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1. 发明申请

US20150232938A1 METHODS FOR INCREASING FETAL FRACTION IN MATERNAL BLOOD 审中-公开
标题翻译：用于增加母体中的胎儿分数的方法
公开(公告)号：US20150232938A1
公开(公告)日：2015-08-20
申请号：US14704314
申请日：2015-05-05
申请人： Ravi Mhatre , Johan Baner , Bernhard Zimmermann , Matthew Micah Hill , Zachary Demko
发明人： Ravi Mhatre , Johan Baner , Bernhard Zimmermann , Matthew Micah Hill , Zachary Demko
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A23D9/00 , C12Q2600/118 , C12Q2600/156
摘要： The invention provides methods of increasing the fetal fraction in maternal blood and plasma. This increase in fetal fraction improves the accuracy and decreases the “no call” rate for prenatal testing that measures fetal DNA in maternal blood.
摘要翻译：本发明提供了增加母体血液和血浆中胎儿分数的方法。胎儿分数的这种增加提高了准确性，降低了测量母体血液胎儿DNA的产前测试的“无呼叫”率。

2. 发明申请

US20140065621A1 METHODS FOR INCREASING FETAL FRACTION IN MATERNAL BLOOD 审中-公开
标题翻译：用于增加母体中的胎儿分数的方法
公开(公告)号：US20140065621A1
公开(公告)日：2014-03-06
申请号：US13793316
申请日：2013-03-11
申请人： Ravi Mhatre , Johan Baner , Bernhard Zimmermann , Matthew Hill , Zachary Demko
发明人： Ravi Mhatre , Johan Baner , Bernhard Zimmermann , Matthew Hill , Zachary Demko
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A23D9/00 , C12Q2600/118 , C12Q2600/156
摘要： The invention provides methods of increasing the fetal fraction in maternal blood and plasma. This increase in fetal fraction improves the accuracy and decreases the “no call” rate for prenatal testing that measures fetal DNA in maternal blood.
摘要翻译：本发明提供了增加母体血液和血浆中胎儿分数的方法。胎儿分数的这种增加提高了准确性，降低了测量母体血液胎儿DNA的产前测试的“无呼叫”率。

3. 发明申请

US20110288780A1 Methods for Non-Invasive Prenatal Ploidy Calling 有权
标题翻译：非侵入性产前倍性调用方法
公开(公告)号：US20110288780A1
公开(公告)日：2011-11-24
申请号：US13110685
申请日：2011-05-18
申请人： Matthew Rabinowitz , George Gemelos , Milena Banjevic , Allison Ryan , Zachary Demko , Matthew Hill , Bernhard Zimmermann , Johan Baner
发明人： Matthew Rabinowitz , George Gemelos , Milena Banjevic , Allison Ryan , Zachary Demko , Matthew Hill , Bernhard Zimmermann , Johan Baner
IPC分类号： G06F19/00 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q1/6869 , C12Q2537/161 , C12Q2537/165 , C12Q2600/112 , C12Q2600/156 , C12Q2600/16 , C12Q2600/172 , G06F19/00 , G06F19/12 , G06F19/18 , G06F19/22 , G06F19/34 , G16H50/30
摘要： Methods for non-invasive prenatal ploidy calling are disclosed herein. Methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a sample of DNA from the mother of the fetus and from the fetus, and from genotypic data from the mother and optionally also from the father are disclosed herein. The ploidy state is determined by using a joint distribution model to create a set of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. In an embodiment, the mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias.
摘要翻译：本文公开了非侵入性产前倍性呼叫的方法。本文公开了从胎儿母体和胎儿的DNA样本以及来自母亲和任选也来自父亲的基因型数据测量的基因型数据中确定妊娠胎儿染色体倍性状态的方法。通过使用联合分布模型来确定给定父母基因型数据的不同可能胎儿倍性状态的一组预期等位基因分布，并将预期等位基因分布与在混合样品中测量的测量等位基因分布的模式进行比较来确定倍性状态，并选择其预期等位基因分布模式与观察到的等位基因分布模式最接近的倍性状态。在一个实施方案中，DNA的混合样品可以以使等位基因偏倚最小化的方式优先富集在多个多态位点。

4. 发明授权

US10017812B2 Methods for non-invasive prenatal ploidy calling 有权
公开(公告)号：US10017812B2
公开(公告)日：2018-07-10
申请号：US13300235
申请日：2011-11-18
申请人： Matthew Rabinowitz , George Gemelos , Milena Banjevic , Allison Ryan , Zachary Demko , Matthew Hill , Bernhard Zimmermann , Johan Baner
发明人： Matthew Rabinowitz , George Gemelos , Milena Banjevic , Allison Ryan , Zachary Demko , Matthew Hill , Bernhard Zimmermann , Johan Baner
IPC分类号： G01N33/48 , G01N31/00 , G06G7/48 , G06G7/58 , C12Q1/6869 , C12Q1/6827 , G06F19/18 , C12Q1/6883 , C12Q1/6862 , G06F19/24
CPC分类号： C12Q1/6869 , C12Q1/6806 , C12Q1/6827 , C12Q1/686 , C12Q1/6862 , C12Q1/6874 , C12Q1/6883 , C12Q2600/156 , C12Q2600/16 , G06F19/34 , G16B20/00 , G16B40/00 , C12Q2537/161 , C12Q2537/165 , C12Q2537/143
摘要： The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.

5. 发明授权

US08825412B2 Methods for non-invasive prenatal ploidy calling 有权
标题翻译：非侵入性产前倍性调用方法
公开(公告)号：US08825412B2
公开(公告)日：2014-09-02
申请号：US13110685
申请日：2011-05-18
申请人： Matthew Rabinowitz , George Gemelos , Milena Banjevic , Allison Ryan , Zachary Demko , Matthew Hill , Bernhard Zimmermann , Johan Baner
发明人： Matthew Rabinowitz , George Gemelos , Milena Banjevic , Allison Ryan , Zachary Demko , Matthew Hill , Bernhard Zimmermann , Johan Baner
IPC分类号： G01N33/48 , G06F19/00 , G01N31/00 , G06G7/48 , G06G7/58 , G06F19/12 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q1/6869 , C12Q2537/161 , C12Q2537/165 , C12Q2600/112 , C12Q2600/156 , C12Q2600/16 , C12Q2600/172 , G06F19/00 , G06F19/12 , G06F19/18 , G06F19/22 , G06F19/34 , G16H50/30
摘要： Methods for non-invasive prenatal ploidy calling are disclosed herein. Methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a sample of DNA from the mother of the fetus and from the fetus, and from genotypic data from the mother and optionally also from the father are disclosed herein. The ploidy state is determined by using a joint distribution model to create a set of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. In an embodiment, the mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias.
摘要翻译：本文公开了非侵入性产前倍性呼叫的方法。本文公开了从胎儿母体和胎儿的DNA样本以及来自母亲和任选也来自父亲的基因型数据测量的基因型数据中确定妊娠胎儿染色体倍性状态的方法。通过使用联合分布模型来确定给定父母基因型数据的不同可能胎儿倍性状态的一组预期等位基因分布，并将预期等位基因分布与在混合样品中测量的测量等位基因分布的模式进行比较来确定倍性状态，并选择其预期等位基因分布模式与观察到的等位基因分布模式最接近的倍性状态。在一个实施方案中，DNA的混合样品可以以使等位基因偏倚最小化的方式优先富集在多个多态位点。

6. 发明申请

US20130178373A1 METHODS FOR NON-INVASIVE PRENATAL PLOIDY CALLING 有权
公开(公告)号：US20130178373A1
公开(公告)日：2013-07-11
申请号：US13791397
申请日：2013-03-08
申请人： Matthew Rabinowitz , George Gemelos , Milena Banjevic , Allison Ryan , Zachary Demko , Matthew Hill , Bernhard Zimmermann , Johan Baner
发明人： Matthew Rabinowitz , George Gemelos , Milena Banjevic , Allison Ryan , Zachary Demko , Matthew Hill , Bernhard Zimmermann , Johan Baner
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6806 , C12Q1/6827 , C12Q1/6862 , C12Q1/6874 , C12Q1/6883 , C12Q2600/156 , G06F19/18 , G06F19/24 , C12Q2537/161 , C12Q2537/165
摘要： The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.

7. 发明申请

US20100097694A1 METHOD AND ARRANGEMENT FOR CONTROLLED ACTUATION OF A MICROSCOPE, IN PARTICULAR OF A LASER SCANNING MICROSCOPE 有权
标题翻译：用于控制微波激光的方法和装置，特别是激光扫描显微镜
公开(公告)号：US20100097694A1
公开(公告)日：2010-04-22
申请号：US12578202
申请日：2009-10-13
申请人： Bernhard Zimmermann , Ralf Netz , Frank Hecht , Joerg-Michael Funk , Ralf Engelmann
发明人： Bernhard Zimmermann , Ralf Netz , Frank Hecht , Joerg-Michael Funk , Ralf Engelmann
IPC分类号： G02B21/06
CPC分类号： G02B21/06 , G02B21/00 , G02B21/0032 , G02B21/0076 , G02B27/0972
摘要： Method for actuation control of a microscope, in particular of a Laser Scanning Microscope, in which, at least one first illumination light, preferably moving at least in one direction, as well as at least one second illumination light moving at least in one direction, illuminate a sample through a beam combiner, a detection of the light coming from the sample takes place, whereby, at least one part of the illumination light is generated through the splitting of the light from a common illuminating unit, characterized in that, by means of a common control unit, a controlled splitting into the first and the second illumination light takes place, in which the intensity of the first illuminating light, specified by the user or specified automatically, is assigned a higher priority (is prioritized) compared to the specified value for the second illumination light, and an adjustment for the second illumination light takes place until a maximum value is obtained, which is determined by the value specified for the first illumination light.
摘要翻译：显微镜，特别是激光扫描显微镜的致动控制方法，其中至少一个至少在一个方向上移动的第一照明光以及至少沿一个方向移动的至少一个第二照明光，通过光束组合器照射样品，发生来自样品的光的检测，由此通过从公共照明单元分离光而产生照明光的至少一部分，其特征在于，通过装置发生公共控制单元的受控分割，进入第一和第二照明光，其中由用户指定或自动指定的第一照明光的强度被分配为比较高的优先级（优先化）对于第二照明光的指定值，并且进行第二照明光的调整，直到获得最大值，其由v 为第一个照明灯指定。

8. 发明申请

US20090046360A1 Raster scanning light microscope with line pattern scanning and applications 审中-公开
标题翻译：光栅扫描光学显微镜与线图扫描和应用
公开(公告)号：US20090046360A1
公开(公告)日：2009-02-19
申请号：US11987218
申请日：2007-11-28
申请人： Joerg-Michael Funk , Ralf Wolleschensky , Bernhard Zimmermann , Stefan Wilhelm , Ralf Engelmann
发明人： Joerg-Michael Funk , Ralf Wolleschensky , Bernhard Zimmermann , Stefan Wilhelm , Ralf Engelmann
IPC分类号： G02B21/06
CPC分类号： G02B21/0032
摘要： Raster scanning light microscope with line pattern scanning with at least one illumination module, in which the means to achieve a variable partition of the laser light into least two illumination channels are envisioned and joint illumination of a sample takes place at the same or at different areas of the sample.
摘要翻译：具有至少一个照明模块的线阵扫描的光栅扫描光学显微镜，其中实现将激光可变分割成至少两个照明通道的装置，并且在相同或不同的区域发生样品的联合照明的样品。

9. 发明授权

US07119898B2 Method for the detection of fluorescent light 有权
标题翻译：检测荧光灯的方法
公开(公告)号：US07119898B2
公开(公告)日：2006-10-10
申请号：US10763649
申请日：2004-01-23
申请人： Bernhard Zimmermann , Eva Simbuerger , Mary Dickinson
发明人： Bernhard Zimmermann , Eva Simbuerger , Mary Dickinson
IPC分类号： G01J3/30
CPC分类号： G02B21/008 , G01N21/64 , G01N2021/6419 , G01N2021/6441 , G02B21/0032 , G02B21/0076 , G02B21/0084 , G02B21/16
摘要： A method for the detection and evaluation of the light generated in a fluorescing specimen by a short pulse laser, wherein at least a first and a second fluorophore and/or a self-fluorescing specimen are separately irradiated with different wavelengths and the specimen light is recorded in a wavelength-dependent manner with at least one nondescanned detector as reference spectrum and a separation into individual spectra is carried out during the irradiation of at least two fluorophores and/or self-fluorescing specimens simultaneously from the measured spectrum and the reference spectra through regression analysis, wherein the wavelength of the short pulse laser is advantageously changed continuously in at least one wavelength region.
摘要翻译：一种用于通过短脉冲激光检测和评估在荧光样品中产生的光的方法，其中至少第一和第二荧光团和/或自发荧光样品被不同波长分开照射并且记录样本光以至少一个非扫描检测器作为参考光谱的波长依赖性方式，并且在从测量的光谱和参考光谱通过回归同时从至少两个荧光团和/或自发荧光样品的照射期间进行分离成单个光谱分析，其中短脉冲激光器的波长有利地在至少一个波长区域中连续地改变。

10. 发明申请

US20050032830A1 Ether substituted imidazopyridines 失效
标题翻译：醚取代的咪唑并吡啶
公开(公告)号：US20050032830A1
公开(公告)日：2005-02-10
申请号：US10916125
申请日：2004-08-11
申请人： Joseph Dellaria , Kyle Lindstrom , Luke Dressel , Daniel Duffy , Philip Heppner , John Jacobsen , Joan Moseman , William Moser , Matthew Radmer , Doris Stoermer , Bernhard Zimmermann
发明人： Joseph Dellaria , Kyle Lindstrom , Luke Dressel , Daniel Duffy , Philip Heppner , John Jacobsen , Joan Moseman , William Moser , Matthew Radmer , Doris Stoermer , Bernhard Zimmermann
IPC分类号： A61K31/437 , A61K31/444 , A61K31/506 , A61K31/5377 , A61P7/00 , A61P17/00 , A61P17/14 , A61P17/16 , A61P25/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07D471/04 , C07D471/14 , C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： Imidazopyridine compounds that contain an ether or thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
摘要翻译：在1位含有醚或硫醚官能团的咪唑并吡啶化合物可用作免疫应答调节剂。本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。还公开了制备可用于制备化合物的化合物和中间体的方法。

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