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1. 发明申请

US20070059781A1 System for size based separation and analysis 审中-公开
标题翻译：基于尺寸的分离和分析系统
公开(公告)号：US20070059781A1
公开(公告)日：2007-03-15
申请号：US11229336
申请日：2005-09-15
申请人： Ravi Kapur , Mehmet Toner , Lotion Huang , Tom Barber , Bruce Carvalho , Darren Gray
发明人： Ravi Kapur , Mehmet Toner , Lotion Huang , Tom Barber , Bruce Carvalho , Darren Gray
IPC分类号： G01N33/567 , G06F19/00 , C12M3/00
CPC分类号： B01L3/502753 , B01L3/502746 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2400/0409 , B01L2400/0472 , B01L2400/086 , B82Y15/00 , B82Y30/00 , G01N1/40 , G01N2035/00237
摘要： The invention relates to one or more size-based separation modules adapted to increase a concentration of a first analyte in a sample by at least 10,000 fold, wherein said first analyte has an initial concentration in said sample of less than 1×10−3 analytes/μL, and an analyzer for analyzing said first analytes in an enriched medium.
摘要翻译：本发明涉及一种或多种基于尺寸的分离模块，其适于将样品中的第一分析物的浓度增加至少10,000倍，其中所述第一分析物在所述样品中的初始浓度小于1×10 -3 分析物/ muL，以及用于分析富集介质中的所述第一分析物的分析器。

2. 发明申请

US20050282293A1 System for delivering a diluted solution 审中-公开
标题翻译：递送稀释溶液的系统
公开(公告)号：US20050282293A1
公开(公告)日：2005-12-22
申请号：US11071270
申请日：2005-03-03
申请人： Maury Cosman , Ravi Kapur , Bruce Carvalho , Tom Barber , Ulysses Balis , Mehmet Toner , Lotien Huang , Darren Gray
发明人： Maury Cosman , Ravi Kapur , Bruce Carvalho , Tom Barber , Ulysses Balis , Mehmet Toner , Lotien Huang , Darren Gray
IPC分类号： B01L3/00 , B01L3/14 , G01N1/10 , G01N1/14 , G01N1/38 , G01N35/10
CPC分类号： G01N1/14 , B01L3/5027 , B01L3/50825 , B01L2200/026 , G01N1/38 , G01N35/1095 , Y10T436/2575
摘要： The invention features methods and devices for the delivery of a fluid medium containing analytes, e.g., particles, solutes, or solvents, to an analytical device. The systems are designed to minimize contact with potentially hazardous, fragile, or valuable samples. The systems allow for the dilution, mixing, and introduction of the fluid medium to an analytical device, followed by possible further analysis or sample manipulation.
摘要翻译：本发明的特征在于将含有分析物例如颗粒，溶质或溶剂的流体介质输送到分析装置的方法和装置。这些系统旨在最大程度地减少与潜在的危险，易碎或有价值的样品的接触。该系统允许将流体介质稀释，混合和引入分析装置，随后进行可能的进一步分析或样品操作。

3. 发明申请

US20050266433A1 Magnetic device for isolation of cells and biomolecules in a microfluidic environment 审中-公开
标题翻译：用于在微流体环境中分离细胞和生物分子的磁性装置
公开(公告)号：US20050266433A1
公开(公告)日：2005-12-01
申请号：US11071679
申请日：2005-03-03
申请人： Ravi Kapur , Mehmet Toner , Bruce Carvalho , Tom Barber , Lotien Huang
发明人： Ravi Kapur , Mehmet Toner , Bruce Carvalho , Tom Barber , Lotien Huang
IPC分类号： B01L3/00 , C12M1/34 , C12Q1/68 , G01N33/53 , G01N33/543
CPC分类号： G01N33/54326 , B01L3/5027
摘要： The present invention features a new and useful magnetic device and methods of its use for isolation, enrichment, and purification of cells, proteins, DNA, and other molecules. In general the device includes magnetic regions or obstacles to which magnetic particles can bind. The chemical groups, i.e., capture moieties, on the surface of the magnetic particles may then be used to bind particles, e.g., cells, or molecules of interest from complex samples, and the bound species may then be selectively released for downstream collection or further analysis.
摘要翻译：本发明的特征在于一种新的有用的磁性装置及其用于细胞，蛋白质，DNA和其他分子的分离，富集和纯化的方法。通常，该装置包括磁性颗粒可以结合的磁性区域或障碍物。然后可以将磁性颗粒表面上的化学基团，即捕获部分用于结合来自复杂样品的颗粒，例如细胞或感兴趣的分子，然后可以选择性地释放结合的物质用于下游收集或进一步分析。

4. 发明申请

US20070026381A1 Devices and methods for enrichment and alteration of cells and other particles 有权
标题翻译：用于浓缩和改变细胞和其他颗粒的装置和方法
公开(公告)号：US20070026381A1
公开(公告)日：2007-02-01
申请号：US11449149
申请日：2006-06-08
申请人： Lotien Huang , Thomas Barber , Bruce Carvalho , Ravi Kapur , Paul Vernucci , Mehmet Toner , Zihua Wang
发明人： Lotien Huang , Thomas Barber , Bruce Carvalho , Ravi Kapur , Paul Vernucci , Mehmet Toner , Zihua Wang
IPC分类号： C12Q1/00 , C12M1/34
CPC分类号： B03C1/30 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/043 , B01L2400/0472 , B01L2400/0487 , B01L2400/086 , B03C1/32 , B03C2201/18 , B33Y80/00 , C12M47/04 , C12M47/06 , G01N1/40 , G01N1/4077 , G01N33/5044 , G01N2035/00237 , Y10T137/0318 , Y10T137/8593 , Y10T436/25 , Y10T436/25375
摘要： The invention features devices and methods for the deterministic separation of particles. Exemplary methods include the enrichment of a sample in a desired particle or the alteration of a desired particle in the device. The devices and methods are advantageously employed to enrich for rare cells, e.g., fetal cells, present in a sample, e.g., maternal blood and rare cell components, e.g., fetal cell nuclei. The invention further provides a method for preferentially lysing cells of interest in a sample, e.g., to extract clinical information from a cellular component, e.g., a nucleus, of the cells of interest. In general, the method employs differential lysis between the cells of interest and other cells (e.g., other nucleated cells) in the sample.
摘要翻译：本发明的特征在于确定性分离颗粒的装置和方法。示例性的方法包括在所需颗粒中富集样品或改变装置中所需的颗粒。该装置和方法有利地用于富集存在于样品中的稀有细胞，例如胎儿细胞，例如母体血液和稀有细胞成分，例如胎儿细胞核。本发明还提供了用于优先裂解样品中感兴趣的细胞的方法，例如从目的细胞的细胞组分（例如细胞核）提取临床信息。通常，该方法在样品中感兴趣的细胞和其他细胞（例如其他有核细胞）之间使用差异裂解。

5. 发明申请

US20060121624A1 Methods and systems for fluid delivery 审中-公开
标题翻译：流体输送的方法和系统
公开(公告)号：US20060121624A1
公开(公告)日：2006-06-08
申请号：US11227469
申请日：2005-09-15
申请人： Lotien Huang , Maury Cosman , Bruce Carvalho , Paul Vernucci , Ravi Kapur
发明人： Lotien Huang , Maury Cosman , Bruce Carvalho , Paul Vernucci , Ravi Kapur
IPC分类号： B01L3/00
CPC分类号： B01L3/0289 , B01F13/0059 , B01L3/5027 , B01L3/50825 , B01L2200/027 , B01L2400/0487 , G01N1/14 , G01N1/38 , G01N35/1095 , Y10T436/2575
摘要： The systems and methods herein involve the use of an automated, high-throughput system that utilizes pressure to transfer a fluid medium containing an analyte. In preferred embodiments, the sample is delivered to an analytical device. The sample can comprise one or more analytes, e.g., solvents, solutes, or particles, including rare cells. The systems are designed to minimize contact with potentially hazardous, fragile, or valuable samples. The systems allow for the dilution, mixing, and introduction of the fluid medium to an analytical device, followed by possible further analysis or sample manipulation. The systems and methods herein allow for partial or substantially complete depletion of a sample container to avoid wasting rare analytes or prevent retention of desired material in a first container.
摘要翻译：本文的系统和方法涉及使用自动化的高通量系统，其利用压力来传送含有分析物的流体介质。在优选的实施方案中，样品被递送到分析装置。样品可以包含一种或多种分析物，例如溶剂，溶质或颗粒，包括稀有细胞。这些系统旨在最大程度地减少与潜在的危险，易碎或有价值的样品的接触。该系统允许将流体介质稀释，混合和引入分析装置，随后进行可能的进一步分析或样品操作。这里的系统和方法允许样品容器的部分或基本上完全的耗尽，以避免浪费罕见的分析物或防止将所需材料保留在第一容器中。

6. 发明申请

US20060194264A1 Affinity based system for detecting particulates in a fluid 审中-公开
标题翻译：用于检测流体中的微粒的基于亲和性的系统
公开(公告)号：US20060194264A1
公开(公告)日：2006-08-31
申请号：US11247080
申请日：2005-10-11
申请人： Norman Sheppard , Alec Mian , Gregory Kellogg , Stephen Kieffer-Higgins , Bruce Carvalho
发明人： Norman Sheppard , Alec Mian , Gregory Kellogg , Stephen Kieffer-Higgins , Bruce Carvalho
IPC分类号： G01N33/542 , C12M1/34
CPC分类号： G01N35/00069 , A61K38/00 , B01F13/0059 , B01F15/0233 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/00 , B01L2200/0605 , B01L2200/10 , B01L2300/021 , B01L2300/024 , B01L2300/069 , B01L2300/0806 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/168 , B01L2300/1805 , B01L2300/1861 , B01L2400/0406 , B01L2400/0409 , B01L2400/0661 , B01L2400/0677 , C07K14/79 , C12N9/2462 , G01N15/14 , G01N21/07 , G01N33/54366 , G01N33/569 , G01N33/68 , Y10S366/03 , Y10T436/111666 , Y10T436/25375 , Y10T436/2575
摘要： This invention provides methods and apparatus for detecting and quantifying particulate matter suspended in a fluid. Specifically, the invention provides an integrated, affinity-binding based, analytical system comprising a platform for performing an affinity-binding based assay for specifically binding particulates including microbial cells, and a detection means for detecting the particulates specifically bound to a defined surface or chamber comprising the platform. Methods for using the analytical systems of the invention are also provided.
摘要翻译：本发明提供了用于检测和定量悬浮在流体中的颗粒物质的方法和装置。具体地，本发明提供了一种基于亲和力结合的集成分析系统，其包括用于进行用于特异性结合包含微生物细胞的微粒的基于亲和力结合的测定的平台和用于检测特异性结合到限定表面或室的微粒的检测装置包括平台。还提供了使用本发明的分析系统的方法。

7. 发明授权

US08506908B2 Electrochemical detection system 有权
标题翻译：电化学检测系统
公开(公告)号：US08506908B2
公开(公告)日：2013-08-13
申请号：US12045611
申请日：2008-03-10
申请人： Jim Benn , Bruce Carvalho , Andy Gover , Roger Morris
发明人： Jim Benn , Bruce Carvalho , Andy Gover , Roger Morris
IPC分类号： G01N27/26 , G01N27/00 , G01N33/00 , G01N27/30 , A61J1/06 , C25B9/00 , C12M3/00 , G01N21/00 , G01N21/75 , G01N1/00 , B01D61/00
CPC分类号： G01N35/00029 , B01L2300/0645 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/123 , B01L2400/0481 , G01N2035/00148 , G01N2035/00158 , G01N2035/00881
摘要： An electrochemical detection system having a disposable cartridge capable of performing a plurality of assay protocols is disclosed. The cartridge includes a blister pack for the long-term storage and controlled release of multiple reagents. The blister pack is bonded to and operatively associated with a fluidic backbone for providing the fluid pathways, storage capacity, and fluid control functions for performing multiple assay protocols. The cartridge further includes a plurality of sensors having a multiple electrode arrangement in operative association with a respective flow cell defined by the fluidic backbone. After the user has transferred a sample into the cartridge and engaged the cartridge to the reader, the reader operatively interfaces with the cartridge such that different assay protocols may be simultaneously performed in isolation from one another inside the cartridge. The reader may be one of many readers that operatively communicate data to a remote server for processing.
摘要翻译：公开了具有能够执行多个测定方案的一次性盒的电化学检测系统。墨盒包括用于长期储存和控制释放多种试剂的泡罩包装。泡罩包装物与流体主链结合并可操作地连接，用于提供用于执行多个测定方案的流体路径，储存容量和流体控制功能。墨盒还包括多个传感器，其具有与由流体主链限定的相应流动池有效关联的多个电极布置。在用户已经将样品转移到盒中并将盒与接纸盒接合到阅读器之后，读取器与盒可操作地连接，使得可以在盒内彼此隔离地同时执行不同的测定方案。读者可能是许多阅读器之一，可操作地将数据传输到远程服务器进行处理。

8. 发明申请

US20080217246A1 ELECTROCHEMICAL DETECTION SYSTEM 有权
标题翻译：电化学检测系统
公开(公告)号：US20080217246A1
公开(公告)日：2008-09-11
申请号：US12045611
申请日：2008-03-10
申请人： Jim Benn , Bruce Carvalho , Andy Gover , Roger Morris
发明人： Jim Benn , Bruce Carvalho , Andy Gover , Roger Morris
IPC分类号： G01N33/50 , B05D5/12 , B32B37/28
CPC分类号： G01N35/00029 , B01L2300/0645 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/123 , B01L2400/0481 , G01N2035/00148 , G01N2035/00158 , G01N2035/00881
摘要： An electrochemical detection system having a disposable cartridge capable of performing a plurality of assay protocols is disclosed. The cartridge includes a blister pack for the long-term storage and controlled release of multiple reagents. The blister pack is bonded to and operatively associated with a fluidic backbone for providing the fluid pathways, storage capacity, and fluid control functions for performing multiple assay protocols. The cartridge further includes a plurality of sensors having a multiple electrode arrangement in operative association with a respective flow cell defined by the fluidic backbone. After the user has transferred a sample into the cartridge and engaged the cartridge to the reader, the reader operatively interfaces with the cartridge such that different assay protocols may be simultaneously performed in isolation from one another inside the cartridge. The reader may be one of many readers that operatively communicate data to a remote server for processing.
摘要翻译：公开了具有能够执行多个测定方案的一次性盒的电化学检测系统。墨盒包括用于长期储存和控制释放多种试剂的泡罩包装。泡罩包装物与流体主链结合并可操作地连接，用于提供用于执行多个测定方案的流体路径，储存容量和流体控制功能。墨盒还包括多个传感器，其具有与由流体主链限定的相应流动池有效关联的多个电极布置。在用户已经将样品转移到盒中并将盒与接纸盒接合到阅读器之后，读取器与盒可操作地连接，使得可以在盒内彼此隔离地同时执行不同的测定方案。读者可能是许多阅读器之一，可操作地将数据传输到远程服务器进行处理。

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