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1. 发明授权

US08097282B2 Methods of administering liquid droplet aerosols of nanoparticulate drugs 失效
标题翻译：施用纳米颗粒药物的液滴气溶胶的方法
公开(公告)号：US08097282B2
公开(公告)日：2012-01-17
申请号：US12081670
申请日：2008-04-18
申请人： Ray W. Wood , Lan DeCastro , H. William Bosch
发明人： Ray W. Wood , Lan DeCastro , H. William Bosch
IPC分类号： A61K9/04 , A61K9/14
CPC分类号： A61K9/0078 , A61K9/145 , A61K9/146 , A61K49/00 , A61K49/049 , B82Y5/00
摘要： There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble therapeutic or diagnostic agent particles having a surface modifier on the surface thereof. There is also disclosed a method for making the aerosol and methods for treatment and diagnosis using the aerosol.
摘要翻译：公开了一种包含纳米颗粒的水分散体的液滴的气溶胶，所述纳米颗粒包含在其表面上具有表面改性剂的不溶性治疗剂或诊断剂颗粒。还公开了一种制造气溶胶的方法以及使用该气溶胶的治疗和诊断方法。

2. 发明申请

US20090074873A1 Nanoparticulate beclomethasone dipropionate compositions 审中-公开
标题翻译：纳米颗粒倍氯米松二丙酸酯组合物
公开(公告)号：US20090074873A1
公开(公告)日：2009-03-19
申请号：US12292092
申请日：2008-11-12
申请人： Ray W. Wood , Lan DeCastro , H. William Bosch
发明人： Ray W. Wood , Lan DeCastro , H. William Bosch
IPC分类号： A61K9/14 , A61K31/566 , A61P11/00
CPC分类号： A61K9/0078 , A61K9/145 , A61K9/146 , A61K49/00 , A61K49/049 , B82Y5/00
摘要： There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble therapeutic or diagnostic agent particles having a surface modifier on the surface thereof. There is also disclosed a method for making the aerosol and methods for treatment and diagnosis using the aerosol.
摘要翻译：公开了一种包含纳米颗粒的水分散体的液滴的气溶胶，所述纳米颗粒包含在其表面上具有表面改性剂的不溶性治疗剂或诊断剂颗粒。还公开了一种制造气溶胶的方法以及使用该气溶胶的治疗和诊断方法。

3. 发明申请

US20080274044A1 Methods of administering liquid droplet aerosols of nanoparticulate drugs 失效
标题翻译：施用纳米颗粒药物的液滴气溶胶的方法
公开(公告)号：US20080274044A1
公开(公告)日：2008-11-06
申请号：US12081670
申请日：2008-04-18
申请人： Ray W. Wood , Lan DeCastro , H. William Bosch
发明人： Ray W. Wood , Lan DeCastro , H. William Bosch
IPC分类号： A61K51/12 , A61K9/12
CPC分类号： A61K9/0078 , A61K9/145 , A61K9/146 , A61K49/00 , A61K49/049 , B82Y5/00
摘要： There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble therapeutic or diagnostic agent particles having a surface modifier on the surface thereof. There is also disclosed a method for making the aerosol and methods for treatment and diagnosis using the aerosol.
摘要翻译：公开了一种包含纳米颗粒的水分散体的液滴的气溶胶，所述纳米颗粒包含在其表面上具有表面改性剂的不溶性治疗剂或诊断剂颗粒。还公开了一种制造气溶胶的方法以及使用该气溶胶的治疗和诊断方法。

4. 发明授权

US06264922B1 Nebulized aerosols containing nanoparticle dispersions 失效
标题翻译：含有纳米颗粒分散体的雾化气溶胶
公开(公告)号：US06264922B1
公开(公告)日：2001-07-24
申请号：US08948216
申请日：1997-10-09
申请人： Ray W. Wood , Lan DeCastro , H. William Bosch
发明人： Ray W. Wood , Lan DeCastro , H. William Bosch
IPC分类号： A61L904
CPC分类号： A61K9/0078 , A61K9/145 , A61K9/146 , A61K49/00 , A61K49/049 , B82Y5/00
摘要： There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble therapeutic or diagnostic agent particles having a surface modifier on the surface thereof. There is also disclosed a method for making the aerosol and methods for treatment and diagnosis using the aerosol.
摘要翻译：公开了一种包含纳米颗粒的水分散体的液滴的气溶胶，所述纳米颗粒包含在其表面上具有表面改性剂的不溶性治疗剂或诊断剂颗粒。还公开了一种制造气溶胶的方法以及使用该气溶胶的治疗和诊断方法。

5. 发明授权

US5747001A Aerosols containing beclomethazone nanoparticle dispersions 失效
标题翻译：含有倍氯米松纳米粒子分散体的气溶胶
公开(公告)号：US5747001A
公开(公告)日：1998-05-05
申请号：US393973
申请日：1995-02-24
申请人： Timothy S. Wiedmann , Ray W. Wood , Lan DeCastro
发明人： Timothy S. Wiedmann , Ray W. Wood , Lan DeCastro
IPC分类号： A61K9/12 , A61K9/00 , A61K9/14 , A61K9/51 , A61K9/72 , A61K31/57 , A61K47/30 , A61P11/02
CPC分类号： A61K9/0078 , A61K31/573 , A61K9/146
摘要： There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble beclomethazone particles having a surface modifier on the surface thereof. There is also disclosed a method for making the aerosol and methods for treatment using the aerosol.
摘要翻译：公开了一种包含纳米颗粒的水分散体的液滴的气溶胶，所述纳米颗粒包含在其表面上具有表面改性剂的不溶性倍氯米松颗粒。还公开了一种制造气溶胶的方法和使用该气溶胶的处理方法。

6. 发明申请

US20080171091A1 NANOPARTICULATE COMPOSITIONS OF IMMUNOSUPPRESSIVE AGENTS 审中-公开
标题翻译：免疫抑制剂的纳米颗粒组合物
公开(公告)号：US20080171091A1
公开(公告)日：2008-07-17
申请号：US12051448
申请日：2008-03-19
申请人： Ray W. Wood , Ian DeCastro , H. William Bosch
发明人： Ray W. Wood , Ian DeCastro , H. William Bosch
IPC分类号： A61K9/50 , A61K31/56
CPC分类号： A61K9/0078 , A61K9/145 , A61K9/146 , A61K49/00 , A61K49/049 , B82Y5/00
摘要： There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble therapeutic or diagnostic agent particles having a surface modifier on the surface thereof. There is also disclosed a method for making the aerosol and methods for treatment and diagnosis using the aerosol.
摘要翻译：公开了一种包含纳米颗粒的水分散体的液滴的气溶胶，所述纳米颗粒包含在其表面上具有表面改性剂的不溶性治疗剂或诊断剂颗粒。还公开了一种制造气溶胶的方法以及使用该气溶胶的治疗和诊断方法。

7. 发明授权

US5547471A In-line drug delivery device for use with a standard IV administration set and a method for delivery 失效
标题翻译：与标准IV给药组一起使用的在线药物递送装置和用于递送的方法
公开(公告)号：US5547471A
公开(公告)日：1996-08-20
申请号：US156347
申请日：1993-11-22
申请人： Stacey S. Thompson , James McShane , Joseph Wong , Ray W. Wood
发明人： Stacey S. Thompson , James McShane , Joseph Wong , Ray W. Wood
IPC分类号： A61J1/05 , A61J1/00 , A61J1/20 , A61M5/14 , A61M5/28 , A61M37/00 , A61M39/00
CPC分类号： A61M5/284 , A61J1/2089 , A61J1/2096 , A61M5/1409 , A61J1/10 , A61J1/1475 , A61J1/201 , A61J1/2013 , A61M5/282
摘要： A receptacle (500) is provided for coupling an adaptor (10) having a vial (54) including a beneficial agent to an IV administration set (526). In an embodiment, the receptacle (500) includes an injection site (512) for receiving a cannula (26) from the adaptor (10). A resilient divider (516) separates the receptacle (500) into two sections defined by an upper fitment (508) and a lower fitment (510). A container (520) holding a solution is in fluid communication with the receptacle (500) via an inlet (502). A through bore (518) allows the solution from the container (520) to pass through the resilient divider (516) when the adaptor (10) is removed from the receptacle (500).
摘要翻译：提供容器（500），用于将具有包含有益剂的小瓶（54）的适配器（10）连接到IV给药组（526）。在一个实施例中，容器（500）包括用于从适配器（10）接收套管（26）的注射部位（512）。弹性分隔器（516）将容器（500）分成由上配件（508）和下配件（510）限定的两个部分。保持溶液的容器（520）经由入口（502）与容器（500）流体连通。当适配器（10）从容器（500）移除时，通孔（518）允许来自容器（520）的溶液通过弹性分隔件（516）。

8. 发明授权

US5385547A Adaptor for drug delivery 失效
标题翻译：用于药物输送的适配器
公开(公告)号：US5385547A
公开(公告)日：1995-01-31
申请号：US978555
申请日：1992-11-19
申请人： Joseph Wong , Ray W. Wood , James McShane
发明人： Joseph Wong , Ray W. Wood , James McShane
IPC分类号： A61J1/05 , A61J1/00 , A61J1/20 , A61M5/14 , A61M5/28 , A61M37/00
CPC分类号： A61J1/2089 , A61J1/2096 , A61M5/1409 , A61M5/284 , A61J1/10 , A61J1/1475 , A61J1/201 , A61J1/2013 , A61M5/282
摘要： A drug delivery device is provided for coupling a first container including a beneficial agent to a second member. In an embodiment, the device includes a substantially hollow member having a cannula mounted within a wall that divides the substantially hollow member into a first and second section. The first section includes means for receiving at least a portion of a first container. The substantially hollow member includes a wall that defines an exterior of the first section that is substantially flexible. A number of different cannula and flow path structures within the hollow member are possible pursuant to the present invention.
摘要翻译：提供了一种药物输送装置，用于将包含有益剂的第一容器与第二构件相结合。在一个实施例中，该装置包括基本上中空的构件，其具有安装在壁内的套管，其将基本上中空的构件分成第一和第二区段。第一部分包括用于接收第一容器的至少一部分的装置。基本上中空的构件包括限定第一部分的外部基本上柔性的壁。根据本发明，中空构件内的多个不同的插管和流动路径结构是可能的。

9. 发明授权

US5226900A Cannula for use in drug delivery systems and systems including same 失效
标题翻译：用于药物输送系统和包括其的系统的插管
公开(公告)号：US5226900A
公开(公告)日：1993-07-13
申请号：US924262
申请日：1992-08-03
申请人： Joseph A. Bancsi , Charles Eller , Thomas A. Fowles , Brian J. Gorman , Terrance J. Hebron , Charles Jersild , Donald A. Jess , Joseph C. T. Wong , Ray W. Wood
发明人： Joseph A. Bancsi , Charles Eller , Thomas A. Fowles , Brian J. Gorman , Terrance J. Hebron , Charles Jersild , Donald A. Jess , Joseph C. T. Wong , Ray W. Wood
IPC分类号： A61J1/05 , A61J3/00 , A61M5/14 , A61M39/02
CPC分类号： A61M5/1409 , Y10S604/905
摘要： The present invention provides an improved cannula that can be used to reconstitute powdered drugs in a drug delivery system. Furthermore, the present invention provides a cannula and drug delivery system incorporating same. To this end, the present invention provides a cannula structure for use in a reconstitution device for reconstituting a powdered drug comprising a cannula having a first end and a second end, and defining a channel in an interior thereof between the first and second ends. The first end is closed and includes a member for piercing a septum. The cannula includes at least two slots providing fluid communication between the channel and an exterior of the cannula. The slots are located in juxtaposition to the first end and have a width, as measured along a length of the cannula, that is less than a length, as measured around the cannula. The slots also have a minimum projected area equal to or greater than the cross-sectional area of the channel.
摘要翻译：本发明提供了可用于在药物递送系统中重建粉末药物的改进的套管。此外，本发明提供了一种并入其的套管和药物输送系统。为此，本发明提供一种用于重建装置的插管结构，用于重构包含具有第一端和第二端的套管的粉末药物，并且在其内部在第一和第二端之间限定通道。第一端是封闭的并且包括用于刺穿隔膜的构件。套管包括至少两个槽，其在通道和套管的外部之间提供流体连通。狭槽位于与第一端并列的位置，并沿着插管的长度测量的宽度小于在套管周围测量的长度。槽也具有等于或大于通道的横截面面积的最小投影面积。

10. 发明授权

US5266492A Rapid method for determining critical vapor pressure 失效
标题翻译：用于确定临界蒸气压的快速方法
公开(公告)号：US5266492A
公开(公告)日：1993-11-30
申请号：US975641
申请日：1992-11-13
申请人： Ray W. Wood , Lee D. Hansen , John W. Crawford
发明人： Ray W. Wood , Lee D. Hansen , John W. Crawford
IPC分类号： G01N25/48 , G01N25/56 , G01N7/16 , G01N25/20
CPC分类号： G01N25/56 , G01N25/4846
摘要： A method of determining the critical vapor pressure of a hygroscopic material, such as a drug. A drug sample is placed in a substantially isothermal environment. A vapor, such as water vapor, at a given pressure is then placed in the ambient air over the drug. The rate of heat production from this sample at the given water vapor pressure, or the humidity of the air above the sample, is then measured. The water vapor pressure over the drug is gradually increased. Simultaneously, the rate of increase in heat production from the drug sample, or the rate of change of the relative humidity of the air above the drug sample, is measured. A marked increase in the rate of heat production generated by the drug, or a marked change in the relative humidity of the air over the sample, signals the attainment of the critical water vapor pressure.
摘要翻译：确定吸湿材料如药物的临界蒸气压的方法。将药物样品置于基本上等温的环境中。然后在给定压力下的蒸气（例如水蒸汽）被放置在药物上的环境空气中。然后测量在给定水蒸气压下该样品的热量产生率或样品上方空气的湿度。药物上的水蒸汽压力逐渐增加。同时，测定药物样品的产生热量的增加率，或药物样品上方的空气相对湿度的变化率。药物产生的热量产生明显增加，或样品上空气的相对湿度发生明显变化，表明达到临界水汽压力。

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