙酮及其互变异构体，其中Z为氢，卤素，低级烷基，环烷基，低级烷氧基，三氟甲基，硝基或取代或未取代的氨磺酰基，m为1 或2，R是氢，芳基或低级烷基，R1是氢或低级烷基，R2是低级烷基，环烷基，芳基，环烷基 - 低级烷基，芳基 - 低级烷基或取代或未取代的吡啶基，R3是氢或低级烷基， n为1或2，2' - [N-（对甲氧基苯基） - 氨基] -2-（甲基 - 亚磺酰基） - 苯乙酮，2'-氨基-2-（甲基亚磺酰基） - 苯乙酮，2' - 氨基-5'-氯-2-（甲基亚磺酰基） - 苯乙酮，2'-甲基氨基-2-（甲基亚磺酰基） - 苯乙酮，2'-氨基-5'-甲基-2-（甲基亚磺酰基） - 苯乙酮，氨基-4'-氯-2-（甲基亚磺酰基） - 苯乙酮，2'-氨基-6'-氯-2-（甲基亚磺酰基） - 苯乙酮，2'-氨基-5'，6'-二甲氧基-2-（甲基亚磺酰基） - 苯乙酮和2'-氨基-4'，5'-二甲氧基-2-（甲基亚磺酰基） - 苯乙酮 ne，以及它们的盐。这些化合物具有纤维蛋白溶解和抗炎作用。

2. 发明授权

US4192873A Anti-inflammatory 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophenones 失效
标题翻译：抗炎2-磺酰基 - （或 - 亚磺酰基）-2'-氨基苯乙酮
公开(公告)号：US4192873A
公开(公告)日：1980-03-11
申请号：US846305
申请日：1977-10-28
申请人： Pier G. Ferrini , Richard Goschke , Alfred Sallmann , Alberto Rossi
发明人： Pier G. Ferrini , Richard Goschke , Alfred Sallmann , Alberto Rossi
IPC分类号： A61K31/135 , A61K31/18 , A61K31/255 , A61K31/44 , A61P7/02 , A61P29/00 , C07C67/00 , C07C313/00 , C07C315/04 , C07C317/28 , C07D213/70 , C07D213/71 , C07C87/50 , C07C87/60
CPC分类号： A61K31/255
摘要： The invention relates to novel ortho-aminoacetophenones of the formula I ##STR1## and their tautomers, in which Z is hydrogen, halogen, lower alkyl, cycloalkyl, lower alkoxy, trifluoromethyl, nitro or substituted or unsubstituted sulphamoyl, m is 1 or 2, R is hydrogen, aryl or lower alkyl, R.sub.1 is hydrogen or lower alkyl, R.sub.2 is lower alkyl, cycloalkyl, aryl, cycloalkyl-lower alkyl, aryl-lower alkyl or substituted or unsubstituted pyridyl, R.sub.3 is hydrogen or lower alkyl and n is 1 or 2, with the exception of 2'-[N-(p-methoxyphenyl)-amino]-2-(methyl-sulphinyl)-acetophenone, 2'-amino-2-(methylsulphinyl)-acetophenone, 2'-amino-5'-chloro-2-(methylsulphinyl)-acetophenone, 2'-methylamino-2-(methylsulphinyl)-acetophenone, 2'-amino-5'-methyl-2-(methylsulphinyl)-acetophenone, 2'-amino-4'-chloro-2-(methylsulphinyl)-acetophenone, 2'-amino-6'-chloro-2-(methylsulphinyl)-acetophenone, 2'-amino-5',6'-dimethoxy-2-(methylsulphinyl)-acetophenone and 2'-amino-4',5'-dimethoxy-2-(methylsulphinyl)-acetophenone, and also to their salts.These compounds have a fibrinolytic and an antiinflammatory action.
摘要翻译：本发明涉及式I（I）的新型邻氨基苯乙酮及其互变异构体，其中Z为氢，卤素，低级烷基，环烷基，低级烷氧基，三氟甲基，硝基或取代或未取代的氨磺酰基，m为1 或2，R是氢，芳基或低级烷基，R1是氢或低级烷基，R2是低级烷基，环烷基，芳基，环烷基 - 低级烷基，芳基 - 低级烷基或取代或未取代的吡啶基，R3是氢或低级烷基， n为1或2，2' - [N-（对甲氧基苯基） - 氨基] -2-（甲基 - 亚磺酰基） - 苯乙酮，2'-氨基-2-（甲基亚磺酰基） - 苯乙酮，2' - 氨基-5'-氯-2-（甲基亚磺酰基） - 苯乙酮，2'-甲基氨基-2-（甲基亚磺酰基） - 苯乙酮，2'-氨基-5'-甲基-2-（甲基亚磺酰基） - 苯乙酮，氨基-4'-氯-2-（甲基亚磺酰基） - 苯乙酮，2'-氨基-6'-氯-2-（甲基亚磺酰基） - 苯乙酮，2'-氨基-5'，6'-二甲氧基-2-（甲基亚磺酰基） - 苯乙酮和2'-氨基-4'，5'-二甲氧基-2-（甲基亚磺酰基） - 苯乙酮 ne，以及它们的盐。这些化合物具有纤维蛋白溶解和抗炎作用。

3. 发明授权

US4476132A Acylquinolinone derivatives, and antiallergic preparations and methods of inhibiting allergic reactions using them 失效
标题翻译：酰基喹啉酮衍生物和抗过敏制剂以及使用它们抑制过敏反应的方法
公开(公告)号：US4476132A
公开(公告)日：1984-10-09
申请号：US360016
申请日：1982-03-19
申请人： Richard Goschke , Pier G. Ferrini , Alfred Sallmann
发明人： Richard Goschke , Pier G. Ferrini , Alfred Sallmann
IPC分类号： A61K31/47 , A61P37/08 , C07D209/34 , C07D209/38 , C07D215/48 , C07D215/56 , C07D265/26 , C07D215/22
CPC分类号： C07D265/26 , C07D209/34 , C07D209/38 , C07D215/48 , C07D215/56
摘要： Quinolinone derivatives of the formula (I) ##STR1## in which X represents oxy or a direct bond, R.sub.1 represents an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclic-aliphatic radical or hydrogen, Ph represents an optionally additionally substituted 1,2-phenylene radical containing the group R.sub.1 --X--C(O)--, and one of the radicals R.sub.2 and R.sub.3 represents an optionally esterified or amidated carboxy group R.sub.4 and the other represents hydrogen or an aliphatic radical or, in the case of a radical R.sub.3, hydroxy, and in which either R.sub.A and R.sub.B together represent oxo, R.sub.C and R.sub.D together represent an additional bond, or, when R.sub.2 represents a radical R.sub.4, R.sub.C is hydrogen and R.sub.3 and R.sub.D together represent oxo, and R.sub.E represents a radical R.sub.5 which represents hydrogen or an aliphatic, cycloaliphatic, araliphatic heterocyclic-aliphatic radical, or R.sub.A represents an optionally etherified hydroxy group and R.sub.B together with R.sub.C and also R.sub.D together with R.sub.E represent an additional bond in each case, or, when R.sub.2 represents a radical R.sub.4, R.sub.B and R.sub.C together represent an additional bond and R.sub.3 and R.sub.D together represent oxo and R.sub.E represents a radical R.sub.5, and their salts, have antiallergic properties. They are manufactured, for example, by subjecting a compound of the formula (IV) ##STR2## in which Z represents a removable radical, or a tautomer and/or salt thereof, to intramolecular cyclisation.
摘要翻译：式（I）的喹啉酮衍生物其中X表示氧基或直接键，R1表示脂族，脂环族，芳族，芳脂族，杂环或杂环 - 脂族基团或氢，Ph表示任选另外取代的含有R1-XC（O） - 基团的1,2-亚苯基，其中一个基团R 2和R 3表示任选酯化或酰胺化的羧基R 4，另一个表示氢或脂族基，或者在基团R3，羟基，其中RA和RB一起代表氧代，RC和RD一起表示另外的键，或者当R 2表示基团R 4时，RC是氢，R 3和R 4一起代表氧代，并且RE表示基团代表氢或脂族，脂环族，脂环族杂环脂族基团的R 5或RA表示任选醚化的羟基，RB与RC一起，并且RD与RE一起代表另外的键或者当R 2代表基团R 4时，R b和R c一起代表另外的键，并且R 3和R 4一起代表氧代，RE代表基团R 5，并且它们的盐具有抗过敏性质。它们例如通过使其中Z表示可除去的基团或其互变异构体和/或其盐的式（IV）的化合物（IV）进行分子内环化来制备。

4. 发明授权

US4344957A Benz-acyl-benzimidazole derivatives and antiallergic compositions 失效
标题翻译：苯酰基 - 苯并咪唑衍生物和抗过敏组合物
公开(公告)号：US4344957A
公开(公告)日：1982-08-17
申请号：US107980
申请日：1979-12-28
申请人： Ernst Habicht , Pier G. Ferrini , Alfred Sallmann
发明人： Ernst Habicht , Pier G. Ferrini , Alfred Sallmann
IPC分类号： C07D235/06 , A61K31/415 , A61K31/4184 , A61P11/00 , A61P25/00 , A61P25/26 , A61P27/02 , A61P27/14 , A61P27/16 , A61P31/04 , A61P37/08 , C07C45/46 , C07C49/807 , C07C49/813 , C07D235/08 , C07D235/12 , C07D235/14 , C07D235/16 , C07D235/24 , C07D239/28 , C07D401/06 , C07D405/06 , C07D409/10
CPC分类号： C07D235/12 , C07C205/45 , C07C45/46 , C07C49/807 , C07C49/813
摘要： New heterocyclylcarboxylic acid derivatives which are acylated in the nucleus, especially benz-acyl-benzimidazole-2-carboxylic acid derivatives of the formula ##STR1## in which R is a free, esterified or amidated carboxyl group or a free, etherified or esterified hydroxymethyl group, R.sub.1 is an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclic-aliphatic radical, R.sub.2 is hydrogen or an aliphatic radical and Ph is a 1,2-phenylene group containing the radical R.sub.1 --C(.dbd.O)--, with the proviso that R.sub.1 contains at least 2 carbon atoms if Ph is otherwise unsubstituted, R.sub.2 is ethyl and R is acetoxymethyl, and salts of such compounds having salt-forming properties, are useful as anti-allergic agents.
摘要翻译：在核中酰化的新的杂环基羧酸衍生物，特别是式（I）的苯甲酰基 - 苯并咪唑-2-羧酸衍生物，其中R是游离的，酯化的或酰胺化的羧基或游离的醚化的或醚化的酯化的羟甲基，R 1是脂族，脂环族，芳族，芳脂族，杂环或杂环 - 脂族基团，R 2是氢或脂族基团，Ph是含有基团R 1 -C（= O） - 条件是如果Ph为未取代的，则R 1为至少2个碳原子，R 2为乙基且R为乙酰氧基甲基，并且具有成盐性的这些化合物的盐可用作抗过敏剂。

5. 发明授权

US4322431A Pharmaceutical preparations containing benzimidazole 2-derivatives 失效
标题翻译：含有苯并咪唑2-衍生物的药物制剂
公开(公告)号：US4322431A
公开(公告)日：1982-03-30
申请号：US116138
申请日：1980-01-28
申请人： Ernst Habicht , Pier G. Ferrini , Alfred Sallmann
发明人： Ernst Habicht , Pier G. Ferrini , Alfred Sallmann
IPC分类号： A61K31/415 , A61K31/4184 , A61P37/08 , C07D235/12
CPC分类号： C07D235/12
摘要： Benzimidazole 2-derivatives that are acylated in the nucleus and have the formula ##STR1## in which R.sub.1 represents an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclic-aliphatic radical,R.sub.2 represents hydrogen or an aliphatic radical, andPh represents a 1,2-phenylene group containing the radical R.sub.1 --C(.dbd.O)--,have anti-allergic properties, serve as medicaments and can be used as medicinal active substances in pharmaceutical preparations.
摘要翻译：在核中被酰化并具有式（I）的苯并咪唑2-衍生物，其中R 1表示脂族，脂环族，芳族，芳脂族，杂环或杂环 - 脂族基团，R 2表示氢或脂族基团，Ph 表示含有基团R 1 -C（= O） - 的1,2-亚苯基，具有抗过敏性，用作药物，可用作药物制剂中的药用活性物质。

6. 发明授权

US4323688A Benzimidazole-2-carboxylic acid and derivatives thereof 失效
标题翻译：苯并咪唑-2-羧酸及其衍生物
公开(公告)号：US4323688A
公开(公告)日：1982-04-06
申请号：US928632
申请日：1978-07-27
申请人： Ernst Habicht , Pier G. Ferrini , Alfred Sallmann
发明人： Ernst Habicht , Pier G. Ferrini , Alfred Sallmann
IPC分类号： A61K31/415 , A61K31/4184 , A61P37/08 , A61P43/00 , C07C45/46 , C07D235/12 , C07D235/16 , C07D235/24 , C07D235/32 , C07D405/02 , C07D235/04
CPC分类号： C07D235/24 , C07C205/45 , C07C45/46 , C07D235/12 , Y10S514/826 , Y10S514/861
摘要： Novel substituted heterocyclyl compounds of the formula ##STR1## in which R is a free, esterified or amidated carboxyl group or a free, etherified or esterified hydroxymethyl group, R.sub.1 is an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclic-aliphatic radical, R.sub.2 is hydrogen or an aliphatic radical and Ph is a 1,2-phenylene group containing the radical R.sub.1 -X, and X is lower alkylidene or a direct bond, and pharmaceutically usable salts of compounds of the formula I with salt-forming properties as medicaments, pharmaceutical preparations containing these, their use as medicaments and also novel compounds of the formula I and salts of compounds of the formula I with salt-forming properties, with the proviso that R.sub.1 -X-Ph differs from 1,2-phenylene substituted by methyl in the 4- and/or 5-position when R is carboxyl, carbamyl or hydroxymethyl and R.sub.2 is hydrogen, and pharmaceutically acceptable salts thereof are useful as anti-allergic agents.
摘要翻译：式（I）的新型取代的杂环基化合物，其中R是游离的，酯化的或酰胺化的羧基或游离的醚化或酯化的羟甲基，R1是脂族，脂环族，芳族，芳脂族，杂环或杂环 - 脂族基团，R 2为氢或脂族基团，Ph为含有基团R 1-X的1,2-亚苯基，X为低级亚烷基或直接键，以及式I化合物与盐 - 作为药物的形成性质，含有它们的药物制剂，它们作为药物的用途以及式I的新型化合物和具有成盐性质的式I化合物的盐，条件是R1-X-Ph与1,2不同当R是羧基，氨基甲酰基或羟甲基，R 2是氢时，其在4-和/或5-位被甲基取代，其药学上可接受的盐可用作抗过敏剂。

7. 发明授权

US4213993A Acyl-benzimidazole-2-methanol derivatives 失效
标题翻译：酰基 - 苯并咪唑-2-甲醇衍生物
公开(公告)号：US4213993A
公开(公告)日：1980-07-22
申请号：US962426
申请日：1978-11-20
申请人： Ernst Habicht , Pier G. Ferrini , Alfred Sallmann
发明人： Ernst Habicht , Pier G. Ferrini , Alfred Sallmann
IPC分类号： C07D235/06 , A61K31/415 , A61K31/4184 , A61P11/00 , A61P25/00 , A61P25/26 , A61P27/02 , A61P27/14 , A61P27/16 , A61P31/04 , A61P37/08 , C07C45/46 , C07C49/807 , C07C49/813 , C07D235/08 , C07D235/12 , C07D235/14 , C07D235/16 , C07D235/24 , C07D239/28 , C07D401/06 , C07D405/06 , C07D409/10
CPC分类号： C07D235/12 , C07C205/45 , C07C45/46 , C07C49/807 , C07C49/813
摘要： New heterocyclylcarboxylic acid derivatives which are acylated in the nucleus, especially benz-acyl-benzimidazole-2-carboxylic acid derivatives of the formula ##STR1## in which R is a free, esterified or amidated carboxyl group or a free, etherified or esterified hydroxymethyl group, R.sub.1 is an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclic-aliphatic radical, R.sub.2 is hydrogen or an aliphatic radical and Ph is a 1,2-phenylene group containing the radical R.sub.1 --C(.dbd.O)--, with the proviso that R.sub.1 contains at least 2 carbon atoms if Ph is otherwise unsubstituted, R.sub.2 is ethyl and R is acetoxymethyl, and salts of such compounds having salt-forming properties, are useful as anti-allergic agents.
摘要翻译：在核中酰化的新的杂环基羧酸衍生物，特别是式（I）的苯甲酰基 - 苯并咪唑-2-羧酸衍生物，其中R是游离的，酯化的或酰胺化的羧基或游离的醚化的或醚化的酯化的羟甲基，R 1是脂族，脂环族，芳族，芳脂族，杂环或杂环 - 脂族基团，R 2是氢或脂族基团，Ph是含有基团R 1 -C（= O） - 条件是如果Ph为未取代的，则R 1为至少2个碳原子，R 2为乙基且R为乙酰氧基甲基，并且具有成盐性的这些化合物的盐可用作抗过敏剂。

8. 发明授权

US4141982A Benz-acylbenzimidazole-2-carboxylic acid derivatives 失效
标题翻译：苯甲酰基苯并咪唑-2-羧酸衍生物
公开(公告)号：US4141982A
公开(公告)日：1979-02-27
申请号：US825630
申请日：1977-08-18
申请人： Ernst Habicht , Pier G. Ferrini , Alfred Sallmann
发明人： Ernst Habicht , Pier G. Ferrini , Alfred Sallmann
IPC分类号： C07D235/06 , A61K31/415 , A61K31/4184 , A61P11/00 , A61P25/00 , A61P25/26 , A61P27/02 , A61P27/14 , A61P27/16 , A61P31/04 , A61P37/08 , C07C45/46 , C07C49/807 , C07C49/813 , C07D235/08 , C07D235/12 , C07D235/14 , C07D235/16 , C07D235/24 , C07D239/28 , C07D401/06 , C07D405/06 , C07D409/10
CPC分类号： C07D235/12 , C07C205/45 , C07C45/46 , C07C49/807 , C07C49/813
摘要： New heterocyclylcarboxylic acid derivatives which are acylated in the nucleus, especially benz-acyl-benzimidazole-2-carboxylic acid derivatives of the formula ##STR1## in which R is a free, esterified or amidated carboxyl group or a free, etherified or esterified hydroxymethyl group, R.sub.1 is an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclic-aliphatic radical, R.sub.2 is hydrogen or an aliphatic radical and Ph is a 1,2-phenylene group containing the radical R.sub.1 --C(.dbd.O)--, with the proviso that R.sub.1 contains at least 2 carbon atoms if Ph is otherwise unsubstituted, R.sub.2 is ethyl and R is acetoxymethyl, and salts of such compounds having salt-forming properties, are useful as anti-allergic agents.
摘要翻译：在核中酰化的新的杂环基羧酸衍生物，特别是式（I）的苯甲酰基 - 苯并咪唑-2-羧酸衍生物，其中R是游离的，酯化的或酰胺化的羧基或游离的醚化的或醚化的酯化的羟甲基，R 1是脂族，脂环族，芳族，芳脂族，杂环或杂环 - 脂族基团，R 2是氢或脂族基团，Ph是含有基团R 1 -C（= O） - 条件是如果Ph为未取代的，则R 1为至少2个碳原子，R 2为乙基且R为乙酰氧基甲基，并且具有成盐性的这些化合物的盐可用作抗过敏剂。

9. 发明授权

US4296128A Carboxylic acid hydrazides and processes for their manufacture 失效
标题翻译：羧酸酰肼及其制备方法
公开(公告)号：US4296128A
公开(公告)日：1981-10-20
申请号：US147458
申请日：1980-05-07
申请人： Alfred Sallmann , Richard Goschke
发明人： Alfred Sallmann , Richard Goschke
IPC分类号： A61K31/16 , A61K20060101 , A61K31/15 , A61K31/19 , A61K31/195 , A61K31/22 , A61K31/24 , A61P7/02 , C07C20060101 , C07C67/00 , C07C313/00 , C07C323/60 , C07C149/43
CPC分类号： C07C321/00
摘要： New carboxylic acid hydrazides of the formula ##STR1## in which R represents an optionally esterified carboxy group,and salts of the compound of the formula I, in which R represents carboxy, possess antithrombotic properties and can be used as medicinal active substances in pharmaceutical preparations.
摘要翻译：其中R表示任意酯化的羧基的式（I）的新的羧酸酰肼和其中R表示羧基的式I化合物的盐具有抗血栓性质并可用作药物活性物质在药物制剂中。

10. 发明授权

US6107343A Ophthalmic and aural compositions containing diclofenac potassium 失效
标题翻译：含双氯芬酸钾的眼科和听觉组合物
公开(公告)号：US6107343A
公开(公告)日：2000-08-22
申请号：US223198
申请日：1998-12-30
申请人： Alfred Sallmann , Gyorgy Lajos Kis , Wolfgang Blum , Alica Huxley
发明人： Alfred Sallmann , Gyorgy Lajos Kis , Wolfgang Blum , Alica Huxley
IPC分类号： A61K31/195 , A61K31/196
CPC分类号： A61K31/196 , Y10S514/912 , Y10S514/913
摘要： The present invention describes an ophthalmic composition comprising diclofenac potassium, the use of said composition as a medicament for treating inflammatory conditions of the eye, for treating glaucoma or for treating ear inflammatory and/or painful conditions (otitis); as well as the use of diclofenac potassium in the preparation of a pharmaceutical composition for treating any inflammatory condition of the eye, for treating glaucoma or for treating ear inflammatory and/or painful conditions (otitis).
摘要翻译：本发明描述了一种眼用组合物，其包含双氯芬酸钾，所述组合物用作治疗眼炎症状的药物，用于治疗青光眼或用于治疗耳炎症和/或疼痛状况（耳炎）的用途; 以及双氯芬酸钾在制备用于治疗眼睛的任何炎性疾病，治疗青光眼或治疗耳炎症和/或疼痛病症（耳炎）的药物组合物中的用途。

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